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    Synopsis

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    Chemistry

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    Also known as: 124-90-3, Oxycodone hcl, Oxecta, Oxycontin, Endocodone, Roxicodone
    Molecular Formula
    C18H22ClNO4
    Molecular Weight
    351.8  g/mol
    InChI Key
    MUZQPDBAOYKNLO-RKXJKUSZSA-N
    FDA UNII
    C1ENJ2TE6C
    Oxycodone Hydrochloride
    A semisynthetic derivative of CODEINE.
    1 2D Structure

    Oxycodone Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C18H21NO4.ClH/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10;/h3-4,13,16,21H,5-9H2,1-2H3;1H/t13-,16+,17+,18-;/m1./s1
    2.1.3 InChI Key
    MUZQPDBAOYKNLO-RKXJKUSZSA-N
    2.1.4 Canonical SMILES
    CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)OC)O4)O.Cl
    2.1.5 Isomeric SMILES
    CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    C1ENJ2TE6C
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dihydrohydroxycodeinone

    2. Dihydrone

    3. Dinarkon

    4. Eucodal

    5. Oxiconum

    6. Oxycodeinon

    7. Oxycodone

    8. Oxycone

    9. Oxycontin

    10. Pancodine

    11. Theocodin

    2.3.2 Depositor-Supplied Synonyms

    1. 124-90-3

    2. Oxycodone Hcl

    3. Oxecta

    4. Oxycontin

    5. Endocodone

    6. Roxicodone

    7. Oxycodone Hydrochloride Cii

    8. Chebi:7859

    9. 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride

    10. (4r,4as,7ar,12bs)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride

    11. (4r,4as,7ar,12bs)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydron;chloride

    12. Roxicodone (tn)

    13. Oxycontin (tn)

    14. (4r,4as,7ar,12bs)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride

    15. Oxecta (tn)

    16. Roxybond

    17. Oxycodone Monohydrochloride

    18. Schembl30095

    19. Oxycodone Hydrochloride (usp)

    20. Chembl1200890

    21. Dtxsid80924674

    22. Oxycodone Hydrochloride [mi]

    23. Oxycodone Hydrochloride [usan]

    24. Akos024457896

    25. Oxycodone Hydrochloride [mart.]

    26. Oxycodone Hydrochloride [vandf]

    27. Anhydrous Oxycodone Hydrochloride

    28. Oxycodone Hydrochloride [who-dd]

    29. Oxycodone Hydrochloride, Analytical Standard

    30. Oxycodone Hydrochloride [orange Book]

    31. Oxycodone Hydrochloride Cii [usp-rs]

    32. Oxycodone Hydrochloride [ep Monograph]

    33. Tylox Component Oxycodone Hydrochloride

    34. C08026

    35. Codoxy Component Oxycodone Hydrochloride

    36. D00847

    37. Oxycet Component Oxycodone Hydrochloride

    38. Oxycodone Hydrochloride [usp Monograph]

    39. Roxicet Component Oxycodone Hydrochloride

    40. Roxilox Component Oxycodone Hydrochloride

    41. Troxyca Component Oxycodone Hydrochloride

    42. Combunox Component Oxycodone Hydrochloride

    43. Oxycodone Hydrochloride Component Of Tylox

    44. Percocet Component Oxycodone Hydrochloride

    45. Percodan Component Oxycodone Hydrochloride

    46. Roxiprin Component Oxycodone Hydrochloride

    47. Targiniq Component Oxycodone Hydrochloride

    48. Xartemis Component Oxycodone Hydrochloride

    49. Oxycodone Hydrochloride Component Of Codoxy

    50. Oxycodone Hydrochloride Component Of Oxycet

    51. Oxycodone Hydrochloride Component Of Roxicet

    52. Oxycodone Hydrochloride Component Of Roxilox

    53. Oxycodone Hydrochloride Component Of Troxyca

    54. Oxycodone Hydrochloride Component Of Combunox

    55. Oxycodone Hydrochloride Component Of Percocet

    56. Oxycodone Hydrochloride Component Of Percodan

    57. Oxycodone Hydrochloride Component Of Roxiprin

    58. Oxycodone Hydrochloride Component Of Targiniq

    59. Oxycodone Hydrochloride Component Of Xartemis

    60. Percodan-demi Component Oxycodone Hydrochloride

    61. Q27107601

    62. Oxycodone Hydrochloride Component Of Percodan-demi

    63. 14-hydroxy-3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one Hydrochloride

    64. Oxycodone Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    65. Oxycodone Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    66. (5?)-4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride

    67. (5alpha,17s)-14-hydroxy-3-methoxy-17-methyl-6-oxo-4,5-epoxymorphinan-17-ium Chloride

    68. 4,5.alpha.-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride

    69. Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, Hydrochloride, (5.alpha.)-

    70. Oxycodone Hydrochloride Solution, 1.0 Mg/ml In Methanol, Analytical Standard, For Drug Analysis

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 351.8 g/mol
    Molecular Formula C18H22ClNO4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count1
    Exact Mass351.1237359 g/mol
    Monoisotopic Mass351.1237359 g/mol
    Topological Polar Surface Area59 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity553
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameOxecta
    Drug LabelOXECTA (oxycodone HCl, USP) tablets are an immediate-release opioid analgesic intended for oral administration only. OXECTA contains oxycodone HCl, USP as the active analgesic ingredient. The tablets are round, convex, white and debossed with the str...
    Active IngredientOxycodone hydrochloride
    Dosage FormTablet
    RouteOral
    Strength7.5mg; 5mg
    Market StatusPrescription
    CompanyAcura Pharms

    2 of 4  
    Drug NameOxycodone hydrochloride
    Drug LabelDESCRIPTIONOxyContin (oxycodone hydrochloride controlled-release) Tablets are an opioid analgesic supplied in 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg, and 160 mg tablet strengths for oral administration...
    Active IngredientOxycodone hydrochloride
    Dosage FormTablet, extended release; Tablet; Capsule; Solution
    Routeoral; Oral
    Strength30mg; 100mg/5ml; 15mg; 5mg; 10mg; 5mg/5ml; 80mg; 40mg; 20mg
    Market StatusTentative Approval; Prescription
    CompanyCorepharma; Vintage Pharms; Amneal Pharms; Impax Pharms; Aurolife Pharma; Avanthi; Teva; Endo Pharms; Sun Pharm Inds; Coastal Pharms; Rhodes Pharms; Mallinckrodt; Roxane; Lannett Holdings; Nesher Pharms; Vistapharm; Actavis Elizabeth; Lehigh Valley; Alvog

    3 of 4  
    Drug NameOxecta
    Drug LabelOXECTA (oxycodone HCl, USP) tablets are an immediate-release opioid analgesic intended for oral administration only. OXECTA contains oxycodone HCl, USP as the active analgesic ingredient. The tablets are round, convex, white and debossed with the str...
    Active IngredientOxycodone hydrochloride
    Dosage FormTablet
    RouteOral
    Strength7.5mg; 5mg
    Market StatusPrescription
    CompanyAcura Pharms

    4 of 4  
    Drug NameOxycodone hydrochloride
    Drug LabelDESCRIPTIONOxyContin (oxycodone hydrochloride controlled-release) Tablets are an opioid analgesic supplied in 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg, and 160 mg tablet strengths for oral administration...
    Active IngredientOxycodone hydrochloride
    Dosage FormTablet, extended release; Tablet; Capsule; Solution
    Routeoral; Oral
    Strength30mg; 100mg/5ml; 15mg; 5mg; 10mg; 5mg/5ml; 80mg; 40mg; 20mg
    Market StatusTentative Approval; Prescription
    CompanyCorepharma; Vintage Pharms; Amneal Pharms; Impax Pharms; Aurolife Pharma; Avanthi; Teva; Endo Pharms; Sun Pharm Inds; Coastal Pharms; Rhodes Pharms; Mallinckrodt; Roxane; Lannett Holdings; Nesher Pharms; Vistapharm; Actavis Elizabeth; Lehigh Valley; Alvog

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Analgesics, Opioid

    Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

    Narcotics

    Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Opioid Agonist [EPC]; Full Opioid Agonists [MoA]

    API Reference Price

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    [{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1672079400,"product":"OXYCODONE HYDROCHLORIDE API-EP-0-0-0","address":"A-43, GROUND FLOOR G.T.KARNAL ROAD INDUSTRIAL AREA,","city":"NEW DELHI","supplier":"WOOD & COMPANY FINANCIAL SERVICES","supplierCountry":"SLOVAKIA","foreign_port":"NA","customer":"VENOR PHARMA LIMITED","customerCountry":"INDIA","quantity":"2.04","actualQuantity":"2.04","unit":"KGS","unitRateFc":"1426","totalValueFC":"3166.5","currency":"EUR","unitRateINR":"127912.2","date":"27-Dec-2022","totalValueINR":"260940.89","totalValueInUsd":"3166.5","indian_port":"DELHI AIR","hs_no":"29391100","bill_no":"3922566","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVAK REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"A-43, GROUND FLOOR G.T.KARNAL ROAD INDUSTRIAL AREA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728066600,"product":"OXYCODONE HYDROCHLORIDE","address":"MSN HOUSE, PLOT NO. C-24,","city":"HYDERABAD. AP","supplier":"WELDING GMBH & CO.KG","supplierCountry":"GERMANY","foreign_port":"HAMBURG - FUHLSBUETT","customer":"MSN LABORATORIES","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"2630","totalValueFC":"2950","currency":"EUR","unitRateINR":"247877.5","date":"05-Oct-2024","totalValueINR":"247877.5","totalValueInUsd":"2950","indian_port":"Madras Air","hs_no":"29391900","bill_no":"5964294","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"HAMBURG - FUHLSBUETT","supplierAddress":"POST BOX 3058 40 20318 HAMBURG ESPLANADE 39.20354 HAMBURG GERMANY DE","customerAddress":"MSN HOUSE, PLOT NO. C-24,"}]
    27-Dec-2022
    05-Oct-2024
    KGS
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    (USD/KGS)    		 Number of Transactions

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    DOSAGE - CAPSULE;ORAL - 5MG

    USFDA APPLICATION NUMBER - 200534

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    DOSAGE - SOLUTION;ORAL - 100MG/5ML

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    DOSAGE - TABLET;ORAL - 7.5MG

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 325M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 204031

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 13....DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 13.5MG

    USFDA APPLICATION NUMBER - 208090

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 18M...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 18MG

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 27M...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 27MG

    USFDA APPLICATION NUMBER - 208090

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 36M...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 36MG

    USFDA APPLICATION NUMBER - 208090

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 9MG

    USFDA APPLICATION NUMBER - 208090

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 10MG

    USFDA APPLICATION NUMBER - 22272

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 15MG

    USFDA APPLICATION NUMBER - 22272

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 20MG

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 30MG

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 40MG

    USFDA APPLICATION NUMBER - 22272

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 60MG

    USFDA APPLICATION NUMBER - 22272

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 80MG

    USFDA APPLICATION NUMBER - 22272

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    DOSAGE - TABLET;ORAL - 325MG;5MG

    USFDA APPLICATION NUMBER - 87003

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