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Chemistry

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Also known as: 2315-02-8, Oxymetazoline hcl, Ocuclear, Afrazine, Afrin hydrochloride, Sch 9384
Molecular Formula
C16H25ClN2O
Molecular Weight
296.83  g/mol
InChI Key
BEEDODBODQVSIM-UHFFFAOYSA-N
FDA UNII
K89MJ0S5VY

Oxymetazoline Hydrochloride
A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
1 2D Structure

Oxymetazoline Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol;hydrochloride
2.1.2 InChI
InChI=1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1H
2.1.3 InChI Key
BEEDODBODQVSIM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C.Cl
2.2 Other Identifiers
2.2.1 UNII
K89MJ0S5VY
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Hydrochloride, Oxymetazoline

2. Oxymetazoline

2.3.2 Depositor-Supplied Synonyms

1. 2315-02-8

2. Oxymetazoline Hcl

3. Ocuclear

4. Afrazine

5. Afrin Hydrochloride

6. Sch 9384

7. Rhofade

8. Oxymetazoline (hydrochloride)

9. Visine L.r.

10. Vicks Sinex

11. Nsc-757254

12. K89mj0s5vy

13. 6-tert-butyl-3-(4,5-dihydro-1h-imidazol-2-ylmethyl)-2,4-dimethylphenol;hydrochloride

14. Mls000038040

15. Chebi:7863

16. Agn-199201

17. Sch-9384

18. Smr000059324

19. 2-(4-t-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolinium Chloride

20. 2,6-dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazoline Hydrochloride

21. 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Monohydrochloride

22. 6-tert-butyl-3-(4,5-dihydro-1h-imidazol-2-ylmethyl)-2,4-dimethylphenol Hydrochloride

23. Phenol, 3-((4,5-dihydro-1h-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-, Monohydrochloride

24. 2-(3-hydroxy-2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline

25. Lliadine

26. Nasivin

27. Nasivine

28. Neonabel

29. Nostrilla

30. Nafrine Hydrochloride

31. 4-way Nasal Spray

32. Duration Nasal Spray

33. Oxymetazoline Chloride

34. Lliadin Mini Paediatric

35. Sr-01000002705

36. Neo-synephrine 12 Hour

37. Neo-synephrine 12 Hour Ntz

38. Sinex

39. Anefrin Nasal

40. Duration 12 Hour Nasal Spray

41. Benzedrex Nasal Spray 12 Hour

42. Dristan Long Lasting Nasal Mist

43. Sudafed Om

44. Ocuclear (tn)

45. Prestwick_373

46. Einecs 219-015-0

47. St. Joseph Nasal Spray For Children

48. Mfcd00058147

49. Rhfade (tn)

50. Upneeq

51. Opera_id_32

52. 2-(3-hydroxy-2,6-dimethyl-4-t-butylbenzyl)-2-imidazoline Hydrochloride

53. Unii-k89mj0s5vy

54. 3-[(4,5-dihydro-

55. Schembl41247

56. Mls002222207

57. Spectrum1500453

58. Oxymetazoline Hydrochloride,(s)

59. Chembl1200791

60. Hy-b0427a

61. Dtxsid80177729

62. Oximetazoline Hydrochloride

63. Hms1568n09

64. Hms1920d18

65. Pharmakon1600-01500453

66. Tox21_500903

67. Ccg-40216

68. Nsc757254

69. 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Hydrochloride

70. Akos000280887

71. Oxymetazoline Hydrochloride (jan/usp)

72. Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-, Hydrochloride

73. Ks-5222

74. Lp00903

75. Nsc 757254

76. Oxymetazoline Hydrochloride [mi]

77. Ncgc00094218-01

78. Ncgc00094218-02

79. Ncgc00094218-03

80. Ncgc00094218-04

81. Ncgc00094218-05

82. Ncgc00261588-01

83. Oxymetazoline Hydrochloride [jan]

84. 2315-02-8 (hcl)

85. Oxymetazoline Hydrochloride [usan]

86. Oxymetazoline Hydrochloride [mart.]

87. Oxymetazoline Hydrochloride [vandf]

88. 4-(2-boc-amino-pyridin-4-yl)-benzoicacid

89. Oxymetazoline Hydrochloride [who-dd]

90. Oxymetazoline Hydrochloride, >=99%, Solid

91. Eu-0100903

92. Ft-0673462

93. O0520

94. Oxymetazoline Hydrochloride [usan:usp:jan]

95. Sw196632-3

96. D01022

97. D91882

98. O 2378

99. Oxymetazoline Hydrochloride, Analytical Standard

100. Oxymetazoline Hydrochloride [orange Book]

101. 315o028

102. A910982

103. Oxymetazoline Hydrochloride [ep Monograph]

104. Oxymetazoline Hydrochloride [usp Impurity]

105. Oxymetazoline Hydrochloride [usp Monograph]

106. Kovanaze Component Oxymetazoline Hydrochloride

107. Sr-01000002705-2

108. Sr-01000002705-4

109. Sr-01000002705-7

110. W-107424

111. Q27107602

112. Oxymetazoline Hydrochloride Component Of Kovanaze

113. Sinex Vapospray Moisturizing 12-hour Decongestant Ultrafine Mist

114. 2,6-dimethyl-4-tertiarybutyl-3-hydroxyphenyl)methylimidazoline Hydrochloride

115. 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolinium Chloride

116. 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Hydrochloride

117. Oxymetazoline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

118. 1h-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol Hydrochloride

119. 2-(3-hydroxy-2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline Hydrochloride

120. 2-(4-tert-butyl-3-hydroxy-2,6-dimethylbenzyl)-4,5-dihydro-1h-imidazol-1-ium Chloride

121. 6-(tert-butyl)-3-((4,5-dihydro-1h-imidazol-2-yl)methyl)-2,4-dimethylphenol Hydrochloride

122. 6-tert-butyl-3-((4,5-dihydro-1h-imidazol-2-yl)methyl)-2,4-dimethylphenol Hydrochloride

123. Oxymetazoline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

124. Oxymetazoline Hydrochloride, United States Pharmacopeia (usp) Reference Standard

125. 3-[(4,5-dihydro-1h-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-phenol Hydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 296.83 g/mol
Molecular Formula C16H25ClN2O
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass296.1655411 g/mol
Monoisotopic Mass296.1655411 g/mol
Topological Polar Surface Area44.6 Ų
Heavy Atom Count20
Formal Charge0
Complexity345
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Nasal Decongestants

Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)


Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Adrenergic alpha-Agonists

Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)


4.2 FDA Pharmacological Classification
4.2.1 Pharmacological Classes
Increased Sympathetic Activity [PE]; Vasoconstriction [PE]; Vasoconstrictor [EPC]; Imidazolines [CS]

API Reference Price

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K","customer":"AS PER INVOICE","customerCountry":"UNITED STATES","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"1375","totalValueFC":"6774.4","currency":"USD","unitRateINR":113539.84,"date":"26-Sep-2024","totalValueINR":"567699.2","totalValueInUsd":"6774.4","indian_port":"Bombay Air","hs_no":"29332990","bill_no":"4351560","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"SURVEY NO.91, OPP.NAVIN FLOURINE, SURAT\/GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727289000,"product":"OXYMETAZOLINE HYDROCHLORIDE USP-B\/N OXY0021223, PHARMACEUTICAL BULK DRUGS ALLOPATHIC HARMLESS RAW MATERIAL IN POWDER FOR","address":"337 & 338, Commodity Exchange Building","city":"Vashi","supplier":"G-RISH PHARMA PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"BUENAVENTURA","customer":"TO THE ORDER OF","customerCountry":"COLOMBIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"995","totalValueFC":"1872.5","currency":"USD","unitRateINR":78460.5,"date":"26-Sep-2024","totalValueINR":"156921","totalValueInUsd":"1872.5","indian_port":"Bombay Air","hs_no":"29332990","bill_no":"4344917","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"COLOMBIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"337 & 338, Commodity Exchange Building, Vashi","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1687717800,"product":"OXYMETAZOLINE HYDROCHLORIDE USP","address":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE","city":"AHMEDABAD","supplier":"SIEGFRIED AG","supplierCountry":"GERMANY","foreign_port":"NA","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"7000","totalValueFC":"7707.2","currency":"EUR","unitRateINR":"633499.8","date":"26-Jun-2023","totalValueINR":"633499.832","totalValueInUsd":"7707.2","indian_port":"BOMBAY AIR","hs_no":"29332990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE"}]
10-Jan-2021
26-Sep-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

Upgrade, download data, analyse, strategize, subscribe with us contact

Europe

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01

Farmak JSC

Ukraine
SupplySide West 2024
Not Confirmed
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Farmak JSC

Ukraine
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SupplySide West 2024
Not Confirmed

Oxymetazoline

Brand Name : Rinazoline

Dosage Form : Nasal Spray

Dosage Strength : 0.5MG/ML

Packaging : 15ML

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Ukraine

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02

GlaxoSmithKline Consumer

United Kingdom
SupplySide West 2024
Not Confirmed
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GlaxoSmithKline Consumer

United Kingdom
arrow
SupplySide West 2024
Not Confirmed

oxymetazoline hydrochloride

Brand Name : Nasin

Dosage Form : NASAL SPRAY, SOLUTION

Dosage Strength : 0.25 MG / ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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03

GlaxoSmithKline Consumer

United Kingdom
SupplySide West 2024
Not Confirmed
arrow

GlaxoSmithKline Consumer

United Kingdom
arrow
SupplySide West 2024
Not Confirmed

oxymetazoline hydrochloride

Brand Name : Nezeril

Dosage Form : NASAL DROPS, SOLUTION IN SINGLE-DOSE CONTAINERS

Dosage Strength : 0.5 MG / ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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04

GlaxoSmithKline Consumer

United Kingdom
SupplySide West 2024
Not Confirmed
arrow

GlaxoSmithKline Consumer

United Kingdom
arrow
SupplySide West 2024
Not Confirmed

oxymetazoline hydrochloride

Brand Name : Nezeril

Dosage Form : NASAL SPRAY, SOLUTION

Dosage Strength : 0.5 MG / ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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05

SupplySide West 2024
Not Confirmed
arrow
arrow
SupplySide West 2024
Not Confirmed

oxymetazoline hydrochloride

Brand Name : Iliadin

Dosage Form : NASAL DROPS, SOLUTION

Dosage Strength : 0.1 MG / ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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06

SupplySide West 2024
Not Confirmed
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arrow
SupplySide West 2024
Not Confirmed

Oxymetazoline hydrochloride

Brand Name : Nasivin Pur

Dosage Form : Metered Spray

Dosage Strength : 0.01%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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07

SupplySide West 2024
Not Confirmed
arrow
arrow
SupplySide West 2024
Not Confirmed

Oxymetazoline

Brand Name :

Dosage Form : NASAL SPRAY

Dosage Strength : 0.01%

Packaging : 10 Ml/Bottle

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : Turkey

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08

CCS Healthcare AB

Country
SupplySide West 2024
Not Confirmed
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CCS Healthcare AB

Country
arrow
SupplySide West 2024
Not Confirmed

oximetazolinhydroklorid

Brand Name : Oxidropz

Dosage Form : NÄSDROPPAR, LÖSNING I ENDOSBEHÅLLARE

Dosage Strength : 0,1 MG/ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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09

CCS Healthcare AB

Country
SupplySide West 2024
Not Confirmed
arrow

CCS Healthcare AB

Country
arrow
SupplySide West 2024
Not Confirmed

oximetazolinhydroklorid

Brand Name : Oxidropz

Dosage Form : NÄSDROPPAR, LÖSNING I ENDOSBEHÅLLARE

Dosage Strength : 0,25 MG/ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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10

WICK Pharma

Country
SupplySide West 2024
Not Confirmed
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WICK Pharma

Country
arrow
SupplySide West 2024
Not Confirmed

oximetazolinhydroklorid

Brand Name : Vicks Sinex

Dosage Form : NÄSSPRAY, LÖSNING

Dosage Strength : 0,5 MG/ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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South Africa

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01

arrow
World Vaccine Congress
Not Confirmed

Oxymetazoline hydrochloride

Brand Name : Oxylin Liquifilm Sterile Ophthalmic Solution

Dosage Form : OPD

Dosage Strength : 5mg/ml

Packaging : 15X1mg/ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

Abbvie Company Banner

02

Bayer (Pty) Ltd

Germany
World Vaccine Congress
Not Confirmed
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Bayer (Pty) Ltd

Germany
arrow
World Vaccine Congress
Not Confirmed

Oxymetazoline Hydrochloride

Brand Name : Drixine 0.05% Adult

Dosage Form : NSS

Dosage Strength : 40mg

Packaging : 20X1mg/ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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03

Bayer (Pty) Ltd

Germany
World Vaccine Congress
Not Confirmed
arrow

Bayer (Pty) Ltd

Germany
arrow
World Vaccine Congress
Not Confirmed

Oxymetazoline Hydrochloride

Brand Name : Drixine 0.05% Adult

Dosage Form : NAS

Dosage Strength : 200mg

Packaging : 20X1mg/ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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04

World Vaccine Congress
Not Confirmed
arrow
arrow
World Vaccine Congress
Not Confirmed

Oxymetazoline

Brand Name : Drixine 0.025% Paediatric

Dosage Form : NAS

Dosage Strength : 5mg/ml

Packaging : 1X1mg/ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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05

World Vaccine Congress
Not Confirmed
arrow
arrow
World Vaccine Congress
Not Confirmed

Oxymetazoline

Brand Name : Dristan Long Lasting Vapour Nasal Spray (Squeeze spray bottle)

Dosage Form : NAS

Dosage Strength : 100mg

Packaging : 15X1mg/g

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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06

World Vaccine Congress
Not Confirmed
arrow
arrow
World Vaccine Congress
Not Confirmed

Oxymetazoline

Brand Name : Dristan Long Lasting Vapour Nasal Spray (Metered Pump Spray)

Dosage Form : NAS

Dosage Strength : 40mg

Packaging : 15X1mg/g

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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07

World Vaccine Congress
Not Confirmed
arrow
arrow
World Vaccine Congress
Not Confirmed

Oxymetazoline Hcl

Brand Name : Iliadin Nasal Spray 0.05%

Dosage Form : NAS

Dosage Strength : 15mg/30 ml

Packaging : 20X1mg/ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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08

Sandoz SA (Pty) Ltd

Switzerland
World Vaccine Congress
Not Confirmed
arrow

Sandoz SA (Pty) Ltd

Switzerland
arrow
World Vaccine Congress
Not Confirmed

Oxymetazoline hydrochloride

Brand Name : ZADIN 0,05% Nasal Drops

Dosage Form : DRO

Dosage Strength : 250mg

Packaging : 10X1mg/ml

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

blank

09

Sandoz SA (Pty) Ltd

Switzerland
World Vaccine Congress
Not Confirmed
arrow

Sandoz SA (Pty) Ltd

Switzerland
arrow
World Vaccine Congress
Not Confirmed

Oxymetazoline hydrochloride

Brand Name : ZADIN 0,025% Nasal Spray

Dosage Form : NAS

Dosage Strength : 250mg

Packaging : 10X1mg/ml

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

blank

10

Sandoz SA (Pty) Ltd

Switzerland
World Vaccine Congress
Not Confirmed
arrow

Sandoz SA (Pty) Ltd

Switzerland
arrow
World Vaccine Congress
Not Confirmed

Oxymetazoline hydrochloride

Brand Name : ZADIN 0,05% Nasal Spray

Dosage Form : NAS

Dosage Strength : 250mg

Packaging : 10X1mg/ml

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

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Thickeners and Stabilizers

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Controlled & Modified Release

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Taste Masking

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Emulsifying Agents

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Surfactant & Foaming Agents

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API Stability Enhancers

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Chewable & Orodispersible Aids

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Lubricants & Glidants

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Empty Capsules

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