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Oxymetazoline Hydrochloride

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ACTIVE PHARMA INGREDIENTS

11 API Suppliers, 4 USDMF, 2 CEP/COS, 1 JDMF, 1 EU WC, 7 NDC API, 9 Listed Suppliers, $ API Reference Price

11 API Suppliers
4 USDMF
2 CEP/COS
1 JDMF
1 EU WC
7 NDC API
9 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

11 Drugs in Development

11 Drugs in Development

FINISHED DOSAGE FORMULATIONS

84 FDF Dossiers, 7 FDA Orange Book, 25 Europe, 14 Canada, 4 Australia, 30 South Africa, 4 Listed Dossiers

84 FDF Dossiers
7 FDA Orange Book
25 Europe
14 Canada
4 Australia
30 South Africa
4 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Evonik, 4 Rochem International Inc, 4 SPI Pharma, 2 Seqens, 6 DKSH, 1 Pharm-RX Chemical, 1 Faran Shimi Pharmaceutical, 6 Boai NKY Pharmaceuticals Ltd, 10 Gangwal Healthcare, 10 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 17 Actylis, 2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 27 BASF, 3 Clariant, 10 Corel Pharma Chem, 1 Curia, 2 DFE Pharma, 4 Finar, 9 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 15 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 7 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 2 Novo Excipients, 2 Pharmatrans-Sanaq, 2 Pluviaendo, 1 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 18 Roquette, 15 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 8 Sigachi Industries, 3 The Dow Chemical Company, 2 Ulanqab Kema New Material, 1 Valens Pharmachem, 1 Vasa Pharmachem, 1 Zhejiang Huakang Pharmaceutical

relatedExcipients
1 Evonik
4 Rochem International Inc
4 SPI Pharma
2 Seqens
6 DKSH
1 Pharm-RX Chemical
1 Faran Shimi Pharmaceutical
6 Boai NKY Pharmaceuticals Ltd
10 Gangwal Healthcare
10 Nanjing Well Pharmaceutical
1 ACG Worldwide
17 Actylis
2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
27 BASF
3 Clariant
10 Corel Pharma Chem
1 Curia
2 DFE Pharma
4 Finar
9 Gangwal Chemicals
5 Ideal Cures Pvt Ltd
15 Kerry
4 Kima Chemical
6 Lonza Capsugel
7 Microlex e.U
1 Nanjing Bold Chemical
2 Nomisma Healthcare
2 Novo Excipients
2 Pharmatrans-Sanaq
2 Pluviaendo
1 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
1 Qualicaps
18 Roquette
15 Seppic
3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
8 Sigachi Industries
3 The Dow Chemical Company
2 Ulanqab Kema New Material
1 Valens Pharmachem
1 Vasa Pharmachem
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

49 Coating Systems & Additives, 39 Topical, 37 Thickeners and Stabilizers, 37 Fillers, Diluents & Binders, 36 Solubilizers, 29 Controlled & Modified Release, 25 Parenteral, 25 Film Formers & Plasticizers, 21 Direct Compression, 14 Rheology Modifiers, 14 Co-Processed Excipients, 14 Granulation, 10 Taste Masking, 9 Disintegrants & Superdisintegrants, 8 Emulsifying Agents, 7 Surfactant & Foaming Agents, 7 API Stability Enhancers, 5 Chewable & Orodispersible Aids, 5 Lubricants & Glidants, 5 Empty Capsules, 4 Vegetarian Capsules, 2 Coloring Agents, 1 Soft Gelatin

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 23 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
23 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 3 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
3 Finished Drug Prices

MARKET PLACE

17 APIs, 1 FDF Dossiers

marketPlace
17 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

22 US Patents

patents
22 US Patents

REF. STANDARDS & IMPURITIES

2 EDQM , 2 USP , 3 Others

otherSolutions
2 EDQM
2 USP
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 1,184

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

11DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

2,723,415

Annual Reports (USD Million)

Finished Drug Prices

224 RELATED EXCIPIENT COMPANIES

403EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 2315-02-8, Oxymetazoline hcl, Ocuclear, Afrazine, Afrin hydrochloride, Sch 9384

Molecular Formula

C₁₆H₂₅ClN₂O

Molecular Weight

296.83 g/mol

InChI Key

BEEDODBODQVSIM-UHFFFAOYSA-N

FDA UNII

K89MJ0S5VY

A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)

1 2D Structure

Oxymetazoline Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol;hydrochloride

2.1.2 InChI

InChI=1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1H

2.1.3 InChI Key

BEEDODBODQVSIM-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C.Cl

2.2 Other Identifiers

2.2.1 UNII

K89MJ0S5VY

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Hydrochloride, Oxymetazoline

2. Oxymetazoline

2.3.2 Depositor-Supplied Synonyms

1. 2315-02-8

2. Oxymetazoline Hcl

3. Ocuclear

4. Afrazine

5. Afrin Hydrochloride

6. Sch 9384

7. Rhofade

8. Oxymetazoline (hydrochloride)

9. Visine L.r.

10. Vicks Sinex

11. Nsc-757254

12. K89mj0s5vy

13. 6-tert-butyl-3-(4,5-dihydro-1h-imidazol-2-ylmethyl)-2,4-dimethylphenol;hydrochloride

14. Mls000038040

15. Chebi:7863

16. Agn-199201

17. Sch-9384

18. Smr000059324

19. 2-(4-t-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolinium Chloride

20. 2,6-dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazoline Hydrochloride

21. 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Monohydrochloride

22. 6-tert-butyl-3-(4,5-dihydro-1h-imidazol-2-ylmethyl)-2,4-dimethylphenol Hydrochloride

23. Phenol, 3-((4,5-dihydro-1h-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-, Monohydrochloride

24. 2-(3-hydroxy-2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline

25. Lliadine

26. Nasivin

27. Nasivine

28. Neonabel

29. Nostrilla

30. Nafrine Hydrochloride

31. 4-way Nasal Spray

32. Duration Nasal Spray

33. Oxymetazoline Chloride

34. Lliadin Mini Paediatric

35. Sr-01000002705

36. Neo-synephrine 12 Hour

37. Neo-synephrine 12 Hour Ntz

38. Sinex

39. Anefrin Nasal

40. Duration 12 Hour Nasal Spray

41. Benzedrex Nasal Spray 12 Hour

42. Dristan Long Lasting Nasal Mist

43. Sudafed Om

44. Ocuclear (tn)

45. Prestwick_373

46. Einecs 219-015-0

47. St. Joseph Nasal Spray For Children

48. Mfcd00058147

49. Rhfade (tn)

50. Upneeq

51. Opera_id_32

52. 2-(3-hydroxy-2,6-dimethyl-4-t-butylbenzyl)-2-imidazoline Hydrochloride

53. Unii-k89mj0s5vy

54. 3-[(4,5-dihydro-

55. Schembl41247

56. Mls002222207

57. Spectrum1500453

58. Oxymetazoline Hydrochloride,(s)

59. Chembl1200791

60. Hy-b0427a

61. Dtxsid80177729

62. Oximetazoline Hydrochloride

63. Hms1568n09

64. Hms1920d18

65. Pharmakon1600-01500453

66. Tox21_500903

67. Ccg-40216

68. Nsc757254

69. 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Hydrochloride

70. Akos000280887

71. Oxymetazoline Hydrochloride (jan/usp)

72. Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-, Hydrochloride

73. Ks-5222

74. Lp00903

75. Nsc 757254

76. Oxymetazoline Hydrochloride [mi]

77. Ncgc00094218-01

78. Ncgc00094218-02

79. Ncgc00094218-03

80. Ncgc00094218-04

81. Ncgc00094218-05

82. Ncgc00261588-01

83. Oxymetazoline Hydrochloride [jan]

84. 2315-02-8 (hcl)

85. Oxymetazoline Hydrochloride [usan]

86. Oxymetazoline Hydrochloride [mart.]

87. Oxymetazoline Hydrochloride [vandf]

88. 4-(2-boc-amino-pyridin-4-yl)-benzoicacid

89. Oxymetazoline Hydrochloride [who-dd]

90. Oxymetazoline Hydrochloride, >=99%, Solid

91. Eu-0100903

92. Ft-0673462

93. O0520

94. Oxymetazoline Hydrochloride [usan:usp:jan]

95. Sw196632-3

96. D01022

97. D91882

98. O 2378

99. Oxymetazoline Hydrochloride, Analytical Standard

100. Oxymetazoline Hydrochloride [orange Book]

101. 315o028

102. A910982

103. Oxymetazoline Hydrochloride [ep Monograph]

104. Oxymetazoline Hydrochloride [usp Impurity]

105. Oxymetazoline Hydrochloride [usp Monograph]

106. Kovanaze Component Oxymetazoline Hydrochloride

107. Sr-01000002705-2

108. Sr-01000002705-4

109. Sr-01000002705-7

110. W-107424

111. Q27107602

112. Oxymetazoline Hydrochloride Component Of Kovanaze

113. Sinex Vapospray Moisturizing 12-hour Decongestant Ultrafine Mist

114. 2,6-dimethyl-4-tertiarybutyl-3-hydroxyphenyl)methylimidazoline Hydrochloride

115. 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolinium Chloride

116. 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Hydrochloride

117. Oxymetazoline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

118. 1h-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol Hydrochloride

119. 2-(3-hydroxy-2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline Hydrochloride

120. 2-(4-tert-butyl-3-hydroxy-2,6-dimethylbenzyl)-4,5-dihydro-1h-imidazol-1-ium Chloride

121. 6-(tert-butyl)-3-((4,5-dihydro-1h-imidazol-2-yl)methyl)-2,4-dimethylphenol Hydrochloride

122. 6-tert-butyl-3-((4,5-dihydro-1h-imidazol-2-yl)methyl)-2,4-dimethylphenol Hydrochloride

123. Oxymetazoline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

124. Oxymetazoline Hydrochloride, United States Pharmacopeia (usp) Reference Standard

125. 3-[(4,5-dihydro-1h-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-phenol Hydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₂₅ClN₂O
Molecular Weight	296.83 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	296.1655411 g/mol
Monoisotopic Mass	296.1655411 g/mol
Topological Polar Surface Area	44.6 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	345
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Nasal Decongestants

Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

Adrenergic alpha-Agonists

Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

Increased Sympathetic Activity [PE]; Vasoconstriction [PE]; Vasoconstrictor [EPC]; Imidazolines [CS]

API SUPPLIERS

01

Cohance Lifesciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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India

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Jai Radhe Sales

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

Jai Radhe Sales is your partner for all your sourcing needs.

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India

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

03

Pharm-RX Chemical

U.S.A

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CPHI Middle east

Not Confirmed

Pharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

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U.S.A

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Corporate PDF

04

Chynops Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

iPHEX India

Attending

Chynops Pharma is an ideal sourcing partner for high-quality APIs, advanced intermediates, speciality chemicals & excipients.

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05

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Attending

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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India

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF AU, MX

AUDIT

06

Nortec Quimica

Brazil

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

Nortec Quimica is the largest API manufacturer in Latin America.

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Brazil

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

07

Siegfried AG

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Not Confirmed

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USDMF

01

Ctx Life Sciences Pvt Ltd

India

Antibody Engineering

Not Confirmed

02

Lusochimica Spa

Italy

Antibody Engineering

Not Confirmed

03

Siegfried Pharmachemikalien Minden G...

Switzerland

Antibody Engineering

Not Confirmed

04

Siegfried Ag

Switzerland

Antibody Engineering

Not Confirmed

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CEP/COS

01

CTX LIFESCIENCES PVT. LIMITED Surat...

India

Antibody Engineering

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02

SIEGFRIED PHARMACHEMIKALIEN MINDEN ...

Switzerland

Antibody Engineering

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JDMF

01

Siegfried PharmaChemikalien Minden ...

Switzerland

Switzerland

Antibody Engineering

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07

Spectrum Laboratory Products, Inc.

U.S.A

Antibody Engineering

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Listed Suppliers

01

Cohance Lifesciences

India

Medlab Asia & Asia Health

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Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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India

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Oxymetazoline Hydrochloride

About the Company : Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our...

Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our expertise in complex chemistries, we provide end-to-end CDMO services to global innovators and have delivered numerous projects from concept to commercialization over the years.As a global API player, we serve customers across nearly 60 countries with 80+ molecules backed by robust R&D, regulatory capabilities and manufacturing infrastructure. We are among the top backward integrated exporters of pellets and have strong development and manufacturing capabilities.

02

Jai Radhe Sales

India

Medlab Asia & Asia Health

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Jai Radhe Sales is your partner for all your sourcing needs.

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India

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Oxymetazoline Hydrochloride

About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.

03

Pharm-RX Chemical

U.S.A

Medlab Asia & Asia Health

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Pharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

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U.S.A

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Oxymetazoline Hydrochloride

About the Company : Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritio...

Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritional supplement, and food industries. The company maintains an exceptionally selective approach to its suppliers, personally visiting manufacturers overseas to ensure the highest standards. The sustained growth of Pharm-Rx can be attributed to its steadfast commitment to three core values: quality ingredients, competitive pricing, and unparalleled customer service.

Corporate PDF

04

Chynops Pharma

India

iPHEX India

Attending

Chynops Pharma is an ideal sourcing partner for high-quality APIs, advanced intermediates, speciality chemicals & excipients.

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India

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Digital Content

Oxymetazoline Hydrochloride

About the Company : Chynops Pharma, a company certified with ISO 9001:2015, is situated in Ahmedabad, India. We specialize in exporting, supplying, and trading a wide range of products, including APIs...

Chynops Pharma, a company certified with ISO 9001:2015, is situated in Ahmedabad, India. We specialize in exporting, supplying, and trading a wide range of products, including APIs, Advanced Drug Intermediates, Impurity Standards, Working Standards, KSMs, Industrial Chemicals, Specialty Chemicals, Excipients, Amino Acids, Vitamins, Minerals, Herbal Extracts, Essential Oils, Prebiotics & Probiotics, Veterinary APIs, Solvents, and more from India. Our commitment extends to providing these products to valued customers in both the domestic and global markets.

05

HRV Global Life Sciences

India

CPHI Middle east

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HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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Oxymetazoline Hydrochloride

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

06

Nortec Quimica

Brazil

Medlab Asia & Asia Health

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Nortec Quimica is the largest API manufacturer in Latin America.

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Brazil

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Oxymetazoline Hydrochloride

About the Company : Nortec Química stands as the largest manufacturer of Active Pharmaceutical Ingredients (IFAs) in Latin America, embarking on its mission to ensure the availability of quality medi...

Nortec Química stands as the largest manufacturer of Active Pharmaceutical Ingredients (IFAs) in Latin America, embarking on its mission to ensure the availability of quality medicines with IFAs developed in Brazil. The company's approach involves leveraging the expertise of major National Research Centers and tapping into the experience of the Brazilian Chemical and Petrochemical Industry. Nortec Química plays a significant role in the Brazilian pharmaceutical landscape and the Unified Health System (SUS), producing APIs for branded, generic, and similar medicines, as well as medicines dedicated to addressing neglected diseases.

07

CTX Lifesciences

India

Medlab Asia & Asia Health

Not Confirmed

08

Globela Pharma

India

Medlab Asia & Asia Health

Not Confirmed

09

Siegfried AG

Switzerland

Medlab Asia & Asia Health

Not Confirmed

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API Reference Price

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