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    Chemistry

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    Also known as: 79-57-2, Terramycin, Oxyterracine, Oxytetracyclin, Adamycin, Oxymycin
    Molecular Formula
    C22H24N2O9
    Molecular Weight
    460.4  g/mol
    InChI Key
    OWFJMIVZYSDULZ-PXOLEDIWSA-N
    FDA UNII
    SLF0D9077S
    Oxytetracycline Dihydrate
    A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.
    Oxytetracycline anhydrous is a Tetracycline-class Antimicrobial.
    1 2D Structure

    Oxytetracycline Dihydrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4S,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
    2.1.2 InChI
    InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25-26,28,30,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1
    2.1.3 InChI Key
    OWFJMIVZYSDULZ-PXOLEDIWSA-N
    2.1.4 Canonical SMILES
    CC1(C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O
    2.1.5 Isomeric SMILES
    C[C@@]1([C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    SLF0D9077S
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bisolvomycin

    2. Geomycin

    3. Hydroxytetracycline

    4. Oxyterracin

    5. Oxyterracine

    6. Oxytetracid

    7. Oxytetracycline Anhydrous

    8. Oxytetracycline Calcium

    9. Oxytetracycline Dihydrate

    10. Oxytetracycline Hydrochloride

    11. Oxytetracycline Monohydrochloride

    12. Oxytetracycline Sulfate (2:1)

    13. Oxytetracycline, (4a Beta,5 Beta,5a Beta,12a Beta)-isomer

    14. Oxytetracycline, (5 Beta)-isomer

    15. Oxytetracycline, Anhydrous

    16. Oxytetracycline, Calcium (1:1) Salt

    17. Oxytetracycline, Disodium Salt, Dihydrate

    18. Oxytetracycline, Sodium Salt

    19. Terramycin

    2.3.2 Depositor-Supplied Synonyms

    1. 79-57-2

    2. Terramycin

    3. Oxyterracine

    4. Oxytetracyclin

    5. Adamycin

    6. Oxymycin

    7. Terrafungine

    8. Oxyterracin

    9. Oxytetracycline Anhydrous

    10. Oxitetraciclina

    11. Oxitetracyclin

    12. Biostat

    13. Geomycin

    14. Ryomycin

    15. Oxytetracycline (anhydrous)

    16. Oxitetracyclinum

    17. Oxytetracyclinum

    18. Oxyterracyne

    19. Solkaciclina

    20. Dabicycline

    21. Fanterrin

    22. Geotilin

    23. Imperacin

    24. Lenocycline

    25. Oksisyklin

    26. Proteroxyna

    27. Riomitsin

    28. Terramitsin

    29. Ursocyclin

    30. Ursocycline

    31. Oxypam

    32. Tarocyn

    33. Tarosin

    34. Teravit

    35. Tetran

    36. Antibiotic Tm 25

    37. Oxytetracycline Amphoteric

    38. 5-hydroxytetracycline

    39. Liquamycin La 200

    40. Biostat Pa

    41. Oxytetracycline [inn]

    42. Bisolvomycin

    43. Oxysteclin

    44. Oxymykoin

    45. Vendarcin

    46. Ossitetraciclina

    47. Pennox 200

    48. Oxy-kesso-tetra

    49. Oxytetracycline (terramycin)

    50. Berkmycen

    51. Mycoshield Tmqthc 20

    52. Dalimycin

    53. Oxacycline

    54. Unimycin

    55. Nsc-9169

    56. Oxytetracycline Calcium

    57. Stevacin

    58. Macocyn

    59. Medamycin

    60. Mepatar

    61. (4s,4ar,5s,5ar,6s,12as)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

    62. Otc (antibiotic)

    63. Mls000069429

    64. Nsc 9169

    65. Slf0d9077s

    66. Tetracycline, 5-hydroxy-

    67. Chebi:27701

    68. Oxitetracycline

    69. Terramycine

    70. Nitox

    71. Oxytetracycline (internal Use)

    72. Stecsolin

    73. Oxydon

    74. Tm 5

    75. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-

    76. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4s,4ar,5s,5ar,6s,12as)-

    77. Oxytetracid

    78. E703

    79. Nci-c56473

    80. Smr000059000

    81. Terramycin Im

    82. Terramycin Q50

    83. Ossitetraciclina [dcit]

    84. (4s,4ar,5s,5ar,6s,12as)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide

    85. Oxytetracycline Base

    86. Oxytetracyclinum [inn-latin]

    87. Oxitetraciclina [inn-spanish]

    88. Terramicina Oftalmica

    89. Geomycin (streptomyces Vimosus)

    90. Hsdb 3145

    91. Nsc-757262

    92. Oxytetracycline Dehydrate

    93. Einecs 201-212-8

    94. La 200

    95. Brn 2714587

    96. Unii-slf0d9077s

    97. Embryostat

    98. Galsenomycin

    99. Sr-01000003006

    100. Hydroxytetracyclinum

    101. (4s,4ar,5s,5ar,6s,12ar)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide

    102. Oxytetracycline,(s)

    103. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4s-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha))-

    104. 5-hydroxy-tetracycline

    105. Spectrum_001055

    106. Opera_id_661

    107. Oxytetracyclinum Dihydras

    108. Prestwick0_000307

    109. Prestwick1_000307

    110. Prestwick2_000307

    111. Prestwick3_000307

    112. Spectrum2_000988

    113. Spectrum3_000536

    114. Spectrum4_000466

    115. Spectrum5_001148

    116. Oxytetracycline(terramycin)

    117. Schembl2899

    118. Chembl1517

    119. Dsstox_cid_14260

    120. Dsstox_rid_79133

    121. Oxytetracycline [mi]

    122. Dsstox_gsid_34260

    123. Bspbio_000274

    124. Bspbio_002151

    125. Doxycycline Impurity E

    126. Kbiogr_000912

    127. Kbioss_001535

    128. 4-14-00-02633 (beilstein Handbook Reference)

    129. Divk1c_000225

    130. Schembl560497

    131. Spbio_001055

    132. Spbio_002493

    133. Bpbio1_000302

    134. Chembl461529

    135. Chembl1401333

    136. Chembl4280957

    137. Nsc9169 (hcl)

    138. Oxytetracycline [who-dd]

    139. Schembl13169109

    140. Schembl13782651

    141. Gtpl10919

    142. Kbio1_000225

    143. Kbio2_001535

    144. Kbio2_004103

    145. Kbio2_006671

    146. Kbio3_001651

    147. 6153-64-6 (di-hydrate)

    148. Ninds_000225

    149. Bdbm241973

    150. 2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4s-(4.alpha.,4a.alpha.,5.alpha.,5a.alpha.,6.beta.,12a.alpha.))-

    151. 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

    152. 79-57-2 (anhydrous)

    153. Hy-b0275

    154. 2058-46-0 (mono-hydrochloride)

    155. Tox21_302380

    156. Lmpk07000005

    157. Mfcd00003700

    158. S1773

    159. Zinc95626782

    160. Akos015951277

    161. Akos015961254

    162. Zinc100026355

    163. Zinc100303028

    164. Ccg-269334

    165. Db00595

    166. Cas-79-57-2

    167. Idi1_000225

    168. Ncgc00091268-04

    169. Ncgc00091268-05

    170. Ncgc00091268-06

    171. Ncgc00091268-07

    172. Ncgc00091268-08

    173. Ncgc00091268-09

    174. Ncgc00091268-10

    175. Ncgc00091268-11

    176. Ncgc00091268-12

    177. Ncgc00188956-01

    178. Ncgc00255168-01

    179. Ac-12777

    180. Ac-13466

    181. 7179-50-2 (calcium (1:1) Salt)

    182. Oxytetracycline (anhydrous) [hsdb]

    183. Sbi-0051473.p003

    184. Sw196796-3

    185. 3,5,6,10,12,12a-hexahydroxy-6-methyl-

    186. C06624

    187. E75911

    188. Oxytetra Selective Supplement, For Microbiology

    189. Oxytetracycline 1000 Microg/ml In Acetonitrile

    190. Ab00053514_04

    191. Ab00053514_05

    192. Ab01274728-01

    193. Ab01274728_02

    194. 6153-65-7 (di-hydrochloride Salt, Di-hydrate)

    195. A839720

    196. Q411646

    197. (4s,4ar,5s,5ar,6s,12as)-4-(dimethylamino)-

    198. Doxycycline Hyclate Impurity E [ep Impurity]

    199. Sr-01000003006-5

    200. Q63393012

    201. Doxycycline Monohydrate Impurity E [ep Impurity]

    202. 1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene

    203. Oxytetracycline, British Pharmacopoeia (bp) Reference Standard

    204. Oxytetracycline, European Pharmacopoeia (ep) Reference Standard

    205. (4s,4ar,5s,5ar,6s,12as)-4-(dimethylamino)-3,5,6,10,12,12ahexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

    206. 2z,4s,4ar,5s,5ar,6s,12as)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione

    2.4 Create Date
    2011-12-26
    3 Chemical and Physical Properties
    Molecular Weight 460.4 g/mol
    Molecular Formula C22H24N2O9
    XLogP3-1.6
    Hydrogen Bond Donor Count7
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count2
    Exact Mass460.14818035 g/mol
    Monoisotopic Mass460.14818035 g/mol
    Topological Polar Surface Area202 Ų
    Heavy Atom Count33
    Formal Charge0
    Complexity1000
    Isotope Atom Count0
    Defined Atom Stereocenter Count6
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Mesh Heading: anti-bacterial agents

    National Library of Medicine, SIS; ChemIDplus Record for Oxytetracycline (79-57-2). Available from, as of April 13, 2006: https://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

    Antibiotics, Tetracycline

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    ... Possess wide range of antimicrobial activity against gram-positive and gram-negative bacteria ... some microorganisms innately insensitive to many chemotherapeutic agents, such as rickettsiae, mycoplasma, chlamydia agents of lymphogranuloma venerum, psittacosis, inclusion conjunctivitis, and trachoma and amebae. /Tetracyclines/

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1117

    The tetracyclines are active against a wide range of aerobic and anaerobic gram-positive and gram-negative bacteria. They also are effective against some microorganisms that are resistant to cell-wall-active antimicrobial agents, such as Rickettsiae, Coxiella burnetii, Mycoplasma pneumoniae, Chlamydia spp, Legionella spp, Ureaplasma, some atypical mycobacteria, and Plasmodium spp. They are not active against fungi. /Tetracyclines/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 1240

    For more Therapeutic Uses (Complete) data for OXYTETRACYCLINE (28 total), please visit the HSDB record page.

    4.2 Drug Warning

    GENERIC INEQUIVALENCE HAS BEEN DEMONSTRATED FOR SOME OXYTETRACYCLINE FORMULATIONS, ALTHOUGH INDIVIDUAL VARIATION PREVENTED SIGNIFICANT DIFFERENCES BEING SHOWN IN ALL BUT MOST EXTREME CASES.

    The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 172

    FOOD, MILK, NONSYSTEMIC ANTACIDS & IRON PREPN INTERFERE WITH ORAL ABSORPTION.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1142

    ... Not active against any true viruses, yeasts, or fungi. /Tetracyclines/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1184

    Topical admin is best avoided because of high risk of sensitization, except for use in eye ... Should never be injected intrathecally. /Tetracyclines/

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1120

    For more Drug Warnings (Complete) data for OXYTETRACYCLINE (38 total), please visit the HSDB record page.

    4.3 Drug Indication

    Oxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Oxytetracycline is known as a broad-spectrum antibiotic due to its activity against such a wide range of infections. It was the second of the tetracyclines to be discovered. Oxytetracycline, like other tetracyclines, is used to treat many infections common and rare. Its better absorption profile makes it preferable to tetracycline for moderately severe acne, but alternatives sould be sought if no improvement occurs by 3 months.

    5.2 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    OXYTETRACYCLINE ANHYDROUS
    5.3.2 FDA UNII
    SLF0D9077S
    5.3.3 Pharmacological Classes
    Chemical Structure [CS] - Tetracyclines
    5.4 ATC Code

    D - Dermatologicals

    D06 - Antibiotics and chemotherapeutics for dermatological use

    D06A - Antibiotics for topical use

    D06AA - Tetracycline and derivatives

    D06AA03 - Oxytetracycline

    G - Genito urinary system and sex hormones

    G01 - Gynecological antiinfectives and antiseptics

    G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids

    G01AA - Antibiotics

    G01AA07 - Oxytetracycline

    J - Antiinfectives for systemic use

    J01 - Antibacterials for systemic use

    J01A - Tetracyclines

    J01AA - Tetracyclines

    J01AA06 - Oxytetracycline

    S - Sensory organs

    S01 - Ophthalmologicals

    S01A - Antiinfectives

    S01AA - Antibiotics

    S01AA04 - Oxytetracycline

    5.5 Absorption, Distribution and Excretion

    Absorption

    Readily absorbed following oral administration.

    SERUM HALF-LIFE ... IN HORSES IS ... 15.7 HR & 10.5 HR AFTER IV & IM INJECTIONS, RESPECTIVELY. ... /A FACTOR/ MAY BE THE INFLUENCE OF DOSE-DEPENDENT KINETICS ... .

    The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 174

    The percentage of an oral dose that is absorbed (when the stomach is empty) ... for oxytetracycline /is/ 60 to 80% ... After a single oral dose, the peak plasma concn /of oxytetracycline/ is attained in 2 to 4 hr. /It has a half-life/ in the range of 6 to 12 hr and ... frequently admin 2 to 4 times daily ... The admin of 250 mg every 6 hr produces peak plasma concn of 2 to 2.5 ug/mL ... Increasing the dosage above 1 g every 6 hr does not produce significantly higher plasma concn ... Approx 10 to 35% of a dose of oxytetracycline is excreted in active form in urine, in which it is detectable within 30 min and reaches a peak concn about 5 hr after it is admin.

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 1242

    /Oxytetracycline is/ bound to plasma proteins ... approx ... 20-25%.

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1119

    /Absorption is/ much less complete from lower ... tract ... Biliary concn ... /is/ 5 to 10 times higher than ... plasma. /Tetracyclines/

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1119

    For more Absorption, Distribution and Excretion (Complete) data for OXYTETRACYCLINE (20 total), please visit the HSDB record page.

    5.6 Biological Half-Life

    BIOLOGIC HALF-LIFE ... MAY BE 3-4 DAYS IN ANURIA.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1142

    The serum half-life of oxytetracycline is 6 to 10 hours in adults with normal renal function and is reported to be 47 to 66 hours in patients with severe renal impairment. In patients with normal renal function, approximately 60 to 70 percent of a single oral dose of oxytetracycline is excreted in urine within 72 hours as active drug.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1992 (Plus Supplements 1992)., p. 319

    A two-way crossover study was conducted in crossbred male calves (6-8 months old) to determine the bioavailability, pharmacokinetics and dosage regimens for a long-acting formulation of oxytetracycline (OTC-LA). The half-lives of oxytetracycline after intravenous and intramuscular administration were 7.8 hr and 24 hr, respectively. ....

    PMID:10066127 Kumar R, Malik JK; Vet Res Commun 22 (8): 533-44 (1998)

    The pharmacokinetic properties of oxytetracycline were studied following a single injection of a long-acting formulation (20 mg/kg body weight) into the semimembranosus muscle of healthy dogs and of dogs that had been experimentally infected with Ehrlichia canis. ... The mean apparent elimination half-life (t(1/2) beta) was significantly increased following infection. ... The absorption half-life (t(1/2) ab) was significantly decreased after infection.

    PMID:11469510 Kikuvi GM et al; Vet Res Commun 25 (5): 391-400 (2001)

    SERUM HALF-LIFE ... IN HORSES IS ... 15.7 HR & 10.5 HR AFTER IV & IM INJECTIONS, RESPECTIVELY. ... /A FACTOR/ MAY BE THE INFLUENCE OF DOSE-DEPENDENT KINETICS ... .

    The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 174

    5.7 Mechanism of Action

    Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.

    Tetracyclines inhibit bacterial protein synthesis by binding to the 30 S bacterial ribosome and preventing access of aminoacyl tRNA to the acceptor (A) site on the mRNA-ribosome complex. They enter gram-negative bacteria by passive diffusion through the hydrophilic channels formed by the porin proteins of the outer cell membrane, and active transport by an energy-dependent system that pumps all tetracyclines across cytoplasmic membrane. Although permeation of these drugs into gram-positive bacteria is less well understood, it also is energy requiring. At high concn, these cmpd impair protein synthesis in mammalian cells. However, because mammalian cells lack the active transport system found in bacteria, and the ribosomal target is less sensitive, tetracyclines are selectively active against bacteria. /Tetracyclines/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 1241

    The tetracycline antibiotics ... can produce neuromuscular blockade, possibly by chelation of Ca+2. /Tetracyclines/

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 203

    API SUPPLIERS

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    Century Pharmaceuticals

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    Century Pharmaceuticals

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    Oxytetracycline USP & Oxytetracycline Dihydrate BP/EP

    Date of Issue : 2022-11-02

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    API Reference Price

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    16-Feb-2021
    26-Jul-2024
    KGS
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    01

    Brand Name : Terramycin-Polymyxin B

    U.S.A
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    Saudi International Expo
    Not Confirmed

    Brand Name : Terramycin-Polymyxin B

    U.S.A
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    Saudi International Expo
    Not Confirmed

    Pfizer AS

    Oxytetracycline Dihydrate

    Dosage Form : Salve

    Dosage Strength : 30 mg/10,000 IE

    Price Per Pack (Euro) : 12.353

    Published in :

    Country : Norway

    RX/OTC/DISCN :

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    02

    Brand Name : Cosmiciclina

    Country
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    Saudi International Expo
    Not Confirmed

    Brand Name : Cosmiciclina

    Country
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    Not Confirmed

    ALFA INTES (IND.TER.SPLENDORE)

    Oxytetracycline Dihydrate; Chloramphenicol Succinate Acid; Sulfacetamide

    Dosage Form :

    Dosage Strength : Pom Oftalm Oto 5 G  

    Price Per Pack (Euro) : 5.2

    Published in :

    Country : Italy

    RX/OTC/DISCN : Class C

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