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    Chemistry

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    Also known as: 199739-10-1, Invega sustenna, Xeplion, Invega trinza, Ro92670, Ro 92670
    Molecular Formula
    C39H57FN4O4
    Molecular Weight
    664.9  g/mol
    InChI Key
    VOMKSBFLAZZBOW-UHFFFAOYSA-N
    FDA UNII
    R8P8USM8FR
    Paliperidone Palmitate
    A benzisoxazole derivative and active metabolite of RISPERIDONE that functions as a DOPAMINE D2 RECEPTOR ANTAGONIST and SEROTONIN 5-HT2 RECEPTOR ANTAGONIST. It is an ANTIPSYCHOTIC AGENT used in the treatment of SCHIZOPHRENIA.
    1 2D Structure

    Paliperidone Palmitate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl] hexadecanoate
    2.1.2 InChI
    InChI=1S/C39H57FN4O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-18-36(45)47-34-17-16-24-44-38(34)41-29(2)32(39(44)46)23-27-43-25-21-30(22-26-43)37-33-20-19-31(40)28-35(33)48-42-37/h19-20,28,30,34H,3-18,21-27H2,1-2H3
    2.1.3 InChI Key
    VOMKSBFLAZZBOW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCCCCCCCCCCCCCC(=O)OC1CCCN2C1=NC(=C(C2=O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F)C
    2.2 Other Identifiers
    2.2.1 UNII
    R8P8USM8FR
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3-(2-(4-(6-fluoro-3-(1,2-benzisoxazolyl))-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido(1,2-a)pyrimidin-4-one

    2. 9 Hydroxy Risperidone

    3. 9 Hydroxyrisperidone

    4. 9 Oh Risperidone

    5. 9-hydroxy-risperidone

    6. 9-hydroxyrisperidone

    7. 9-oh-risperidone

    8. Invega

    9. Invega Sustenna

    10. Paliperidone

    11. Palmitate, Paliperidone

    12. R 76477

    13. R-76477

    14. R76477

    15. Sustenna, Invega

    2.3.2 Depositor-Supplied Synonyms

    1. 199739-10-1

    2. Invega Sustenna

    3. Xeplion

    4. Invega Trinza

    5. Ro92670

    6. Ro 92670

    7. Paliperidone Palmitate [usan]

    8. R8p8usm8fr

    9. 3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4h-pyrido[1,2-a]pyrimidin-9-yl Palmitate

    10. Jns010

    11. Hexadecanoic Acid, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-4-oxo-4h-pyrido(1,2-a)pyrimidin-9-yl Ester

    12. Chebi:83808

    13. Jns-010

    14. Ro-92670

    15. R092670

    16. (9rs)-3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4h-pyrido(1,2-a)pyrimidin-9-yl Hexadecanoate

    17. 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydro-4h-pyrido[1,2-a]pyrimidin-9-yl Hexadecanoate

    18. R-092670

    19. Trinza

    20. [3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl] Hexadecanoate

    21. Hexadecanoic Acid, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl Ester

    22. Unii-r8p8usm8fr

    23. 9-hydroxyrisperidone Palmitate

    24. Jns 010

    25. Pp3m

    26. Paliperidone Janssen

    27. Palperidone Palmitate

    28. Paliperidone Palmitate-[d4]

    29. Schembl1871384

    30. Chembl2107360

    31. Schembl12415674

    32. Hy-a0019a

    33. Dtxsid70870217

    34. Paliperidone Palmitate [mi]

    35. Bcp08473

    36. Paliperidone Palmitate [jan]

    37. Mfcd24386477

    38. S5624

    39. Paliperidone Palmitate [vandf]

    40. Paliperidone Palmitate [mart.]

    41. Paliperidone Palmitate [who-dd]

    42. Sb17398

    43. Ncgc00522023-01

    44. Paliperidone Palmitate [ema Epar]

    45. Ac-32485

    46. As-77089

    47. Paliperidone Palmitate [orange Book]

    48. Cs-0016387

    49. Ft-0673476

    50. D83646

    51. Q27157250

    52. 3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4h-pyrido[1,2-a]pyrimidin-9-ylpalmitate

    53. 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl Hexadecanoate

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 664.9 g/mol
    Molecular Formula C39H57FN4O4
    XLogP310.1
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count20
    Exact Mass664.43638447 g/mol
    Monoisotopic Mass664.43638447 g/mol
    Topological Polar Surface Area88.2 Ų
    Heavy Atom Count48
    Formal Charge0
    Complexity1090
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Xeplion is indicated for maintenance treatment of schizophrenia in adult patients stabilised with paliperidone or risperidone.

    In selected adult patients with schizophrenia and previous responsiveness to oral paliperidone or risperidone, Xeplion may be used without prior stabilisation with oral treatment if psychotic symptoms are mild to moderate and a long-acting injectable treatment is needed.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine D2 Receptor Antagonists

    Compounds and drugs that bind to and inhibit or block the activation of DOPAMINE D2 RECEPTORS. (See all compounds classified as Dopamine D2 Receptor Antagonists.)

    Serotonin 5-HT2 Receptor Antagonists

    Drugs that bind to but do not activate SEROTONIN 5-HT2 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT2 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more specific 5-HT2 receptor subtypes. (See all compounds classified as Serotonin 5-HT2 Receptor Antagonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Atypical Antipsychotic [EPC]
    5.3 ATC Code

    N05AX13

    API Reference Price

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    12-Mar-2021
    24-Jul-2024
    KGS
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