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Chemistry

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Also known as: 57248-88-1, Aredia, Aminomux, Disodium pamidronate, Pamidronate disodium salt, Pamidronic acid disodium salt
Molecular Formula
C3H9NNa2O7P2
Molecular Weight
279.03  g/mol
InChI Key
CEYUIFJWVHOCPP-UHFFFAOYSA-L
FDA UNII
C7S8VWP5DH

Disodium Pamidronate Pentahydrate
An aminobisphosphonate that inhibits BONE RESORPTION and is used for the treatment of osteolytic lesions, bone pain, and severe HYPERCALCEMIA associated with malignancies.
1 2D Structure

Disodium Pamidronate Pentahydrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate
2.1.2 InChI
InChI=1S/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;/q;2*+1/p-2
2.1.3 InChI Key
CEYUIFJWVHOCPP-UHFFFAOYSA-L
2.1.4 Canonical SMILES
C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
C7S8VWP5DH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (3-amino-1-hydroxypropylidene)-1,1-biphosphonate

2. 1 Hydroxy 3 Aminopropane 1,1 Diphosphonic Acid

3. 1-hydroxy-3-aminopropane-1,1-diphosphonic Acid

4. Ahprbp

5. Amidronate

6. Amino 1 Hydroxypropane 1,1 Diphosphonate

7. Amino-1-hydroxypropane-1,1-diphosphonate

8. Aminohydroxypropylidene Diphosphonate

9. Aminopropanehydroxydiphosphonate

10. Aredia

11. Pamidronate

12. Pamidronate Calcium

13. Pamidronate Monosodium

14. Pamidronic Acid

2.3.2 Depositor-Supplied Synonyms

1. 57248-88-1

2. Aredia

3. Aminomux

4. Disodium Pamidronate

5. Pamidronate Disodium Salt

6. Pamidronic Acid Disodium Salt

7. Cgp 23339a

8. Pamidronate Disodium Anhydrous

9. Pamidronate Disodium Monohydrate

10. Pamidronate (disodium)

11. C7s8vwp5dh

12. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate

13. Cgp-23339ae

14. Disodium Pamidronate Hydrate

15. Phosphonic Acid, (3-amino-1-hydroxypropylidene)bis-, Disodium Salt

16. Pamidronate (disodium Pentahydrate)

17. Pamedronate Disodium Salt

18. Pamidronatedisodium

19. Pamidronic Acid Sodium Salt

20. Pamindronate Disodium

21. Nsc-722600

22. Cgp 23339 A

23. Einecs 260-647-1

24. Unii-c7s8vwp5dh

25. Sodium 3-amino-1-hydroxypropane-1,1-diylbis(hydrogenphosphonate)

26. Pamidronate Sodium

27. Ahprbp

28. Aminohydroxypropylidene Diphosphonate Disodium Salt

29. (3-amino-1-hydroxypropylidene)diphosphonic Acid Disodium Salt

30. Disodium Dihydrogen (3-amino-1-hydroxypropylidene)bisphosphonate

31. Pamidronate (sodium Salt)

32. Chembl676

33. Schembl18751

34. Dtxsid5042667

35. Pamidronate Disodium Salt Hydrate

36. 3-amino-1-hydroxypropane-1,1-diphosphonic Acid Disodium Salt

37. Cgp-23339a

38. Gcp-23339a

39. Bcp22745

40. Anhydrous Pamidronate Disodium

41. Mfcd00867072

42. S1311

43. Akos015905512

44. Akos025401590

45. Ccg-267232

46. Ig-7913

47. Nsc 722600

48. Cgp 23339a Pound>>gcp23339a

49. Ac-22572

50. Ac-22753

51. Bp164229

52. Pamidronic Acid Disodium Salt [mi]

53. Db-053025

54. Pamidronic Acid Sodium Salt Hydrate- Bio-x

55. D3921

56. Ft-0630698

57. H11402

58. W-105479

59. Q27275302

60. (3-amino-1-hydroxypropylidene)bisphosphonic Acid Disodium

61. Disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)]

62. Disodium Dihydrogen (3-amino-1-hydroxypropylidene)diphosphonate

63. Disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 279.03 g/mol
Molecular Formula C3H9NNa2O7P2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass278.96496419 g/mol
Monoisotopic Mass278.96496419 g/mol
Topological Polar Surface Area167 Ų
Heavy Atom Count15
Formal Charge0
Complexity238
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameAredia
Active IngredientPamidronate disodium
Dosage FormInjectable
Routeinjection; Injection
Strength30mg/vial; 60mg/vial; 90mg/vial
Market StatusPrescription
CompanyNovartis

2 of 4  
Drug NamePamidronate disodium
PubMed HealthPamidronate (Injection)
Drug ClassesCalcium Regulator
Drug LabelPamidronate Disodium is a sterile bone-resorption inhibitor available in 30 mg and 90 mg vials for intravenous administration. The pamidronate disodium obtained by combining pamidronic acid and sodium hydroxide is provided in a sterile, ready to use...
Active IngredientPamidronate disodium
Dosage FormInjectable
RouteInjection
Strength90mg/vial; 30mg/10ml (3mg/ml); 60mg/10ml (6mg/ml); 30mg/vial; 60mg/vial; 90mg/10ml (9mg/ml)
Market StatusPrescription
CompanyPliva Lachema; Areva Pharms; Hospira; Teva Pharms Usa; Sun Pharma Global; Fresenius Kabi Usa; Luitpold; Mustafa Nevzat; Eurohlth Intl; Agila Speclts

3 of 4  
Drug NameAredia
Active IngredientPamidronate disodium
Dosage FormInjectable
Routeinjection; Injection
Strength30mg/vial; 60mg/vial; 90mg/vial
Market StatusPrescription
CompanyNovartis

4 of 4  
Drug NamePamidronate disodium
PubMed HealthPamidronate (Injection)
Drug ClassesCalcium Regulator
Drug LabelPamidronate Disodium is a sterile bone-resorption inhibitor available in 30 mg and 90 mg vials for intravenous administration. The pamidronate disodium obtained by combining pamidronic acid and sodium hydroxide is provided in a sterile, ready to use...
Active IngredientPamidronate disodium
Dosage FormInjectable
RouteInjection
Strength90mg/vial; 30mg/10ml (3mg/ml); 60mg/10ml (6mg/ml); 30mg/vial; 60mg/vial; 90mg/10ml (9mg/ml)
Market StatusPrescription
CompanyPliva Lachema; Areva Pharms; Hospira; Teva Pharms Usa; Sun Pharma Global; Fresenius Kabi Usa; Luitpold; Mustafa Nevzat; Eurohlth Intl; Agila Speclts

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Diphosphonates [CS]; Bisphosphonate [EPC]

API Reference Price

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16-Apr-2022
19-Aug-2023
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