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    Chemistry

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    Also known as: 57248-88-1, Aredia, Aminomux, Disodium pamidronate, Pamidronate disodium salt, Pamidronic acid disodium salt
    Molecular Formula
    C3H9NNa2O7P2
    Molecular Weight
    279.03  g/mol
    InChI Key
    CEYUIFJWVHOCPP-UHFFFAOYSA-L
    FDA UNII
    C7S8VWP5DH
    Disodium Pamidronate Pentahydrate
    An aminobisphosphonate that inhibits BONE RESORPTION and is used for the treatment of osteolytic lesions, bone pain, and severe HYPERCALCEMIA associated with malignancies.
    1 2D Structure

    Disodium Pamidronate Pentahydrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate
    2.1.2 InChI
    InChI=1S/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;/q;2*+1/p-2
    2.1.3 InChI Key
    CEYUIFJWVHOCPP-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    C7S8VWP5DH
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (3-amino-1-hydroxypropylidene)-1,1-biphosphonate

    2. 1 Hydroxy 3 Aminopropane 1,1 Diphosphonic Acid

    3. 1-hydroxy-3-aminopropane-1,1-diphosphonic Acid

    4. Ahprbp

    5. Amidronate

    6. Amino 1 Hydroxypropane 1,1 Diphosphonate

    7. Amino-1-hydroxypropane-1,1-diphosphonate

    8. Aminohydroxypropylidene Diphosphonate

    9. Aminopropanehydroxydiphosphonate

    10. Aredia

    11. Pamidronate

    12. Pamidronate Calcium

    13. Pamidronate Monosodium

    14. Pamidronic Acid

    2.3.2 Depositor-Supplied Synonyms

    1. 57248-88-1

    2. Aredia

    3. Aminomux

    4. Disodium Pamidronate

    5. Pamidronate Disodium Salt

    6. Pamidronic Acid Disodium Salt

    7. Cgp 23339a

    8. Pamidronate Disodium Anhydrous

    9. Pamidronate Disodium Monohydrate

    10. Pamidronate (disodium)

    11. C7s8vwp5dh

    12. Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate

    13. Cgp-23339ae

    14. Disodium Pamidronate Hydrate

    15. Phosphonic Acid, (3-amino-1-hydroxypropylidene)bis-, Disodium Salt

    16. Pamidronate (disodium Pentahydrate)

    17. Pamedronate Disodium Salt

    18. Pamidronatedisodium

    19. Pamidronic Acid Sodium Salt

    20. Pamindronate Disodium

    21. Nsc-722600

    22. Cgp 23339 A

    23. Einecs 260-647-1

    24. Unii-c7s8vwp5dh

    25. Sodium 3-amino-1-hydroxypropane-1,1-diylbis(hydrogenphosphonate)

    26. Pamidronate Sodium

    27. Ahprbp

    28. Aminohydroxypropylidene Diphosphonate Disodium Salt

    29. (3-amino-1-hydroxypropylidene)diphosphonic Acid Disodium Salt

    30. Disodium Dihydrogen (3-amino-1-hydroxypropylidene)bisphosphonate

    31. Pamidronate (sodium Salt)

    32. Chembl676

    33. Schembl18751

    34. Dtxsid5042667

    35. Pamidronate Disodium Salt Hydrate

    36. 3-amino-1-hydroxypropane-1,1-diphosphonic Acid Disodium Salt

    37. Cgp-23339a

    38. Gcp-23339a

    39. Bcp22745

    40. Anhydrous Pamidronate Disodium

    41. Mfcd00867072

    42. S1311

    43. Akos015905512

    44. Akos025401590

    45. Ccg-267232

    46. Ig-7913

    47. Nsc 722600

    48. Cgp 23339a Pound>>gcp23339a

    49. Ac-22572

    50. Ac-22753

    51. Bp164229

    52. Pamidronic Acid Disodium Salt [mi]

    53. Db-053025

    54. Pamidronic Acid Sodium Salt Hydrate- Bio-x

    55. D3921

    56. Ft-0630698

    57. H11402

    58. W-105479

    59. Q27275302

    60. (3-amino-1-hydroxypropylidene)bisphosphonic Acid Disodium

    61. Disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)]

    62. Disodium Dihydrogen (3-amino-1-hydroxypropylidene)diphosphonate

    63. Disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 279.03 g/mol
    Molecular Formula C3H9NNa2O7P2
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count4
    Exact Mass278.96496419 g/mol
    Monoisotopic Mass278.96496419 g/mol
    Topological Polar Surface Area167 Ų
    Heavy Atom Count15
    Formal Charge0
    Complexity238
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameAredia
    Active IngredientPamidronate disodium
    Dosage FormInjectable
    Routeinjection; Injection
    Strength30mg/vial; 60mg/vial; 90mg/vial
    Market StatusPrescription
    CompanyNovartis

    2 of 4  
    Drug NamePamidronate disodium
    PubMed HealthPamidronate (Injection)
    Drug ClassesCalcium Regulator
    Drug LabelPamidronate Disodium is a sterile bone-resorption inhibitor available in 30 mg and 90 mg vials for intravenous administration. The pamidronate disodium obtained by combining pamidronic acid and sodium hydroxide is provided in a sterile, ready to use...
    Active IngredientPamidronate disodium
    Dosage FormInjectable
    RouteInjection
    Strength90mg/vial; 30mg/10ml (3mg/ml); 60mg/10ml (6mg/ml); 30mg/vial; 60mg/vial; 90mg/10ml (9mg/ml)
    Market StatusPrescription
    CompanyPliva Lachema; Areva Pharms; Hospira; Teva Pharms Usa; Sun Pharma Global; Fresenius Kabi Usa; Luitpold; Mustafa Nevzat; Eurohlth Intl; Agila Speclts

    3 of 4  
    Drug NameAredia
    Active IngredientPamidronate disodium
    Dosage FormInjectable
    Routeinjection; Injection
    Strength30mg/vial; 60mg/vial; 90mg/vial
    Market StatusPrescription
    CompanyNovartis

    4 of 4  
    Drug NamePamidronate disodium
    PubMed HealthPamidronate (Injection)
    Drug ClassesCalcium Regulator
    Drug LabelPamidronate Disodium is a sterile bone-resorption inhibitor available in 30 mg and 90 mg vials for intravenous administration. The pamidronate disodium obtained by combining pamidronic acid and sodium hydroxide is provided in a sterile, ready to use...
    Active IngredientPamidronate disodium
    Dosage FormInjectable
    RouteInjection
    Strength90mg/vial; 30mg/10ml (3mg/ml); 60mg/10ml (6mg/ml); 30mg/vial; 60mg/vial; 90mg/10ml (9mg/ml)
    Market StatusPrescription
    CompanyPliva Lachema; Areva Pharms; Hospira; Teva Pharms Usa; Sun Pharma Global; Fresenius Kabi Usa; Luitpold; Mustafa Nevzat; Eurohlth Intl; Agila Speclts

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Bone Density Conservation Agents

    Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Diphosphonates [CS]; Bisphosphonate [EPC]

    API Reference Price

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    [{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1650047400,"product":"PAMIDRONIC ACID WS - REFS-PMDA-1005-N","address":"PLOT No.30, GALAXY , 1ST MAIN ROAD, J.P. NAGAR, THIRD PH","city":"BENGALURU","supplier":"CHEMWERTH INC","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"STERISCIENCE SPECIALTIES PRIVATE ","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"30","totalValueFC":"305.4","currency":"USD","unitRateINR":"2304","date":"16-Apr-2022","totalValueINR":"23040","totalValueInUsd":"305.4","indian_port":"BANGALORE AIR","hs_no":"29319090","bill_no":"8304403","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT No.30, GALAXY , 1ST MAIN ROAD, J.P. NAGAR, THIRD PH"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726597800,"product":"HISY-PMDA-I005-N PAMIDRONIC ACID","address":"PLOT No.30, GALAXY ,","city":"BENGALURU","supplier":"CHEMWERTH INC","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK - JOHN F. K","customer":"STERISCIENCE SPECIALTIES PRIVATE ","customerCountry":"INDIA","quantity":"2.95","actualQuantity":"2.953","unit":"KGS","unitRateFc":"110000","totalValueFC":"329696.9","currency":"USD","unitRateINR":"9356250.3","date":"18-Sep-2024","totalValueINR":"27629007","totalValueInUsd":"329696.9","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"5664332","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK - JOHN F. K","supplierAddress":"1764 LITCHFIELD TURNPIKE SUITE 202 WOODBRIDGE SDNF US","customerAddress":"PLOT No.30, GALAXY ,"}]
    16-Apr-2022
    18-Sep-2024
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