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Chemistry

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Also known as: 61-25-6, Cardoverina, Cardiospan, Papaversan, Artegodan, Forpavin
Molecular Formula
C20H22ClNO4
Molecular Weight
375.8  g/mol
InChI Key
UOTMYNBWXDUBNX-UHFFFAOYSA-N
FDA UNII
23473EC6BQ

Papaverine Hydrochloride
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
1 2D Structure

Papaverine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline;hydrochloride
2.1.2 InChI
InChI=1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H
2.1.3 InChI Key
UOTMYNBWXDUBNX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC.Cl
2.2 Other Identifiers
2.2.1 UNII
23473EC6BQ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cerespan

2. Hydrochloride, Papaverine

3. Papaverine

4. Pavabid

5. Pavatym

2.3.2 Depositor-Supplied Synonyms

1. 61-25-6

2. Cardoverina

3. Cardiospan

4. Papaversan

5. Artegodan

6. Forpavin

7. Papalease

8. Pavatest

9. Pavabid

10. Dispamil

11. Drapavel

12. Paverolan

13. Alapav

14. Cerebid

15. Delapav

16. Dilaves

17. Durapav

18. Dynovas

19. Myobid

20. Pameion

21. Papacon

22. Pavacap

23. Pavacen

24. Paveron

25. Pavnell

26. Vasal

27. Papaverine Hcl

28. Ro-papav

29. Vaso-pav

30. 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline Hydrochloride

31. Cerespan

32. Papaverinium Chloride

33. Papanerin-hcl

34. Papavarine Chlorhydrate

35. Pap-kaps-150

36. Papaverine Chlorohydrate

37. Papaverine, Hcl

38. Pap H

39. Papaverine (hydrochloride)

40. Papaverine Monohydrochloride

41. Nci-c56359

42. Vasorin

43. Chlorhydrate De Papaverine

44. Nsc 35443

45. 6,7-dimethoxy-1-veratrylisoquinoline Hydrochloride

46. Nsc-35443

47. Mls000028497

48. 23473ec6bq

49. Cepaverin

50. Optenyl

51. Pavagrant

52. Pavakey

53. Pavased

54. Smr000058283

55. Therapav

56. Dipav

57. Lapav

58. Dsstox_cid_5825

59. Spasmo-nit

60. Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-, Hydrochloride

61. Dsstox_rid_77939

62. Dsstox_gsid_25825

63. Papanerin-hcl [german]

64. 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline;hydrochloride

65. Nsc35443

66. Ccris 3804

67. Cas-61-25-6

68. Sr-01000003098

69. Chlorhydrate De Papaverine [french]

70. Ncgc00015810-02

71. Einecs 200-502-1

72. Pamelon

73. Unii-23473ec6bq

74. Papaverine Hydrochloride [jan]

75. Qua Bid

76. Prestwick_376

77. Papaverine Hydrochloride [usp:jan]

78. Pavabid (tn)

79. Component Of Copavin

80. Mfcd00012745

81. Isoquinoline, 6,7-dimethoxy-1-veratryl-, Hydrochloride

82. 6,7,3',4'-tetramethoxy-1-benzylisoquinoline Hydrochloride

83. Papaverini Hydrochloridum

84. Papaverine, Hydrochloride

85. Opera_id_1617

86. Regid_for_cid_6084

87. Mls001148655

88. Mls002222208

89. Chembl98123

90. Schembl121268

91. Spectrum1500459

92. Papaverine Hydrochloride, Powder

93. Dtxsid9025825

94. Cas 61-25-6

95. Hms1569f08

96. Hms1920f06

97. Pharmakon1600-01500459

98. Tox21_110226

99. Tox21_500957

100. Ccg-40065

101. Hy-18077a

102. Nsc757256

103. Papaverine Hydrochloride [mi]

104. Papaverine Hydrochloride (jp17/usp)

105. Akos005111070

106. Tox21_110226_1

107. Cs-5015

108. Lp00957

109. Nsc-757256

110. Papaverine Hydrochloride [hsdb]

111. Papaverine Hydrochloride [mart.]

112. Papaverine Hydrochloride [vandf]

113. Ncgc00015810-12

114. Ncgc00094258-01

115. Ncgc00094258-02

116. Ncgc00094258-03

117. Ncgc00094258-04

118. Ncgc00094258-05

119. Ncgc00094258-06

120. Ncgc00261642-01

121. Papaverine Hydrochloride [usp-rs]

122. Papaverine Hydrochloride [who-dd]

123. Papaverine Hydrochloride [who-ip]

124. As-13262

125. 1-(3,7-dimethoxyisoquinoline Hydrochloride

126. Db-053821

127. Eu-0100957

128. P0016

129. D02218

130. D86684

131. P 3510

132. Papaverine Hydrochloride [ep Monograph]

133. Papaverine Hydrochloride [usp Monograph]

134. Papaverini Hydrochloridum [who-ip Latin]

135. Isoquinoline,7-dimethoxy-1-veratryl-, Hydrochloride

136. Sr-01000003098-2

137. Sr-01000003098-4

138. Sr-01000003098-9

139. Wln: T66 Cnj B1r Co1 Do1& Ho1 Io1 &gh

140. Q27253713

141. Sr-01000003098-11

142. 6,3',4'-tetramethoxy-1-benzylisoquinoline Hydrochloride

143. 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinolinehydrochloride

144. Isoquinoline,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, Hydrochloride

145. Papaverine Hydrochloride, British Pharmacopoeia (bp) Reference Standard

146. Papaverine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

147. Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-, Hydrochloride (1:1)

148. Papaverine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

149. Papaverine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 375.8 g/mol
Molecular Formula C20H22ClNO4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass375.1237359 g/mol
Monoisotopic Mass375.1237359 g/mol
Topological Polar Surface Area49.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity407
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Phosphodiesterase Inhibitors

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases. (See all compounds classified as Phosphodiesterase Inhibitors.)


Urological Agents

Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)


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05-Jan-2021
21-Feb-2025
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Looking for 61-25-6 / Papaverine Hydrochloride API manufacturers, exporters & distributors?

Papaverine Hydrochloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Papaverine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Papaverine Hydrochloride manufacturer or Papaverine Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Papaverine Hydrochloride manufacturer or Papaverine Hydrochloride supplier.

PharmaCompass also assists you with knowing the Papaverine Hydrochloride API Price utilized in the formulation of products. Papaverine Hydrochloride API Price is not always fixed or binding as the Papaverine Hydrochloride Price is obtained through a variety of data sources. The Papaverine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Papaverine Hydrochloride

Synonyms

61-25-6, Cardoverina, Cardiospan, Papaversan, Artegodan, Forpavin

Cas Number

61-25-6

Unique Ingredient Identifier (UNII)

23473EC6BQ

About Papaverine Hydrochloride

An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.

Papaverine Hydrochloride Manufacturers

A Papaverine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Papaverine Hydrochloride, including repackagers and relabelers. The FDA regulates Papaverine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Papaverine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Papaverine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Papaverine Hydrochloride Suppliers

A Papaverine Hydrochloride supplier is an individual or a company that provides Papaverine Hydrochloride active pharmaceutical ingredient (API) or Papaverine Hydrochloride finished formulations upon request. The Papaverine Hydrochloride suppliers may include Papaverine Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Papaverine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Papaverine Hydrochloride USDMF

A Papaverine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Papaverine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Papaverine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Papaverine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Papaverine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Papaverine Hydrochloride USDMF includes data on Papaverine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Papaverine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Papaverine Hydrochloride suppliers with USDMF on PharmaCompass.

Papaverine Hydrochloride JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Papaverine Hydrochloride Drug Master File in Japan (Papaverine Hydrochloride JDMF) empowers Papaverine Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Papaverine Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Papaverine Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Papaverine Hydrochloride suppliers with JDMF on PharmaCompass.

Papaverine Hydrochloride KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Papaverine Hydrochloride Drug Master File in Korea (Papaverine Hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Papaverine Hydrochloride. The MFDS reviews the Papaverine Hydrochloride KDMF as part of the drug registration process and uses the information provided in the Papaverine Hydrochloride KDMF to evaluate the safety and efficacy of the drug.

After submitting a Papaverine Hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Papaverine Hydrochloride API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Papaverine Hydrochloride suppliers with KDMF on PharmaCompass.

Papaverine Hydrochloride WC

A Papaverine Hydrochloride written confirmation (Papaverine Hydrochloride WC) is an official document issued by a regulatory agency to a Papaverine Hydrochloride manufacturer, verifying that the manufacturing facility of a Papaverine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Papaverine Hydrochloride APIs or Papaverine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Papaverine Hydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Papaverine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Papaverine Hydrochloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Papaverine Hydrochloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Papaverine Hydrochloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Papaverine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Papaverine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Papaverine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Papaverine Hydrochloride suppliers with NDC on PharmaCompass.

Papaverine Hydrochloride GMP

Papaverine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Papaverine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Papaverine Hydrochloride GMP manufacturer or Papaverine Hydrochloride GMP API supplier for your needs.

Papaverine Hydrochloride CoA

A Papaverine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Papaverine Hydrochloride's compliance with Papaverine Hydrochloride specifications and serves as a tool for batch-level quality control.

Papaverine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Papaverine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Papaverine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Papaverine Hydrochloride EP), Papaverine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Papaverine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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