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Nuray Parecoxib Sodium

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Lifecare Parecoxib Sodium

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xyz-pharma-m-2024-10-07

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Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

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CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

14 API Suppliers, 2 USDMF, 5 EU WC, 3 NDC API, 10 Listed Suppliers, $ API Reference Price

14 API Suppliers
2 USDMF
5 EU WC
3 NDC API
10 Listed Suppliers
$ API Reference Price

INTERMEDIATES

3 Intermediates Suppliers

3 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

20 FDF Dossiers, 10 Europe, 4 South Africa, 6 Listed Dossiers

20 FDF Dossiers
10 Europe
4 South Africa
6 Listed Dossiers

DIGITAL CONTENT

3 NEWS #PharmaBuzz

media
3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

6 Finished Drug Prices

globalSalesInformation
6 Finished Drug Prices

MARKET PLACE

3 APIs, 1 FDF Dossiers, 1 EXCIPIENTS

marketPlace
3 APIs
1 FDF Dossiers
1 EXCIPIENTS

REF. STANDARDS & IMPURITIES

7 Others

otherSolutions
7 Others

Nuray Parecoxib Sodium

Synopsis

ACTIVE PHARMA INGREDIENTS

14

API Suppliers

2

USDMF

0

CEP/COS

CEP/COS Certifications

0

JDMF

5

EU WC

0

KDMF

3

NDC API

0

VMF

10

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 9,746

MARKET PLACE

3

API

1

FDF

3INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

20

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

10

Europe

0

Canada

0

Australia

4

South Africa

6

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

7

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

3

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

NA

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 198470-85-8, Dynastat, Parecoxib (sodium), Rayzon, Parecoxib sodium salt, Sc 69124a

Molecular Formula

C₁₉H₁₇N₂NaO₄S

Molecular Weight

392.4 g/mol

InChI Key

HQPVVKXJNZEAFW-UHFFFAOYSA-M

FDA UNII

EB87433V6F

Parecoxib Sodium

Parecoxib Sodium is a water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.

1 2D Structure

Parecoxib Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl-propanoylazanide

2.1.2 InChI

InChI=1S/C19H18N2O4S.Na/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;/h4-12H,3H2,1-2H3,(H,21,22);/q;+1/p-1

2.1.3 InChI Key

HQPVVKXJNZEAFW-UHFFFAOYSA-M

2.1.4 Canonical SMILES

CCC(=O)[N-]S(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C.[Na+]

2.2 Other Identifiers

2.2.1 UNII

EB87433V6F

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Dynastat

2. N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamide

3. N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamine, Sodium Salt

4. N-(((me-p)-p)s)p

5. Parecoxib

2.3.2 Depositor-Supplied Synonyms

1. 198470-85-8

2. Dynastat

3. Parecoxib (sodium)

4. Rayzon

5. Parecoxib Sodium Salt

6. Sc 69124a

7. Parecoxib Na

8. Sc-69124a

9. Parecoxib Sodium [usan]

10. Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide

11. Eb87433v6f

12. 197502-82-2

13. Parecoxib Sodium (usan)

14. N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propanamide, Sodium Salt

15. Sodium;[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl-propanoylazanide

16. Ncgc00181773-01

17. Unii-eb87433v6f

18. Dynastat (tn)

19. Dsstox_cid_28596

20. Dsstox_rid_82867

21. N-[4-(5-methyl-3-phenylisoxazol-4-yl)phenylsulfonyl]propionamide, Sodium Salt

22. Dsstox_gsid_48670

23. Mls001424308

24. Schembl117192

25. Chembl296913

26. Dtxsid6048670

27. Parecoxib Sodium [mart.]

28. Parecoxib Sodium [who-dd]

29. Hms2052f09

30. Hms3394f09

31. Hms3886m04

32. Parecoxib Sodium Salt [mi]

33. Bcp06888

34. Tox21_113040

35. Hy-17474a

36. Mfcd04972608

37. S5418

38. Ym-978

39. Akos015951182

40. Sodium (4-(5-methyl-3-phenylisoxazol-4-yl)phenylsulfonyl)(propionyl)amide

41. Am84679

42. Ccg-101177

43. Ccg-268554

44. Cs-1960

45. N-((4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propanamide, Sodium Salt

46. Ac-25455

47. Bp164231

48. Smr000469594

49. Cas-198470-85-8

50. Ft-0673518

51. D03717

52. 470p858

53. A854885

54. J-523328

55. Q27277097

56. Acetamide, 2,2,2-trichloro-n-[3-(trifluoromethyl)phenyl]-

57. Sodium((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide

58. N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propanamide Sodium

59. Propanamide, N-((4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)-, Sodium Salt

2.4 Create Date

2007-02-12

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₁₇N₂NaO₄S
Molecular Weight	392.4 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	392.08067248 g/mol
Monoisotopic Mass	392.08067248 g/mol
Topological Polar Surface Area	86.6 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	581
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

For the short-term treatment of postoperative pain in adults.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Cyclooxygenase 2 Inhibitors

A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2. (See all compounds classified as Cyclooxygenase 2 Inhibitors.)

5.2 ATC Code

M01AH04

API SUPPLIERS

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USDMF

01

Chengdu Sino-strong Pharmaceutical C...

China

Medlab Asia & Asia Health

Not Confirmed

02

Msn Organics Private Ltd

India

Medlab Asia & Asia Health

Not Confirmed

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EU WC

01

Nuray Chemicals Private Limited

India

Medlab Asia & Asia Health

Not Confirmed

Nuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

Contact Supplier

Contact Supplier

India

Digital Content

Parecoxib Sodium IH

Date of Issue : 2024-02-20

Valid Till : 2026-12-06

Written Confirmation Number : WC-0416

Address of the Firm : Plot No. 111 SIDCO Industrial Estate, Kakkalur Thiruvallur-602003 Tamil Nadu, In...

Nuray Chemicals

Product Web Link

Digital Content

02

MSN Laboratories

India

Medlab Asia & Asia Health

Not Confirmed

03

MSN Laboratories

India

Medlab Asia & Asia Health

Not Confirmed

04

MSN Laboratories

India

Medlab Asia & Asia Health

Not Confirmed

05

Viatris

U.S.A

Medlab Asia & Asia Health

Not Confirmed

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NDC API

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Listed Suppliers

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API Reference Price

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","customerCountry":"MEXICO","quantity":"2.00","actualQuantity":"2000","unit":"GMS","unitRateFc":"45000","totalValueFC":"19672.6","currency":"USD","unitRateINR":824.29399999999998,"date":"09-Sep-2024","totalValueINR":"1648588","totalValueInUsd":"19672.6","indian_port":"Hyderabad Air","hs_no":"29329990","bill_no":"3875322","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MEXICO","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"MSN HOUSE, PLOT NO.C-24,, HYDERABAD. AP.","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704479400,"product":"PARECOXIB SODIUM (TEST LICENCE NO.TL\/AZ\/23\/003423 DTD. 30.11.2023) (0.5KG X16600\/KG=8300$)","address":"304, SAMAAN-II, OPP. RELIANCE","city":"GARDEN SATELLITE, AHMEDABAD-GUJARAT","supplier":"HANGZHOU ASCENT PHARMA-TECH CO. 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Number of Transactions

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Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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