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ACTIVE PHARMA INGREDIENTS

14 API Suppliers, 2 USDMF, 5 EU WC, 3 NDC API, 10 Listed Suppliers, $ API Reference Price

14 API Suppliers
2 USDMF
5 EU WC
3 NDC API
10 Listed Suppliers
$ API Reference Price

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3 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

20 FDF Dossiers, 10 Europe, 4 South Africa, 6 Listed Dossiers

20 FDF Dossiers
10 Europe
4 South Africa
6 Listed Dossiers

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6 Finished Drug Prices

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6 Finished Drug Prices

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3 APIs, 1 FDF Dossiers, 1 EXCIPIENTS

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3 APIs
1 FDF Dossiers
1 EXCIPIENTS

REF. STANDARDS & IMPURITIES

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7 Others

Nuray Parecoxib Sodium

Synopsis

ACTIVE PHARMA INGREDIENTS

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CEP/COS

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Data Compilation #PharmaFlow

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Chemistry

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Also known as: 198470-85-8, Dynastat, Parecoxib (sodium), Rayzon, Parecoxib sodium salt, Sc 69124a

Molecular Formula

C₁₉H₁₇N₂NaO₄S

Molecular Weight

392.4 g/mol

InChI Key

HQPVVKXJNZEAFW-UHFFFAOYSA-M

FDA UNII

EB87433V6F

Parecoxib Sodium is a water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.

1 2D Structure

Parecoxib Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl-propanoylazanide

2.1.2 InChI

InChI=1S/C19H18N2O4S.Na/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;/h4-12H,3H2,1-2H3,(H,21,22);/q;+1/p-1

2.1.3 InChI Key

HQPVVKXJNZEAFW-UHFFFAOYSA-M

2.1.4 Canonical SMILES

CCC(=O)[N-]S(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C.[Na+]

2.2 Other Identifiers

2.2.1 UNII

EB87433V6F

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Dynastat

2. N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamide

3. N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamine, Sodium Salt

4. N-(((me-p)-p)s)p

5. Parecoxib

2.3.2 Depositor-Supplied Synonyms

1. 198470-85-8

2. Dynastat

3. Parecoxib (sodium)

4. Rayzon

5. Parecoxib Sodium Salt

6. Sc 69124a

7. Parecoxib Na

8. Sc-69124a

9. Parecoxib Sodium [usan]

10. Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide

11. Eb87433v6f

12. 197502-82-2

13. Parecoxib Sodium (usan)

14. N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propanamide, Sodium Salt

15. Sodium;[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl-propanoylazanide

16. Ncgc00181773-01

17. Unii-eb87433v6f

18. Dynastat (tn)

19. Dsstox_cid_28596

20. Dsstox_rid_82867

21. N-[4-(5-methyl-3-phenylisoxazol-4-yl)phenylsulfonyl]propionamide, Sodium Salt

22. Dsstox_gsid_48670

23. Mls001424308

24. Schembl117192

25. Chembl296913

26. Dtxsid6048670

27. Parecoxib Sodium [mart.]

28. Parecoxib Sodium [who-dd]

29. Hms2052f09

30. Hms3394f09

31. Hms3886m04

32. Parecoxib Sodium Salt [mi]

33. Bcp06888

34. Tox21_113040

35. Hy-17474a

36. Mfcd04972608

37. S5418

38. Ym-978

39. Akos015951182

40. Sodium (4-(5-methyl-3-phenylisoxazol-4-yl)phenylsulfonyl)(propionyl)amide

41. Am84679

42. Ccg-101177

43. Ccg-268554

44. Cs-1960

45. N-((4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propanamide, Sodium Salt

46. Ac-25455

47. Bp164231

48. Smr000469594

49. Cas-198470-85-8

50. Ft-0673518

51. D03717

52. 470p858

53. A854885

54. J-523328

55. Q27277097

56. Acetamide, 2,2,2-trichloro-n-[3-(trifluoromethyl)phenyl]-

57. Sodium((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide

58. N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propanamide Sodium

59. Propanamide, N-((4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)-, Sodium Salt

2.4 Create Date

2007-02-12

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₁₇N₂NaO₄S
Molecular Weight	392.4 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	392.08067248 g/mol
Monoisotopic Mass	392.08067248 g/mol
Topological Polar Surface Area	86.6 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	581
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

For the short-term treatment of postoperative pain in adults.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Cyclooxygenase 2 Inhibitors

A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2. (See all compounds classified as Cyclooxygenase 2 Inhibitors.)

5.2 ATC Code

M01AH04

API SUPPLIERS

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USDMF

01

Chengdu Sino-strong Pharmaceutical C...

China

BioFlorida Conference

Not Confirmed

02

Msn Organics Private Ltd

India

BioFlorida Conference

Not Confirmed

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EU WC

01

Nuray Chemicals Private Limited

India

CPhI India 2024

Attending

Nuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

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India

Virtual Booth

Digital Content

Parecoxib Sodium IH

Date of Issue : 2024-02-20

Valid Till : 2026-12-06

Written Confirmation Number : WC-0416

Address of the Firm : Plot No. 111 SIDCO Industrial Estate, Kakkalur Thiruvallur-602003 Tamil Nadu, In...

02

MSN Laboratories

India

BioFlorida Conference

Not Confirmed

03

MSN Laboratories

India

BioFlorida Conference

Not Confirmed

04

MSN Laboratories

India

BioFlorida Conference

Not Confirmed

05

Viatris

U.S.A

BioFlorida Conference

Not Confirmed

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NDC API

01

Pharmacia & Upjohn Company LLC

U.S.A

BioFlorida Conference

Not Confirmed

Pfizer CentreOne is a global CDMO and a leading supplier of Specialty APIs.

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U.S.A

Virtual Booth

Digital Content

PARECOXIB SODIUM

NDC Package Code : 0009-0046

Start Marketing Date : 2014-07-03

End Marketing Date : 2025-12-31

Dosage Form (Strength) : INJECTION, POWDER, FOR SOLUTION (40mg/1)

Marketing Category : DRUG FOR FURTHER PROCESSING

Product Web Link

02

MSN Organics Private Limited

India

BioFlorida Conference

Not Confirmed

03

Viatris Pharmaceuticals LLC

U.S.A

BioFlorida Conference

Not Confirmed

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Listed Suppliers

01

Nuray Chemicals Private Limited

India

CPhI India 2024

Attending

Nuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

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India

Virtual Booth

Digital Content

Parecoxib Sodium

About the Company : Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in th...

Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in the Indian state of Tamil Nadu. Nuray’s expertise and experience lie in developing the chemistry requirements of the pharmaceutical industry, including the synthesis of NCEs, impurities, metabolites, method development, advanced intermediates and APIs for commercial launch. With its focus on maintaining the highest levels of quality, reliability and transparency, Nuray has emerged as a trusted partner in the global generic market.

02

Lifecare Laboratories Pvt Ltd

India

CPhI India 2024

Attending

Lifecare Labs has been developing innovative products in specialist areas of medicine.

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India

Virtual Booth

Digital Content

Parecoxib Sodium

About the Company : Lifecare Labs specializes in producing bulk drugs (APIs) and intermediates that adhere to the industry's stringent quality parameters. Its objective is to deliver excellence throug...

Lifecare Labs specializes in producing bulk drugs (APIs) and intermediates that adhere to the industry's stringent quality parameters. Its objective is to deliver excellence through its "quality designed for excellence" mission and meet its customers' requirements. Cost-effectiveness is a top priority for the company, and it aims to establish long-term relationships with its clients. Lifecare Labs possesses state-of-the-art facilities for manufacturing bulk drugs (APIs) and intermediates and has dedicated units for products. Its mission is to become a globally recognized company responsible for its customers, business partners and society.

03

Shandong Loncom Pharmaceutical

China

BioFlorida Conference

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Shandong Loncom is an R&D-focused manufacturer of Anti-cancer APIs.

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China

Virtual Booth

Digital Content

Parecoxib Sodium

About the Company : Established in May 2012, Shandong Loncom Pharmaceutical operates as a fully owned subsidiary of Shandong Bestcomm Pharmaceutical Co., Ltd. Situated in the Qihe Economic Development...

Established in May 2012, Shandong Loncom Pharmaceutical operates as a fully owned subsidiary of Shandong Bestcomm Pharmaceutical Co., Ltd. Situated in the Qihe Economic Development Zone, Shandong Province, Shandong Loncom has operational API pilot tests and production bases adhering to international standards. With 13 production lines dedicated to oral solid preparations, oral liquid preparations and API, it is actively expanding its preparation workshops for small-volume injections, soft capsules, eye drops, topical medicines and innovative drug R&D centres.

Shandong Loncom Pharmaceutical company banner

Portfolio PDF

Product Web Link

U.S.A

BioFlorida Conference

Not Confirmed

10

Yangtze River Pharmaceutical Group

China

BioFlorida Conference

Not Confirmed

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API Reference Price

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