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Also known as: 198470-85-8, Dynastat, Parecoxib (sodium), Rayzon, Parecoxib sodium salt, Sc 69124a
Molecular Formula
C19H17N2NaO4S
Molecular Weight
392.4  g/mol
InChI Key
HQPVVKXJNZEAFW-UHFFFAOYSA-M
FDA UNII
EB87433V6F

Parecoxib Sodium
Parecoxib Sodium is a water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.
1 2D Structure

Parecoxib Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl-propanoylazanide
2.1.2 InChI
InChI=1S/C19H18N2O4S.Na/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;/h4-12H,3H2,1-2H3,(H,21,22);/q;+1/p-1
2.1.3 InChI Key
HQPVVKXJNZEAFW-UHFFFAOYSA-M
2.1.4 Canonical SMILES
CCC(=O)[N-]S(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C.[Na+]
2.2 Other Identifiers
2.2.1 UNII
EB87433V6F
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Dynastat

2. N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamide

3. N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamine, Sodium Salt

4. N-(((me-p)-p)s)p

5. Parecoxib

2.3.2 Depositor-Supplied Synonyms

1. 198470-85-8

2. Dynastat

3. Parecoxib (sodium)

4. Rayzon

5. Parecoxib Sodium Salt

6. Sc 69124a

7. Parecoxib Na

8. Sc-69124a

9. Parecoxib Sodium [usan]

10. Sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide

11. Eb87433v6f

12. 197502-82-2

13. Parecoxib Sodium (usan)

14. N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propanamide, Sodium Salt

15. Sodium;[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl-propanoylazanide

16. Ncgc00181773-01

17. Unii-eb87433v6f

18. Dynastat (tn)

19. Dsstox_cid_28596

20. Dsstox_rid_82867

21. N-[4-(5-methyl-3-phenylisoxazol-4-yl)phenylsulfonyl]propionamide, Sodium Salt

22. Dsstox_gsid_48670

23. Mls001424308

24. Schembl117192

25. Chembl296913

26. Dtxsid6048670

27. Parecoxib Sodium [mart.]

28. Parecoxib Sodium [who-dd]

29. Hms2052f09

30. Hms3394f09

31. Hms3886m04

32. Parecoxib Sodium Salt [mi]

33. Bcp06888

34. Tox21_113040

35. Hy-17474a

36. Mfcd04972608

37. S5418

38. Ym-978

39. Akos015951182

40. Sodium (4-(5-methyl-3-phenylisoxazol-4-yl)phenylsulfonyl)(propionyl)amide

41. Am84679

42. Ccg-101177

43. Ccg-268554

44. Cs-1960

45. N-((4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propanamide, Sodium Salt

46. Ac-25455

47. Bp164231

48. Smr000469594

49. Cas-198470-85-8

50. Ft-0673518

51. D03717

52. 470p858

53. A854885

54. J-523328

55. Q27277097

56. Acetamide, 2,2,2-trichloro-n-[3-(trifluoromethyl)phenyl]-

57. Sodium((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide

58. N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propanamide Sodium

59. Propanamide, N-((4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)-, Sodium Salt

2.4 Create Date
2007-02-12
3 Chemical and Physical Properties
Molecular Weight 392.4 g/mol
Molecular Formula C19H17N2NaO4S
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass392.08067248 g/mol
Monoisotopic Mass392.08067248 g/mol
Topological Polar Surface Area86.6 Ų
Heavy Atom Count27
Formal Charge0
Complexity581
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

For the short-term treatment of postoperative pain in adults.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Cyclooxygenase 2 Inhibitors

A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2. (See all compounds classified as Cyclooxygenase 2 Inhibitors.)


5.2 ATC Code

M01AH04


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Nuray Chemicals Private Limited

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Lifecare Laboratories Pvt Ltd

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MSN Laboratories

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Viatris

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","customerCountry":"TAIWAN","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"15000","totalValueFC":"44496.2","currency":"USD","unitRateINR":1234666.6666666667,"date":"20-Dec-2023","totalValueINR":"3704000","totalValueInUsd":"44496.2","indian_port":"Hyderabad Air","hs_no":"29329990","bill_no":"6173680","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"MSN HOUSE, PLOT NO.C-24,, HYDERABAD. AP.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1710873000,"product":"PARECOXIB SODIUM","address":"MSN HOUSE, PLOT NO.C-24,","city":"HYDERABAD. 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AP.","supplier":"MSN ORGANICS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"BASLE","customer":"AIRPHARM","customerCountry":"SWITZERLAND","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"9900","totalValueFC":"48848.1","currency":"USD","unitRateINR":815562.19999999995,"date":"07-Jun-2024","totalValueINR":"4077811","totalValueInUsd":"48848.1","indian_port":"Hyderabad Air","hs_no":"29329990","bill_no":"1515174","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"MSN HOUSE, PLOT NO.C-24,, HYDERABAD. AP.","customerAddress":""}]
05-Mar-2021
07-Jun-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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FDF Dossiers

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01

Grupo Azevedos

Portugal
SupplySide West 2024
Not Confirmed
arrow

Grupo Azevedos

Portugal
arrow
SupplySide West 2024
Not Confirmed

Parecoxib Sodium

Brand Name :

Dosage Form : Powder for solution for infusion

Dosage Strength : 40MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Portugal

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02

Pfizer Inc

U.S.A
SupplySide West 2024
Not Confirmed
arrow

Pfizer Inc

U.S.A
arrow
SupplySide West 2024
Not Confirmed

parecoxib sodium

Brand Name : Dynastat

Dosage Form : POWDER AND SOLVENT FOR SOLUTION FOR INJECTION

Dosage Strength : 40 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

blank

03

Pfizer Inc

U.S.A
SupplySide West 2024
Not Confirmed
arrow

Pfizer Inc

U.S.A
arrow
SupplySide West 2024
Not Confirmed

parecoxib sodium

Brand Name : Dynastat

Dosage Form : POWDER FOR SOLUTION FOR INJECTION

Dosage Strength : 20 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

blank

04

Pfizer Inc

U.S.A
SupplySide West 2024
Not Confirmed
arrow

Pfizer Inc

U.S.A
arrow
SupplySide West 2024
Not Confirmed

parecoxib

Brand Name : Dynastat

Dosage Form :

Dosage Strength : 10 Vials Im Ev 20 Mg  

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

blank

05

Pfizer Inc

U.S.A
SupplySide West 2024
Not Confirmed
arrow

Pfizer Inc

U.S.A
arrow
SupplySide West 2024
Not Confirmed

parecoxib

Brand Name : Dyna State

Dosage Form : Powder and liquid to the injection fluid, resolution

Dosage Strength : 40 mg

Packaging : Set

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

blank

06

Pfizer Inc

U.S.A
SupplySide West 2024
Not Confirmed
arrow

Pfizer Inc

U.S.A
arrow
SupplySide West 2024
Not Confirmed

parecoxib

Brand Name : Dyna State

Dosage Form : Powder for injection fluid, resolution

Dosage Strength : 40 mg

Packaging : Hood glass

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

blank

07

Pfizer Inc

U.S.A
SupplySide West 2024
Not Confirmed
arrow

Pfizer Inc

U.S.A
arrow
SupplySide West 2024
Not Confirmed

Parecoxib sodium

Brand Name : Dynastat

Dosage Form : Powder for solution for injection

Dosage Strength : 40 mg

Packaging : Vials 10 40mg

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

blank

08

Pfizer Inc

U.S.A
SupplySide West 2024
Not Confirmed
arrow

Pfizer Inc

U.S.A
arrow
SupplySide West 2024
Not Confirmed

Parecoxib

Brand Name : Rayzon 40mg IV/IM

Dosage Form : INJ

Dosage Strength : 40mg/2ml

Packaging : 2X10mg/2ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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09

SupplySide West 2024
Not Confirmed
arrow
arrow
SupplySide West 2024
Not Confirmed

Parecoxib Sodium

Brand Name :

Dosage Form : Injection

Dosage Strength : 20MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : China

blank

10

SupplySide West 2024
Not Confirmed
arrow
arrow
SupplySide West 2024
Not Confirmed

parecoxib sodium

Brand Name :

Dosage Form : Injection

Dosage Strength : 40MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : China

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