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    Chemistry

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    Also known as: 635702-64-6, Pazopanib hcl, Votrient, Pazopanib (hydrochloride), Armala, Unii-33y9anm545
    Molecular Formula
    C21H24ClN7O2S
    Molecular Weight
    474.0  g/mol
    InChI Key
    MQHIQUBXFFAOMK-UHFFFAOYSA-N
    FDA UNII
    33Y9ANM545
    Pazopanib Hydrochloride
    Pazopanib Hydrochloride is the hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.
    1 2D Structure

    Pazopanib Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
    2.1.3 InChI Key
    MQHIQUBXFFAOMK-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    33Y9ANM545
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Gw 780604

    2. Gw 786034b

    3. Gw-780604

    4. Gw-786034b

    5. Gw780604

    6. Gw786034b

    7. Pazopanib

    8. Votrient

    2.3.2 Depositor-Supplied Synonyms

    1. 635702-64-6

    2. Pazopanib Hcl

    3. Votrient

    4. Pazopanib (hydrochloride)

    5. Armala

    6. Unii-33y9anm545

    7. Pazopanib Monohydrochloride

    8. Pazopanib Hcl (gw786034 Hcl)

    9. Gw786034b

    10. Gw-786034b

    11. Pazopanib (as Hydrochloride)

    12. Gw786034 (hydrochloride)

    13. 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride

    14. Chebi:71217

    15. 33y9anm545

    16. S1035

    17. 5-((4-((2,3-dimethyl-2h-indazol-6-yl)(methyl)amino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide Hydrochloride

    18. 5-((4-((2,3-dimethyl-2h-indazol-6-yl)methylamino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide Monohydrochloride

    19. 5-({4-[(2,3-dimethyl-2h-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide Hydrochloride

    20. 5-{4-[(2,3-dimethyl-2h-indazol-6-yl)-methyl-amino]-pyrimidin-2-ylamino}-2-methyl-benzenesulfonamide Hydrochloride

    21. Benzenesulfonamide, 5-((4-((2,3-dimethyl-2h-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-, Monohydrochloride

    22. Patorma

    23. Gw786034 Hcl

    24. Votrient Hcl

    25. Votrient (tn)

    26. 5-({4-[(2,3-dimethyl-2h-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide Hydrochloride

    27. Pazopanib Hydrochloride [usan:jan]

    28. Mls004774147

    29. Schembl159487

    30. Pazopanib Hydrochloride- Bio-x

    31. Pazopanib Hydrochloride [usan]

    32. Chembl1201733

    33. Dtxsid70212956

    34. Ex-a956

    35. Pazopanib Hcl (gw786034 )

    36. Bcp02203

    37. Pazopanib Hydrochloride (jan/usan)

    38. Pazopanib Hydrochloride [mi]

    39. Mfcd12546138

    40. Nsc737754

    41. Pazopanib Hydrochloride [jan]

    42. Akos015958593

    43. Bcp9001052

    44. Ccg-269485

    45. Cs-0126

    46. Gsk-786034

    47. Ks-1458

    48. Nsc-737754

    49. Pazopanib Hydrochloride [mart.]

    50. Pb31655

    51. Sb10367

    52. Pazopanib Hydrochloride [who-dd]

    53. Ac-24726

    54. Bp166746

    55. Hy-12009

    56. Smr003500790

    57. Am20090655

    58. Ft-0687642

    59. P2243

    60. Pazopanib Hydrochloride [orange Book]

    61. Sw218082-2

    62. Ec-000.2347

    63. D05380

    64. A834417

    65. Q27888072

    66. 5-({4-[(2,3-dimethyl-2h-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzenesulfonamide Hydrochloride

    67. 5-(4-((2,3-dimethyl-2h-indazol-6-yl)(methyl)amino)pyrimidin-2-ylamino)-2-methylbenzenesulfonamide Hydrochloride

    68. 5-(4-((2,3-dimethyl-2h-indazol-6-yl)(methyl)amino)pyrimidin-2-ylamino)-2-methylbenzenesulfonamide Hydrochloride;5-[[4-[(2,3-dimethylindazol-6-yl)-methyl-amino]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide Hydrochloride

    69. 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Hydrochloride

    70. Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2h-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-, Hydrochloride (1:1)

    2.4 Create Date
    2006-10-26
    3 Chemical and Physical Properties
    Molecular Weight 474.0 g/mol
    Molecular Formula C21H24ClN7O2S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count5
    Exact Mass473.1400719 g/mol
    Monoisotopic Mass473.1400719 g/mol
    Topological Polar Surface Area127 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity717
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameVotrient
    PubMed HealthPazopanib (By mouth)
    Drug ClassesAntineoplastic Agent, Immunological Agent
    Active IngredientPazopanib hydrochloride
    Dosage FormTablet
    RouteOral
    Strengtheq 200mg base; eq 400mg base
    Market StatusPrescription
    CompanyGlaxosmithkline

    2 of 2  
    Drug NameVotrient
    PubMed HealthPazopanib (By mouth)
    Drug ClassesAntineoplastic Agent, Immunological Agent
    Active IngredientPazopanib hydrochloride
    Dosage FormTablet
    RouteOral
    Strengtheq 200mg base; eq 400mg base
    Market StatusPrescription
    CompanyGlaxosmithkline

    4.2 Drug Indication

    * Renal-cell carcinoma (RCC):

    Votrient is indicated in adults for the first-line treatment of advanced renal-cell carcinoma (RCC) and for patients who have received prior cytokine therapy for advanced disease.

    * Soft-tissue sarcoma (STS):

    Votrient is indicated for the treatment of adult patients with selective subtypes of advanced soft-tissue sarcoma (STS) who have received prior chemotherapy for metastatic disease or who have progressed within 12 months after (neo)adjuvant therapy.

    Efficacy and safety have only been established in certain STS histological tumour subtypes.

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Pharmacological Classes
    Cytochrome P450 2D6 Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]; Kinase Inhibitor [EPC]; Protein Kinase Inhibitors [MoA]; Cytochrome P450 2C8 Inhibitors [MoA]
    5.2 ATC Code

    L01XE11

    API Reference Price

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    11-Jan-2021
    17-Dec-2024
    KGS
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    DOSAGE - TABLET;ORAL - EQ 400MG BASE **Federa...DOSAGE - TABLET;ORAL - EQ 400MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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    ABOUT THIS PAGE

    Pazopanib Hydrochloride Manufacturers

    A Pazopanib Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pazopanib Hydrochloride, including repackagers and relabelers. The FDA regulates Pazopanib Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pazopanib Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Pazopanib Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Pazopanib Hydrochloride Suppliers

    A Pazopanib Hydrochloride supplier is an individual or a company that provides Pazopanib Hydrochloride active pharmaceutical ingredient (API) or Pazopanib Hydrochloride finished formulations upon request. The Pazopanib Hydrochloride suppliers may include Pazopanib Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Pazopanib Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Pazopanib Hydrochloride USDMF

    A Pazopanib Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Pazopanib Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Pazopanib Hydrochloride DMFs exist exist since differing nations have different regulations, such as Pazopanib Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Pazopanib Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Pazopanib Hydrochloride USDMF includes data on Pazopanib Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Pazopanib Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Pazopanib Hydrochloride suppliers with USDMF on PharmaCompass.

    Pazopanib Hydrochloride KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Pazopanib Hydrochloride Drug Master File in Korea (Pazopanib Hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Pazopanib Hydrochloride. The MFDS reviews the Pazopanib Hydrochloride KDMF as part of the drug registration process and uses the information provided in the Pazopanib Hydrochloride KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Pazopanib Hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Pazopanib Hydrochloride API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Pazopanib Hydrochloride suppliers with KDMF on PharmaCompass.

    Pazopanib Hydrochloride WC

    A Pazopanib Hydrochloride written confirmation (Pazopanib Hydrochloride WC) is an official document issued by a regulatory agency to a Pazopanib Hydrochloride manufacturer, verifying that the manufacturing facility of a Pazopanib Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Pazopanib Hydrochloride APIs or Pazopanib Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Pazopanib Hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Pazopanib Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Pazopanib Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Pazopanib Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Pazopanib Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Pazopanib Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Pazopanib Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Pazopanib Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Pazopanib Hydrochloride suppliers with NDC on PharmaCompass.

    Pazopanib Hydrochloride GMP

    Pazopanib Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Pazopanib Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pazopanib Hydrochloride GMP manufacturer or Pazopanib Hydrochloride GMP API supplier for your needs.

    Pazopanib Hydrochloride CoA

    A Pazopanib Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Pazopanib Hydrochloride's compliance with Pazopanib Hydrochloride specifications and serves as a tool for batch-level quality control.

    Pazopanib Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Pazopanib Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Pazopanib Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Pazopanib Hydrochloride EP), Pazopanib Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pazopanib Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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