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Also known as: 635702-64-6, Pazopanib hcl, Votrient, Pazopanib (hydrochloride), Armala, Unii-33y9anm545
Molecular Formula
C21H24ClN7O2S
Molecular Weight
474.0  g/mol
InChI Key
MQHIQUBXFFAOMK-UHFFFAOYSA-N
FDA UNII
33Y9ANM545

Pazopanib Hydrochloride
Pazopanib Hydrochloride is the hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.
1 2D Structure

Pazopanib Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride
2.1.2 InChI
InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
2.1.3 InChI Key
MQHIQUBXFFAOMK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
2.2 Other Identifiers
2.2.1 UNII
33Y9ANM545
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Gw 780604

2. Gw 786034b

3. Gw-780604

4. Gw-786034b

5. Gw780604

6. Gw786034b

7. Pazopanib

8. Votrient

2.3.2 Depositor-Supplied Synonyms

1. 635702-64-6

2. Pazopanib Hcl

3. Votrient

4. Pazopanib (hydrochloride)

5. Armala

6. Unii-33y9anm545

7. Pazopanib Monohydrochloride

8. Pazopanib Hcl (gw786034 Hcl)

9. Gw786034b

10. Gw-786034b

11. Pazopanib (as Hydrochloride)

12. Gw786034 (hydrochloride)

13. 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride

14. Chebi:71217

15. 33y9anm545

16. S1035

17. 5-((4-((2,3-dimethyl-2h-indazol-6-yl)(methyl)amino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide Hydrochloride

18. 5-((4-((2,3-dimethyl-2h-indazol-6-yl)methylamino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamide Monohydrochloride

19. 5-({4-[(2,3-dimethyl-2h-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide Hydrochloride

20. 5-{4-[(2,3-dimethyl-2h-indazol-6-yl)-methyl-amino]-pyrimidin-2-ylamino}-2-methyl-benzenesulfonamide Hydrochloride

21. Benzenesulfonamide, 5-((4-((2,3-dimethyl-2h-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-, Monohydrochloride

22. Patorma

23. Gw786034 Hcl

24. Votrient Hcl

25. Votrient (tn)

26. 5-({4-[(2,3-dimethyl-2h-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide Hydrochloride

27. Pazopanib Hydrochloride [usan:jan]

28. Mls004774147

29. Schembl159487

30. Pazopanib Hydrochloride- Bio-x

31. Pazopanib Hydrochloride [usan]

32. Chembl1201733

33. Dtxsid70212956

34. Ex-a956

35. Pazopanib Hcl (gw786034 )

36. Bcp02203

37. Pazopanib Hydrochloride (jan/usan)

38. Pazopanib Hydrochloride [mi]

39. Mfcd12546138

40. Nsc737754

41. Pazopanib Hydrochloride [jan]

42. Akos015958593

43. Bcp9001052

44. Ccg-269485

45. Cs-0126

46. Gsk-786034

47. Ks-1458

48. Nsc-737754

49. Pazopanib Hydrochloride [mart.]

50. Pb31655

51. Sb10367

52. Pazopanib Hydrochloride [who-dd]

53. Ac-24726

54. Bp166746

55. Hy-12009

56. Smr003500790

57. Am20090655

58. Ft-0687642

59. P2243

60. Pazopanib Hydrochloride [orange Book]

61. Sw218082-2

62. Ec-000.2347

63. D05380

64. A834417

65. Q27888072

66. 5-({4-[(2,3-dimethyl-2h-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzenesulfonamide Hydrochloride

67. 5-(4-((2,3-dimethyl-2h-indazol-6-yl)(methyl)amino)pyrimidin-2-ylamino)-2-methylbenzenesulfonamide Hydrochloride

68. 5-(4-((2,3-dimethyl-2h-indazol-6-yl)(methyl)amino)pyrimidin-2-ylamino)-2-methylbenzenesulfonamide Hydrochloride;5-[[4-[(2,3-dimethylindazol-6-yl)-methyl-amino]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide Hydrochloride

69. 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Hydrochloride

70. Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2h-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-, Hydrochloride (1:1)

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 474.0 g/mol
Molecular Formula C21H24ClN7O2S
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass473.1400719 g/mol
Monoisotopic Mass473.1400719 g/mol
Topological Polar Surface Area127 Ų
Heavy Atom Count32
Formal Charge0
Complexity717
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameVotrient
PubMed HealthPazopanib (By mouth)
Drug ClassesAntineoplastic Agent, Immunological Agent
Active IngredientPazopanib hydrochloride
Dosage FormTablet
RouteOral
Strengtheq 200mg base; eq 400mg base
Market StatusPrescription
CompanyGlaxosmithkline

2 of 2  
Drug NameVotrient
PubMed HealthPazopanib (By mouth)
Drug ClassesAntineoplastic Agent, Immunological Agent
Active IngredientPazopanib hydrochloride
Dosage FormTablet
RouteOral
Strengtheq 200mg base; eq 400mg base
Market StatusPrescription
CompanyGlaxosmithkline

4.2 Drug Indication

* Renal-cell carcinoma (RCC):

Votrient is indicated in adults for the first-line treatment of advanced renal-cell carcinoma (RCC) and for patients who have received prior cytokine therapy for advanced disease.

* Soft-tissue sarcoma (STS):

Votrient is indicated for the treatment of adult patients with selective subtypes of advanced soft-tissue sarcoma (STS) who have received prior chemotherapy for metastatic disease or who have progressed within 12 months after (neo)adjuvant therapy.

Efficacy and safety have only been established in certain STS histological tumour subtypes.


5 Pharmacology and Biochemistry
5.1 FDA Pharmacological Classification
5.1.1 Pharmacological Classes
Cytochrome P450 2D6 Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]; Kinase Inhibitor [EPC]; Protein Kinase Inhibitors [MoA]; Cytochrome P450 2C8 Inhibitors [MoA]
5.2 ATC Code

L01XE11


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11-Jan-2021
24-Sep-2024
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DOSAGE - TABLET;ORAL - EQ 200MG BASE

USFDA APPLICATION NUMBER - 22465

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DOSAGE - TABLET;ORAL - EQ 400MG BASE **Federa...DOSAGE - TABLET;ORAL - EQ 400MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22465

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