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1. 2589 R.b.
2. Abactal
3. Dihydrate, Pefloxacin Mesylate
4. Mesylate Dihydrate, Pefloxacin
5. Mesylate, Pefloxacin
6. Peflacine
7. Pefloxacin Mesylate
8. Pefloxacin Mesylate Dihydrate
9. Pefloxacin, Silver
10. Pefloxacine
11. R.b., 2589
12. Silver Pefloxacin
1. 70458-92-3
2. Pefloxacine
3. Pefloxacino
4. Pefloxacinum
5. Pflx
6. 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid
7. Pefloxacinium
8. Eu-5306
9. 1589 Rb
10. 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic Acid
11. Eu 5306
12. Pefloxacinium Mesylate
13. Chebi:50199
14. 2h52z9f2q5
15. 3-quinolinecarboxylic Acid, 1,4-dihydro-1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-
16. 3-quinolinecarboxylic Acid,1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-
17. 1589-rb
18. Pefloxacin [inn-french]
19. Pefloxacinum [inn-latin]
20. Pefloxacino [inn-spanish]
21. Perfloxacin
22. Am-725
23. Labocton
24. Mls001049009
25. 1584rb
26. Smr000273037
27. Sr-01000356843
28. Pefloxacin (usan/inn)
29. Smr000387024
30. Einecs 274-611-8
31. Brn 0567618
32. Pefloxacin [usan:inn:ban]
33. Unii-2h52z9f2q5
34. Ccris 8210
35. Pefloxacin,(s)
36. 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)-3-quinolinecarboxylic Acid
37. 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid
38. Bas 00463355
39. Pefloxacin [mi]
40. Pefloxacin [inn]
41. Spectrum2_000034
42. Spectrum3_001971
43. Pefloxacin [usan]
44. 3-quinolinecarboxylic Acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo
45. 3-quinolinecarboxylic Acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-
46. Pefloxacin [who-dd]
47. Oprea1_063677
48. Oprea1_546341
49. Schembl34292
50. Bspbio_003571
51. Mls000713556
52. Mls006011797
53. Spbio_000127
54. Chembl267648
55. Cid_119525
56. Zinc1894
57. Dtxsid3048493
58. Bdbm57936
59. Kbio3_002945
60. Hms1613e05
61. Hms2090h09
62. Hms3713g04
63. Bcp20511
64. Hy-b0147
65. Bbl008795
66. Mfcd00865015
67. Stk169677
68. Akos000280245
69. Ccg-111464
70. Cs-1961
71. Db00487
72. Ncgc00177986-04
73. Vs-01991
74. Sbi-0206758.p001
75. Db-055417
76. Ft-0630798
77. Vu0243371-6
78. D02306
79. P-1198
80. Ab00600922-12
81. Ab00600922-14
82. Ab00600922_15
83. Ab00600922_16
84. 458p923
85. Pefloxacin, Antibiotic For Culture Media Use Only
86. Q2601859
87. Sr-01000356843-1
88. Sr-01000356843-6
89. Brd-k55034111-001-02-0
90. Brd-k55034111-066-02-3
91. Brd-k55034111-066-07-2
92. F5577-0091
93. 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methylpiperazinyl)quinoline-3-carboxylic Acid
94. 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1- Piperazinyl)-4-oxo-3-quinolinecarboxylic Acid
95. 1-ethyl-6-fluoro-4-keto-7-(4-methylpiperazino)quinoline-3-carboxylic Acid;mesylic Acid
96. 1-ethyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carbo
97. 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylicacid
98. 1-ethyl-6-fluoro-7-(4-methylpiperazin-4-ium-1-yl)-4-oxoquinoline-3-carboxylate
99. 1-ethyl-6-fluoranyl-7-(4-methylpiperazin-1-yl)-4-oxidanylidene-quinoline-3-carboxylic Acid;methanesulfonic Acid
100. 1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid;methanesulfonic Acid
| Molecular Weight | 333.36 g/mol |
|---|---|
| Molecular Formula | C17H20FN3O3 |
| XLogP3 | 0.3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 3 |
| Exact Mass | 333.14886967 g/mol |
| Monoisotopic Mass | 333.14886967 g/mol |
| Topological Polar Surface Area | 64.1 Ų |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 545 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.
Pefloxacin is a fluoroquinolone antibiotic. Flouroquinolones such as pefloxacin possess excellent activity against gram-negative aerobic bacteria such as E.coli and Neisseria gonorrhoea as well as gram-positive bacteria including S. pneumoniae and Staphylococcus aureus. They also posses effective activity against shigella, salmonella, campylobacter, gonococcal organisms, and multi drug resistant pseudomonas and enterobacter.
Topoisomerase II Inhibitors
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)
Cytochrome P-450 CYP1A2 Inhibitors
Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)
Anti-Bacterial Agents
Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)
J - Antiinfectives for systemic use
J01 - Antibacterials for systemic use
J01M - Quinolone antibacterials
J01MA - Fluoroquinolones
J01MA03 - Pefloxacin
Absorption
Well absorbed by the oral route.
Hepatic. Primary metabolites are pefloxacin N-oxide and norfloxacin.
8.6 hours
The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.
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ABOUT THIS PAGE
47
PharmaCompass offers a list of Pefloxacin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pefloxacin manufacturer or Pefloxacin supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Pefloxacin manufacturer or Pefloxacin supplier.
PharmaCompass also assists you with knowing the Pefloxacin API Price utilized in the formulation of products. Pefloxacin API Price is not always fixed or binding as the Pefloxacin Price is obtained through a variety of data sources. The Pefloxacin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Pefloxacin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pefloxacin, including repackagers and relabelers. The FDA regulates Pefloxacin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pefloxacin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Pefloxacin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Pefloxacin supplier is an individual or a company that provides Pefloxacin active pharmaceutical ingredient (API) or Pefloxacin finished formulations upon request. The Pefloxacin suppliers may include Pefloxacin API manufacturers, exporters, distributors and traders.
click here to find a list of Pefloxacin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
Pefloxacin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Pefloxacin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pefloxacin GMP manufacturer or Pefloxacin GMP API supplier for your needs.
A Pefloxacin CoA (Certificate of Analysis) is a formal document that attests to Pefloxacin's compliance with Pefloxacin specifications and serves as a tool for batch-level quality control.
Pefloxacin CoA mostly includes findings from lab analyses of a specific batch. For each Pefloxacin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Pefloxacin may be tested according to a variety of international standards, such as European Pharmacopoeia (Pefloxacin EP), Pefloxacin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pefloxacin USP).
