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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

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CEP/COS

CEP/COS Certifications

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JDMF

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EU WC

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KDMF

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NDC API

NDC API

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VMF

NDC API

API REF. PRICE (USD/KG)

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MARKET PLACE

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API

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FDF

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Europe

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Canada

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Australia

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Listed Dossiers

Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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Chemistry

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Also known as: 257933-82-7, Ekb-569, Pelitinib (ekb-569), Way-ekb 569, Ekb 569, Way-ekb-569
Molecular Formula
C24H23ClFN5O2
Molecular Weight
467.9  g/mol
InChI Key
WVUNYSQLFKLYNI-AATRIKPKSA-N
FDA UNII
X5DWL380Z6

Pelitinib
Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors.
1 2D Structure

Pelitinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
2.1.2 InChI
InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+
2.1.3 InChI Key
WVUNYSQLFKLYNI-AATRIKPKSA-N
2.1.4 Canonical SMILES
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)C=CCN(C)C
2.1.5 Isomeric SMILES
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)/C=C/CN(C)C
2.2 Other Identifiers
2.2.1 UNII
X5DWL380Z6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (2e)-n-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide

2. Ekb 569

3. Ekb-569

4. Eki 569

5. Eki-569

2.3.2 Depositor-Supplied Synonyms

1. 257933-82-7

2. Ekb-569

3. Pelitinib (ekb-569)

4. Way-ekb 569

5. Ekb 569

6. Way-ekb-569

7. 326894-84-2

8. (e)-n-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

9. (e)-n-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

10. X5dwl380z6

11. (2e)-n-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide

12. (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide

13. Chebi:38927

14. (e)-n-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

15. Mfcd09837868

16. (e)-n-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide

17. (e)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide

18. 2-butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-, (2e)-

19. Pelitinib [usan]

20. Eki-569

21. Pelitinib [usan:inn]

22. Unii-x5dwl380z6

23. Ekb569

24. Eki 569

25. (2e)-n-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

26. (2e)-n-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide

27. 93j

28. Pelitinib [inn]

29. Pelitinib (usan/inn)

30. Pelitinib - Ekb-569

31. 2-butenamide, (e)-,

32. Pelitinib [who-dd]

33. Schembl93756

34. Schembl93757

35. Mls006010062

36. Chembl607707

37. Gtpl7644

38. Bdbm31090

39. Cid_6445562

40. Ex-a061

41. Bcpp000118

42. Bcpp000119

43. Zinc602803

44. Bcp02376

45. Nsc729742

46. Nsc800841

47. S1392

48. Akos005146343

49. Ccg-264890

50. Db05524

51. Nsc-729742

52. Nsc-800841

53. Way-172569

54. Ncgc00263103-09

55. Ncgc00263103-10

56. (e)-n-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide

57. Ac-24700

58. Ac-25029

59. As-16280

60. Hy-32718

61. Smr004701222

62. Pelitinib (ekb-569; Way-ekb 569)

63. P2529

64. Sw219267-1

65. Ec-000.2259

66. D05399

67. 933p827

68. A818030

69. Q-101404

70. Brd-k08799216-001-01-2

71. Q27088290

72. (2e)-n-(-((3-chloro-4-fluorophenyl)amino)3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

73. (2e)-n-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide Pelitinib

74. (2e)-n-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-dimethylamino-2-butenamide

75. (e)-n-[3-cyano-4-[(4-fluoro-3-chlorophenyl)amino]-7-ethoxyquinoline-6-yl]-4-(dimethylamino)-2-buteneamide

76. (e)-n-[4-(3-chloro-4-fluoroanilino)-cyano-7-ethoxyquinolin-6-yl]-4-(dimethlyamino)but-2-enamide, (iupac)

77. (e)-n-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-dimethylaminobut-2-enamide

78. 3-cyano-4-[(3-chloro-4-fluorophenyl)amino]-6-[[4-(n,n-dimethylamino)-1-oxo-2-buten-1-yl]amino]-7-ethoxyquinoline

79. 4-dimethylaminobut-2-enoic Acid, [4-(3-chloro-4-fluoro Phenylamino)-3-cyano-7-ethoxyquinoline-6-yl]amide

2.4 Create Date
2006-04-29
3 Chemical and Physical Properties
Molecular Weight 467.9 g/mol
Molecular Formula C24H23ClFN5O2
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass467.1524308 g/mol
Monoisotopic Mass467.1524308 g/mol
Topological Polar Surface Area90.3 Ų
Heavy Atom Count33
Formal Charge0
Complexity729
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in colorectal cancer and lung cancer.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


ABOUT THIS PAGE

Pelitinib Manufacturers

A Pelitinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pelitinib, including repackagers and relabelers. The FDA regulates Pelitinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pelitinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Pelitinib manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Pelitinib Suppliers

A Pelitinib supplier is an individual or a company that provides Pelitinib active pharmaceutical ingredient (API) or Pelitinib finished formulations upon request. The Pelitinib suppliers may include Pelitinib API manufacturers, exporters, distributors and traders.

click here to find a list of Pelitinib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Pelitinib GMP

Pelitinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pelitinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pelitinib GMP manufacturer or Pelitinib GMP API supplier for your needs.

Pelitinib CoA

A Pelitinib CoA (Certificate of Analysis) is a formal document that attests to Pelitinib's compliance with Pelitinib specifications and serves as a tool for batch-level quality control.

Pelitinib CoA mostly includes findings from lab analyses of a specific batch. For each Pelitinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pelitinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Pelitinib EP), Pelitinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pelitinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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