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ACTIVE PHARMA INGREDIENTS

2 KDMF

2 KDMF

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1 FDF Dossiers, 1 FDA Orange Book

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1 FDA Orange Book

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Synopsis

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Chemistry

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Also known as: 100299-08-9, Alamast, Pemirolast potassium salt, Pemilaston, Alegysal, Bmy 26517

Molecular Formula

C₁₀H₇KN₆O

Molecular Weight

266.30 g/mol

InChI Key

NMMVKSMGBDRONO-UHFFFAOYSA-N

FDA UNII

497A17OUUE

Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by blocking the antigen-mediated calcium ion influx into mast cells. This prevents mast cell degranulation, resulting in mast cell stabilization and inhibition of the release of inflammatory mediators, histamine and leukotrienes, which are involved in the allergic process. Pemirolast potassium also prevents inflammatory mediator release from eosinophils.

1 2D Structure

Pemirolast

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

potassium;9-methyl-3-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)pyrido[1,2-a]pyrimidin-4-one

2.1.2 InChI

InChI=1S/C10H7N6O.K/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8;/h2-5H,1H3;/q-1;+1

2.1.3 InChI Key

NMMVKSMGBDRONO-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CC=CN2C1=NC=C(C2=O)C3=NN=N[N-]3.[K+]

2.2 Other Identifiers

2.2.1 UNII

497A17OUUE

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-one

2. 9-tbx

3. Alamast

4. Bmy 26517

5. Bmy-26517

6. Pemirolast

7. Pemirolast Potassium Salt

2.3.2 Depositor-Supplied Synonyms

1. 100299-08-9

2. Alamast

3. Pemirolast Potassium Salt

4. Pemilaston

5. Alegysal

6. Bmy 26517

7. Bmy-26517

8. Twt-8152

9. 497a17ouue

10. Tbx

11. 100299-08-9 (potassium)

12. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-one, Potassium Salt

13. Potassium 5-(9-methyl-4-oxo-4h-pyrido[1,2-a]pyrimidin-3-yl)tetrazol-1-ide

14. 4h-pyrido(1,2-a)pyrimidin-4-one, 9-methyl-3-(1h-tetrazol-5-yl)-, Potassium Salt

15. Dsstox_cid_26623

16. Dsstox_rid_81773

17. Dsstox_gsid_46623

18. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-one Potassium Salt

19. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido[1,2-a]pyrimidin-4-one Potassium Salt

20. Ccris 3562

21. Cas-100299-08-9

22. Pemirolast Potassium [usan:jan]

23. Ncgc00167434-01

24. Unii-497a17ouue

25. Pemilaston (tn)

26. Alegysal (tn)

27. Alamast (tn)

28. Permirolast Potassium

29. Pemirolast Potassium- Bio-x

30. Alamast, Pemirolast Potassium

31. Schembl865789

32. Chembl1201050

33. Dtxsid7046623

34. Hms3713g17

35. Pemirolast Potassium [jan]

36. Pemirolast Potassium [usan]

37. Bcp21138

38. Pemirolast Potassium (jp17/usan)

39. Pemirolast Potassium [vandf]

40. Tox21_112438

41. Bdbm50248065

42. De-068

43. Pemirolast (bmy 26517) Potassium

44. Pemirolast Potassium [mart.]

45. Permirolast Potassium [vandf]

46. S4008

47. Pemirolast Potassium [who-dd]

48. Akos015901748

49. Pemirolast Potassium Salt [mi]

50. Tox21_112438_1

51. Ac-8303

52. Ccg-220358

53. Hs-0020

54. Pemirolast Potassium, >=98% (hplc)

55. Sb18793

56. Ncgc00167434-02

57. Ac-22387

58. Bp164244

59. Pemirolast Potassium [orange Book]

60. Ft-0631005

61. P1995

62. P2547

63. D01088

64. T71519

65. 299p089

66. J-000087

67. Q27259246

68. 9-methyl-3-(2h-tetrazol-5-yl)-4h-pyrido[1,2-a]pyrimidin-4-one Potassium Salt;alamast

69. Potassium;9-methyl-3-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)pyrido[1,2-a]pyrimidin-4-one

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₇KN₆O
Molecular Weight	266.30 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	1
Exact Mass	266.03184035 g/mol
Monoisotopic Mass	266.03184035 g/mol
Topological Polar Surface Area	72.3 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	495
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Histamine Antagonists

Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)

KDMF