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Chemistry

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Also known as: 100299-08-9, Alamast, Pemirolast potassium salt, Pemilaston, Alegysal, Bmy 26517
Molecular Formula
C10H7KN6O
Molecular Weight
266.30  g/mol
InChI Key
NMMVKSMGBDRONO-UHFFFAOYSA-N
FDA UNII
497A17OUUE

Pemirolast
Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by blocking the antigen-mediated calcium ion influx into mast cells. This prevents mast cell degranulation, resulting in mast cell stabilization and inhibition of the release of inflammatory mediators, histamine and leukotrienes, which are involved in the allergic process. Pemirolast potassium also prevents inflammatory mediator release from eosinophils.
1 2D Structure

Pemirolast

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
potassium;9-methyl-3-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)pyrido[1,2-a]pyrimidin-4-one
2.1.2 InChI
InChI=1S/C10H7N6O.K/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8;/h2-5H,1H3;/q-1;+1
2.1.3 InChI Key
NMMVKSMGBDRONO-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC=CN2C1=NC=C(C2=O)C3=NN=N[N-]3.[K+]
2.2 Other Identifiers
2.2.1 UNII
497A17OUUE
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-one

2. 9-tbx

3. Alamast

4. Bmy 26517

5. Bmy-26517

6. Pemirolast

7. Pemirolast Potassium Salt

2.3.2 Depositor-Supplied Synonyms

1. 100299-08-9

2. Alamast

3. Pemirolast Potassium Salt

4. Pemilaston

5. Alegysal

6. Bmy 26517

7. Bmy-26517

8. Twt-8152

9. 497a17ouue

10. Tbx

11. 100299-08-9 (potassium)

12. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-one, Potassium Salt

13. Potassium 5-(9-methyl-4-oxo-4h-pyrido[1,2-a]pyrimidin-3-yl)tetrazol-1-ide

14. 4h-pyrido(1,2-a)pyrimidin-4-one, 9-methyl-3-(1h-tetrazol-5-yl)-, Potassium Salt

15. Dsstox_cid_26623

16. Dsstox_rid_81773

17. Dsstox_gsid_46623

18. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-one Potassium Salt

19. 9-methyl-3-(1h-tetrazol-5-yl)-4h-pyrido[1,2-a]pyrimidin-4-one Potassium Salt

20. Ccris 3562

21. Cas-100299-08-9

22. Pemirolast Potassium [usan:jan]

23. Ncgc00167434-01

24. Unii-497a17ouue

25. Pemilaston (tn)

26. Alegysal (tn)

27. Alamast (tn)

28. Permirolast Potassium

29. Pemirolast Potassium- Bio-x

30. Alamast, Pemirolast Potassium

31. Schembl865789

32. Chembl1201050

33. Dtxsid7046623

34. Hms3713g17

35. Pemirolast Potassium [jan]

36. Pemirolast Potassium [usan]

37. Bcp21138

38. Pemirolast Potassium (jp17/usan)

39. Pemirolast Potassium [vandf]

40. Tox21_112438

41. Bdbm50248065

42. De-068

43. Pemirolast (bmy 26517) Potassium

44. Pemirolast Potassium [mart.]

45. Permirolast Potassium [vandf]

46. S4008

47. Pemirolast Potassium [who-dd]

48. Akos015901748

49. Pemirolast Potassium Salt [mi]

50. Tox21_112438_1

51. Ac-8303

52. Ccg-220358

53. Hs-0020

54. Pemirolast Potassium, >=98% (hplc)

55. Sb18793

56. Ncgc00167434-02

57. Ac-22387

58. Bp164244

59. Pemirolast Potassium [orange Book]

60. Ft-0631005

61. P1995

62. P2547

63. D01088

64. T71519

65. 299p089

66. J-000087

67. Q27259246

68. 9-methyl-3-(2h-tetrazol-5-yl)-4h-pyrido[1,2-a]pyrimidin-4-one Potassium Salt;alamast

69. Potassium;9-methyl-3-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)pyrido[1,2-a]pyrimidin-4-one

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 266.30 g/mol
Molecular Formula C10H7KN6O
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Exact Mass266.03184035 g/mol
Monoisotopic Mass266.03184035 g/mol
Topological Polar Surface Area72.3 Ų
Heavy Atom Count18
Formal Charge0
Complexity495
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Histamine Antagonists

Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)


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