Find Penbutolol manufacturers, exporters & distributors on PharmaCompass

PENBUTOLOL SULFATE

Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 USDMF, 1 NDC API

2 API Suppliers
2 USDMF
1 NDC API

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers, 2 FDA Orange Book

2 FDF Dossiers
2 FDA Orange Book

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP , 1 Others

otherSolutions
1 EDQM
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Penbutolol sulfate, Betapressin, 38363-32-5, Penbutolol sulfate (200 mg), Hoe-893d, Hoe-39893d

Molecular Formula

C₁₈H₃₁NO₆S

Molecular Weight

389.5 g/mol

InChI Key

KTXVDQNRHZQBOR-RSAXXLAASA-N

A nonselective beta-blocker used as an antihypertensive and an antianginal agent.

1 2D Structure

Penbutolol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol;sulfuric acid

2.1.2 InChI

InChI=1S/C18H29NO2.H2O4S/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14;1-5(2,3)4/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3;(H2,1,2,3,4)/t15-;/m0./s1

2.1.3 InChI Key

KTXVDQNRHZQBOR-RSAXXLAASA-N

2.1.4 Canonical SMILES

CC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O.OS(=O)(=O)O

2.1.5 Isomeric SMILES

CC(C)(C)NC[C@@H](COC1=CC=CC=C1C2CCCC2)O.OS(=O)(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Betapressin

2. Hoe 893d

3. Hoe-893d

4. Hoe893d

5. Penbutolol

6. Penbutolol Sulfate

7. Penbutolol Sulfate (2:1)

8. Sulfate, Penbutolol

2.2.2 Depositor-Supplied Synonyms

1. Penbutolol Sulfate

2. Betapressin

3. 38363-32-5

4. Penbutolol Sulfate (200 Mg)

5. Hoe-893d

6. Hoe-39893d

7. Schembl41409

8. Chembl1200363

9. Pharmakon1600-01505567

10. Nsc760043

11. Ccg-213484

12. 363p325

2.3 Create Date

2006-07-28

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₃₁NO₆S
Molecular Weight	389.5 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	389.18720888 g/mol
Monoisotopic Mass	389.18720888 g/mol
Topological Polar Surface Area	125 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	375
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Levatol
PubMed Health	Penbutolol (By mouth)
Drug Classes	Antianginal, Antihypertensive, Cardiovascular Agent
Drug Label	levatol (penbutolol sulfate) is a synthetic -receptor antagonist for oral administration. The chemical name of penbutolol sulfate is (S)-1-tert-butylamino-3-(o-cyclopentylphenoxy)-2-propanol sulfate. It is provided as the levorotatory isomer. The...
Active Ingredient	Penbutolol sulfate
Dosage Form	Tablet
Route	Oral
Strength	20mg
Market Status	Prescription
Company	Auxilium Pharms

2 of 2
Drug Name	Levatol
PubMed Health	Penbutolol (By mouth)
Drug Classes	Antianginal, Antihypertensive, Cardiovascular Agent
Drug Label	levatol (penbutolol sulfate) is a synthetic -receptor antagonist for oral administration. The chemical name of penbutolol sulfate is (S)-1-tert-butylamino-3-(o-cyclopentylphenoxy)-2-propanol sulfate. It is provided as the levorotatory isomer. The...
Active Ingredient	Penbutolol sulfate
Dosage Form	Tablet
Route	Oral
Strength	20mg
Market Status	Prescription
Company	Auxilium Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Adrenergic beta-Antagonists

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

API SUPPLIERS