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Penfluridol

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 Listed Suppliers

1 API Suppliers
1 Listed Suppliers

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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$ 0

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Chemistry

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Also known as: 26864-56-2, Semap, 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol, Penfluridolum, Mcn-jr-16,341, Tlp-607

Molecular Formula

C₂₈H₂₇ClF₅NO

Molecular Weight

524.0 g/mol

InChI Key

MDLAAYDRRZXJIF-UHFFFAOYSA-N

FDA UNII

25TLU22Q8H

One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS.

1 2D Structure

Penfluridol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol

2.1.2 InChI

InChI=1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

2.1.3 InChI Key

MDLAAYDRRZXJIF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F

2.2 Other Identifiers

2.2.1 UNII

25TLU22Q8H

2.3 Synonyms

2.3.1 MeSH Synonyms

1. R 16341

2. R-16341

3. R16341

4. Semap

2.3.2 Depositor-Supplied Synonyms

1. 26864-56-2

2. Semap

3. 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

4. Penfluridolum

5. Mcn-jr-16,341

6. Tlp-607

7. R-16341

8. 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol

9. Micefal

10. 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol

11. R 16341

12. Nsc-759179

13. Chembl47050

14. 4-piperidinol, 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)-

15. 25tlu22q8h

16. Mcn-jr-16341

17. R 16,341

18. 4-piperidinol, 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-

19. Ncgc00165865-01

20. Dsstox_cid_28947

21. Dsstox_rid_83212

22. Dsstox_gsid_49021

23. Penfluridolum [inn-latin]

24. Cas-26864-56-2

25. Einecs 248-074-5

26. Brn 1558826

27. Unii-25tlu22q8h

28. Longoperidol

29. Penfluridol [usan:inn:ban]

30. 1-(4,4-bis(p-fluorophenyl)butyl)-4-(4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-4-piperidinol

31. 1-[4,4-bis(p-fluorophenyl)butyl]-4-(4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-4-piperidinol

32. Mfcd00866714

33. Semap (tn)

34. Penfluridol [mi]

35. Penfluridol [inn]

36. Penfluridol [jan]

37. Penfluridol (usan/inn)

38. Penfluridol [usan]

39. Penfluridol [mart.]

40. Schembl93939

41. Penfluridol [who-dd]

42. 1-(4,4-bis(p-fluorophenyl)butyl)-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-piperidinol

43. 5-21-02-00409 (beilstein Handbook Reference)

44. Mls004774011

45. Dtxsid5049021

46. Chebi:92278

47. Hms3264l13

48. Hms3652g22

49. Pharmakon1600-01505691

50. Act03196

51. Bcp03695

52. Hy-b1077

53. Zinc4217252

54. Tox21_113546

55. Bdbm50026066

56. Nsc759179

57. Pdsp1_000470

58. Pdsp2_000468

59. Akos005065828

60. Tox21_113546_1

61. Bcp9000014

62. Ccg-269878

63. Cs-4633

64. Db13791

65. Ks-5104

66. Nsc 759179

67. Penfluridol, >=97% (hplc), Powder

68. 4-piperidinol,1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-

69. Ncgc00165865-02

70. Ncgc00165865-03

71. 4-piperidinol, 1-(4,4-bis(p-fluorophenyl)butyl)-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-

72. 4-piperidinol, 4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-1-(4,4-bis(p-fluorophenyl)butyl)-

73. Ac-15413

74. Smr003500704

75. Bcp0726000159

76. Sbi-0206898.p001

77. Db-017683

78. Ft-0645031

79. P2076

80. S4151

81. Sw219540-1

82. D02630

83. Ab01566919_01

84. 864p562

85. A818637

86. L001145

87. Sr-05000001779

88. Q2149707

89. Sr-05000001779-1

90. W-107147

91. Brd-k15409150-001-01-7

92. 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloranyl-3-(trifluoromethyl)phenyl]piperidin-4-ol

93. 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-piperidin-4-ol

94. 1-[4,4-bis-(4-fluoro-phenyl)-butyl]-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidin-4-ol

95. 1-[4,4-bis(p-flurophenyl)butyl]-4-(4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-4-piperidinol

96. 4-piperidinol, 4-(4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-1-(4,4-bis(p-fluorophenyl)butyl)-

97. Penfluridol1-[4,4-bis-(4-fluoro-phenyl)-butyl]-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidin-4-ol

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₂₈H₂₇ClF₅NO
Molecular Weight	524.0 g/mol
XLogP3	7.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	523.1701330 g/mol
Monoisotopic Mass	523.1701330 g/mol
Topological Polar Surface Area	23.5 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	647
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

4.2 ATC Code

N05AG03

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

N - Nervous system

N05 - Psycholeptics

N05A - Antipsychotics

N05AG - Diphenylbutylpiperidine derivatives

N05AG03 - Penfluridol

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ABOUT THIS PAGE

Penfluridol Manufacturers

A Penfluridol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Penfluridol, including repackagers and relabelers. The FDA regulates Penfluridol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Penfluridol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Penfluridol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Penfluridol Suppliers

A Penfluridol supplier is an individual or a company that provides Penfluridol active pharmaceutical ingredient (API) or Penfluridol finished formulations upon request. The Penfluridol suppliers may include Penfluridol API manufacturers, exporters, distributors and traders.

click here to find a list of Penfluridol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Penfluridol GMP

Penfluridol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Penfluridol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Penfluridol GMP manufacturer or Penfluridol GMP API supplier for your needs.

Penfluridol CoA

A Penfluridol CoA (Certificate of Analysis) is a formal document that attests to Penfluridol's compliance with Penfluridol specifications and serves as a tool for batch-level quality control.

Penfluridol CoA mostly includes findings from lab analyses of a specific batch. For each Penfluridol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Penfluridol may be tested according to a variety of international standards, such as European Pharmacopoeia (Penfluridol EP), Penfluridol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Penfluridol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.