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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

15 API Suppliers, 4 USDMF, 2 CEP/COS, 2 JDMF, 4 NDC API, 10 Listed Suppliers

15 API Suppliers
4 USDMF
2 CEP/COS
2 JDMF
4 NDC API
10 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

33 FDF Dossiers, 9 FDA Orange Book, 2 Europe, 2 Canada, 8 Australia, 10 South Africa, 2 Listed Dossiers

33 FDF Dossiers
9 FDA Orange Book
2 Europe
2 Canada
8 Australia
10 South Africa
2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - 150,000 UNITS/ML;150,000 UNITS/ML, INJECTABLE;INJECTION - 300,000 UNITS/ML;300,000 UNITS/ML, INJECTABLE;INJECTION - 900,000 UNITS/2ML;300,000 UNITS/2ML, INJECTABLE;INJECTION - 300,000 UNITS/ML, INJECTABLE;INJECTION - 600,000 UNITS/ML

drugProductComposition
INJECTABLE;INJECTION - 150,000 UNITS/ML;150,000 UNITS/ML
INJECTABLE;INJECTION - 300,000 UNITS/ML;300,000 UNITS/ML
INJECTABLE;INJECTION - 900,000 UNITS/2ML;300,000 UNITS/2ML
INJECTABLE;INJECTION - 300,000 UNITS/ML
INJECTABLE;INJECTION - 600,000 UNITS/ML

RELATED EXCIPIENT COMPANIES

1 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 1 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 9 BASF, 1 Gangwal Chemicals, 1 Kerry, 1 Microlex e.U, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 1 Pluviaendo

relatedExcipients
1 Faran Shimi Pharmaceutical
1 Boai NKY Pharmaceuticals Ltd
1 Gangwal Healthcare
1 Nanjing Well Pharmaceutical
9 BASF
1 Gangwal Chemicals
1 Kerry
1 Microlex e.U
1 Novo Excipients
1 Pharmatrans-Sanaq
1 Pluviaendo

EXCIPIENTS BY APPLICATIONS

7 Solubilizers, 7 Fillers, Diluents & Binders, 5 Granulation, 4 Controlled & Modified Release, 4 Direct Compression, 3 Parenteral, 2 Coating Systems & Additives, 1 Thickeners and Stabilizers, 1 Film Formers & Plasticizers, 1 Co-Processed Excipients, 1 Emulsifying Agents, 1 Disintegrants & Superdisintegrants

excipientsByApplications
7 Solubilizers
7 Fillers, Diluents & Binders
5 Granulation
4 Controlled & Modified Release
4 Direct Compression
3 Parenteral
2 Coating Systems & Additives
1 Thickeners and Stabilizers
1 Film Formers & Plasticizers
1 Co-Processed Excipients
1 Emulsifying Agents
1 Disintegrants & Superdisintegrants

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 5 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
5 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 4 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
4 Finished Drug Prices

MARKET PLACE

8 APIs, 6 FDF Dossiers

marketPlace
8 APIs
6 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP

otherSolutions
1 EDQM
1 USP

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

3,738,217

Annual Reports (USD Million)

Finished Drug Prices

19 RELATED EXCIPIENT COMPANIES

37EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Benzathine benzylpenicillin, Cepacilina, Lentopenil, Tardocillin, Beacillin, Penidural

Molecular Formula

C₄₈H₅₆N₆O₈S₂

Molecular Weight

909.1 g/mol

InChI Key

BVGLIYRKPOITBQ-ANPZCEIESA-N

Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine.

1 2D Structure

Penicillin G Benzathine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

benzyl-[2-(benzylazaniumyl)ethyl]azanium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

2.1.2 InChI

InChI=1S/2C16H18N2O4S.C16H20N2/c2*1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;1-3-7-15(8-4-1)13-17-11-12-18-14-16-9-5-2-6-10-16/h2*3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);1-10,17-18H,11-14H2/t2*11-,12+,14-;/m11./s1

2.1.3 InChI Key

BVGLIYRKPOITBQ-ANPZCEIESA-N

2.1.4 Canonical SMILES

CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.C1=CC=C(C=C1)C[NH2+]CC[NH2+]CC2=CC=CC=C2

2.1.5 Isomeric SMILES

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.C1=CC=C(C=C1)C[NH2+]CC[NH2+]CC2=CC=CC=C2

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Bencelin

2. Benzathine Benzylpnicilline Panpharma

3. Benzathine Benzylpenicillin

4. Benzathine Penicillin

5. Benzathine, Penicillin G

6. Benzetacil

7. Benzylpenicillin, Benzathine

8. Bicillin

9. Bicillin L A

10. Bicillin La

11. Brevicilina

12. Cepacilina

13. Debecillin

14. Extencilline

15. Pendepon

16. Penduran

17. Pendysin

18. Penicillin G Benzathine

19. Penicillin G Benzathine Anhydrous

20. Penicillin, Benzathine

21. Penidural

22. Peniroger Retard

23. Permapen

24. Provipen Benzatina

25. Tardocillin

2.2.2 Depositor-Supplied Synonyms

1. Benzathine Benzylpenicillin

2. Cepacilina

3. Lentopenil

4. Tardocillin

5. Beacillin

6. Penidural

7. Chebi:51352

8. Benzylpenicillin Dibenzylethylenediamine Salt

9. Penicillin G Salt Of N,n'-dibenzylethylenediamine

10. N,n'-dibenzylethylenediamine Bis(benzyl Penicillin)

11. Epitope Id:224559

12. Db09323

13. N,n'-dibenzylethane-1,2-diaminium Bis{2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylate}

2.3 Create Date

2009-01-30

3 Chemical and Physical Properties

Molecular Formula	C₄₈H₅₆N₆O₈S₂
Molecular Weight	909.1 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	13
Exact Mass	908.36010511 g/mol
Monoisotopic Mass	908.36010511 g/mol
Topological Polar Surface Area	263 Å²
Heavy Atom Count	64
Formal Charge	0
Complexity	696
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Bicillin l-a
PubMed Health	Penicillin G Benzathine (Injection)
Drug Classes	Antibiotic
Drug Label	Bicillin L-A (penicillin G benzathine injectable suspension) is available for deep intramuscular injection. Penicillin G benzathine is prepared by the reaction of dibenzylethylene diamine with two molecules of penicillin G. It is chemically designate...
Active Ingredient	Penicillin g benzathine
Dosage Form	Injectable
Route	Injection
Strength	300,000 units/ml; 600,000 units/ml
Market Status	Prescription
Company	King Pharms

2 of 2
Drug Name	Bicillin l-a
PubMed Health	Penicillin G Benzathine (Injection)
Drug Classes	Antibiotic
Drug Label	Bicillin L-A (penicillin G benzathine injectable suspension) is available for deep intramuscular injection. Penicillin G benzathine is prepared by the reaction of dibenzylethylene diamine with two molecules of penicillin G. It is chemically designate...
Active Ingredient	Penicillin g benzathine
Dosage Form	Injectable
Route	Injection
Strength	300,000 units/ml; 600,000 units/ml
Market Status	Prescription
Company	King Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

5.2 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01C - Beta-lactam antibacterials, penicillins

J01CE - Beta-lactamase sensitive penicillins

J01CE08 - Benzathine benzylpenicillin

API SUPPLIERS

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USDMF

01

Bristol Europe Spa

United Kingdom

Antibody Engineering

Not Confirmed

02

Pfizer Inc

U.S.A

Antibody Engineering

Not Confirmed

03

Sandoz Gmbh

Switzerland

Antibody Engineering

Not Confirmed

04

Wyeth-ayerst Laboratories

U.S.A

Antibody Engineering

Not Confirmed

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CEP/COS

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JDMF

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NDC API

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Listed Suppliers

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FDF Dossiers

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FDA Orange Book

01

CASPER PHARMA LLC

U.S.A

U.S.A

Antibody Engineering

Not Confirmed

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Europe

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Canada

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Australia

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South Africa

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Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

Do you need Business Intel? Ask us

DOSAGE - INJECTABLE;INJECTION - 150,000 UNITS...DOSAGE - INJECTABLE;INJECTION - 150,000 UNITS/ML;150,000 UNITS/ML

USFDA APPLICATION NUMBER - 50138

DOSAGE - INJECTABLE;INJECTION - 300,000 UNITS...DOSAGE - INJECTABLE;INJECTION - 300,000 UNITS/ML;300,000 UNITS/ML

USFDA APPLICATION NUMBER - 50138

DOSAGE - INJECTABLE;INJECTION - 900,000 UNITS...DOSAGE - INJECTABLE;INJECTION - 900,000 UNITS/2ML;300,000 UNITS/2ML

USFDA APPLICATION NUMBER - 50138

DOSAGE - INJECTABLE;INJECTION - 300,000 UNITS...DOSAGE - INJECTABLE;INJECTION - 300,000 UNITS/ML

USFDA APPLICATION NUMBER - 50141

DOSAGE - INJECTABLE;INJECTION - 600,000 UNITS...DOSAGE - INJECTABLE;INJECTION - 600,000 UNITS/ML

USFDA APPLICATION NUMBER - 50141

Related Excipient Companies

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Excipients by Applications

Click here to find the perfect excipient manufacturers by their capabilities

Solubilizers

Fillers, Diluents & Binders

Granulation

Controlled & Modified Release

Direct Compression

Parenteral

Coating Systems & Additives

Thickeners and Stabilizers

Film Formers & Plasticizers

Co-Processed Excipients

Emulsifying Agents

Disintegrants & Superdisintegrants

Digital Content

Create Content with PharmaCompass, ask us

DATA COMPILATION #PharmaFlow

NEWS #PharmaBuzz

Global Sales Information

Do you need Business Intel? Ask us

US Medicaid Prescriptions

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Finished Drug Prices

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Market Place

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APIs

Penicillin G Benzathine (13 kg) API needed in India [ENA19253]

A research-based company that focuses on diabetes, oncology, immunology, and other non-communicable diseases is looking for suppliers of Penicillin G Benzathine (13 kg) API for development purposes. The suppliers must support this enquiry with USDMF & CoA.

27 Mar 2024

USP or BP Grade Benzathine Penicillin (100 kg) API needed in Macedonia [ENA17836]

A company that deals in various pharmaceutical products is looking for suppliers of USP or BP Grade Benzathine Penicillin (100 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.

17 Aug 2023

Various APIs needed in Argentina [ENA12419]

A global pharmaceutical sourcing company that deals in several portfolios such as cardiovascular, gastroenterology, central nervous system, anti-infective, respiratory tract, women's health, endocrinology, dermatology and urology is looking for suppliers of Various APIs for development purpose. The required quantity is 1000 BoU for each. The suppliers must support this enquiry with CoA. 1. Penicillin G Benzathine API with Lecithin 2. Penicillin G Procaine API 3. Penicillin G Sodium API

15 Jan 2022

Various APIs needed in India [ENA07793]

A large CRO that focuses on global discovery, development & manufacturing, providing integrated scientific services to pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries is looking for suppliers of Various APIs for formulation R&D & developmental purposes. The required quantity is 1 kg & 5 kg for each. The suppliers must support this enquiry with USDMF. The final market is the US. 1. Edaravone 2. Nelarabine 3. Methylene Blue 4. Penicillin G Benzathine 5. Cyclophosphamide 6. Clevidipine 7. Hydrocortisone Sodium Succinate 8. Phytonadione

04 Jul 2020

Various APIs needed in India [ENA06023]

One of the fastest-growing pharmaceutical companies in India offering a wide range of formulation products is looking for suppliers of APIs. 1. Dobutamine Hydrochloride 2. Tranexamic Acid 3. Ampicillin Sodium 4. Cloxacillin Sodium 5. Benzathine Benzylpenicillin (Sterile)

11 Dec 2019

Penicillin G Benzathine API needed in Korea [ENA04657]

A leading pharmaceutical company expanding business in various fields ranging from raw material pharmaceuticals, animal drugs, and chemical products is looking for suppliers of Penicillin G Benzathine API. The suppliers must support this enquiry with certificates mentioned below: 1. GMP and DMF available 2. KDMF register support 3. Overseas certificate available(CEP, USDMF, JDMF, etc.) 4. Working Standard and impurity standard sample.

19 Jul 2019

Benzathine Penicillin API (100 kg) needed in India [ENA03333]

Gaurang International, a trading and distribution company is looking for suppliers of Benzathine Penicillin API (100 kg). Interested suppliers can contact Sunil Dhimmar via Email: gaurangexim@yahoo.com or Tel: +919824903703.

04 Feb 2019

Benzathine Benzylpenicillin API (30 MT/year) needed in the United Kingdom [ENA02865]

A UK based company specialized in providing professional, reliable custom synthesized and bulk commercial chemicals to global companies is looking for suppliers of Benzathine Benzylpenicillin API (30 MT/year) for domestic consumption.

06 Dec 2018

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FDF DOSSIERS

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REF. STANDARDS & IMPURITIES

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EDQM

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USP

ABOUT THIS PAGE

Find Penicillin G Benzathine manufacturers, exporters & distributors on PharmaCompass

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

15 API Suppliers

4 USDMF

2 CEP/COS

2 JDMF

4 NDC API

10 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

33 FDF Dossiers

9 FDA Orange Book

2 Europe

2 Canada

8 Australia

10 South Africa

2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - 150,000 UNITS/ML;150,000 UNITS/ML

INJECTABLE;INJECTION - 300,000 UNITS/ML;300,000 UNITS/ML

INJECTABLE;INJECTION - 900,000 UNITS/2ML;300,000 UNITS/2ML

INJECTABLE;INJECTION - 300,000 UNITS/ML

INJECTABLE;INJECTION - 600,000 UNITS/ML

RELATED EXCIPIENT COMPANIES

1 Faran Shimi Pharmaceutical

1 Boai NKY Pharmaceuticals Ltd

1 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

9 BASF

1 Gangwal Chemicals

1 Kerry

1 Microlex e.U

1 Novo Excipients

1 Pharmatrans-Sanaq

1 Pluviaendo

EXCIPIENTS BY APPLICATIONS

7 Solubilizers

7 Fillers, Diluents & Binders

5 Granulation

4 Controlled & Modified Release

4 Direct Compression

3 Parenteral

2 Coating Systems & Additives

1 Thickeners and Stabilizers

1 Film Formers & Plasticizers

1 Co-Processed Excipients

1 Emulsifying Agents

1 Disintegrants & Superdisintegrants

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow

5 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

4 Finished Drug Prices

MARKET PLACE

8 APIs

6 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 EDQM

1 USP

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

37EXCIPIENTS BY APPLICATIONS

01

01

02

02