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Also known as: Penicillin v potassium salt, 132-98-9, Penicillin vk, Antibiocin, Phenoxymethylpenicillin potassium, Beepen-vk
Molecular Formula
C16H17KN2O5S
Molecular Weight
388.5  g/mol
InChI Key
HCTVWSOKIJULET-LQDWTQKMSA-M
FDA UNII
146T0TU1JB

Penicillin V Potassium
A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
1 2D Structure

Penicillin V Potassium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
potassium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
2.1.2 InChI
InChI=1S/C16H18N2O5S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
2.1.3 InChI Key
HCTVWSOKIJULET-LQDWTQKMSA-M
2.1.4 Canonical SMILES
CC1(C(N2C(S1)C(C2=O)NC(=O)COC3=CC=CC=C3)C(=O)[O-])C.[K+]
2.1.5 Isomeric SMILES
CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)COC3=CC=CC=C3)C(=O)[O-])C.[K+]
2.2 Other Identifiers
2.2.1 UNII
146T0TU1JB
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Apocillin

2. Beromycin

3. Beromycin, Penicillin

4. Berromycin, Penicillin

5. Betapen

6. Fenoxymethylpenicillin

7. Pen Vk

8. Penicillin Beromycin

9. Penicillin Berromycin

10. Penicillin V

11. Penicillin V Sodium

12. Penicillin Vk

13. Penicillin, Phenoxymethyl

14. Phenoxymethyl Penicillin

15. Phenoxymethylpenicillin

16. Potassium, Penicillin V

17. Sodium, Penicillin V

18. V Cillin K

19. V Sodium, Penicillin

20. V-cillin K

21. Vcillin K

22. Vegacillin

2.3.2 Depositor-Supplied Synonyms

1. Penicillin V Potassium Salt

2. 132-98-9

3. Penicillin Vk

4. Antibiocin

5. Phenoxymethylpenicillin Potassium

6. Beepen-vk

7. Potassium Penicillin V

8. Primcillin

9. Veetids

10. Ledercillin Vk

11. Pfizerpen Vk

12. Uticillin Vk

13. Betapen-vk

14. V-cillin K

15. Pen-vee K

16. Suspen

17. Penapar-vk

18. Penicillin-vk

19. Penicillin Potassium Phenoxymethyl

20. Beromycin

21. Vamosyn

22. Penicillin V (potassium)

23. 146t0tu1jb

24. Chebi:7967

25. Calciopen K

26. Phenoxymethylpenicillin Potassium Salt

27. Sk-penicillin Vk

28. Nsc-757258

29. Monopotassium (2s,5r,6r)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate

30. Phenoxymethylpenicillinic Acid Potassium

31. Arcacil

32. Cliacil

33. Isocillin

34. Ispenoral

35. Kavepenin

36. Ospeneff

37. Pedipen

38. Penagen

39. Pencompren

40. Penvikal

41. Roscopenin

42. Icipen

43. Orapen

44. Megacillin Oral

45. Vepen

46. Compocillin-vk

47. Robicillin Vk

48. Dsstox_cid_1102

49. Veetids '125'

50. Veetids '250'

51. Veetids '500'

52. Rocillin-vk

53. Distaquaine V-k

54. Penapar Vk

55. Sumapen Vk

56. Distakaps V-k

57. Oracil-vk

58. Qidpen Vk

59. Apsin Vk

60. Aspin Vk

61. Dov-k

62. Dsstox_rid_75941

63. Dsstox_gsid_21102

64. Pen-v-k Powder

65. Dowpen V-k

66. Pen-vee-k Powder

67. Dqv-k

68. Potassium Penicillin V Salt

69. Pen Vk

70. V-cil-k

71. Beromycin (penicillin)

72. Potassium Phenoxymethylpenicillin

73. Potassium Phenoxymethyl Penicillin

74. Stabillin Vk Syrup 125

75. Phenoxymethylpenicillin Potassium (jan)

76. Stabillin Vk Syrup 62.5

77. Cas-132-98-9

78. Potassium (2s,5r,6r)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

79. Potassium (2s,5r,6r)-3,3-dimethyl-7-oxo-6-{[(phenyloxy)acetyl]amino}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

80. Ccris 750

81. Penicillin V Potassium [usan]

82. Phenoxymethylpenicillin Potassium [jan]

83. Hsdb 6315

84. Einecs 205-086-5

85. Mfcd00051771

86. Unii-146t0tu1jb

87. D-alpha-phenoxymethylpenicillinate K Salt

88. Potassium;(2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

89. Penicillin V Potassium [usan:usp]

90. Veetids (tn)

91. Penicilline V Potassium

92. Schembl41271

93. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-6-(( Phenoxyacetyl)amino)-, Monopotassium Salt, (2s-(2alpha,5alpha,6beta))-

94. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-6-(2 -phenoxyacetamido)-, Monopotassium Salt

95. Penicillinvpotassiumsalt

96. Spectrum1500467

97. Penicillin V Potassium (usp)

98. Chembl1200852

99. Dtxsid7021102

100. Hms502g21

101. Hms1920f14

102. Hms2091n14

103. Hy-b0975

104. Tox21_202176

105. Tox21_302914

106. Ccg-39570

107. Penicillin V Potassium [hsdb]

108. Phenoxymethylpenicillin Potassium,(s)

109. Akos024418766

110. Penicillin V Potassium [vandf]

111. Cs-4465

112. Nsc 757258

113. Mehyl-7-azaindole-4-carboxylate

114. Penicillin V Potassium [usp-rs]

115. Ncgc00164005-01

116. Ncgc00256459-01

117. Ncgc00259725-01

118. Penicillin Phenoxymethyl Potassium

119. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, Monopotassium Salt, (2s,5r,6r)-

120. As-83778

121. Penicillin V Potassium [green Book]

122. Penicillin V Potassium [orange Book]

123. Penicillin V Potassium [usp Impurity]

124. Penicillin V Potassium [usp Monograph]

125. C72320

126. D00497

127. Phenoxymethylpenicillin Potassium [mart.]

128. Penicilline V Potassium 100 Microg/ml In Methanol

129. Phenoxymethylpenicillin Potassium [who-dd]

130. Phenoxymethylpenicillin Potassium [who-ip]

131. W-109072

132. Q27107637

133. Phenoxymethylpenicillin Potassium [ep Monograph]

134. Phenoxymethylpenicillinum Kalicum [who-ip Latin]

135. Penicillin V Potassium Salt, Vetranal(tm), Analytical Standard

136. Penicillin V Potassium Salt, Powder, Bioreagent, Suitable For Cell Culture

137. Penicillin V Potassium, United States Pharmacopeia (usp) Reference Standard

138. Phenoxymethylpenicillin Potassium, Antibiotic For Culture Media Use Only

139. Phenoxymethylpenicillinic Acid Potassium Salt, Potency: >=1460 Units Per Mg

140. Potassium 2,2-dimethyl-6beta-(phenoxyacetamido)penam-3alpha-carboxylate

141. Phenoxymethylpenicillin Potassium, British Pharmacopoeia (bp) Reference Standard

142. Phenoxymethylpenicillin Potassium, European Pharmacopoeia (ep) Reference Standard

143. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-6-((2-phenoxyacetyl)amino)-, Potassium Salt (1:1), (2s,5r,6r)-

144. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, Monopotassium Salt, (2s-(2.alpha.,5.alpha.,6.beta.))-

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 388.5 g/mol
Molecular Formula C16H17KN2O5S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass388.04952431 g/mol
Monoisotopic Mass388.04952431 g/mol
Topological Polar Surface Area124 Ų
Heavy Atom Count25
Formal Charge0
Complexity553
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NamePenicillin v potassium
Drug LabelPenicillin V is the phenoxymethyl analog of penicillin G. Penicillin V potassium is the potassium salt of penicillin V. Penicillin V Potassium is designated chemically as 4-Thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo- 6-[(...
Active IngredientPenicillin v potassium
Dosage FormTablet; For solution
RouteOral
Strengtheq 250mg base/5ml; eq 500mg base; eq 250mg base; eq 125mg base/5ml
Market StatusPrescription
CompanyAurobindo Pharma; Sandoz; Hikma Pharms; Dava Pharms

2 of 2  
Drug NamePenicillin v potassium
Drug LabelPenicillin V is the phenoxymethyl analog of penicillin G. Penicillin V potassium is the potassium salt of penicillin V. Penicillin V Potassium is designated chemically as 4-Thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo- 6-[(...
Active IngredientPenicillin v potassium
Dosage FormTablet; For solution
RouteOral
Strengtheq 250mg base/5ml; eq 500mg base; eq 250mg base; eq 125mg base/5ml
Market StatusPrescription
CompanyAurobindo Pharma; Sandoz; Hikma Pharms; Dava Pharms

4.2 Therapeutic Uses

Penicillins

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


Penicillin V /is/ indicated in the treatment of acute otitis media caused by susceptible organisms. /Included in US product labeling/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 2149


Penicillin V /is/ indicated in the treatment of bacterial pharyngitis cuased by susceptible organisms. /Included in US product labeling/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 2149


Penicillin V /is/ indicated in the treatment of sinusitis caused by susceptible organisms. /Included in US product labeling/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 2150


For more Therapeutic Uses (Complete) data for PENICILLIN VK (18 total), please visit the HSDB record page.


4.3 Drug Warning

Penicillins are distributed into breast milk, some in low concentrations. Although significant problems in humans have not been documented, the use of penicillins by nursing mothers may lead to sensitization, diarrhea, candidiasis, and skin rash in the infant. /Penicillins/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 2151


Many penicillins have been used in pediatric patients and no pediatrics-specific problems have been documented to date. However, the incompletely developed renal function of neonates and young infants may delay the excretion of renally eliminated penicillins. /Penicillins/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 2151


Penicillins have been used in geriatric patients and no geriatrics-specific problems have been documented to date. However, elderly patients are more likely to have age-related renal function impairment, which may require an adjustment in dosage in patients receiving penicillins. /Penicillins/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 2151


Prolonged use of penicillins may lead to the development of oral candidiasis. /Penicillins/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 2151


For more Drug Warnings (Complete) data for PENICILLIN VK (9 total), please visit the HSDB record page.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Penicillins [CS]; Penicillin-class Antibacterial [EPC]
5.3 Absorption, Distribution and Excretion

A dose of 1,000,000 units of the acid gives peak plasma levels of about 2 to 3 ug/ml, but the potassium salt will provide levels of 4.5 to 9 ug/ml.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1142


Penicillin VK provides faster and higher blood levels of antibiotic than Penicillin V.

Osol A, Hoover JE et al (eds); Remington's Pharmaceutical Sciences. 14th ed. Easton, PA: Mack Publishing Co., p. 1230 (1975)


5.4 Biological Half-Life

The half-life is 0.5 to 0.6 hr.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1142


5.5 Mechanism of Action

The penicillins and their metabolites are potent immunogens because of their ability to combine with proteins and act as haptens for acute antibody-mediated reactions. The most frequent (about 95 percent) or "major" determinant of penicillin allergy is the penicilloyl determinant produced by opening the beta-lactam ring of the penicillin. This allows linkage of the penicillin to protein at the amide group. "Minor" determinants (less frequent) are the other metabolites formed, including native penicillin and penicilloic acids. /Penicillins/

Haddad, L.M., Clinical Management of Poisoning and Drug Overdose. 2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990., p. 953


Bactericidal; inhibit bacterial cell wall synthesis. Action is dependent on the ability of penicillins to reach and bind penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Penicillin-binding proteins (which include transpeptidases, carboxypeptidases, and endopeptidases) are enzymes that are involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Penicillins bind to, and inactivate, penicillin-binding proteins, resulting in the weakening of the bacterial cell wall and lysis. /Penicillins/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 2150


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11-Jan-2021
27-Nov-2024
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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ABOUT THIS PAGE

Penicillin V Potassium Manufacturers

A Penicillin V Potassium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Penicillin V Potassium, including repackagers and relabelers. The FDA regulates Penicillin V Potassium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Penicillin V Potassium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Penicillin V Potassium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Penicillin V Potassium Suppliers

A Penicillin V Potassium supplier is an individual or a company that provides Penicillin V Potassium active pharmaceutical ingredient (API) or Penicillin V Potassium finished formulations upon request. The Penicillin V Potassium suppliers may include Penicillin V Potassium API manufacturers, exporters, distributors and traders.

click here to find a list of Penicillin V Potassium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Penicillin V Potassium USDMF

A Penicillin V Potassium DMF (Drug Master File) is a document detailing the whole manufacturing process of Penicillin V Potassium active pharmaceutical ingredient (API) in detail. Different forms of Penicillin V Potassium DMFs exist exist since differing nations have different regulations, such as Penicillin V Potassium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Penicillin V Potassium DMF submitted to regulatory agencies in the US is known as a USDMF. Penicillin V Potassium USDMF includes data on Penicillin V Potassium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Penicillin V Potassium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Penicillin V Potassium suppliers with USDMF on PharmaCompass.

Penicillin V Potassium CEP

A Penicillin V Potassium CEP of the European Pharmacopoeia monograph is often referred to as a Penicillin V Potassium Certificate of Suitability (COS). The purpose of a Penicillin V Potassium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Penicillin V Potassium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Penicillin V Potassium to their clients by showing that a Penicillin V Potassium CEP has been issued for it. The manufacturer submits a Penicillin V Potassium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Penicillin V Potassium CEP holder for the record. Additionally, the data presented in the Penicillin V Potassium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Penicillin V Potassium DMF.

A Penicillin V Potassium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Penicillin V Potassium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Penicillin V Potassium suppliers with CEP (COS) on PharmaCompass.

Penicillin V Potassium NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Penicillin V Potassium as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Penicillin V Potassium API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Penicillin V Potassium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Penicillin V Potassium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Penicillin V Potassium NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Penicillin V Potassium suppliers with NDC on PharmaCompass.

Penicillin V Potassium GMP

Penicillin V Potassium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Penicillin V Potassium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Penicillin V Potassium GMP manufacturer or Penicillin V Potassium GMP API supplier for your needs.

Penicillin V Potassium CoA

A Penicillin V Potassium CoA (Certificate of Analysis) is a formal document that attests to Penicillin V Potassium's compliance with Penicillin V Potassium specifications and serves as a tool for batch-level quality control.

Penicillin V Potassium CoA mostly includes findings from lab analyses of a specific batch. For each Penicillin V Potassium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Penicillin V Potassium may be tested according to a variety of international standards, such as European Pharmacopoeia (Penicillin V Potassium EP), Penicillin V Potassium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Penicillin V Potassium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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