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ACTIVE PHARMA INGREDIENTS

16 API Suppliers, 3 USDMF, 2 CEP/COS, 1 JDMF, 5 NDC API, 1 VMF, 15 Listed Suppliers, $ API Reference Price

16 API Suppliers
3 USDMF
2 CEP/COS
1 JDMF
5 NDC API
1 VMF
15 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

12 FDF Dossiers, 9 FDA Orange Book, 1 Canada, 2 Listed Dossiers

12 FDF Dossiers
9 FDA Orange Book
1 Canada
2 Listed Dossiers

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3 APIs

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3 APIs

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1 EDQM , 2 USP , 3 Others

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1 EDQM
2 USP
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

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JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 154,538

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API

FDF

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FDA Orange Book

Europe

Canada

Australia

South Africa

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0 DRUGS IN DEVELOPMENT

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EDQM

USP

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Chemistry

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Also known as: 66104-23-2, Permax, Pergolide methanesulfonate, Pergolide mesylate salt, Pergolide mesilate, Pergolide (mesylate)

Molecular Formula

C₂₀H₃₀N₂O₃S₂

Molecular Weight

410.6 g/mol

InChI Key

UWCVGPLTGZWHGS-ZORIOUSZSA-N

FDA UNII

55B9HQY616

A long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.

1 2D Structure

Pergolide Mesylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(6aR,9R,10aR)-9-(methylsulfanylmethyl)-7-propyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline;methanesulfonic acid

2.1.2 InChI

InChI=1S/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21;1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3;1H3,(H,2,3,4)/t13-,16-,18-;/m1./s1

2.1.3 InChI Key

UWCVGPLTGZWHGS-ZORIOUSZSA-N

2.1.4 Canonical SMILES

CCCN1CC(CC2C1CC3=CNC4=CC=CC2=C34)CSC.CS(=O)(=O)O

2.1.5 Isomeric SMILES

CCCN1C[C@@H](C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)CSC.CS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

55B9HQY616

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Celance

2. Ly-127,809

3. Ly-127809

4. Ly127,809

5. Ly127809

6. Mesylate, Pergolide

7. Parkotil

8. Pergolide

9. Permax

10. Pharken

2.3.2 Depositor-Supplied Synonyms

1. 66104-23-2

2. Permax

3. Pergolide Methanesulfonate

4. Pergolide Mesylate Salt

5. Pergolide Mesilate

6. Pergolide (mesylate)

7. Ly127809

8. Pergolidemesylate

9. Ly-127809

10. Nsc-319773

11. Nsc-758442

12. Ly 127809

13. Mls000069837

14. Chebi:8021

15. 55b9hqy616

16. Mpe

17. Cpd000058504

18. Smr000058504

19. Pergolide Mesilate (jan)

20. Permax (tn)

21. Dsstox_cid_20583

22. Dsstox_rid_77029

23. Dsstox_gsid_40583

24. Pergolide Mesilate [jan]

25. Celance

26. Parkotil

27. Pharken

28. Chembl1275

29. Pergolide Mesylate [usan]

30. Sr-01000075395

31. Ncgc00017366-04

32. Nopar

33. Unii-55b9hqy616

34. (8b)-8-[(methylsulfanyl)methyl]-6-propylergoline Methanesulfonate

35. Sr-01000721840

36. Pergolide Mesylate [usan:usp]

37. (6ar,9r,10ar)-9-(methylsulfanylmethyl)-7-propyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline;methanesulfonic Acid

38. Prestwick_652

39. Cas-66104-23-2

40. Pergolide Monomesylate

41. Opera_id_186

42. Pergolide Mehanesulfonate

43. 8-beta-((methylthio)methyl)-6-propylergoline Methanesulfonate

44. 8beta-((methylthio)methyl)-6-propylergoline Monomethanesulfonate

45. 8-beta-((methylthio)methyl)-6-propylergoline Monomethane Sulfonate

46. Pergolide Mesylate (usp)

47. Pergolide Monomethanesulfonate

48. Schembl26920

49. Mls001148155

50. Mls001424320

51. Mls002222236

52. Spectrum1503269

53. Dtxsid6040583

54. Hms501g04

55. Ergoline, Methanesulfonate (1:1)

56. Hms1568l12

57. Hms1922o13

58. Hms2052h09

59. Hms2093c05

60. Hms2095l12

61. Hms2231f08

62. Hms3263e09

63. Hms3712l12

64. Hms3885k16

65. Pergolide Mesylate [vandf]

66. Pharmakon1600-01503269

67. Pergolide Mesilate [mart.]

68. Ex-a1334

69. Ly-141-b

70. Pergolide Mesilate [who-dd]

71. Pergolide Mesylate [usp-rs]

72. Tox21_110820

73. Tox21_500984

74. Ccg-39478

75. Hy-13720a

76. Nsc319773

77. Nsc758442

78. S4000

79. Akos015896681

80. Ergoline, 8-((methylthio)methyl)-6-propyl-, Monomethanesulfonate, (8beta)-

81. Ergoline, 8-beta-((methylthio)methyl)-6-propyl-, Methanesulfonate (1:1)

82. Tox21_110820_1

83. Ac-6874

84. Lp00984

85. Nc00428

86. Nsc 319773

87. Nsc 758442

88. Pergolide Mesylate [green Book]

89. Pergolide Methanesulfonate [mi]

90. Pergolide Mesylate [orange Book]

91. Ncgc00017366-08

92. Ncgc00094284-01

93. Ncgc00094284-02

94. Ncgc00094284-03

95. Ncgc00261669-01

96. Pergolide Mesilate [ep Monograph]

97. Pergolide Mesylate Salt, >=98%, Solid

98. As-76940

99. Pergolide Mesylate [usp Monograph]

100. Ergoline, (8.beta.)-, Monomethanesulfonate

101. Eu-0100984

102. D00502

103. D95035

104. P 8828

105. 104p232

106. Q-201548

107. Sr-01000075395-1

108. Sr-01000075395-3

109. Sr-01000721840-3

110. Q27107641

111. 8-[(methylthio)methyl]-6-propylergoline Methanesulfonate

112. (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline Methanesulfonate

113. 8-.beta.-[(methylthio)methyl]-6-propylergoline Methanesulfonate

114. Pergolide Mesilate, European Pharmacopoeia (ep) Reference Standard

115. (8beta)-8-[(methylsulfanyl)methyl]-6-propylergolin-6-ium Methanesulfonate

116. 8.beta.-((methylthio)methyl)-6-propylergoline Monomethanesulfonate

117. 8.beta.-((methylthio)methyl)-6-propylergoline Monomethanesulphonate

118. Pergolide Mesylate, United States Pharmacopeia (usp) Reference Standard

119. Ergoline, 8-((methylthio)methyl)-6-propyl-, Monomethanesulfonate, (8.beta.)-

120. Ergoline, 8-((methylthio)methyl)-6-propyl-, Monomethanesulphonate, (8.beta.)-

121. (6ar,9r,10ar)-9-((methylthio)methyl)-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline Methanesulfonate

122. (6ar,9r,10ar)-9-(methylthiomethyl)-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline Methanesulfonate

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₃₀N₂O₃S₂
Molecular Weight	410.6 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	410.16978517 g/mol
Monoisotopic Mass	410.16978517 g/mol
Topological Polar Surface Area	107 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	480
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Dopamine Agonists

Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)

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API Reference Price

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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1650825000,"product":"PERGOLIDE SULFOXIDE (QTY:1X0.2 GMS,PRICE: USD 475.92)(FOC)","address":"P.NO. 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1676572200,"product":"PERGOLIDE MESYLATE","address":"MURASOLI MARAN TOWERS,73,MRC NAGAR","city":"CHENNAI,TAMILNADU","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"SPICEJET LIMITED","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"50","unit":"GMS","unitRateFc":"250","totalValueFC":"12660.4","currency":"USD","unitRateINR":"20912.5","date":"17-Feb-2023","totalValueINR":"1045625","totalValueInUsd":"12660.4","indian_port":"GMR HYDERABAD AVIATION-SEZ","hs_no":"29396290","bill_no":"1000897","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"VIA. LIVELLI I CASALETTO, LODIGIANO FRAZ MAIRANO LO PostalCode: 26852, ITALY ITALY","customerAddress":"MURASOLI MARAN TOWERS,73,MRC NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706639400,"product":"PERGOLIDE MESYLATE","address":"MURASOLI MARAN TOWERS,73,MRC NAGAR","city":"CHENNAI,TAMILNADU","supplier":"OLON SPA","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"SPICEJET LIMITED","customerCountry":"INDIA","quantity":"0.04","actualQuantity":"40","unit":"GMS","unitRateFc":"250","totalValueFC":"10118.9","currency":"USD","unitRateINR":"21025","date":"31-Jan-2024","totalValueINR":"841000","totalValueInUsd":"10118.9","indian_port":"GMR HYDERABAD AVIATION-SEZ","hs_no":"29396290","bill_no":"1000715","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"MURASOLI MARAN TOWERS,73,MRC NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706639400,"product":"PERGOLIDE MESYLATE ( 0.03 KGS)","address":"#28 CANTON ROWS, PETBASHEERBAD","city":"HYDERABAD","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"AIZANT DRUG RESEARCH SOLUTIONS PVT. 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RIVOLTANA KM 6\/720053 RODANO (MI), ITALY IT","customerAddress":"#28 CANTON ROWS, PETBASHEERBAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721068200,"product":"702220 PERGOLIDE MESYLATE (FOR R & D PURPOSE)","address":"B2-B 10TH FLAT PLOT NO.27,SECTOR-1","city":"DWARKA NEW DELHI,DELHI","supplier":"TEVA API","supplierCountry":"NETHERLANDS","foreign_port":"ZURICH","customer":"FELIX GENERICS PRIVATE ","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"0.05","unit":"KGS","unitRateFc":"180000","totalValueFC":"9092.5","currency":"USD","unitRateINR":"15201000","date":"16-Jul-2024","totalValueINR":"760050","totalValueInUsd":"9092.5","indian_port":"Delhi Air","hs_no":"29396900","bill_no":"4527549","productDescription":"API","marketType":"REGULATED MARKET","country":"NETHERLANDS","selfForZScoreResived":"Pharma Grade","supplierPort":"ZURICH","supplierAddress":"PIET HEIN BUILDING, PIETHEINKADE 107 1019 GMAMSTERDAM NETHERLANDS","customerAddress":"B2-B 10TH FLAT PLOT NO.27,SECTOR-1"}]