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Perindoprilate

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 95153-31-4, Perindoprilate, Perindoprilato, Perindoprilatum, S-9780, Perindopril related compound b

Molecular Formula

C₁₇H₂₈N₂O₅

Molecular Weight

340.4 g/mol

InChI Key

ODAIHABQVKJNIY-PEDHHIEDSA-N

FDA UNII

2UV6ZNQ92K

Perindoprilat is a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Perindoprilat inhibits ACE and, thus, the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.

Perindoprilat is an Angiotensin Converting Enzyme Inhibitor. The mechanism of action of perindoprilat is as an Angiotensin-converting Enzyme Inhibitor.

1 2D Structure

Perindoprilate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid

2.1.2 InChI

InChI=1S/C17H28N2O5/c1-3-6-12(16(21)22)18-10(2)15(20)19-13-8-5-4-7-11(13)9-14(19)17(23)24/h10-14,18H,3-9H2,1-2H3,(H,21,22)(H,23,24)/t10-,11-,12-,13-,14-/m0/s1

2.1.3 InChI Key

ODAIHABQVKJNIY-PEDHHIEDSA-N

2.1.4 Canonical SMILES

CCCC(C(=O)O)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O

2.1.5 Isomeric SMILES

CCC[C@@H](C(=O)O)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O

2.2 Other Identifiers

2.2.1 UNII

2UV6ZNQ92K

2.3 Synonyms

2.3.1 MeSH Synonyms

1. S-9780

2.3.2 Depositor-Supplied Synonyms

1. 95153-31-4

2. Perindoprilate

3. Perindoprilato

4. Perindoprilatum

5. S-9780

6. Perindopril Related Compound B

7. Perindopril Diacid Form

8. 2uv6znq92k

9. (2s,3as,7as)-1-((s)-2-(((s)-1-carboxybutyl)amino)propanoyl)octahydro-1h-indole-2-carboxylic Acid

10. (2s,3as,7as)-1-((s)-n-((s)-1-carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic Acid

11. S 9780

12. Perindoprilate [french]

13. Perindoprilatum [latin]

14. Perindoprilato [spanish]

15. (2s,3as,7as)-1-(((s)-1-carboxybutyl)-l-alanyl)octahydro-1h-indole-2-carboxylic Acid

16. Perindoprilat [inn:ban]

17. Unii-2uv6znq92k

18. Brn 4207072

19. Perondropilat

20. Perondroprilat

21. Perindoprilat [inn]

22. Schembl564053

23. Gtpl6373

24. Chembl1201368

25. Dtxsid90869249

26. Chebi:132041

27. Hy-b1433

28. Zinc4217270

29. Perindopril Diacid Form [mi]

30. Akos026750118

31. Ccg-213925

32. Db14213

33. Ncgc00389603-01

34. (2s,3as,7as)-1-[(2s)-2-[[(1s)-1-carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic Acid

35. (2s,3as,7as)-1-[(2s)-2-[[(2s)-1-hydroxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic Acid

36. 1h-indole-2-carboxylic Acid, Octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl)-, (2s-(1(r*(r*)),2-alpha,3a-beta,7a-beta))-

37. Cs-0013140

38. C21517

39. Perindopril Related Compound B [usp-rs]

40. Ab01563365_01

41. 153p314

42. A1-06488

43. Q27088302

44. Perindopril Tert-butylamine Impurity B [ep Impurity]

45. Discontinued. Please See P287531 Or P287535 Or P287585.

46. N-{(2s)-1-[(2s,3as,7as)-2-carboxyoctahydro-1h-indol-1-yl]-1-oxopropan-2-yl}-l-norvaline

47. (2s,3as,7as)-1-((s)-2-(((s)-1-carboxybutyl)amino)propanoyl)octahydro-1h-indole-2-carboxylicacid

48. (2s,3as,7as)-1-[(2s)-2-[[(1s)-1-carboxybutyl]amino]-1-oxopropyl]octahydro-1h-indole-2-carboxylic Acid

49. (2s,3as,7as)-1-[(2s)-2-[[(2s)-1-hydroxy-1-oxopentan-2-yl]amino] Propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic Acid

50. (2s,3as,7as)-1-[(2s)-2-{[(1s)-1-carboxybutyl]amino}propanoyl]octahydro-1h-indole-2-carboxylic Acid

51. (2s,3as,7as)-1-[(2s)-2-{[(1s)-1-carboxybutyl]amino}propanoyl]octahydro-1h-indole-2-carboxylic Acid (non-preferred Name)

52. [2s-[1[r*(r*)],2alpha,3abeta,7abeta]]-1-[2-[(1-carboxybutyl)amino]-1-oxopropyl]octahydro-1h-indole-2-carboxylic Acid

53. X94

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₈N₂O₅
Molecular Weight	340.4 g/mol
XLogP3	0.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	340.19982200 g/mol
Monoisotopic Mass	340.19982200 g/mol
Topological Polar Surface Area	107 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	495
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Angiotensin-Converting Enzyme Inhibitors

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

4.2 FDA Pharmacological Classification

4.2.1 Active Moiety

PERINDOPRILAT

4.2.2 FDA UNII

2UV6ZNQ92K

4.2.3 Pharmacological Classes

Mechanisms of Action [MoA] - Angiotensin-converting Enzyme Inhibitors

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ABOUT THIS PAGE

Perindoprilate Manufacturers

A Perindoprilate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Perindoprilate, including repackagers and relabelers. The FDA regulates Perindoprilate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Perindoprilate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Perindoprilate Suppliers

A Perindoprilate supplier is an individual or a company that provides Perindoprilate active pharmaceutical ingredient (API) or Perindoprilate finished formulations upon request. The Perindoprilate suppliers may include Perindoprilate API manufacturers, exporters, distributors and traders.

Perindoprilate GMP

Perindoprilate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Perindoprilate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Perindoprilate GMP manufacturer or Perindoprilate GMP API supplier for your needs.

Perindoprilate CoA

A Perindoprilate CoA (Certificate of Analysis) is a formal document that attests to Perindoprilate's compliance with Perindoprilate specifications and serves as a tool for batch-level quality control.

Perindoprilate CoA mostly includes findings from lab analyses of a specific batch. For each Perindoprilate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Perindoprilate may be tested according to a variety of international standards, such as European Pharmacopoeia (Perindoprilate EP), Perindoprilate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Perindoprilate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.