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Chemistry

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Also known as: 132-20-7, Inhiston, Trimetose, Daneral, Naphcon a, Pheniramine hydrogen maleate
Molecular Formula
C20H24N2O4
Molecular Weight
356.4  g/mol
InChI Key
SSOXZAQUVINQSA-BTJKTKAUSA-N
FDA UNII
NYW905655B

Pheniramine Maleate
One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.
1 2D Structure

Pheniramine Maleate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(Z)-but-2-enedioic acid;N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine
2.1.2 InChI
InChI=1S/C16H20N2.C4H4O4/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16;5-3(6)1-2-4(7)8/h3-10,12,15H,11,13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
2.1.3 InChI Key
SSOXZAQUVINQSA-BTJKTKAUSA-N
2.1.4 Canonical SMILES
CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
2.2 Other Identifiers
2.2.1 UNII
NYW905655B
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Avil

2. Bimaleate, Pheniramine

3. Daneral

4. Histapyridamine

5. Maleate, Pheniramine

6. Pheniramine

7. Pheniramine Bimaleate

8. Propheniramine

9. Prophenpyridamine

2.3.2 Depositor-Supplied Synonyms

1. 132-20-7

2. Inhiston

3. Trimetose

4. Daneral

5. Naphcon A

6. Pheniramine Hydrogen Maleate

7. Pheniramine Maleate Salt

8. Prophenpyridamine Maleate

9. Antolozine

10. Fervex

11. Pheniramine (maleate)

12. 1-phenyl-1-(2-pyridyl)-3-dimethylaminopropane Maleate

13. Nsc-757270

14. Chebi:31990

15. Nyw905655b

16. Pm-241

17. Avil-retard

18. N,n-dimethyl-3-phenyl-3-(2-pyridyl)propylamine Hydrogen Maleate

19. 2-pyridinepropanamine, N,n-dimethyl-gamma-phenyl-, (2z)-2-butenedioate (1:1)

20. Pheniramine Maleate [usan]

21. Ccris 6265

22. Sr-01000075263

23. Einecs 205-051-4

24. Ho 11513

25. N,n-dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine Maleate

26. Unii-nyw905655b

27. Pheniramine Maleate [usan:usp]

28. Prestwick_769

29. Mfcd00079250

30. 2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine, Maleate

31. 2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine, Bimaleate

32. Phenyl(2-pyridyl)(beta-n,n-dimethylaminomethyl) Methane Maleate

33. 1-(n,n-dimethylamino)-3-(phenyl-3-alpha-pyridyl)propane Maleate

34. 2-pyridinepropanamine, N,n-dimethyl-gamma-phenyl-, (z)-2-butenedioate (1:1)

35. Chembl1653

36. Schembl25318

37. Mls001148181

38. Spectrum1500478

39. Pheniramine Maleate (jan/usp)

40. 2-(alpha-(2-dimethylaminoethyl)benzyl)pyridine Bimaleate

41. Pheniramine Maleate [mi]

42. Hms500l17

43. Pheniramine Maleate [jan]

44. (z)-but-2-enedioic Acid;n,n-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine

45. Hms1568k19

46. Hms1920f22

47. Hms2091p04

48. Hms2095k19

49. Hms2232i20

50. Hms3263e03

51. Hms3712k19

52. Hms3885m20

53. Pharmakon1600-01500478

54. Pheniramine Maleate [vandf]

55. Hy-b0971

56. Pheniramine Maleate [mart.]

57. Tox21_500981

58. Ccg-39109

59. Nsc757270

60. Pheniramine Maleate [usp-rs]

61. Pheniramine Maleate [who-dd]

62. Pyridine, 2-(alpha-(2-(dimethylamino)ethyl)benzyl)-, Maleate (1:1)

63. (2z)-but-2-enedioic Acid; Dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine

64. Akos026749878

65. Cs-4460

66. Lp00981

67. Nsc 757270

68. 2-pyridinepropanamine, N,n-dimethyl-.gamma.-phenyl-, (2z)-2-butenedioate (1:1)

69. 2-pyridinepropanamine, N,n-dimethyl-.gamma.-phenyl-, (z)-2-butenedioate (1:1)

70. Ncgc00094281-01

71. Ncgc00094281-02

72. Ncgc00094281-03

73. Ncgc00094281-04

74. Ncgc00094281-05

75. Ncgc00261666-01

76. Pheniramine Maleate [ep Impurity]

77. Pheniramine Maleate [orange Book]

78. Ac-15941

79. As-12971

80. Bp166247

81. Pheniramine Maleate [ep Monograph]

82. Smr000653458

83. Pheniramine Maleate [usp Monograph]

84. Eu-0100981

85. P2271

86. S4045

87. Sw196908-3

88. Visine-a Component Pheniramine Maleate

89. Naphcon-a Component Pheniramine Maleate

90. D01174

91. P 6902

92. Pheniramine Maleate Component Of Opcon-a

93. Pheniramine Maleate Component Of Visine-a

94. Pheniramine Maleate Component Of Naphcon-a

95. J-006144

96. Sr-01000075263-1

97. Sr-01000075263-4

98. Sr-01000075263-7

99. Q27114744

100. Benzenepropanoic Acid, 4-(1-methylethyl)-.alpha.-oxo-

101. 1-phenyl-1-(2-pyridyl)-3-dimethaminopropane Maleinate

102. 2-(.alpha.-(2-dimethylaminoethyl)benzyl)pyridine Bimaleate

103. Pheniramine Maleate, European Pharmacopoeia (ep) Reference Standard

104. 2-(.alpha.-(2-(dimethylamino)ethyl)benzyl)pyridine Bimaleate

105. Pheniramine Maleate, United States Pharmacopeia (usp) Reference Standard

106. Pyridine, 2-(.alpha.-(2-(dimethylamino)ethyl)benzyl)-, Maleate (1:1)

107. 155683-11-7

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 356.4 g/mol
Molecular Formula C20H24N2O4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass356.17360725 g/mol
Monoisotopic Mass356.17360725 g/mol
Topological Polar Surface Area90.7 Ų
Heavy Atom Count26
Formal Charge0
Complexity340
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antipruritics

Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)


Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)


Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)


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DKSH

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Emay Pharmaceuticals

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Jai Radhe Sales

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Pharm-RX Chemical

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Supriya Lifescience

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Tenatra Chemie

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Harika Drugs

India

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Kongo Chemical Co., Ltd.

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Kongo Chemical Co., Ltd.

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Keshava Organics

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Merck & Co

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02-Jan-2021
28-Feb-2025
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DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.02675%...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.02675%;0.315%

USFDA APPLICATION NUMBER - 20065

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DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.025%;0...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.025%;0.3%

USFDA APPLICATION NUMBER - 20485

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ABOUT THIS PAGE

Looking for 155683-11-7 / Pheniramine Maleate API manufacturers, exporters & distributors?

Pheniramine Maleate manufacturers, exporters & distributors 1

46

PharmaCompass offers a list of Pheniramine Maleate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pheniramine Maleate manufacturer or Pheniramine Maleate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Pheniramine Maleate manufacturer or Pheniramine Maleate supplier.

PharmaCompass also assists you with knowing the Pheniramine Maleate API Price utilized in the formulation of products. Pheniramine Maleate API Price is not always fixed or binding as the Pheniramine Maleate Price is obtained through a variety of data sources. The Pheniramine Maleate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Pheniramine Maleate

Synonyms

132-20-7, Inhiston, Trimetose, Daneral, Naphcon a, Pheniramine hydrogen maleate

Cas Number

155683-11-7

Unique Ingredient Identifier (UNII)

NYW905655B

About Pheniramine Maleate

One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.

Pheniramine Manufacturers

A Pheniramine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pheniramine, including repackagers and relabelers. The FDA regulates Pheniramine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pheniramine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Pheniramine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Pheniramine Suppliers

A Pheniramine supplier is an individual or a company that provides Pheniramine active pharmaceutical ingredient (API) or Pheniramine finished formulations upon request. The Pheniramine suppliers may include Pheniramine API manufacturers, exporters, distributors and traders.

click here to find a list of Pheniramine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Pheniramine USDMF

A Pheniramine DMF (Drug Master File) is a document detailing the whole manufacturing process of Pheniramine active pharmaceutical ingredient (API) in detail. Different forms of Pheniramine DMFs exist exist since differing nations have different regulations, such as Pheniramine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Pheniramine DMF submitted to regulatory agencies in the US is known as a USDMF. Pheniramine USDMF includes data on Pheniramine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Pheniramine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Pheniramine suppliers with USDMF on PharmaCompass.

Pheniramine CEP

A Pheniramine CEP of the European Pharmacopoeia monograph is often referred to as a Pheniramine Certificate of Suitability (COS). The purpose of a Pheniramine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Pheniramine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Pheniramine to their clients by showing that a Pheniramine CEP has been issued for it. The manufacturer submits a Pheniramine CEP (COS) as part of the market authorization procedure, and it takes on the role of a Pheniramine CEP holder for the record. Additionally, the data presented in the Pheniramine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Pheniramine DMF.

A Pheniramine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Pheniramine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Pheniramine suppliers with CEP (COS) on PharmaCompass.

Pheniramine WC

A Pheniramine written confirmation (Pheniramine WC) is an official document issued by a regulatory agency to a Pheniramine manufacturer, verifying that the manufacturing facility of a Pheniramine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Pheniramine APIs or Pheniramine finished pharmaceutical products to another nation, regulatory agencies frequently require a Pheniramine WC (written confirmation) as part of the regulatory process.

click here to find a list of Pheniramine suppliers with Written Confirmation (WC) on PharmaCompass.

Pheniramine NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Pheniramine as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Pheniramine API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Pheniramine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Pheniramine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Pheniramine NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Pheniramine suppliers with NDC on PharmaCompass.

Pheniramine GMP

Pheniramine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pheniramine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pheniramine GMP manufacturer or Pheniramine GMP API supplier for your needs.

Pheniramine CoA

A Pheniramine CoA (Certificate of Analysis) is a formal document that attests to Pheniramine's compliance with Pheniramine specifications and serves as a tool for batch-level quality control.

Pheniramine CoA mostly includes findings from lab analyses of a specific batch. For each Pheniramine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pheniramine may be tested according to a variety of international standards, such as European Pharmacopoeia (Pheniramine EP), Pheniramine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pheniramine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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