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    Chemistry

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    Also known as: 132-20-7, Inhiston, Trimetose, Daneral, Naphcon a, Pheniramine hydrogen maleate
    Molecular Formula
    C20H24N2O4
    Molecular Weight
    356.4  g/mol
    InChI Key
    SSOXZAQUVINQSA-BTJKTKAUSA-N
    FDA UNII
    NYW905655B
    Pheniramine Maleate
    One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.
    1 2D Structure

    Pheniramine Maleate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine
    2.1.2 InChI
    InChI=1S/C16H20N2.C4H4O4/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16;5-3(6)1-2-4(7)8/h3-10,12,15H,11,13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
    2.1.3 InChI Key
    SSOXZAQUVINQSA-BTJKTKAUSA-N
    2.1.4 Canonical SMILES
    CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    NYW905655B
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Avil

    2. Bimaleate, Pheniramine

    3. Daneral

    4. Histapyridamine

    5. Maleate, Pheniramine

    6. Pheniramine

    7. Pheniramine Bimaleate

    8. Propheniramine

    9. Prophenpyridamine

    2.3.2 Depositor-Supplied Synonyms

    1. 132-20-7

    2. Inhiston

    3. Trimetose

    4. Daneral

    5. Naphcon A

    6. Pheniramine Hydrogen Maleate

    7. Pheniramine Maleate Salt

    8. Prophenpyridamine Maleate

    9. Antolozine

    10. Fervex

    11. Pheniramine (maleate)

    12. 1-phenyl-1-(2-pyridyl)-3-dimethylaminopropane Maleate

    13. Nsc-757270

    14. Chebi:31990

    15. Nyw905655b

    16. Pm-241

    17. Avil-retard

    18. N,n-dimethyl-3-phenyl-3-(2-pyridyl)propylamine Hydrogen Maleate

    19. 2-pyridinepropanamine, N,n-dimethyl-gamma-phenyl-, (2z)-2-butenedioate (1:1)

    20. Pheniramine Maleate [usan]

    21. Ccris 6265

    22. Sr-01000075263

    23. Einecs 205-051-4

    24. Ho 11513

    25. N,n-dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine Maleate

    26. Unii-nyw905655b

    27. Pheniramine Maleate [usan:usp]

    28. Prestwick_769

    29. Mfcd00079250

    30. 2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine, Maleate

    31. 2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine, Bimaleate

    32. Phenyl(2-pyridyl)(beta-n,n-dimethylaminomethyl) Methane Maleate

    33. 1-(n,n-dimethylamino)-3-(phenyl-3-alpha-pyridyl)propane Maleate

    34. 2-pyridinepropanamine, N,n-dimethyl-gamma-phenyl-, (z)-2-butenedioate (1:1)

    35. Chembl1653

    36. Schembl25318

    37. Mls001148181

    38. Spectrum1500478

    39. Pheniramine Maleate (jan/usp)

    40. 2-(alpha-(2-dimethylaminoethyl)benzyl)pyridine Bimaleate

    41. Pheniramine Maleate [mi]

    42. Hms500l17

    43. Pheniramine Maleate [jan]

    44. (z)-but-2-enedioic Acid;n,n-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine

    45. Hms1568k19

    46. Hms1920f22

    47. Hms2091p04

    48. Hms2095k19

    49. Hms2232i20

    50. Hms3263e03

    51. Hms3712k19

    52. Hms3885m20

    53. Pharmakon1600-01500478

    54. Pheniramine Maleate [vandf]

    55. Hy-b0971

    56. Pheniramine Maleate [mart.]

    57. Tox21_500981

    58. Ccg-39109

    59. Nsc757270

    60. Pheniramine Maleate [usp-rs]

    61. Pheniramine Maleate [who-dd]

    62. Pyridine, 2-(alpha-(2-(dimethylamino)ethyl)benzyl)-, Maleate (1:1)

    63. (2z)-but-2-enedioic Acid; Dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine

    64. Akos026749878

    65. Cs-4460

    66. Lp00981

    67. Nsc 757270

    68. 2-pyridinepropanamine, N,n-dimethyl-.gamma.-phenyl-, (2z)-2-butenedioate (1:1)

    69. 2-pyridinepropanamine, N,n-dimethyl-.gamma.-phenyl-, (z)-2-butenedioate (1:1)

    70. Ncgc00094281-01

    71. Ncgc00094281-02

    72. Ncgc00094281-03

    73. Ncgc00094281-04

    74. Ncgc00094281-05

    75. Ncgc00261666-01

    76. Pheniramine Maleate [ep Impurity]

    77. Pheniramine Maleate [orange Book]

    78. Ac-15941

    79. As-12971

    80. Bp166247

    81. Pheniramine Maleate [ep Monograph]

    82. Smr000653458

    83. Pheniramine Maleate [usp Monograph]

    84. Eu-0100981

    85. P2271

    86. S4045

    87. Sw196908-3

    88. Visine-a Component Pheniramine Maleate

    89. Naphcon-a Component Pheniramine Maleate

    90. D01174

    91. P 6902

    92. Pheniramine Maleate Component Of Opcon-a

    93. Pheniramine Maleate Component Of Visine-a

    94. Pheniramine Maleate Component Of Naphcon-a

    95. J-006144

    96. Sr-01000075263-1

    97. Sr-01000075263-4

    98. Sr-01000075263-7

    99. Q27114744

    100. Benzenepropanoic Acid, 4-(1-methylethyl)-.alpha.-oxo-

    101. 1-phenyl-1-(2-pyridyl)-3-dimethaminopropane Maleinate

    102. 2-(.alpha.-(2-dimethylaminoethyl)benzyl)pyridine Bimaleate

    103. Pheniramine Maleate, European Pharmacopoeia (ep) Reference Standard

    104. 2-(.alpha.-(2-(dimethylamino)ethyl)benzyl)pyridine Bimaleate

    105. Pheniramine Maleate, United States Pharmacopeia (usp) Reference Standard

    106. Pyridine, 2-(.alpha.-(2-(dimethylamino)ethyl)benzyl)-, Maleate (1:1)

    107. 155683-11-7

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 356.4 g/mol
    Molecular Formula C20H24N2O4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count7
    Exact Mass356.17360725 g/mol
    Monoisotopic Mass356.17360725 g/mol
    Topological Polar Surface Area90.7 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity340
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antipruritics

    Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

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    03-Jan-2021
    31-Oct-2024
    KGS
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    DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.02675%...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.02675%;0.315%

    USFDA APPLICATION NUMBER - 20065

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    DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.025%;0...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.025%;0.3%

    USFDA APPLICATION NUMBER - 20485

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