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    Chemistry

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    Also known as: 1197-21-3, Phentermine hcl, Fastin, Oby-trim, Phenteral, Tora
    Molecular Formula
    C10H16ClN
    Molecular Weight
    185.69  g/mol
    InChI Key
    NCAIGTHBQTXTLR-UHFFFAOYSA-N
    FDA UNII
    0K2I505OTV
    Phentermine Hydrochloride
    A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
    1 2D Structure

    Phentermine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-methyl-1-phenylpropan-2-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C10H15N.ClH/c1-10(2,11)8-9-6-4-3-5-7-9;/h3-7H,8,11H2,1-2H3;1H
    2.1.3 InChI Key
    NCAIGTHBQTXTLR-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)(CC1=CC=CC=C1)N.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    0K2I505OTV
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Adipex P

    2. Adipex-p

    3. Adipexp

    4. Duromine

    5. Hydrochloride, Phentermine

    6. Ionamine

    7. Phentermine

    2.3.2 Depositor-Supplied Synonyms

    1. 1197-21-3

    2. Phentermine Hcl

    3. Fastin

    4. Oby-trim

    5. Phenteral

    6. Tora

    7. Ona-mast

    8. Phentermyl Wyncaps

    9. Obestin-30

    10. 2-methyl-1-phenylpropan-2-amine Hydrochloride

    11. Suprenza

    12. Wilpo

    13. Ona-mast Hydrochloride

    14. Adipex-p

    15. Ionamin

    16. Zantryl

    17. Alpha,alpha-dimethylphenethylamine Hydrochloride

    18. Phentermine Hydrochloride [usp]

    19. Mg 18370

    20. S 58

    21. 1,1-dimethyl-2-phenylethylamine Hydrochloride

    22. 1-phenyl-2-methyl-2-aminopropane Hydrochloride

    23. Nsc-44090

    24. Phentermine Hydrochloride Civ

    25. Phenyl-t-butylamine Hydrochloride

    26. 0k2i505otv

    27. Duromine

    28. Dea No. 1640

    29. 2-methyl-1-phenylpropan-2-amine;hydrochloride

    30. Benzeneethanamine, Alpha,alpha-dimethyl, Hydrochloride

    31. .alpha.,.alpha.-dimethylphenethylamine Hydrochloride

    32. Wilpo (van)

    33. Phentermine Hydrochloride (usp)

    34. Chebi:50506

    35. Alpha-methylamphetamine Hydrochloride

    36. Einecs 214-821-9

    37. Nsc 44090

    38. Unii-0k2i505otv

    39. Lomaira

    40. Fastin (tn)

    41. Adipex-p (tn)

    42. Phenteramine Hydrochloride

    43. Schembl41585

    44. Mls003882563

    45. Phenethylamine, Alpha,alpha-dimethyl-, Hydrochloride

    46. Benzeneethanamine, Alpha,alpha-dimethyl-, Hydrochloride

    47. Chembl1200912

    48. Dtxsid20152550

    49. Wln: Zx1&1&1r &gh

    50. Bcp23776

    51. Nsc44090

    52. Phentermine Hydrochloride [mi]

    53. Akos015891196

    54. .alpha.-methylamphetamine Hydrochloride

    55. Ccg-221139

    56. Phentermine Hydrochloride [mart.]

    57. Phentermine Hydrochloride [vandf]

    58. Mg 18570

    59. Phentermine Hydrochloride [usp-rs]

    60. Phentermine Hydrochloride [who-dd]

    61. Smr000058739

    62. Phentermine Hydrochloride, >=98% (hplc)

    63. 2-methyl-1-phenyl-2-propanamine Hydrochloride

    64. 2-amino-2-methyl-1-phenylpropane Hydrochloride

    65. D05459

    66. Phentermine Hcl; Adipex P; Adipex-p; Adipexp

    67. Phentermine Hydrochloride [orange Book]

    68. Benzeneethanamine,.alpha.-dimethyl, Hydrochloride

    69. Phentermine Hydrochloride [usp Monograph]

    70. Qsymia Component Phentermine Hydrochloride

    71. Phentermine Hydrochloride Component Of Qsymia

    72. Q19885635

    73. Benzeneethanamine, .alpha.,.alpha.-dimethyl-, Hydroch

    74. Phentermine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 185.69 g/mol
    Molecular Formula C10H16ClN
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count2
    Exact Mass185.0971272 g/mol
    Monoisotopic Mass185.0971272 g/mol
    Topological Polar Surface Area26 Ų
    Heavy Atom Count12
    Formal Charge0
    Complexity112
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NamePhentermine hydrochloride
    PubMed HealthPhentermine (By mouth)
    Drug ClassesAppetite Suppressant, Centrally Acting
    Drug LabelPhentermine hydrochloride USP has the chemical name of , -Dimethylphenethylamine hydrochloride. The structural formula is as follows:C10H15NHClM.W. 185.7Phentermine hydrochlor...
    Active IngredientPhentermine hydrochloride
    Dosage FormTablet; Capsule
    RouteOral
    Strength37.5mg; 30mg; 15mg
    Market StatusPrescription
    CompanyVintage Pharms; Aurolife Pharma; Ken Lifescience; Mirror Pharms; Sun Pharm Inds; Sandoz; Invagen Pharms; Lannett Holdings; Lannett; Mutual Pharm; Mikah Pharma; Kvk Tech; Elite Labs; Barr

    2 of 4  
    Drug NameSuprenza
    Drug LabelSuprenza is an orally disintegrating tablet (ODT) of phentermine hydrochloride, USP. Phentermine hydrochloride is a sympathomimetic amine anorectic. Its chemical name is ,,-dimethylphenethylamine hydrochloride. The structural formula is as follow...
    Active IngredientPhentermine hydrochloride
    Dosage FormTablet, orally disintegrating
    RouteOral
    Strength37.5mg; 30mg; 15mg
    Market StatusPrescription
    CompanyCitius Pharms

    3 of 4  
    Drug NamePhentermine hydrochloride
    PubMed HealthPhentermine (By mouth)
    Drug ClassesAppetite Suppressant, Centrally Acting
    Drug LabelPhentermine hydrochloride USP has the chemical name of , -Dimethylphenethylamine hydrochloride. The structural formula is as follows:C10H15NHClM.W. 185.7Phentermine hydrochlor...
    Active IngredientPhentermine hydrochloride
    Dosage FormTablet; Capsule
    RouteOral
    Strength37.5mg; 30mg; 15mg
    Market StatusPrescription
    CompanyVintage Pharms; Aurolife Pharma; Ken Lifescience; Mirror Pharms; Sun Pharm Inds; Sandoz; Invagen Pharms; Lannett Holdings; Lannett; Mutual Pharm; Mikah Pharma; Kvk Tech; Elite Labs; Barr

    4 of 4  
    Drug NameSuprenza
    Drug LabelSuprenza is an orally disintegrating tablet (ODT) of phentermine hydrochloride, USP. Phentermine hydrochloride is a sympathomimetic amine anorectic. Its chemical name is ,,-dimethylphenethylamine hydrochloride. The structural formula is as follow...
    Active IngredientPhentermine hydrochloride
    Dosage FormTablet, orally disintegrating
    RouteOral
    Strength37.5mg; 30mg; 15mg
    Market StatusPrescription
    CompanyCitius Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic Agents

    Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Appetite Depressants

    Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)

    Central Nervous System Stimulants

    A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Increased Sympathetic Activity [PE]; Sympathomimetic Amine Anorectic [EPC]; Appetite Suppression [PE]

    API Reference Price

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    DOSAGE - TABLET;ORAL - 37.5MG

    USFDA APPLICATION NUMBER - 85128

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    DOSAGE - CAPSULE;ORAL - 30MG

    USFDA APPLICATION NUMBER - 86945

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    DOSAGE - CAPSULE;ORAL - 15MG

    USFDA APPLICATION NUMBER - 87190

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    DOSAGE - CAPSULE;ORAL - 30MG

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    DOSAGE - CAPSULE;ORAL - 37.5MG

    USFDA APPLICATION NUMBER - 88023

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