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Phentolamine Mesylate

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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ACTIVE PHARMA INGREDIENTS

10 API Suppliers, 6 USDMF, 1 CEP/COS, 1 EU WC, 15 NDC API, 6 Listed Suppliers, $ API Reference Price

10 API Suppliers
6 USDMF
1 CEP/COS
1 EU WC
15 NDC API
6 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

27 Drugs in Development

27 Drugs in Development

FINISHED DOSAGE FORMULATIONS

12 FDF Dossiers, 5 FDA Orange Book, 2 Canada, 5 Listed Dossiers

12 FDF Dossiers
5 FDA Orange Book
2 Canada
5 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 12 SPI Pharma, 1 Faran Shimi Pharmaceutical, 1 Pfanstiehl, 1 BASF, 2 Gangwal Chemicals, 1 Ingredion Pharma Solutions, 2 Kerry, 2 Microlex e.U, 1 Pluviaendo, 3 Roquette, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Sigachi Industries

relatedExcipients
1 Rochem International Inc
12 SPI Pharma
1 Faran Shimi Pharmaceutical
1 Pfanstiehl
1 BASF
2 Gangwal Chemicals
1 Ingredion Pharma Solutions
2 Kerry
2 Microlex e.U
1 Pluviaendo
3 Roquette
1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
1 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

17 Fillers, Diluents & Binders, 10 Chewable & Orodispersible Aids, 9 Taste Masking, 9 Direct Compression, 4 Co-Processed Excipients, 4 Parenteral, 3 Granulation, 3 Disintegrants & Superdisintegrants, 1 API Stability Enhancers, 1 Thickeners and Stabilizers

excipientsByApplications
17 Fillers, Diluents & Binders
10 Chewable & Orodispersible Aids
9 Taste Masking
9 Direct Compression
4 Co-Processed Excipients
4 Parenteral
3 Granulation
3 Disintegrants & Superdisintegrants
1 API Stability Enhancers
1 Thickeners and Stabilizers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 24 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
24 NEWS #PharmaBuzz

MARKET PLACE

15 APIs, 1 FDF Dossiers

marketPlace
15 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

6 US Patents, 1 US Exclusivities, 2 Health Canada Patents

patents
6 US Patents
1 US Exclusivities
2 Health Canada Patents

REF. STANDARDS & IMPURITIES

3 EDQM , 1 USP , 3 Others

otherSolutions
3 EDQM
1 USP
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 49,534

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

27DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

30 RELATED EXCIPIENT COMPANIES

61EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 65-28-1, Phentolamine mesilate, Phentolamine methanesulfonate, Phentolamine (mesylate), Oraverse, Regitine mesylate

Molecular Formula

C₁₈H₂₃N₃O₄S

Molecular Weight

377.5 g/mol

InChI Key

OGIYDFVHFQEFKQ-UHFFFAOYSA-N

FDA UNII

Y7543E5K9T

A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.

1 2D Structure

Phentolamine Mesylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;methanesulfonic acid

2.1.2 InChI

InChI=1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)

2.1.3 InChI Key

OGIYDFVHFQEFKQ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O.CS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

Y7543E5K9T

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Fentolamin

2. Mesilate, Phentolamine

3. Mesylate, Phentolamine

4. Methanesulfonate, Phentolamine

5. Mono-hydrochloride, Phentolamine

6. Phentolamine

7. Phentolamine Mesilate

8. Phentolamine Methanesulfonate

9. Phentolamine Mono Hydrochloride

10. Phentolamine Mono-hydrochloride

11. Regitine

12. Regityn

13. Rogitine

14. Z-max

2.3.2 Depositor-Supplied Synonyms

1. 65-28-1

2. Phentolamine Mesilate

3. Phentolamine Methanesulfonate

4. Phentolamine (mesylate)

5. Oraverse

6. Regitine Mesylate

7. Phentolamine Methanesulfonate Salt

8. Phentolamine Mesylate [usp]

9. Mesylate Phentolamine

10. 3-(((4,5-dihydro-1h-imidazol-2-yl)methyl)(p-tolyl)amino)phenol Methanesulfonate

11. Nv-101

12. Mls000069487

13. Y7543e5k9t

14. M-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)phenol Monomethanesulfonate (salt)

15. Phenol, 3-(((4,5-dihydro-1h-imidazol-2-yl)methyl)(4-methylphenyl)amino)-, Monomethanesulfonate (salt)

16. Phenol,3-[[(4,5-dihydro-1h-imidazol-2-yl)methyl](4-methylphenyl)amino]-,monomethanesulfonate (salt)

17. Smr000059054

18. 3-[n-(4,5-dihydro-1h-imidazol-2-ylmethyl)-4-methylanilino]phenol;methanesulfonic Acid

19. Phentolamine Mesylate (usp)

20. Vasomax

21. Regitin Methanesulphonate

22. Regitine Methanesulfonate

23. Phenol, M-[n-(2-imidazolin-2-ylmethyl)-p-toluidino]-, Methanesulfonate (1:1)

24. Phentolamine Methanesulphonate

25. Ccris 9022

26. Phentolamine Mesilate [inn:ban]

27. Einecs 200-604-6

28. Vasofem

29. Unii-y7543e5k9t

30. Regitin Mesylate

31. Sr-01000000055

32. Regitine (tn)

33. Z-max

34. Mfcd00134201

35. Opera_id_1599

36. Lopac-p-7561

37. Phentolamine Meslate,(s)

38. Schembl40852

39. Mls001076484

40. Phentolamine, Methyl Sulfonate

41. Regid_for_cid_91430

42. Chembl1200873

43. Hy-b0362a

44. Dtxsid60215315

45. Phentolamine Mesilate (jan/inn)

46. Hms2233a24

47. Hms3263e05

48. Hms3373d03

49. Hms3655b13

50. Hms3884a22

51. Phentolamine Mesilate [jan]

52. Bcp09845

53. Tox21_500982

54. Phentolamine Mesylate [vandf]

55. S2038

56. 3-fluoropyridine-4-boronicacidhydrate

57. Phentolamine Mesilate [mart.]

58. Akos007930193

59. Phentolamine Mesilate [who-dd]

60. Phentolamine Mesylate [usp-rs]

61. Ac-7472

62. Ccg-222286

63. Lp00982

64. 3-[n-(4,5-dihydro-1h-imidazol-2-ylmethyl)-4-methylanilino]phenol; Methanesulfonic Acid

65. Phenol, M-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)-, Monomethanesulfonate (salt)

66. Ncgc00016195-01

67. Ncgc00016195-02

68. Ncgc00094282-01

69. Ncgc00261667-01

70. As-13800

71. Phentolamine Methanesulfonate [mi]

72. Phentolamine Mesylate [orange Book]

73. Phentolamine Mesilate [ep Monograph]

74. Eu-0100982

75. Ft-0603267

76. P1985

77. Phentolamine Mesylate [usp Monograph]

78. Sw196637-3

79. D00509

80. P 7561

81. T72782

82. 134p201

83. A835046

84. Sr-01000000055-3

85. W-104799

86. Q27294332

87. Phentolamine Methanesulfonate Salt, >=98% (tlc), Powder

88. Phentolamine Mesilate, British Pharmacopoeia (bp) Reference Standard

89. 2-[n-(m-hydroxyphenyl)-p-toluidinomethyl]imidazoline Methanesulfonate

90. Phentolamine Mesilate, European Pharmacopoeia (ep) Reference Standard

91. Phentolamine Mesylate, United States Pharmacopeia (usp) Reference Standard

92. 3-(((4,5-dihydro-1h-imidazol-2-yl)methyl)(p-tolyl)amino)phenolmethanesulfonate

93. 3-[[(4,5-dihydro-1h-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol Methanesulfonate

94. 3-[4,5-dihydro-1h-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol; Methanesulfonic Acid

95. 3-[n-(4,5-dihydro-1h-imidazol-1-ium-2-ylmethyl)-4-methylanilino]phenol;methanesulfonate

96. M-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)phenol Monomethanesulphonate (salt)

97. Phentolamine Mesilate For System Suitability, European Pharmacopoeia (ep) Reference Standard

98. Phentolamine Mesylate, Pharmaceutical Secondary Standard; Certified Reference Material

99. Phenol, 3-(((4,5-dihydro-1h-imidazol-2-yl)methyl)(4-methylphenyl)amino)-, Monomethanesulphonate (salt)

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₃N₃O₄S
Molecular Weight	377.5 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	377.14092740 g/mol
Monoisotopic Mass	377.14092740 g/mol
Topological Polar Surface Area	111 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	456
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Phentolamine mesylate
Drug Label	Phentolamine Mesylate for Injection USP, is an antihypertensive, available in vials for intravenous and intramuscular administration. Each vial contains phentolamine mesylate USP, 5 mg and mannitol USP, 25 mg in sterile, lyophilized form.Phentolamine...
Active Ingredient	Phentolamine mesylate
Dosage Form	Injectable
Route	Injection
Strength	5mg/vial
Market Status	Prescription
Company	Eurohlth Intl

2 of 4
Drug Name	Oraverse
PubMed Health	Phentolamine (Injection)
Drug Classes	Antihypertensive, Diagnostic Agent, Pheochromocytoma, Toxicology-Antidote Agent
Drug Label	Phentolamine mesylate is phenol,3-[[(4,5-dihydro-1 H-imidazol-2-yl)methyl](4-methyl-phenyl)amino]-, methanesulfonate (salt), a non-specific alpha adrenergic blocker.Phentolamine mesylate USP is a white to off-white, odorless crystalline powder with a...
Active Ingredient	Phentolamine mesylate
Dosage Form	Injectable
Route	Injection
Strength	0.4mg/1.7ml
Market Status	Prescription
Company	Septodont Holding

3 of 4
Drug Name	Phentolamine mesylate
Drug Label	Phentolamine Mesylate for Injection USP, is an antihypertensive, available in vials for intravenous and intramuscular administration. Each vial contains phentolamine mesylate USP, 5 mg and mannitol USP, 25 mg in sterile, lyophilized form.Phentolamine...
Active Ingredient	Phentolamine mesylate
Dosage Form	Injectable
Route	Injection
Strength	5mg/vial
Market Status	Prescription
Company	Eurohlth Intl

4 of 4
Drug Name	Oraverse
PubMed Health	Phentolamine (Injection)
Drug Classes	Antihypertensive, Diagnostic Agent, Pheochromocytoma, Toxicology-Antidote Agent
Drug Label	Phentolamine mesylate is phenol,3-[[(4,5-dihydro-1 H-imidazol-2-yl)methyl](4-methyl-phenyl)amino]-, methanesulfonate (salt), a non-specific alpha adrenergic blocker.Phentolamine mesylate USP is a white to off-white, odorless crystalline powder with a...
Active Ingredient	Phentolamine mesylate
Dosage Form	Injectable
Route	Injection
Strength	0.4mg/1.7ml
Market Status	Prescription
Company	Septodont Holding

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Adrenergic alpha-Antagonists

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

alpha-Adrenergic Blocker [EPC]; Adrenergic alpha-Antagonists [MoA]

API SUPPLIERS

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

USDMF

01

Apicore Llc (a Wholly Owned Sub Of R...

India

Antibody Engineering

Not Confirmed

02

Synkem Div Plasto Sa

Germany

Antibody Engineering

Not Confirmed

03

Industriale Chimica Srl

Italy

Antibody Engineering

Not Confirmed

04

Jiangsu Lianhuan Pharmaceutical Co L...

China

Antibody Engineering

Not Confirmed

05

Reliable Biopharmaceutical Llc

U.S.A

Antibody Engineering

Not Confirmed

06

Tianish Laboratories Private Ltd

U.S.A

Antibody Engineering

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

CEP/COS

01

Industriale Chimica S.R.L. Saronno ...

Italy

Antibody Engineering

Not Confirmed

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EU WC

01

Apicore LLC

India

Antibody Engineering

Not Confirmed

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NDC API

01

Apicore Pharmaceuticals Private Lim...

India

Antibody Engineering

Not Confirmed

02

Apicore Pharmaceuticals Private Lim...

India

Antibody Engineering

Not Confirmed

03

Qingdao Biopeptek Co., Ltd.

U.S.A

Antibody Engineering

Not Confirmed

04

Industriale Chimica s.r.l.

Italy

Antibody Engineering

Not Confirmed

05

KALCHEM INTERNATIONAL INC

U.S.A

Antibody Engineering

Not Confirmed

06

Professional Compounding Centers of...

United Kingdom

Antibody Engineering

Not Confirmed

07

QINGDAO TIDA BIOTEK CO.,LTD

China

Antibody Engineering

Not Confirmed

08

QINGDAO TIDA BIOTEK CO.,LTD

China

Antibody Engineering

Not Confirmed

09

RAKSHIT DRUGS PRIVATE LIMITED

India

Antibody Engineering

Not Confirmed

10

Reliable Biopharmaceutical LLC

U.S.A

Antibody Engineering

Not Confirmed

Only 10 entries up to this point, click to access all

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Listed Suppliers

01

LGM Pharma

U.S.A

Antibody Engineering

Not Confirmed

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

Phentolamine Mesylate

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.

02

Laboratorium Ofichem B.V

Netherlands

Antibody Engineering

Not Confirmed

Laboratorium Ofichem, offering a flexible, high-tech environment to produce broad range of APIs for Human & Vet pharmaceutical markets.

Contact Supplier

Netherlands

Virtual Booth

Digital Content

Phentolamine Mesylate

About the Company : Laboratorium Ofichem is a GMP-certified and FDA-approved API manufacturer with state-of-the-art development and production facilities in the Netherlands. We develop and manufacture...

Laboratorium Ofichem is a GMP-certified and FDA-approved API manufacturer with state-of-the-art development and production facilities in the Netherlands. We develop and manufacture small molecule APIs in a cost-effective, robust, and compliant way. We have our own portfolio of generic APIs, but we also operate as a CDMO for a wide range of customers. We are a stable family-owned business and with nearly 50 years of experience we have a long history of regulatory compliance and a strong reputation for reliability and quality.

03

CHEMO

Spain

Antibody Engineering

Not Confirmed

04

Jiangsu Lianhuan Pharmaceutical

China

Antibody Engineering

Not Confirmed

05

Shouyuan Chemical

China

Antibody Engineering

Not Confirmed

06

Viatris

U.S.A

Antibody Engineering

Not Confirmed

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API Reference Price

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