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    Chemistry

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    Also known as: 154-41-6, 2-amino-1-phenylpropan-1-ol hydrochloride, 2-amino-1-phenyl-1-propanol hydrochloride, Dl-phenylpropanolamine hydrochloride, Dl-norephedrine hydrochloride, 3198-15-0
    Molecular Formula
    C9H14ClNO
    Molecular Weight
    187.66  g/mol
    InChI Key
    DYWNLSQWJMTVGJ-UHFFFAOYSA-N
    Phenylpropanolamine Hydrochloride
    A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.
    1 2D Structure

    Phenylpropanolamine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-amino-1-phenylpropan-1-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C9H13NO.ClH/c1-7(10)9(11)8-5-3-2-4-6-8;/h2-7,9,11H,10H2,1H3;1H
    2.1.3 InChI Key
    DYWNLSQWJMTVGJ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C(C1=CC=CC=C1)O)N.Cl
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Dexatrim

    2. Hydrochloride, Phenylpropanolamine

    3. Norephedrine

    4. Phenylpropanolamine

    5. Prolamine

    6. Propagest

    7. Triaminic Dm

    2.2.2 Depositor-Supplied Synonyms

    1. 154-41-6

    2. 2-amino-1-phenylpropan-1-ol Hydrochloride

    3. 2-amino-1-phenyl-1-propanol Hydrochloride

    4. Dl-phenylpropanolamine Hydrochloride

    5. Dl-norephedrine Hydrochloride

    6. 3198-15-0

    7. Norephedrine Hydrochloride

    8. 40626-29-7

    9. Prestwick_388

    10. (+)-norephedrine Hydrochloride

    11. Norephedrine Hcl

    12. D-(+)-norephedrine Hydrochloride

    13. 2-amino-1-phenylpropan-1-ol;hydrochloride

    14. Phenylpropanolamine Chloride

    15. Schembl4011782

    16. Chembl1200695

    17. Dtxsid6027185

    18. Phenyl Propanolamine Hydrochloride

    19. Akos027320395

    20. Benzenemethanol, .alpha.-[(1s)-1-aminoethyl]-, Hydrochloride, (.alpha.r)-

    21. 53631-70-2

    22. Db-045612

    23. Db-048135

    24. Db-049620

    25. P0742

    26. Dl-erythro-2-amino-1-phenyl-1-propanol Hydrochloride

    27. Benzenemethanol, .alpha.-[(1r)-1-aminoethyl]-, Hydrochloride (1:1), (.alpha.s)-rel-

    2.3 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 187.66 g/mol
    Molecular Formula C9H14ClNO
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass187.0763918 g/mol
    Monoisotopic Mass187.0763918 g/mol
    Topological Polar Surface Area46.2 Ų
    Heavy Atom Count12
    Formal Charge0
    Complexity110
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adrenergic alpha-Agonists

    Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)

    Nasal Decongestants

    Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Appetite Depressants

    Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)

    API Reference Price

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    08-Mar-2021
    28-Oct-2024
    KGS
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