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Chemistry

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Also known as: 5,5-diphenylhydantoin, 57-41-0, Diphenylhydantoin, Dilantin, 5,5-diphenylimidazolidine-2,4-dione, Phenytoine
Molecular Formula
C15H12N2O2
Molecular Weight
252.27  g/mol
InChI Key
CXOFVDLJLONNDW-UHFFFAOYSA-N
FDA UNII
6158TKW0C5

Phenytoin
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Phenytoin is an Anti-epileptic Agent. The mechanism of action of phenytoin is as a Cytochrome P450 1A2 Inducer, and Cytochrome P450 2B6 Inducer, and Cytochrome P450 2C8 Inducer, and Cytochrome P450 2C19 Inducer, and Cytochrome P450 2D6 Inducer, and Cytochrome P450 3A Inducer, and Cytochrome P450 2C9 Inducer. The physiologic effect of phenytoin is by means of Decreased Central Nervous System Disorganized Electrical Activity.
1 2D Structure

Phenytoin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5,5-diphenylimidazolidine-2,4-dione
2.1.2 InChI
InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
2.1.3 InChI Key
CXOFVDLJLONNDW-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
2.2 Other Identifiers
2.2.1 UNII
6158TKW0C5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5,5-diphenylhydantoin

2. 5,5-diphenylimidazolidine-2,4-dione

3. Antisacer

4. Difenin

5. Dihydan

6. Dilantin

7. Diphenylhydantoin

8. Diphenylhydantoinate, Sodium

9. Epamin

10. Epanutin

11. Fenitoin

12. Hydantol

13. Phenhydan

14. Phenytoin Sodium

15. Sodium Diphenylhydantoinate

2.3.2 Depositor-Supplied Synonyms

1. 5,5-diphenylhydantoin

2. 57-41-0

3. Diphenylhydantoin

4. Dilantin

5. 5,5-diphenylimidazolidine-2,4-dione

6. Phenytoine

7. Epamin

8. Zentropil

9. Lepitoin

10. Dihydantoin

11. Aleviatin

12. Dilabid

13. Diphantoin

14. Diphenylan

15. Diphedan

16. Fenylepsin

17. Phentytoin

18. Sodanton

19. Difenin

20. Dihycon

21. Lehydan

22. Diphenylhydatanoin

23. Dantoinal

24. Di-hydan

25. Dilantine

26. Dillantin

27. Diphenine

28. Diphentyn

29. Ditoinate

30. Elepsindon

31. Epilantin

32. Fenitoina

33. Fenytoine

34. Hidantilo

35. Hidantina

36. Hidantomin

37. Hydantoinal

38. Kessodanten

39. Phanantin

40. Phanatine

41. Phenatoine

42. Sodantoin

43. Sylantoic

44. Thilophenyl

45. Zentronal

46. Auranile

47. Dantinal

48. Dantoine

49. Difetoin

50. Difhydan

51. Dintoin

52. Dintoina

53. Diphedal

54. Diphenin

55. Enkelfel

56. Epifenyl

57. Epihydan

58. Fentoin

59. Hidantal

60. Hydantal

61. Idantoil

62. Idantoin

63. Labopal

64. Phentoin

65. Ritmenal

66. Saceril

67. Sanepil

68. Silantin

69. Solantin

70. Danten

71. Denyl

72. Epelin

73. Epinat

74. Epised

75. Eptal

76. Hidan

77. Lepsin

78. Ekko

79. Ictalis Simple

80. Toin Unicelles

81. Dilantin Acid

82. Dantoinal Klinos

83. Om-hydantoine

84. Di-phetine

85. Epdantoine Simple

86. Hidantina Vitoria

87. Gerot-epilan-d

88. Epilan-d

89. Neosidantoina

90. Comitoina

91. Hidantina Senosian

92. Hydantol

93. Minetoin

94. Novantoina

95. Causoin

96. Convul

97. Di-lan

98. Ekko Capsules

99. Neos-hidantoina

100. 2,4-imidazolidinedione, 5,5-diphenyl-

101. Om Hidantoina Simple

102. Toin

103. Phenhydanin

104. Phenytex

105. Phenytoinum

106. Sinergina

107. Sodanthon

108. Iphenylhydantoin

109. Phenytoin-gerot

110. Difenilhidantoina

111. Fenytoin Dak

112. Didan Tdc 250

113. Dilantin-125

114. 5,5-diphenyl-2,4-imidazolidinedione

115. Epdantoin Simple

116. Phenytoin Awd

117. Epilan D

118. Diphenat

119. Hindatal

120. Hydantin

121. Epanutin

122. Fenitoina [inn-spanish]

123. Phenytoine [inn-french]

124. Phenytoinum [inn-latin]

125. Difenilhidantoina [spanish]

126. Diphenylhydantoine [french]

127. 5,5-dwufenylohydantoina

128. Antisacer

129. Fenantoin Mn Pharma

130. Diphenylhydantoine

131. Di-lan (van)

132. Phenytoin Sodium

133. Diphenylhydantoin (van)

134. Diphentoin

135. Dilantin-30

136. Solantoin

137. Solantyl

138. Eptoin

139. Dph (van)

140. 5,5-diphenylimidazolidin-2,4-dione

141. 5,5-diphenyl-imidazolidine-2,4-dione

142. 5,5-diphenylhydantoin (iupac)

143. Phenytek

144. 5,5-dwufenylohydantoina [polish]

145. Hydantoin, 5,5-diphenyl-

146. Ccris 515

147. Chebi:8107

148. 5,5-diphenyl Hydantoin

149. Nci-c55765

150. 5,5-diphenylhydantoin (phenytoin)

151. Diphenylan Sodium

152. Ai3-52498

153. Nsc-8722

154. Dilantin (tn)

155. Novophenytoin

156. Mls000069789

157. Citrulliamon

158. Phenitoin

159. 5,5-diphenyltetrahydro-1h-2,4-imidazoledione

160. Fenidantoin S

161. Nsc8722

162. Sm-88 Component Phenytoin

163. 6158tkw0c5

164. Epasmir 5

165. Ncgc00021139-03

166. Smr000059026

167. Dsstox_cid_541

168. Fenidantoin "s"

169. Dsstox_rid_75650

170. Dsstox_gsid_20541

171. Epasmir "5"

172. Didan-tdc-250

173. Cas-57-41-0

174. Phenytoin (phn)

175. Component Of Mebroin

176. Fenidantoin ''s''

177. Epasmir ''5''

178. Nsc 8722

179. 630-93-3

180. Einecs 200-328-6

181. Mfcd00005264

182. Unii-6158tkw0c5

183. Sr-01000075211

184. Iflab1_000214

185. Fenidantoin 's'

186. Hsdb 3160

187. Episar (salt/mix)

188. Epasmir '5'

189. Aladdin (salt/mix)

190. Alepsin (salt/mix)

191. Epsolin (salt/mix)

192. Phenytoin (lepitoin)

193. Tacosal (salt/mix)

194. Phenytoin [usan:usp:inn:ban:jan]

195. Antisacer (salt/mix)

196. Epdantoin (salt/mix)

197. Epileptin (salt/mix)

198. Hydantoin,5-diphenyl-

199. Spectrum_001105

200. Fenigramon (salt/mix)

201. Citrullamon (salt/mix)

202. Opera_id_394

203. Phenytoin [inn]

204. Phenytoin [jan]

205. 2, 5,5-diphenyl-

206. Phenytoin [mi]

207. Chembl16

208. Phenytoin [hsdb]

209. Phenytoin [iarc]

210. Phenytoin [usan]

211. Spectrum2_001281

212. Spectrum3_000890

213. Spectrum4_000984

214. Spectrum5_001369

215. Lopac-d-4007

216. Phenytoin [vandf]

217. Epitope Id:117723

218. Phenytoin [mart.]

219. D 4007

220. Phenytoin [usp-rs]

221. Phenytoin [who-dd]

222. Phenytoin [who-ip]

223. Schembl3440

224. Bidd:pxr0090

225. Lopac0_000329

226. Lopac0_000378

227. Oprea1_373280

228. Bspbio_001437

229. Kbiogr_001387

230. Kbioss_001585

231. Mls001074087

232. Mls002454401

233. Bidd:gt0625

234. Divk1c_000507

235. Soluble Phenytoin (salt/mix)

236. Spbio_001281

237. Phenytoin (jp17/usp/inn)

238. Gtpl2624

239. Phenytoin [orange Book]

240. 2-hydroxy-5,5-diphenyl-3,5-dihydro-4h-imidazol-4-one

241. Dtxsid8020541

242. Phenytoin [ep Monograph]

243. Phenytoin [usp Impurity]

244. Kbio1_000507

245. Kbio2_001585

246. Kbio2_004153

247. Kbio2_006721

248. Kbio3_001780

249. Phenytoin [usp Monograph]

250. Wln: T5mvmv Ehj Er& Er

251. 5,5-diphenylhydantoin, >=99%

252. Ninds_000507

253. Phenytoin 1.0 Mg/ml In Methanol

254. Hms1412j16

255. Hms1694o05

256. Hms1791h19

257. Hms1989h19

258. Hms2089e11

259. Hms2236j06

260. Hms3261k17

261. Hms3402h19

262. Hms3657o03

263. Phenytoinum [who-ip Latin]

264. Bcp05960

265. Hy-b0448

266. Hydantoin, 5,5-diphenyl- (8ci)

267. Zinc2510358

268. Tox21_110861

269. Tox21_202299

270. Tox21_300281

271. Tox21_500378

272. Ac-376

273. Bdbm50003655

274. Bdbm50101816

275. S2525

276. Stk058029

277. Stk182871

278. Stl454130

279. Akos000416887

280. Akos003245432

281. Tox21_110861_1

282. 5,5-diphenylimidazolidine-2,4-dione.

283. Ccg-104011

284. Ccg-221682

285. Db00252

286. Lp00378

287. Phenytoin 1000 Microg/ml In Methanol

288. 5,5-di(phenyl)imidazolidine-2,4-dione

289. Idi1_000507

290. Idi1_008433

291. Ncgc00015342-01

292. Ncgc00015342-02

293. Ncgc00015342-03

294. Ncgc00015342-04

295. Ncgc00015342-05

296. Ncgc00015342-06

297. Ncgc00015342-07

298. Ncgc00015342-08

299. Ncgc00015342-09

300. Ncgc00015342-10

301. Ncgc00015342-11

302. Ncgc00015342-12

303. Ncgc00021139-01

304. Ncgc00021139-02

305. Ncgc00021139-04

306. Ncgc00021139-05

307. Ncgc00021139-06

308. Ncgc00021139-07

309. Ncgc00021139-08

310. Ncgc00021139-09

311. Ncgc00021139-10

312. Ncgc00021139-11

313. Ncgc00091492-01

314. Ncgc00091492-02

315. Ncgc00091492-03

316. Ncgc00091492-04

317. Ncgc00091492-05

318. Ncgc00093810-01

319. Ncgc00093810-02

320. Ncgc00254135-01

321. Ncgc00259848-01

322. Ncgc00261063-01

323. 5,5-?diphenyl-?2,4-?imidazolidinedione

324. 5,5-diphenyl-1h-imidazolidine-2,4-dione

325. D0894

326. Eu-0100378

327. Ft-0667653

328. Ft-0699999

329. P-235

330. Sw203757-2

331. En300-16818

332. 5,5-diphenylimidazolidine-2,4-dione;phenytoin

333. C07443

334. D00512

335. E76094

336. 2,4-imidazolidinedione, 5,5-diphenyl- (9ci)

337. 5,5-diphenyl-1h-imidazole-2,4(3h,5h)-dione

338. Ab00374253-10

339. Ab00374253-11

340. Ab00374253_13

341. A831435

342. Q410400

343. Sr-01000003141

344. Sr-01000003141-8

345. Sr-01000075211-2

346. W-105468

347. Brd-k55930204-001-02-7

348. Brd-k55930204-236-11-0

349. Z56786458

350. 4-hydroxy-5,5-diphenyl-1,5-dihydro-2h-imidazol-2-one

351. F0020-1370

352. Phenytoin, European Pharmacopoeia (ep) Reference Standard

353. Phenytoin, United States Pharmacopeia (usp) Reference Standard

354. 5,5-diphenylhydantoin Solution, Drug Standard, 1.0 Mg/ml In Methanol

355. Phenytoin, Pharmaceutical Secondary Standard; Certified Reference Material

356. Phenytoin For System Suitability, European Pharmacopoeia (ep) Reference Standard

357. Phenytoin Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 252.27 g/mol
Molecular Formula C15H12N2O2
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass252.089877630 g/mol
Monoisotopic Mass252.089877630 g/mol
Topological Polar Surface Area58.2 Ų
Heavy Atom Count19
Formal Charge0
Complexity350
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 12  
Drug NameDilantin
PubMed HealthPhenytoin (By mouth)
Drug ClassesAntiarrhythmic, Group IB, Anticonvulsant
Drug LabelPhenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula:...
Active IngredientPhenytoin; Phenytoin sodium
Dosage FormCapsule; Tablet, chewable
RouteOral
Strength100mg extended; 50mg; 30mg extended
Market StatusPrescription
CompanyPfizer Pharms; Parke Davis

2 of 12  
Drug NameDilantin-125
PubMed HealthPhenytoin (By mouth)
Drug ClassesAntiarrhythmic, Group IB, Anticonvulsant
Drug LabelDilantin (phenytoin) is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is 5,5-diphenyl-2,4 imidazolidinedione, having the following structural formula:Each 5 ml of suspension contains 125 mg of phen...
Active IngredientPhenytoin
Dosage FormSuspension
RouteOral
Strength125mg/5ml
Market StatusPrescription
CompanyParke Davis

3 of 12  
Drug NameExtended phenytoin sodium
PubMed HealthPhenytoin
Drug ClassesAntiarrhythmic, Group IB, Anticonvulsant
Drug LabelPhenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula:...
Active IngredientPhenytoin sodium
Dosage FormCapsule
RouteOral
Strength200mg extended; 100mg extended; 300mg extended; 30mg extended
Market StatusPrescription
CompanyWockhardt; Amneal Pharms Ny; Sun Pharm Inds (in); Sun Pharm Inds; Taro; Wockhardt Usa; Mylan

4 of 12  
Drug NamePhenytek
Active IngredientPhenytoin sodium
Dosage FormCapsule
RouteOral
Strength300mg extended; 200mg extended
Market StatusPrescription
CompanyMylan

5 of 12  
Drug NamePhenytoin
Drug LabelPhenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula:...
Active IngredientPhenytoin
Dosage FormSuspension; Tablet, chewable
RouteOral
Strength125mg/5ml; 50mg
Market StatusPrescription
CompanyMylan Pharms; Wockhardt; Taro; Vistapharm

6 of 12  
Drug NamePhenytoin sodium
Drug LabelPhenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula:...
Active IngredientPhenytoin sodium
Dosage FormInjectable
RouteInjection
Strength50mg/ml
Market StatusPrescription
CompanyHospira; Hikma Maple; X-gen Pharms; Luitpold

7 of 12  
Drug NameDilantin
PubMed HealthPhenytoin (By mouth)
Drug ClassesAntiarrhythmic, Group IB, Anticonvulsant
Drug LabelPhenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula:...
Active IngredientPhenytoin; Phenytoin sodium
Dosage FormCapsule; Tablet, chewable
RouteOral
Strength100mg extended; 50mg; 30mg extended
Market StatusPrescription
CompanyPfizer Pharms; Parke Davis

8 of 12  
Drug NameDilantin-125
PubMed HealthPhenytoin (By mouth)
Drug ClassesAntiarrhythmic, Group IB, Anticonvulsant
Drug LabelDilantin (phenytoin) is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is 5,5-diphenyl-2,4 imidazolidinedione, having the following structural formula:Each 5 ml of suspension contains 125 mg of phen...
Active IngredientPhenytoin
Dosage FormSuspension
RouteOral
Strength125mg/5ml
Market StatusPrescription
CompanyParke Davis

9 of 12  
Drug NameExtended phenytoin sodium
PubMed HealthPhenytoin
Drug ClassesAntiarrhythmic, Group IB, Anticonvulsant
Drug LabelPhenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula:...
Active IngredientPhenytoin sodium
Dosage FormCapsule
RouteOral
Strength200mg extended; 100mg extended; 300mg extended; 30mg extended
Market StatusPrescription
CompanyWockhardt; Amneal Pharms Ny; Sun Pharm Inds (in); Sun Pharm Inds; Taro; Wockhardt Usa; Mylan

10 of 12  
Drug NamePhenytek
Active IngredientPhenytoin sodium
Dosage FormCapsule
RouteOral
Strength300mg extended; 200mg extended
Market StatusPrescription
CompanyMylan

11 of 12  
Drug NamePhenytoin
Drug LabelPhenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula:...
Active IngredientPhenytoin
Dosage FormSuspension; Tablet, chewable
RouteOral
Strength125mg/5ml; 50mg
Market StatusPrescription
CompanyMylan Pharms; Wockhardt; Taro; Vistapharm

12 of 12  
Drug NamePhenytoin sodium
Drug LabelPhenytoin sodium is an antiepileptic drug. Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5,5-diphenyl-2, 4-imidazolidinedione, having the following structural formula:...
Active IngredientPhenytoin sodium
Dosage FormInjectable
RouteInjection
Strength50mg/ml
Market StatusPrescription
CompanyHospira; Hikma Maple; X-gen Pharms; Luitpold

4.2 Therapeutic Uses

MEDICATION (VET): PHENYTOIN IS USED IN VETERINARY MEDICINE TO CONTROL EPILEPTIFORM CONVULSIONS IN DOGS. PHENYTOIN SODIUM HAS ALSO BEEN RECOMMENDED AS ANTICONVULSANT FOR DOGS.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V13 206


MEDICATION (VET): ...IS DRUG OF CHOICE IN DIGITALIS INDUCED TOXICITY & VENTRICULAR ARRHYTHMIAS IN DOGS UNRESPONSIVE TO PROCAINE AMIDE. IN CASES OF POOR WOUND HEALING IT MAY STIMULATE COLLAGEN FORMATION & WOUND TENSILE STRENGTH.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 185


Hydantoin anticonvulsants are indicated in the suppression and control of tonic-clonic (grand mal) and simple or complex partial (psychomotor or temporal lobe) seizures. /Hydantoin anticonvulsants; Included in US product labeling./

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 259


Parenteral phenytoin is indicated for the control of tonic-clonic type status epilepticus. Although parenteral benzodiazepines are often used initially for rapid control of status epilepticus, phenytoin is indicated for sustained control of seizure activity. /Included in US product labeling./

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 259


For more Therapeutic Uses (Complete) data for PHENYTOIN (11 total), please visit the HSDB record page.


4.3 Drug Warning

Hydantoin anticonvulsants cross the placenta; risk-benefit must be considered, although a definite cause and effect relationship has not been established between the hydantoins and teratogenic effects. Reports in recent years indicate a higher incidence of congenital abnormalities in children whose mothers used anticonvulsant medication during pregnancy, although most epileptic mothers have delivered normal babies. Reported abnormalities include cleft lip, cleft palate, heart malformations, and the "fetal hydantoin syndrome" (characterized by prenatal growth deficiency, microcephaly, craniofacial abnormalities, hypoplasia of the fingernails, and mental deficiency assoc with intrauterine development during therapy). Medication has not been definitively proven to be the cause of "fetal hydantoin syndrome." The reports, to date, relate primarily to the more widely used anticonvulsants, phenytoin and phenobarbital. Pending availability of more precise info, this risk-benefit consideration of anticonvulsant use during pregnancy is extended to the entire family of anticonvulsant medications. /Hydantoin anticonvulsants/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 261


Because of altered absorption and protein binding and/or increased metabolic clearance of hydantoin anticonvulsants during pregnancy, pregnant women receiving these medications may experience an increased incidence of seizures. Serum hydantoin concentrations must be monitored and doses increased accordingly. A gradual resumption of the patient's usual dosage may be necessary after delivery. However, some patients may experience a rapid reduction in maternal hepatic phenytoin metabolism at time of delivery, requiring the dosage to be reduced within 12 hr postpartum. /Hydantoin anticonvulsants/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 261


Exposure to hydantoins prior to delivery may lead to an increased risk of life-threatening hemorrhage in the neonate, usually within 24 hr of birth. Hydantoins may also produce a deficiency of vitamin K in the mother, causing increased maternal bleeding during delivery. risk of maternal and infant bleeding may be reduced by administering water-soluble vitamin K to the mother during delivery and to the neonate, intramuscularly or sc, immediately after birth. /Hydantoin anticonvulsants/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 261


Phenytoin are distributed into breast milk; significant amounts may be ingested by the infant.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 261


For more Drug Warnings (Complete) data for PHENYTOIN (26 total), please visit the HSDB record page.


4.4 Minimum/Potential Fatal Human Dose

The lethal dose of phenytoin in adults is estimated to be 2 to 5 g. The lethal dose in children in unknown.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 266


4.5 Drug Indication

Phenytoin is indicated to treat grand mal seizures, complex partial seizures, and to prevent and treat seizures during or following neurosurgery. Injectable phenytoin and [Fosphenytoin], which is the phosphate ester prodrug formulation of phenytoin, are indicated to treat tonic-clonic status epilepticus, and for the prevention and treatment of seizures occurring during neurosurgery.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Phenytoin is an anticonvulsant with a narrow therapeutic index. Although the recommended therapeutic range is cited to be between 10-20 mg/L, differences in albumin levels, genetics, comorbidities, and body composition can make achieving an ideal phenytoin dose challenging. For example, studies have confirmed that phenytoin metabolism is impacted by CYP2C9 genotype polymorphisms and possibly by CYP2C19 genotype polymorphisms (the latter has not been as extensively studied). It is worth nothing that although phenytoin is highly protein bound, only the fraction unbound is able to exert a pharmacological effect. Therefore, factors that reduce or increase the percentage of protein bound phenytoin (for example: concomitant administration of drugs that can cause displacement from protein binding sites) can have a marked impact on phenytoin therapy.


5.2 MeSH Pharmacological Classification

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


Cytochrome P-450 CYP1A2 Inducers

Drugs and compounds that induce the synthesis of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inducers.)


Voltage-Gated Sodium Channel Blockers

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
PHENYTOIN
5.3.2 FDA UNII
6158TKW0C5
5.3.3 Pharmacological Classes
Cytochrome P450 1A2 Inducers [MoA]; Cytochrome P450 2B6 Inducers [MoA]; Cytochrome P450 2C19 Inducers [MoA]; Cytochrome P450 2C8 Inducers [MoA]; Cytochrome P450 2C9 Inducers [MoA]; Cytochrome P450 2D6 Inducers [MoA]; Cytochrome P450 3A Inducers [MoA]; Decreased Central Nervous System Disorganized Electrical Activity [PE]; Anti-epileptic Agent [EPC]
5.4 ATC Code

N03AB02

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


N - Nervous system

N03 - Antiepileptics

N03A - Antiepileptics

N03AB - Hydantoin derivatives

N03AB02 - Phenytoin


5.5 Absorption, Distribution and Excretion

Absorption

Given its narrow therapeutic index, therapeutic drug monitoring is recommended to help guide dosing. Phenytoin is completely absorbed. Peak plasma concentration is attained approximately 1.5-3 hours, and 4-12 hours after administration of the immediate release formulation and the extended release formulation, respectively. It should be noted that absorption can be markedly prolonged in situations of acute ingestion.


Route of Elimination

The majority of phenytoin is excreted as inactive metabolites in the bile. An estimated 1-5% of phenytoin is eliminated unchanged in the urine.


Volume of Distribution

The volume of distribution of phenytoin is reported to be approximately 0.75 L/kg.


Clearance

The clearance of phenytoin is non-linear. At lower serum concentrations (less than 10 mg/L), elimination is characterized by first order kinetics. As plasma concentrations increase, the kinetics shift gradually towards zero-order, and finally reach zero-order kinetics once the system is saturated.


Studies using Dilantin have shown that phenytoin and its sodium salt are usually completely absorbed from the GI tract. Bioavailability may vary enough among oral phenytoin sodium preparations of different manufacturers to result in toxic serum concentrations or a loss of seizure control (subtherapeutic serum concentrations)...

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 2217


Absorption of phenytoin is slow and variable among products (poor in neonates) for oral admininstration, immediate for iv administration, and very slow but complete (92%) for intramuscular administration.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 260


Prompt phenytoin capsules are rapidly absorbed and generally produce peak serum concentrations in 1.5-3 hours, while extended phenytoin sodium capsules are more slowly absorbed and generally produce peak serum concentrations in 4-12 hours. When phenytoin sodium is administered im, absorption may be erratic; this may result from crystallization of the drug at the injection site because of the change in pH.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 2217


/Phenytoin/ is distributed into cerebrospinal fluid, saliva, semen, GI fluids, bile, and breast milk; it also crosses the placenta, with fetal serum concentrations equal to those of the mother.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 260


For more Absorption, Distribution and Excretion (Complete) data for PHENYTOIN (15 total), please visit the HSDB record page.


5.6 Metabolism/Metabolites

Phenytoin is extensively metabolized and is first transformed into a reactive _arene oxide intermediate_. It is thought that this reactive intermediate is responsible for many undesirable phenytoin adverse effects such as hepatotoxicity, SJS/TEN, and other idiosyncratic reactions. The _arene oxide_ is metabolized to either a _hydroxyphenytoin_ or _phenytoin dihydrodiol_ metabolite, although the former accounts for about 90% of phenytoin metabolism. Interestingly, two stereoisomers of the _hydroxyphenytoin_ metabolite are formed by CYP2C9 and CYP2C19: _(R)-p-HPPH_ and _(S)-p-HPPH_. When CYP2C19 catalyzes the reaction, the ratio of stereoisomers is roughly 1:1, whereas when CYP2C9 catalyzes the reaction, the ratio heavily favours the "S" stereoisomer. Since the metabolism of phenytoin is in part influenced by genetic polymorphisms of CYP2C9 and CYP2C19, this ratio can be utilized to identify different genomic variants of the enzymes. EPHX1, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 are responsible for producing the _phenytoin dihydrodiol_ metabolite. _Hydroxyphenytoin_ can be metabolized by CYP2C19, CYP3A5, CYP2C9, CYP3A4, CYP3A7, CYP2B6 and CYP2D6 to a _phenytoin catechol_ metabolite or undergo glucuronidation by UGT1A6, UGT1A9, UGT1A1, and UGT1A4 to a _glucuronide metabolite_ that can be eliminated in the urine. On the other hand, the _phenytoin dihydrodiol_ entity is only transformed to the _catechol_ metabolite. The _catechol metabolite_ can undergo methylation by COMT and be subsequently eliminated in the urine, or can spontaneously oxidize to a _phenytoin quinone_ (NQO1 can transform the quinone back to the catechol metabolite). Of note, although CYP2C18 is poorly expressed in the liver, the enzyme is active in the skin and is involved in the primary and secondary hydroxylation of phenytoin. This CYP2C18 mediated bioactivation may be linked to the manifestation of adverse cutaneous drug reactions associated with phenytoin.


The major route of metabolism of phenytoin is oxidation by the liver to the inactive metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH). Because this metabolism is a saturable process, small increases in dosage may produce substantial increases in plasma phenytoin concentrations...

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 2217


The rate of hepatic biotransformation is increased in younger children, in pregnant women, in women during menses, and in patients with acute trauma; rate decreases with advancing age. The major inactive metabolite of phenytoin is 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH). Phenytoin may be metabolized slowly in a small number of individuals due to genetic predisposition, which may cause limited enzyme availability and lack of induction.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 260


... Oxidative metabolism of 1 of geminal phenyl rings of diphenylhydantoin ... 5-meta-hydroxyphenyl-(l) and 5-para-hydroxyphenyl-5-phenylhydantoin were detected in urine of man (approx ratio 1:12) ...

Testa, B. and P. Jenner. Drug Metabolism: Chemical & Biochemical Aspects. New York: Marcel Dekker, Inc., 1976., p. 48


Phenytoin has known human metabolites that include (2S,3S,4S,5R)-6-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)-3,4,5-trihydroxyoxane-2-carboxylic acid, 3'-HPPH, 4-Hydroxyphenytoin, and 5-(3,4-dihydroxycyclohexa-1,5-dien-1-yl)-5-phenylimidazolidine-2,4-dione.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


5.7 Biological Half-Life

Oral administration: The half-life of phenytoin ranges from 7 to 42 hours, and is 22 hours on average. Intravenous administration: The half-life of phenytoin ranges from 10-15 hours.


Following oral administration, the plasma half-life of phenytoin averages about 22 hours, although the half-life has ranged from 7-42 hours in individual patients. The plasma half-life of phenytoin in humans following IV administration ranges from 10-15 hours.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 2217


Because phenytoin exhibits saturable, zero-order, or dose-dependent pharmacokinetics, the apparent half-life of phenytoin changes with dose and serum concentrations. this is due to the saturation of the enzyme system responsible for metabolizing phenytoin, which occurs at therapeutic concentrations of the drug. Thus, a constant amount of drug is metabolized (capacity-limited metabolism), and small increases in dose may cause disproportionately large increases in serum concentrations and apparent half-life, possibly causing unexpected toxicity.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 260


5.8 Mechanism of Action

Although phenytoin first appeared in the literature in 1946, it has taken decades for the mechanism of action to be more specifically elucidated. Although several scientists were convinced that phenytoin altered sodium permeability, it wasnt until the 1980s that this phenomenon was linked to voltage-gated sodium channels. Phenytoin is often described as a non-specific sodium channel blocker and targets almost all voltage-gated sodium channel subtypes. More specifically, phenytoin prevents seizures by inhibiting the positive feedback loop that results in neuronal propagation of high frequency action potentials.


The mechanism of action is not completely known, but it is thought to involve stabilization of neuronal membranes at the cell body, axon, and synapse and limitation of the spread of neuronal or seizure activity. In neurons, phenytoin decreases sodium and calcium ion influx by prolonging channel inactivation time during generation of nerve impulses. Phenytoin blocks the voltage-dependant sodium channels of neurons and inhibits the calcium flux across neuronal membranes, thus helping to stabilize neurons. It also decreases synaptic transmission, and decreases post-tetanic potentiation at the synapse. Phenytoin enhances the sodium ATPase activity of neurons and/or glial cells. It also influences second messenger systems by inhibiting calcium-calmodulin protein phosphorylation and possibly altering cyclic nucleotide production or metabolism.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 259


Phenytoin may act to normalize influx of sodium and calcium to cardiac Purkinje fibers. Abnormal ventricular automaticity and membrane responsiveness are decreased. Also, phenytoin shortens the refractory period, and therefore shortens the QT interval and the duration of the action potential.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 259


Exact mechanism is unknown. Phenytoin may act in the CNS to decrease synaptic transmission or to decrease summation of temporal stimulation leading to neuronal discharge (antikindling). Phenytoin raises the threshold of facial pain and shortens the duration of attacks by diminishing self-maintenance of excitation and repetitive firing.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 259


Phenytoin's mechanisms of action as a muscle relaxant is thought to be similar to its anticonvulsant action. In movement disorders, the membrane stabilizing effect reduces abnormal sustained repetitive firing and potentiation of nerve and muscle cells.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 260


A number of studies suggest that keratinocyte growth factor (KGF) plays a major part in reepithelialization after injury, via binding to the specific KGF receptor (KGFR). Several pharmacological agents, including the anti-epileptic drug phenytoin (PHT), have been widely used clinically to promote wound healing. Although the mechanism of action of PHT in this process is still not well understood, it is possible that the activity of PHT in wound healing is mediated via KGF and the KGFR. In the present study, using the enzyme-linked immunosorbant assay and flow cytometry we have shown that PHT increases KGF secretion and KGFR expression by more than 150% in gingival fibroblasts and epithelial cells, respectively. Moreover, semi-quantitative reverse transcriptase-polymerase chain reaction analysis showed that PHT also markedly increased both KGF and KGFR gene transcription by these cells.

PMID:11352631 Das S et al; Biochem Biophys Res Commun 282 (4): 875-81(2001)


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LIMITED","customerCountry":"INDIA","quantity":"900.00","actualQuantity":"900","unit":"KGS","unitRateFc":"50","totalValueFC":"45172.7","currency":"USD","unitRateINR":"4130","date":"17-May-2023","totalValueINR":"3717000","totalValueInUsd":"45172.7","indian_port":"SEZ\/Mahaboobnagar","hs_no":"29332100","bill_no":"1001209","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"FIUMICINO APT\/ROMA","supplierAddress":"FARMACEUTICA S.P.A. VIA M.CIVITALI 1-20148 MILANO 0","customerAddress":"PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1691605800,"product":"PHENYTOIN SODIUM USP\/PH.EUR","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"FIUMICINO APT\/ROMA","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"65","totalValueFC":"6559.9","currency":"USD","unitRateINR":"5434","date":"10-Aug-2023","totalValueINR":"543400","totalValueInUsd":"6559.9","indian_port":"SEZ\/Mahaboobnagar","hs_no":"29332100","bill_no":"1002208","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"FIUMICINO APT\/ROMA","supplierAddress":"VIA M. CIVITALI, 1, 20148 MILANO, Italy","customerAddress":"PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1696357800,"product":"PHENYTOIN SODIUM","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"FIUMICINO APT\/ROMA","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"1025.00","actualQuantity":"1025","unit":"KGS","unitRateFc":"65","totalValueFC":"67282","currency":"USD","unitRateINR":"5463.3","date":"04-Oct-2023","totalValueINR":"5599831","totalValueInUsd":"67282","indian_port":"SEZ\/Mahaboobnagar","hs_no":"29332100","bill_no":"1002802","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"FIUMICINO APT\/ROMA","supplierAddress":"VIA M.CIVITALI, 1-20148 MILANO, ITA LIA Italy","customerAddress":"PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703010600,"product":"PHENYTOIN SODIUM","address":"INDOCO HOUSE,166 CST RD.VIDYANAGRI,","city":"MUMBAI.MAHARASHTRA","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"INDOCO REMEDIES LIMITED","customerCountry":"INDIA","quantity":"225.00","actualQuantity":"225","unit":"KGS","unitRateFc":"115","totalValueFC":"29049","currency":"EUR","unitRateINR":"10747.2","date":"20-Dec-2023","totalValueINR":"2418126.4","totalValueInUsd":"29049","indian_port":"Bombay Air","hs_no":"29332100","bill_no":"9323001","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"VIA M. CIVITALI, 1-20148 MILANO ITALIASDNF Italy","customerAddress":"INDOCO HOUSE,166 CST RD.VIDYANAGRI,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703615400,"product":"PHENYTOIN SODIUM","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"XXORDXXI IXXUSTXXA CXXMICXXFARXXCEUXXCA XXA","supplierCountry":"ITALY","foreign_port":"FIUMICINO APT\/ROMA","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"4000.00","actualQuantity":"4000","unit":"KGS","unitRateFc":"65","totalValueFC":"261739.2","currency":"USD","unitRateINR":"5447","date":"27-Dec-2023","totalValueINR":"21788000","totalValueInUsd":"261739.2","indian_port":"SEZ\/Mahaboobnagar","hs_no":"29332100","bill_no":"1003656","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"FIUMICINO APT\/ROMA","supplierAddress":"N\/A","customerAddress":"PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711391400,"product":"PHENYTOIN SODIUM (QTY.200 KGS)","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"XXORDXXI IXXUSTXXA CXXMICXXFARXXCEUXXCA XXP.A","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"64.9","totalValueFC":"13111.8","currency":"USD","unitRateINR":"5443.8","date":"26-Mar-2024","totalValueINR":"1088750","totalValueInUsd":"13111.8","indian_port":"SEZ\/Mahaboobnagar","hs_no":"29332100","bill_no":"1000895","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718217000,"product":"PHENYTOIN SODIUM-PHENYTOIN SODIUM (EPAN)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"VIATRIS US SUPPLY HUB LLC","supplierCountry":"UNITED STATES","foreign_port":"CHICAGO O\\'HARE INT\\'L","customer":"VIATRIS","customerCountry":"INDIA","quantity":"720.60","actualQuantity":"720.6","unit":"KGS","unitRateFc":"168.5","totalValueFC":"122614.6","currency":"USD","unitRateINR":"14204.6","date":"13-Jun-2024","totalValueINR":"10235798.73","totalValueInUsd":"122614.6","indian_port":"Bombay Air","hs_no":"29332990","bill_no":"3976809","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"CHICAGO O\\'HARE INT\\'L","supplierAddress":"1000 Mylan Blvd Canonsburg, PA 15317SDNF United States","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718217000,"product":"PHENYTOIN SODIUM-PHENYTOIN SODIUM (EPAN)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"VIATRIS US SUPPLY HUB LLC","supplierCountry":"UNITED STATES","foreign_port":"CHICAGO O\\'HARE INT\\'L","customer":"VIATRIS","customerCountry":"INDIA","quantity":"747.10","actualQuantity":"747.1","unit":"KGS","unitRateFc":"168.5","totalValueFC":"127123.8","currency":"USD","unitRateINR":"14204.6","date":"13-Jun-2024","totalValueINR":"10612219.3","totalValueInUsd":"127123.8","indian_port":"Bombay Air","hs_no":"29332990","bill_no":"3976809","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"CHICAGO O\\'HARE INT\\'L","supplierAddress":"1000 Mylan Blvd Canonsburg, PA 15317SDNF United States","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721154600,"product":"PHENYTOIN SODIUM","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"RECORDATI","supplierCountry":"ITALY","foreign_port":"MALPENSA APT\/MILANO","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"2906.00","actualQuantity":"2906","unit":"KGS","unitRateFc":"79","totalValueFC":"231932.9","currency":"USD","unitRateINR":"6671.6","date":"17-Jul-2024","totalValueINR":"19387524","totalValueInUsd":"231932.9","indian_port":"SEZ\/Mahaboobnagar","hs_no":"29332100","bill_no":"1002309","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MALPENSA APT\/MILANO","supplierAddress":"VIA M, CIVITALI, 1 20148 MILANO, ITALIA IT","customerAddress":"PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722882600,"product":"PHENYTOIN SODIUM","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"RECORDATI INDUSTRIA CHIMICA EFARMACEUTICA S.P.A","supplierCountry":"ITALY","foreign_port":"MALPENSA APT\/MILANO","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"869.00","actualQuantity":"869","unit":"KGS","unitRateFc":"79","totalValueFC":"69241.5","currency":"USD","unitRateINR":"6683.4","date":"06-Aug-2024","totalValueINR":"5807874.6","totalValueInUsd":"69241.5","indian_port":"SEZ\/Mahaboobnagar","hs_no":"29332100","bill_no":"4901694","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MALPENSA APT\/MILANO","supplierAddress":"VIA MEDIANA CISTERNA 404011 CAMPOVE ITALY SDNF Italy","customerAddress":"PLOT NO.2, MAITRIVIHAR,"}]
11-Jan-2021
28-Oct-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

Upgrade, download data, analyse, strategize, subscribe with us contact

FDF Dossiers

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01

arrow
BioFlorida Conference
Not Confirmed

Phenytoin

Brand Name : Phenytoin Sodium

Dosage Form : TAB

Dosage Strength : 100mg

Packaging : 1000X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

Aspen API Comapny Banner

02

arrow
BioFlorida Conference
Not Confirmed

Phenytoin

Brand Name : Phenytoin

Dosage Form : TAB

Dosage Strength : 100mg

Packaging : 90X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

Aspen API Comapny Banner

03

arrow
BioFlorida Conference
Not Confirmed

PHENYTOIN

Brand Name : PHENYTOIN

Dosage Form : SUSPENSION;ORAL

Dosage Strength : 125MG/5ML

Packaging :

Approval Date : 2004-03-08

Application Number : 40521

Regulatory Info : RX

Registration Country : USA

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04

arrow
BioFlorida Conference
Not Confirmed

PHENYTOIN

Brand Name : PHENYTOIN

Dosage Form : TABLET, CHEWABLE;ORAL

Dosage Strength : 50MG

Packaging :

Approval Date : 2014-04-17

Application Number : 200565

Regulatory Info : RX

Registration Country : USA

blank

05

arrow
BioFlorida Conference
Not Confirmed

PHENYTOIN

Brand Name : TARO-PHENYTOIN

Dosage Form : SUSPENSION

Dosage Strength : 125MG/5ML

Packaging : 237ML

Approval Date :

Application Number : 2250896

Regulatory Info : Prescription

Registration Country : Canada

blank

06

BioFlorida Conference
Not Confirmed
arrow
arrow
BioFlorida Conference
Not Confirmed

PHENYTOIN

Brand Name : DILANTIN-125 SUSPENSION

Dosage Form : SUSPENSION

Dosage Strength : 125MG/5ML

Packaging :

Approval Date :

Application Number : 23450

Regulatory Info : Prescription

Registration Country : Canada

blank

07

MS Pharma

Jordan
BioFlorida Conference
Not Confirmed
arrow

MS Pharma

Jordan
arrow
BioFlorida Conference
Not Confirmed

Phenytoin

Brand Name :

Dosage Form : SOLUTION

Dosage Strength : 50MG/ML

Packaging : Vial

Approval Date :

Application Number :

Regulatory Info : Generic CTD-Available

Registration Country : Jordan

blank

08

BioFlorida Conference
Not Confirmed
arrow
arrow
BioFlorida Conference
Not Confirmed

Phenytoin

Brand Name : Dilantin Kapseals

Dosage Form : Capsules

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : India

blank

09

BioFlorida Conference
Not Confirmed
arrow
arrow
BioFlorida Conference
Not Confirmed

PHENYTOIN

Brand Name : PHENYTOIN

Dosage Form : SUSPENSION;ORAL

Dosage Strength : 125MG/5ML

Packaging :

Approval Date : 2002-04-19

Application Number : 40420

Regulatory Info : DISCN

Registration Country : USA

blank

10

Country
BioFlorida Conference
Not Confirmed
arrow

Country
arrow
BioFlorida Conference
Not Confirmed

phenytoin

Brand Name : Lehydan

Dosage Form : TABLET

Dosage Strength : 25 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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FDA Orange Book

read-more
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01

TARO

U.S.A
arrow
euroPLX 86 Munich
Not Confirmed

PHENYTOIN

Brand Name : PHENYTOIN

Dosage Form : SUSPENSION;ORAL

Dosage Strength : 125MG/5ML

Approval Date : 2004-03-08

Application Number : 40521

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

blank

02

TARO

U.S.A
arrow
euroPLX 86 Munich
Not Confirmed

PHENYTOIN

Brand Name : PHENYTOIN

Dosage Form : TABLET, CHEWABLE;ORAL

Dosage Strength : 50MG

Approval Date : 2014-04-17

Application Number : 200565

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

blank

03

euroPLX 86 Munich
Not Confirmed
arrow
arrow
euroPLX 86 Munich
Not Confirmed

PHENYTOIN

Brand Name : PHENYTOIN

Dosage Form : SUSPENSION;ORAL

Dosage Strength : 125MG/5ML

Approval Date : 1992-09-25

Application Number : 89892

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

blank

04

euroPLX 86 Munich
Not Confirmed
arrow
arrow
euroPLX 86 Munich
Not Confirmed

PHENYTOIN

Brand Name : PHENYTOIN

Dosage Form : TABLET, CHEWABLE;ORAL

Dosage Strength : 50MG

Approval Date : 2014-11-28

Application Number : 40884

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

blank

05

euroPLX 86 Munich
Not Confirmed
arrow
arrow
euroPLX 86 Munich
Not Confirmed

PHENYTOIN

Brand Name : PHENYTOIN

Dosage Form : SUSPENSION;ORAL

Dosage Strength : 125MG/5ML

Approval Date : 2002-04-19

Application Number : 40420

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

blank

06

PHARMACIA

U.S.A
euroPLX 86 Munich
Not Confirmed
arrow

PHARMACIA

U.S.A
arrow
euroPLX 86 Munich
Not Confirmed

PHENYTOIN

Brand Name : DILANTIN

Dosage Form : TABLET, CHEWABLE;ORAL

Dosage Strength : 50MG

Approval Date : 1982-01-01

Application Number : 84427

RX/OTC/DISCN : RX

RLD : Yes

TE Code : AB

blank

07

RISING

U.S.A
euroPLX 86 Munich
Not Confirmed
arrow

RISING

U.S.A
arrow
euroPLX 86 Munich
Not Confirmed

PHENYTOIN

Brand Name : PHENYTOIN

Dosage Form : TABLET, CHEWABLE;ORAL

Dosage Strength : 50MG

Approval Date : 2012-12-26

Application Number : 200691

RX/OTC/DISCN : RX

RLD : No

TE Code : AB

blank

08

VIATRIS

U.S.A
euroPLX 86 Munich
Not Confirmed
arrow

VIATRIS

U.S.A
arrow
euroPLX 86 Munich
Not Confirmed

PHENYTOIN

Brand Name : DILANTIN-125

Dosage Form : SUSPENSION;ORAL

Dosage Strength : 125MG/5ML

Approval Date : 1982-01-01

Application Number : 8762

RX/OTC/DISCN : RX

RLD : Yes

TE Code : AB

blank

09

VIATRIS

U.S.A
euroPLX 86 Munich
Not Confirmed
arrow

VIATRIS

U.S.A
arrow
euroPLX 86 Munich
Not Confirmed

PHENYTOIN

Brand Name : DILANTIN-30

Dosage Form : SUSPENSION;ORAL

Dosage Strength : 30MG/5ML

Approval Date : 1982-01-01

Application Number : 8762

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

blank

10

VISTAPHARM

India
euroPLX 86 Munich
Not Confirmed
arrow

VISTAPHARM

India
arrow
euroPLX 86 Munich
Not Confirmed

PHENYTOIN

Brand Name : PHENYTOIN

Dosage Form : SUSPENSION;ORAL

Dosage Strength : 125MG/5ML

Approval Date : 2001-01-31

Application Number : 40342

RX/OTC/DISCN : DISCN

RLD : No

TE Code :

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