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    Chemistry

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    Also known as: 7664-38-2, Orthophosphoric acid, O-phosphoric acid, Wc-reiniger, Acidum phosphoricum, Sonac
    Molecular Formula
    H3O4P
    Molecular Weight
    97.995  g/mol
    InChI Key
    NBIIXXVUZAFLBC-UHFFFAOYSA-N
    FDA UNII
    E4GA8884NN
    Phosphoric Acid
    Phosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++, and Mg++. Phosphoric acid is used in dentistry and orthodontics as an etching solution, to clean and roughen the surfaces of teeth where dental appliances or fillings will be placed. In addition, phosphoric acid is a constituent in bone and teeth, and plays a role in many metabolic processes.
    1 2D Structure

    Phosphoric Acid

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    phosphoric acid
    2.1.2 InChI
    InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)
    2.1.3 InChI Key
    NBIIXXVUZAFLBC-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    OP(=O)(O)O
    2.2 Other Identifiers
    2.2.1 UNII
    E4GA8884NN
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Concise Etchant

    2. Condact

    3. K-etchant

    4. Orthophosphoric Acid

    5. Uni-etch

    2.3.2 Depositor-Supplied Synonyms

    1. 7664-38-2

    2. Orthophosphoric Acid

    3. O-phosphoric Acid

    4. Wc-reiniger

    5. Acidum Phosphoricum

    6. Sonac

    7. Phosphorsaeure

    8. Evits

    9. Acide Phosphorique

    10. Phosphoricum Acidum

    11. Polyphosphoric Acid

    12. Acido Fosforico

    13. Phosphorsaeureloesungen

    14. Fema No. 2900

    15. Oleth-4 Phosphate

    16. Superphosphoric Acid

    17. Fosforzuuroplossingen

    18. Ortho-phosphoric Acid

    19. Vococid

    20. Amberphos 54

    21. Polyphosphoric Acids

    22. Phosphate, Dihydrogen

    23. Poly(phosphoric Acid)

    24. Phosphoric Acid [nf]

    25. Trihydroxidooxidophosphorus

    26. Nsc-80804

    27. H3po4

    28. E4ga8884nn

    29. Ins No.338

    30. Chebi:26078

    31. Ins-338

    32. Mfcd00011340

    33. 62046-92-8

    34. Y-11a06

    35. Phosphoric Acid (nf)

    36. Ncgc00091005-01

    37. E 338

    38. E-338

    39. Dsstox_cid_4263

    40. Dsstox_rid_77346

    41. Dsstox_gsid_24263

    42. 9044-08-0

    43. White Phosphoric Acid

    44. Caswell No. 662

    45. Phosphoric Acid 75%

    46. Phosphoric Acid, Ortho-

    47. Acido Fosforico [italian]

    48. Acide Phosphorique [french]

    49. Fosforzuuroplossingen [dutch]

    50. Cas-7664-38-2

    51. Ccris 2949

    52. Phosphorsaeureloesungen [german]

    53. Phosphoric Acid 85%

    54. Hsdb 1187

    55. Phosphoric Acid Solution

    56. Phosphoric Acid, Acs Reagent, >=85 Wt. % In H2o

    57. Einecs 231-633-2

    58. Nsc 80804

    59. Un1805

    60. Epa Pesticide Chemical Code 076001

    61. Unii-e4ga8884nn

    62. Phospholeum

    63. Phosphoric Cid

    64. Ortho-phosphate

    65. Phosphor-ic Acid

    66. Polyphosphorc Acds

    67. Nfb Orthophosphate

    68. 2hp

    69. Orthophosphate(3-)

    70. Ortho Phosphoric Acid

    71. Phosphate Ion(3-)

    72. Tetraoxophosphoric Acid

    73. Phosphate Anion(3-)

    74. Phosphate (po43-)

    75. Phosphoric Acid, 75%

    76. Phosphoric Acid, 85%

    77. Condensed Phosphoric Acid

    78. Orthophosphate (po43-)

    79. Phosphoric Acid Ion(3-)

    80. Phosphate Ion (po43-)

    81. Ec 231-633-2

    82. Chembl1187

    83. Phosphoric Acid, 10% V/v

    84. Phosphoric Acid [ii]

    85. Phosphoric Acid [mi]

    86. Phosphoric Acid [fcc]

    87. D-mannan, Dihydrogen Phosphate

    88. Phosphoric Acid [fhfi]

    89. Phosphoric Acid [hsdb]

    90. Phosphoric Acid [inci]

    91. Phosphoric Acid [vandf]

    92. Dtxsid5024263

    93. Phosphoric Acid [mart.]

    94. Phosphoric Acid, Ar, >=88%

    95. Phosphoric Acid, Technical Grade

    96. [po(oh)3]

    97. Bdbm14671

    98. Chebi:52641

    99. H3 P O4

    100. Phosphoric Acid [usp-rs]

    101. Phosphoric Acid [who-dd]

    102. Trihydrogen Tetraoxophosphate(3-)

    103. Phosphoric Acid Solution, 1.0 M

    104. Phosphoric Acid, Ar, 88-93%

    105. Phosphoric Acid, Lr, 88-93%

    106. Phosphoric Acid (fragrance Grade)

    107. Phosphoric Acid 85% Reagent Acs

    108. Phosphoricum Acidum [hpus]

    109. Nsc80804

    110. Phosphoric Acid, 85%, Acs Grade

    111. Phosphoric Acid, Puriss., >=99%

    112. Phosphoric Acid, 85%, Hplc Grade

    113. Tox21_111053

    114. Tox21_202285

    115. Tox21_303246

    116. Phosphoric Acid, Acs Reagent, 85%

    117. Phosphoric Acid [orange Book]

    118. Phosphoric Acid, For Hplc, >=85%

    119. Akos028109726

    120. Db09394

    121. Ncgc00091005-02

    122. Ncgc00257071-01

    123. Ncgc00259834-01

    124. 68891-72-5

    125. E338

    126. Isooctanol, Reaction Products With Phosphorus Oxide (p2o5) And Polyethylene Glycol Monotridecyl Ether

    127. Phosphoric Acid [un1805] [corrosive]

    128. Phosphoric Acid, Bioultra, >=85% (t)

    129. P1745

    130. Phosphoric Acid, Saj First Grade, >=85.0%

    131. C00009

    132. D05467

    133. Orthophosphoric Acid, 85% W/w Aqueous Solution

    134. Phosphoric Acid, Jis Special Grade, >=85.0%

    135. Q184782

    136. Etidronate Disodium Impurity A [ep Impurity]

    137. J-523994

    138. Q27110336

    139. Phosphoric Acid Solution, 85 Wt. % In H2o, Fcc, Fg

    140. Phosphoric Acid, P.a., Acs Reagent, Reag. Iso, 85%

    141. Phosphoric Acid, 85% In H2o, 99.99% Trace Metal Basis

    142. Zoledronic Acid Monohydrate Impurity F [ep Impurity]

    143. 730a9101-d5de-4668-97ca-7b6178b84417

    144. Phosphoric Acid, Crystalline, >=99.999% Trace Metals Basis

    145. Phosphoric Acid, Puriss. P.a., Crystallized, >=99.0% (t)

    146. Pamidronate Disodium Pentahydrate Impurity B [ep Impurity]

    147. Phosphoric Acid, 85 Wt. % In H2o, 99.99% Trace Metals Basis

    148. Phosphoric Acid, Bioreagent, Suitable For Insect Cell Culture, 85%

    149. Phosphoric Acid, United States Pharmacopeia (usp) Reference Standard

    150. Phosphoric Acid, >=85 Wt. % In H2o, >=99.999% Trace Metals Basis

    151. Phosphoric Acid, Semiconductor Grade Vlsi Puranal(tm) (honeywell 17644)

    152. Phosphoric Acid, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., >=85%

    153. Phosphoric Acid, Semiconductor Grade Mos Puranal(tm) (honeywell 17938), >=85%

    154. Phosphoric Acid, Semiconductor Grade Puranal(tm) (honeywell 17861), >=85%

    155. Phosphate Atomic Spectroscopy Standard Concentrate 1.00 G Po43-, 1.00 G/l, For 1l Standard Solution, Analytical Standard

    156. Phosphate Atomic Spectroscopy Standard Concentrate 10.00 G Po43-, 10.00 G/l, For 1 L Standard Solution, Analytical Standard

    157. Phosphoric Acid Solution, Nmr Reference Standard, 85% In D2o (99.9 Atom % D), Nmr Tube Size 3 Mm X 8 In.

    158. Phosphoric Acid Solution, Nmr Reference Standard, 85% In D2o (99.9 Atom % D), Nmr Tube Size 4.2 Mm X 8 In. , Wgs-5bl Coaxial Nmr Tube

    159. Phosphoric Acid Solution, Nmr Reference Standard, 85% In D2o (99.9 Atom % D), Nmr Tube Size 5 Mm X 8 In.

    160. Phosphoric Acid, Puriss. P.a., Acs Reagent, Packed In Coated, Shock- And Leak-protected Glass Bottle, >=85% (t)

    161. Phosphoric Acid, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Nf, Fcc, 85.0-88.0%

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 97.995 g/mol
    Molecular Formula H3O4P
    XLogP3-2.1
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count0
    Exact Mass97.97689557 g/mol
    Monoisotopic Mass97.97689557 g/mol
    Topological Polar Surface Area77.8 Ų
    Heavy Atom Count5
    Formal Charge0
    Complexity49.8
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Diluted phosphoric acid national formulary: it has ... been employed in lead poisoning and in other conditions in which it is desired to administer large amount of phosphate and at /the/ same time produce mild acidosis. It has been given in dose of 60 mL daily (5 mL/hr) under carefully controlled conditions.

    Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1263

    Phosphoric acid is used ... to control the pH of the urinary tract in many animals, particularly in mink and cats, to prevent stone formation.

    Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. 17:108

    Medication (Vet): Has been used to treat lead poisoning.

    O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 1266

    4.2 Drug Warning

    Acid cleaning: acids such as sulfuric ... phosphoric, sometimes with chromic or hydrofluoric, are used in water solutions and their splash hazard and corrosive action on skin, clothing, and machinery are well recognized. Bubbles of hydrogen rising from bath carry invisible acid mist. ...

    Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 2280

    Splash contact of concentrated strong acids, such as ... phosphoric/acid/, ... can prove as, severely and devastatingly injurious to the eye as splashes of strong alkalies.

    Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 46

    4.3 Drug Indication

    Phosphoric acid is used in dentistry and orthodontics as an etching solution, to clean and roughen the surfaces of teeth where dental appliances or fillings will be placed.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport.

    5.2 MeSH Pharmacological Classification

    Dental Materials

    Materials used in the production of dental bases, restorations, impressions, prostheses, etc. (See all compounds classified as Dental Materials.)

    5.3 Absorption, Distribution and Excretion

    Absorption

    Ortho phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract.

    Route of Elimination

    In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine.

    Volume of Distribution

    Absorbed phosphoric acid is distributed widely in the body as phosphate. Increased serum phosphate concentrations have been reported rarely after phosphoric acid ingestion

    Clearance

    Absorbed phosphate is filtered at the glomerulus and partially reabsorbed, with phosphate clearance 80 per cent of creatinine clearance.

    The hygroscopic growth of phosphoric acid aerosol (diameter change > 0.5 micrometers) within the human tracheobronchial tree is modeled to investigate changes in deposition characteristics when compared to nonhygroscopic aerosols of identical preinspired size. Phosphoric acid particles are assumed to grow in a stepwise fashion to 99% relative humidity within conducting airways of the lung, having initially reached equilibrium at 90% relative humidity (T= 37 degrees) in the trachea. Deposition efficiencies for growth and no growth are calculated from theoretical equations for inertial impaction, sedimentation, and diffusion. The results show that neglecting the growth of an inhaled phosphoric acid aerosol may result in underestimation of the total deliverable dose by a factor of as much as 600-700%. Significant differences in regional deposition sites for hygroscopic or nonhygroscopic aerosols are predicted. Increased deposition efficiencies imply that measured physical properties (respirable fraction, aerodynamic diameter) of aerosols alone are not sufficient to assess deposition characteristics within the lung; hygroscopic growth must also be considered.

    PMID:6884619 Martonen TB, Clark ML; Fundam Appl Toxicol 3 (1): 10-5 (1983)

    /Ortho/ phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine. In growing children, phosphate balance is positive. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/

    Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1524

    The level of inorganic phosphate in the blood is stabilized by exchange with the mineral deposit in the skeleton through the action of parathyroid hormone. This hormone inhibits tubular reabsorption of phosphates by the kidney and brings about demineralization of bone tissue through the action of osteoclasts. The amount of parathyroid hormone that enters the circulation is probably regulated by the calcium level of the blood.

    WHO/FAO; Joint Expert Committee on Food Additives (JECFA): Phosphoric acid and phosphate salts (WHO Food Additives Series 17). Available from, as of July 28, 2011: https://www.inchem.org/pages/jecfa.html

    5.4 Biological Half-Life

    In infants with normal renal function the serum half-life of phosphate following single oral or rectal overdose is 5-11 hours

    5.5 Mechanism of Action

    Phosphate supplementation of the diet of rodents has been shown to lead to reduction in the incidence of dental caries and different phosphates have different powers in reducing the cariogenic potential of the carbohydrates in a diet. Phosphate supplements seem to exert their cariostatic effect on the tooth surface either directly during eating or by excretion in the saliva.

    Phosphate supplementation of the diet of rodents has been shown to lead to reduction in the incidence of dental caries and different phosphates have different powers in reducing the cariogenic potential of the carbohydrates in a diet. Phosphate supplements seem to exert their cariostatic effect on the tooth surface either directly during eating or by excretion in the saliva.

    WHO/FAO; Joint Expert Committee on Food Additives (JECFA): Phosphoric acid and phosphate salts (WHO Food Additives Series 17). Available from, as of July 28, 2011: https://www.inchem.org/pages/jecfa.html

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    12-Apr-2021
    11-Nov-2024
    KGS
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    Phosphoric Acid Manufacturers

    A Phosphoric Acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Phosphoric Acid, including repackagers and relabelers. The FDA regulates Phosphoric Acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Phosphoric Acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Phosphoric Acid manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Phosphoric Acid Suppliers

    A Phosphoric Acid supplier is an individual or a company that provides Phosphoric Acid active pharmaceutical ingredient (API) or Phosphoric Acid finished formulations upon request. The Phosphoric Acid suppliers may include Phosphoric Acid API manufacturers, exporters, distributors and traders.

    click here to find a list of Phosphoric Acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Phosphoric Acid USDMF

    A Phosphoric Acid DMF (Drug Master File) is a document detailing the whole manufacturing process of Phosphoric Acid active pharmaceutical ingredient (API) in detail. Different forms of Phosphoric Acid DMFs exist exist since differing nations have different regulations, such as Phosphoric Acid USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Phosphoric Acid DMF submitted to regulatory agencies in the US is known as a USDMF. Phosphoric Acid USDMF includes data on Phosphoric Acid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Phosphoric Acid USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Phosphoric Acid suppliers with USDMF on PharmaCompass.

    Phosphoric Acid CEP

    A Phosphoric Acid CEP of the European Pharmacopoeia monograph is often referred to as a Phosphoric Acid Certificate of Suitability (COS). The purpose of a Phosphoric Acid CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Phosphoric Acid EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Phosphoric Acid to their clients by showing that a Phosphoric Acid CEP has been issued for it. The manufacturer submits a Phosphoric Acid CEP (COS) as part of the market authorization procedure, and it takes on the role of a Phosphoric Acid CEP holder for the record. Additionally, the data presented in the Phosphoric Acid CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Phosphoric Acid DMF.

    A Phosphoric Acid CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Phosphoric Acid CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Phosphoric Acid suppliers with CEP (COS) on PharmaCompass.

    Phosphoric Acid GMP

    Phosphoric Acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Phosphoric Acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Phosphoric Acid GMP manufacturer or Phosphoric Acid GMP API supplier for your needs.

    Phosphoric Acid CoA

    A Phosphoric Acid CoA (Certificate of Analysis) is a formal document that attests to Phosphoric Acid's compliance with Phosphoric Acid specifications and serves as a tool for batch-level quality control.

    Phosphoric Acid CoA mostly includes findings from lab analyses of a specific batch. For each Phosphoric Acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Phosphoric Acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Phosphoric Acid EP), Phosphoric Acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Phosphoric Acid USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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