Synopsis
Synopsis
0
API Suppliers
0
USDMF
0
CEP/COS
0
JDMF
0
EU WC
0
KDMF
0
NDC API
0
VMF
0
Listed Suppliers
0
API
0
FDF
0
FDF Dossiers
0
FDA Orange Book
0
Europe
0
Canada
0
Australia
0
South Africa
0
Listed Dossiers
DRUG PRODUCT COMPOSITIONS
0
EDQM
0
USP
0
JP
0
Others
0
US Patents
0
US Exclusivities
0
Health Canada Patents
0
Data Compilation #PharmaFlow
0
Stock Recap #PipelineProspector
0
Weekly News Recap #Phispers
0
News #PharmaBuzz
US Medicaid
NA
Annual Reports
NA
Finished Drug Prices
NA
1. 152811-62-6
2. Sb-207266
3. N-((1-butylpiperidin-4-yl)methyl)-3,4-dihydro-2h-[1,3]oxazino[3,2-a]indole-10-carboxamide
4. N-[(1-butylpiperidin-4-yl)methyl]-3,4-dihydro-2h-[1,3]oxazino[3,2-a]indole-10-carboxamide
5. Sb207256
6. 4uq3s81b25
7. Sb 207266
8. Piboserod,2h-(1,3)oxazino(3,2-a)indole-10-carboxamide, N-((1-butyl-4-piperidinyl)methyl)-3,4-dihydro-
9. N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-2h-[1,3]-oxazino[3,2-a]indole-10-carboxamide
10. Piboserod [inn]
11. Piboserod [inn:ban]
12. Serotonin 5-ht4 Receptor Antagonists
13. Unii-4uq3s81b25
14. Piboserod [mi]
15. Sb207266(piboserod)
16. Piboserod [who-dd]
17. Gtpl225
18. Schembl467339
19. Chembl356359
20. Bdbm85026
21. Dtxsid60165129
22. Bcp15982
23. Ex-a1189
24. Zinc1537633
25. Mfcd00923681
26. Pdsp1_001702
27. Pdsp2_001685
28. Akos015909931
29. Db04873
30. Fd10684
31. Sb 207266-a
32. Ncgc00250378-01
33. Ac-36094
34. As-82492
35. Bp166459
36. Hy-15574
37. Sb 207256
38. Ft-0722955
39. Q75884
40. Sb-207266, >=98% (hplc)
41. L000973
42. N-(1-butylpiperidine-4-ylmethyl)-1,2-(trimethyleneoxy)-1h-indole-3-carboxamide
43. 2h-(1,3)oxazino(3,2-a)indole-10-carboxamide, N-((1-butyl-4-piperidinyl)methyl)-3,4-dihydro-
44. N-((1-butyl-4-piperidyl)-methyl)-3,4-dihydro-2h-(1,3)oxazino(3,2-a)indole-10-carboxamide
45. N-((1-butyl-4-piperidyl)methyl)-3,4-dihydro-2h-(1,3)oxazino(3,2-a)indole-10-carboxamide
46. N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-2h-[1,3]-oxazino[3,2-alpha]indole-10-carboxamide
47. N-[(1-butyl4-piperidinyl)methyl]-3,4-dihydro-2h-[1,3]-oxazino[3,2-a]indole-10-carboxamide
48. N-[(1-butylpiperidin-4-yl)methyl]-2h,3h,4h-[1,3]oxazino[3,2-a]indole-10-carboxamide
| Molecular Weight | 369.5 g/mol |
|---|---|
| Molecular Formula | C22H31N3O2 |
| XLogP3 | 3.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 6 |
| Exact Mass | 369.24162724 g/mol |
| Monoisotopic Mass | 369.24162724 g/mol |
| Topological Polar Surface Area | 46.5 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 492 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the treatment of atrial fibrillation and irritable bowel syndrome (IBS).
GlaxoSmithKline was investigating piboserod, a 5HT4 antagonist, for the treatment of atrial fibrillation. Phase II trials were ongoing in March 2004, but by December of that year, development had been discontinued. Piboserod had previously being investigated for the treatment of irritable bowel syndrome (IBS), but development for this indication was terminated in 1999.
Piboserod appears to act as a specific antagonist of one of the receptors for 5-hydroxytryptamine, the 5-HT4 receptor. The 5-HT4 receptor antagonists are thought to antagonize both the ability of serotonin to sensitize the peristaltic reflex and 5-HT-induced defecation, at least in animal studies. As 5-HT4 receptors are present in human atrial cells and when stimulated may cause atrial arrhythmias, piboserod was under investigation in clinical trials for atrial fibrillation.
ABOUT THIS PAGE
48
PharmaCompass offers a list of Piboserod API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Piboserod manufacturer or Piboserod supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Piboserod manufacturer or Piboserod supplier.
PharmaCompass also assists you with knowing the Piboserod API Price utilized in the formulation of products. Piboserod API Price is not always fixed or binding as the Piboserod Price is obtained through a variety of data sources. The Piboserod Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Piboserod manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Piboserod, including repackagers and relabelers. The FDA regulates Piboserod manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Piboserod API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Piboserod supplier is an individual or a company that provides Piboserod active pharmaceutical ingredient (API) or Piboserod finished formulations upon request. The Piboserod suppliers may include Piboserod API manufacturers, exporters, distributors and traders.
Piboserod Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Piboserod GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Piboserod GMP manufacturer or Piboserod GMP API supplier for your needs.
A Piboserod CoA (Certificate of Analysis) is a formal document that attests to Piboserod's compliance with Piboserod specifications and serves as a tool for batch-level quality control.
Piboserod CoA mostly includes findings from lab analyses of a specific batch. For each Piboserod CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Piboserod may be tested according to a variety of international standards, such as European Pharmacopoeia (Piboserod EP), Piboserod JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Piboserod USP).
