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Pimobendan

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ACTIVE PHARMA INGREDIENTS

10 API Suppliers, 2 CEP/COS, 1 JDMF, 9 NDC API, 5 VMF, 7 Listed Suppliers, $ API Reference Price

10 API Suppliers
2 CEP/COS
1 JDMF
9 NDC API
5 VMF
7 Listed Suppliers
$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

3 FDF Dossiers, 3 Canada

3 FDF Dossiers
3 Canada

MARKET PLACE

7 APIs, 1 FDF Dossiers

marketPlace
7 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

3 Health Canada Patents

patents
3 Health Canada Patents

REF. STANDARDS & IMPURITIES

2 EDQM , 3 USP , 3 Others

otherSolutions
2 EDQM
3 USP
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 74150-27-9, Pimobendane, Acardi, Dl-pimobendan, Vetmedin, D-pimobendan

Molecular Formula

C₁₉H₁₈N₄O₂

Molecular Weight

334.4 g/mol

InChI Key

GLBJJMFZWDBELO-UHFFFAOYSA-N

FDA UNII

9HTU209Z0N

1 2D Structure

Pimobendan

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one

2.1.2 InChI

InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)

2.1.3 InChI Key

GLBJJMFZWDBELO-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC

2.2 Other Identifiers

2.2.1 UNII

9HTU209Z0N

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazole-5-yl)-5-methyl-3(2h)-pyridazinone

2. Pimobendane

3. Ud Cg 115

4. Ud-cg 115

5. Ud-cg115

2.3.2 Depositor-Supplied Synonyms

1. 74150-27-9

2. Pimobendane

3. Acardi

4. Dl-pimobendan

5. Vetmedin

6. D-pimobendan

7. (-)-pimobendan

8. Pimobendan, (-)-

9. (+)-pimobendan

10. Pimobendanum

11. Ud-cg 115 Bs

12. Ud-cg 115

13. 118428-37-8

14. Pimobendan, (+)-

15. Pimobendan (vetmedin)

16. Ud-cg-115bs

17. Racemic Pimobendan

18. 118428-38-9

19. Udcg-115

20. 6-(2-(4-methoxyphenyl)-1h-benzo[d]imidazol-5-yl)-5-methyl-4,5-dihydropyridazin-3(2h)-one

21. Ud-cg-115

22. 3-[2-(4-methoxyphenyl)-3h-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1h-pyridazin-6-one

23. Brn 4207330

24. 34ap3bbp9t

25. Chembl24646

26. 613jxv89su

27. 9htu209z0n

28. Chebi:32003

29. 3(2h)-pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-, (+)-

30. 3(2h)-pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-, (-)-

31. L-pimobendan

32. Racemic Pinobendan

33. 6-(2-(4-methoxyphenyl)-1h-benzo[d]imidazol-6-yl)-5-methyl-4,5-dihydropyridazin-3(2h)-one

34. 6-[2-(4-methoxyphenyl)-1h-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2h)-one

35. Pimobendan [inn-spanish]

36. Pimobendane [inn-french]

37. Pimobendanum [inn-latin]

38. (+)-ud-cg 115bs

39. (-)-ud-cg 115bs

40. Ncgc00274063-01

41. Unii-34ap3bbp9t

42. Unii-613jxv89su

43. Unii-9htu209z0n

44. Pimobendan [usan:inn:ban]

45. Ud-cg115

46. 3-[2-(4-methoxyphenyl)-1h-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1h-pyridazin-6-one

47. Acardi (tn)

48. Pimobendan - Vetmedin

49. Pimobendan [mi]

50. Pimobendan [inn]

51. Pimobendan [jan]

52. Pimobendan [usan]

53. Pimobendan [mart.]

54. (+)-4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-3(2h)-pyridazinone

55. (-)-4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-3(2h)-pyridazinone

56. 4,5-dihydro-6-[2-(4-methoxyphenyl)-1h-benzimidazol-5-yl]-5-methyl-3(2h)-pyridazinone

57. 6-(2-(4-methoxyphenyl)-4,5-dihydro-1h-benzimidazol-5-yl)-5-methyl-3(2h)-pyridazinone

58. Pimobendan [usp-rs]

59. Pimobendan [who-dd]

60. Schembl27623

61. Mls006010188

62. Pimobendan (jan/usan/inn)

63. Pimobendan [green Book]

64. Dtxsid8048280

65. Pimobendan [ep Impurity]

66. Pimobendan, >=98% (hplc)

67. Hms3655i03

68. Hms3884c21

69. Kuc109647n

70. Pimobendan [usp Monograph]

71. Bcp02958

72. Hy-b0204

73. Ac-689

74. Bdbm50282617

75. Mfcd00761648

76. S1550

77. Akos015851937

78. Akos015967705

79. Ccg-267853

80. Db11450

81. Ks-1280

82. 3(2h)-pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-

83. 6-[2-(4-methoxy-phenyl)-1h-benzoimidazol-5-yl]-5-methyl-4,5-dihydro-2h-pyridazin-3-one

84. Ksc-210-009

85. Pimobendan [ema Epar Veterinary]

86. Fortekor Plus Component Pimobendan

87. Ncgc00274063-04

88. Ncgc00274063-05

89. 118428-36-7

90. Pimobendan 100 Microg/ml In Acetonitrile

91. Smr002530068

92. Bcp0726000255

93. Ft-0630830

94. P2779

95. Pimobendan Component Of Fortekor Plus

96. Sw219717-1

97. D01133

98. Ab01274800-01

99. Ab01274800_02

100. 150p279

101. Q414351

102. J-517984

103. Pimobendan, United States Pharmacopeia (usp) Reference Standard

104. 4,5-dihydro-6-[2-(4-methoxy-phenyl)-1h-benzimidazol-5-yl]-5-methyl-3 (2h)-pyridazinone

105. Pimobendan For System Suitability, European Pharmacopoeia (ep) Reference Standard

106. (+/-)-4,5-dihydro-6-(2-(p-methoxyphenyl)-5-benzimidazolyl)-5-methyl-3(2h)-pyridazinone

107. 3(2h)-pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-5-yl)-5-methyl-, (+/-)-

108. 3(2h)-pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1h-benzimidazol-6-yl)-5-methyl-

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₁₈N₄O₂
Molecular Weight	334.4 g/mol
XLogP3	2.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	334.14297583 g/mol
Monoisotopic Mass	334.14297583 g/mol
Topological Polar Surface Area	79.4 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	530
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

Phosphodiesterase Inhibitors

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases. (See all compounds classified as Phosphodiesterase Inhibitors.)

Cardiotonic Agents

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)

API SUPPLIERS

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CEP/COS

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JDMF

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NDC API

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VMF

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Listed Suppliers

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API Reference Price

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PU DONG","customer":"ASHISH LIFE SCIENCE PVT LIMITED","customerCountry":"INDIA","quantity":"2.10","actualQuantity":"2.1","unit":"KGS","unitRateFc":"8300","totalValueFC":"18033.7","currency":"USD","unitRateINR":"714850","date":"02-Dec-2023","totalValueINR":"1501185","totalValueInUsd":"18033.7","indian_port":"Bombay Air","hs_no":"29329990","bill_no":"9042054","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"No.18,Qinghua Road, Sanchang,,Haimen Jiangsu,China 226123SDNF CHINA","customerAddress":"213, LAXMI PLAZA, LAXMI INDL."},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1701973800,"product":"PIMOBENDAN","address":"F 43 DEOLALI PLAZA, LAM ROAD,DEOLA","city":"NASIK,MAHARASHTRA","supplier":"TAIZHOU CRENE BIOTECHNOLOGY ","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"REYAANSH HEALTHCARE","customerCountry":"INDIA","quantity":"0.40","actualQuantity":"0.4","unit":"KGS","unitRateFc":"3500","totalValueFC":"1417.8","currency":"USD","unitRateINR":"295050","date":"08-Dec-2023","totalValueINR":"118020","totalValueInUsd":"1417.8","indian_port":"Bombay Air","hs_no":"29329990","bill_no":"9131288","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"ECONOMIC DEVELOPED ZONE OF TAIZHOUZHEJIANG CHINA Guangzhou, , CHINASDNF CHINA","customerAddress":"F 43 DEOLALI PLAZA, LAM ROAD,DEOLA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704911400,"product":"PIMOBENDAN","address":"213, LAXMI PLAZA, LAXMI INDL.","city":"MUMBAI, MAHARASHTRA","supplier":"XIAMEN ORIGIN BIOTECH ","supplierCountry":"CHINA","foreign_port":"XIAMEN","customer":"ASHISH LIFE SCIENCE PVT LIMITED","customerCountry":"INDIA","quantity":"4.17","actualQuantity":"4.17","unit":"KGS","unitRateFc":"3500","totalValueFC":"14794.9","currency":"USD","unitRateINR":"294875","date":"11-Jan-2024","totalValueINR":"1229628.75","totalValueInUsd":"14794.9","indian_port":"Bombay Air","hs_no":"29329990","bill_no":"9621382","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"XIAMEN","supplierAddress":"NO 7 XIANGYUE ROAD, XIANGANXIAMEN TORCH HI-TECHXIAMEN CHINA","customerAddress":"213, LAXMI PLAZA, LAXMI INDL."},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709577000,"product":"PIMOBENDAN","address":"F 43 DEOLALI PLAZA, LAM ROAD,DEOLA","city":"NASIK,MAHARASHTRA","supplier":"TAIZHOU CRENE BIOTECHNOLOGY ","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"REYAANSH HEALTHCARE","customerCountry":"INDIA","quantity":"2.50","actualQuantity":"2.5","unit":"KGS","unitRateFc":"3500","totalValueFC":"8841.1","currency":"USD","unitRateINR":"293650","date":"05-Mar-2024","totalValueINR":"734125","totalValueInUsd":"8841.1","indian_port":"Bombay Air","hs_no":"29329990","bill_no":"2432482","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"ECONOMIC DEVELOPED ZONE OF TAIZHOUZHEJIANG CHINA Guangzhou, , CHINASDNF CHINA","customerAddress":"F 43 DEOLALI PLAZA, LAM ROAD,DEOLA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718994600,"product":"PIMOBENDAN (BATCH NO-230801)","address":"OFFICE NO.2 LALWANI PLAZA WING-B","city":"SOC.OFF AIRPORT RD.VIMANNAGAR PUNE\/","supplier":"XIAMEN ORIGIN BIOTECH CO., LTD.","supplierCountry":"CHINA","foreign_port":"XIAMEN","customer":"SAVA HEALTHCARE LIMITED","customerCountry":"INDIA","quantity":"0.51","actualQuantity":"0.51","unit":"KGS","unitRateFc":"4350","totalValueFC":"2240.3","currency":"USD","unitRateINR":"366705","date":"22-Jun-2024","totalValueINR":"187019.55","totalValueInUsd":"2240.3","indian_port":"Bombay Air","hs_no":"29329990","bill_no":"4141414","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"XIAMEN","supplierAddress":"NO.7 XIANGYUE ROAD, XIANG\\'AN DISTRICT XIAMEN TORCH HI-TECH, ININDUSTRIL DEVELOPMENT ZONE, XIAMEN, FUJIAN, China","customerAddress":"OFFICE NO.2 LALWANI PLAZA WING-B"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724783400,"product":"PIMOBENDAN USP\/PH. EUR. (TEST LIC. NO. TL\/AZ\/23\/002138) FORR & D PURPOSE NOT FOR SALE","address":"CORPORATE HOUSE, NR. SOLA BRIDGE,,","city":"AHMEDABAD,GUJARAT","supplier":"WOOD & COMPANY FINANCIAL SERVICES","supplierCountry":"SLOVAKIA","foreign_port":"BRATISLAVA","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"1.50","actualQuantity":"1.5","unit":"KGS","unitRateFc":"8924","totalValueFC":"14977.3","currency":"EUR","unitRateINR":"837517.4","date":"28-Aug-2024","totalValueINR":"1256276.1","totalValueInUsd":"14977.3","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"5288320","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVAKIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BRATISLAVA","supplierAddress":"NITRIANSKA 100 920 27 HLOHOVEC Hlohovec, , SLOVAK REPUBLICSDNF SLOVAK REPUBLIC","customerAddress":"CORPORATE HOUSE, NR. SOLA BRIDGE,,"}]