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Chemistry

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Also known as: 1629869-44-8, Vx-787, Pimodivir [usan], Jnj872, Jnj-63623872, Vx-787 anhydrous base
Molecular Formula
C20H19F2N5O2
Molecular Weight
399.4  g/mol
InChI Key
JGPXDNKSIXAZEQ-SBBZOCNPSA-N
FDA UNII
DFC121MXC3

Pimodivir
Pimodivir is an orally bioavailable non-nucleoside inhibitor of the polymerase basic protein 2 (PB2) subunit of the influenza A virus polymerase complex with potential antiviral activity. Upon administration, pimodivir occupies the 7-methyl GTP (m7GTP) binding site of PB2, thereby blocking the cap-snatching activity of the influenza polymerase complex and inhibiting the synthesis of viral mRNA. PB2 is one of three subunits that make up the influenza A viral polymerase complex, which is responsible for replication and transcription of the viral RNA (vRNA) genome in the nuclei of infected cells.
1 2D Structure

Pimodivir

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,3S)-3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid
2.1.2 InChI
InChI=1S/C20H19F2N5O2/c21-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(22)19(27-18)26-16-10-3-1-9(2-4-10)15(16)20(28)29/h5-10,15-16H,1-4H2,(H,23,24)(H,28,29)(H,25,26,27)/t9?,10?,15-,16-/m0/s1
2.1.3 InChI Key
JGPXDNKSIXAZEQ-SBBZOCNPSA-N
2.1.4 Canonical SMILES
C1CC2CCC1C(C2NC3=NC(=NC=C3F)C4=CNC5=C4C=C(C=N5)F)C(=O)O
2.1.5 Isomeric SMILES
C1CC2CCC1[C@@H]([C@H]2NC3=NC(=NC=C3F)C4=CNC5=C4C=C(C=N5)F)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
DFC121MXC3
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (2s,3s)-3-((5-fluoro-2-(5-fluoro-1h-pyrrolo(2,3-b)pyridin-3-yl)-4-pyrimidinyl)amino)bicyclo(2.2.2)octane-2-carboxylic Acid

2. Bicyclo(2.2.2)octane-2-carboxylic Acid, 3-((5-fluoro-2-(5-fluoro-1h-pyrrolo(2,3-b)pyridin-3-yl)-4-pyrimidinyl)amino)-, (2s,3s)-

3. Jnj-63623872

4. Vx-787

2.3.2 Depositor-Supplied Synonyms

1. 1629869-44-8

2. Vx-787

3. Pimodivir [usan]

4. Jnj872

5. Jnj-63623872

6. Vx-787 Anhydrous Base

7. Jnj-63623872-zcd

8. Jnj63623872

9. Dfc121mxc3

10. Chembl3318007

11. Jnj-872

12. (2s,3s)-3-((5-fluoro-2-(5-fluoro-1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic Acid

13. (2s,3s)-3-[[5-fluoranyl-2-(5-fluoranyl-1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic Acid

14. Bicyclo(2.2.2)octane-2-carboxylic Acid, 3-((5-fluoro-2-(5-fluoro-1h-pyrrolo(2,3-b)pyridin-3-yl)-4-pyrimidinyl)amino)-, (2s,3s)-

15. (2s,3s)-3-[[5-fluoro-2-(5-fluoro-1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic Acid

16. 21g

17. Pimodivir(vx-787

18. 4p1u

19. Pimodivir [inn]

20. Pimodivir (usan/inn)

21. Pimodivir (vx-787)

22. Unii-dfc121mxc3

23. Pimodivir [who-dd]

24. Schembl2128140

25. Schembl16728380

26. Schembl20150447

27. Dtxsid801028095

28. Ex-a1387

29. Bdbm50050712

30. Hy-12353a

31. Zinc98208077

32. At13207

33. Cs-6423

34. Db14974

35. Vx -787

36. Ncgc00510523-01

37. Ac-30922

38. Jnj - 63623872 - Zcd

39. D11287

40. Q27276370

41. (1r,2s,3s,4r)-3-{[5-fluoro-2-(5-fluoro-1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino}bicyclo[2.2.2]octane-2-carboxylic Acid

42. (2s,3s)-3-((5-fluoro-2-(5-fluoro-1h-pyrrolo(2,3-b)pyridin- 3-yl)pyrimidin-4-yl)amino)bicyclo(2.2.2)octane-2-carboxylic Acid

43. (2s,3s)-3-(5-fluoro-2-(5-fluoro-1h-pyrrolo(2,3-b)pyridin-3-yl)pyrimidin-4-ylamino)bicyclo(2.2.2)octane-2-carboxylic Acid

44. 1259366-34-1

45. 3-[[5-fluoro-2-(5-fluoro-1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic Acid; Vx787; (2s,3s)-3-((5-fluoro-2-(5-fluoro-1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic Acid

2.4 Create Date
2012-11-30
3 Chemical and Physical Properties
Molecular Weight 399.4 g/mol
Molecular Formula C20H19F2N5O2
XLogP33.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass399.15068119 g/mol
Monoisotopic Mass399.15068119 g/mol
Topological Polar Surface Area104 Ų
Heavy Atom Count29
Formal Charge0
Complexity620
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of influenza


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ABOUT THIS PAGE

Pimodivir Manufacturers

A Pimodivir manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pimodivir, including repackagers and relabelers. The FDA regulates Pimodivir manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pimodivir API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Pimodivir manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Pimodivir Suppliers

A Pimodivir supplier is an individual or a company that provides Pimodivir active pharmaceutical ingredient (API) or Pimodivir finished formulations upon request. The Pimodivir suppliers may include Pimodivir API manufacturers, exporters, distributors and traders.

click here to find a list of Pimodivir suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Pimodivir GMP

Pimodivir Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pimodivir GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pimodivir GMP manufacturer or Pimodivir GMP API supplier for your needs.

Pimodivir CoA

A Pimodivir CoA (Certificate of Analysis) is a formal document that attests to Pimodivir's compliance with Pimodivir specifications and serves as a tool for batch-level quality control.

Pimodivir CoA mostly includes findings from lab analyses of a specific batch. For each Pimodivir CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pimodivir may be tested according to a variety of international standards, such as European Pharmacopoeia (Pimodivir EP), Pimodivir JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pimodivir USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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