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Also known as: 53251-94-8, Dicetel, Pinaverium bromide [inn], Lat-1717, Pinaverium bromide (inn), Morpholinium, 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]-, bromide (1:1)
Molecular Formula
C26H41Br2NO4
Molecular Weight
591.4  g/mol
InChI Key
IKGXLCMLVINENI-UHFFFAOYSA-M

Pinaverium Bromide
Pinaverium Bromide is an orally available bromide salt form of pinaverium, a calcium channel blocker (CCB) with antispasmodic activity. Upon oral administration, pinaverium blocks the voltage-dependent calcium channels and inhibits calcium ion influx into the smooth muscle cells located in the gastrointestinal (GI) tract. This prevents smooth muscle contraction and relaxes the GI tract. In addition, pinaverium may both reduce bowel uptake of and facilitate the function of locally active, co-administered drugs.
1 2D Structure

Pinaverium Bromide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethyl-2-bicyclo[3.1.1]heptanyl)ethoxy]ethyl]morpholin-4-ium;bromide
2.1.2 InChI
InChI=1S/C26H41BrNO4.BrH/c1-26(2)21-6-5-19(22(26)16-21)7-11-31-12-8-28(9-13-32-14-10-28)18-20-15-24(29-3)25(30-4)17-23(20)27;/h15,17,19,21-22H,5-14,16,18H2,1-4H3;1H/q+1;/p-1
2.1.3 InChI Key
IKGXLCMLVINENI-UHFFFAOYSA-M
2.1.4 Canonical SMILES
CC1(C2CCC(C1C2)CCOCC[N+]3(CCOCC3)CC4=CC(=C(C=C4Br)OC)OC)C.[Br-]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 4-(6-bromoveratryl)-4-(2-(2-(6,6-dimethyl-2-norpinyl)ethoxy)ethyl)morpholinium Bromide

2. Dicetel

3. Eldicet

4. Pinaverium

2.2.2 Depositor-Supplied Synonyms

1. 53251-94-8

2. Dicetel

3. Pinaverium Bromide [inn]

4. Lat-1717

5. Pinaverium Bromide (inn)

6. Morpholinium, 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]-, Bromide (1:1)

7. Pinaverii Bromidum

8. 4-(2-bromo-4,5-dimethoxybenzyl)-4-(2-(2-(6,6-dimethylbicyclo[3.1.1]heptan-2-yl)ethoxy)ethyl)morpholin-4-ium Bromide

9. Bromuro De Pinaverio

10. Bromure De Pinaverium

11. Lat 1717

12. Pinaverii Bromidum [inn-latin]

13. Bromure De Pinaverium [inn-french]

14. Bromuro De Pinaverio [inn-spanish]

15. 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethyl-2-bicyclo[3.1.1]heptanyl)ethoxy]ethyl]morpholin-4-ium;bromide

16. 4-(6-bromoveratryl)-4-(2-(2-(6,6-dimethyl-2-norpinyl)ethoxy)ethyl)morpholinium Bromide

17. Ncgc00181763-01

18. Einecs 258-450-0

19. 7scf54h12j

20. Unii-7scf54h12j

21. Pinaveriumbromide-d4

22. Dsstox_cid_28540

23. Dsstox_rid_82812

24. Dsstox_gsid_48614

25. Schembl25474

26. Morpholinium, 4-(2-bromo-4,5-dimethoxy)benzyl-4-(2-(2-(6,6-dimethyl-2-norpinyl)ethoxy)ethyl)-, Bromide

27. Chembl1909298

28. Dtxsid2048614

29. 4-[(2-bromo-4,5-dimethoxy-phenyl)methyl]-4-[2-[2-[(1s,5s)-6,6-dimethylnorpinan-2-yl]ethoxy]ethyl]morpholin-4-ium Bromide

30. Bcp21168

31. Tox21_112949

32. Mfcd01713435

33. Akos015918115

34. Gs-6842

35. 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]-hept-2-yl)ethoxy]ethyl]morpholinium Bromide

36. Cas-53251-94-8

37. Hy-111613

38. Cs-0088569

39. Ft-0673906

40. P2753

41. D07094

42. Lat 1717; Lat-1717; Lat1717

43. A870784

44. Q27268790

45. 4-(2-bromo-4,5-dimethoxybenzyl)-4-{2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl}morpholin-4-ium Bromide

46. 4-[(2-bromo-4,5-dimethoxy-phenyl)methyl]-4-[2-[2-(6,6-dimethylnorpinan-2-yl)ethoxy]ethyl]-1-oxa-4-azoniacyclohexane Bromide

47. 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-(2-{6,6-dimethylbicyclo[3.1.1]heptan-2-yl}ethoxy)ethyl]morpholin-4-ium Bromide

48. Morpholinium,4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]-, Bromide

2.3 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 591.4 g/mol
Molecular Formula C26H41Br2NO4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass591.13818 g/mol
Monoisotopic Mass589.14023 g/mol
Topological Polar Surface Area36.9 Ų
Heavy Atom Count33
Formal Charge0
Complexity596
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count3
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)


Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)


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22-Feb-2021
31-Dec-2024
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ABOUT THIS PAGE

Pinaverium Bromide Manufacturers

A Pinaverium Bromide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pinaverium Bromide, including repackagers and relabelers. The FDA regulates Pinaverium Bromide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pinaverium Bromide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Pinaverium Bromide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Pinaverium Bromide Suppliers

A Pinaverium Bromide supplier is an individual or a company that provides Pinaverium Bromide active pharmaceutical ingredient (API) or Pinaverium Bromide finished formulations upon request. The Pinaverium Bromide suppliers may include Pinaverium Bromide API manufacturers, exporters, distributors and traders.

click here to find a list of Pinaverium Bromide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Pinaverium Bromide USDMF

A Pinaverium Bromide DMF (Drug Master File) is a document detailing the whole manufacturing process of Pinaverium Bromide active pharmaceutical ingredient (API) in detail. Different forms of Pinaverium Bromide DMFs exist exist since differing nations have different regulations, such as Pinaverium Bromide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Pinaverium Bromide DMF submitted to regulatory agencies in the US is known as a USDMF. Pinaverium Bromide USDMF includes data on Pinaverium Bromide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Pinaverium Bromide USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Pinaverium Bromide suppliers with USDMF on PharmaCompass.

Pinaverium Bromide KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Pinaverium Bromide Drug Master File in Korea (Pinaverium Bromide KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Pinaverium Bromide. The MFDS reviews the Pinaverium Bromide KDMF as part of the drug registration process and uses the information provided in the Pinaverium Bromide KDMF to evaluate the safety and efficacy of the drug.

After submitting a Pinaverium Bromide KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Pinaverium Bromide API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Pinaverium Bromide suppliers with KDMF on PharmaCompass.

Pinaverium Bromide WC

A Pinaverium Bromide written confirmation (Pinaverium Bromide WC) is an official document issued by a regulatory agency to a Pinaverium Bromide manufacturer, verifying that the manufacturing facility of a Pinaverium Bromide active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Pinaverium Bromide APIs or Pinaverium Bromide finished pharmaceutical products to another nation, regulatory agencies frequently require a Pinaverium Bromide WC (written confirmation) as part of the regulatory process.

click here to find a list of Pinaverium Bromide suppliers with Written Confirmation (WC) on PharmaCompass.

Pinaverium Bromide NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Pinaverium Bromide as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Pinaverium Bromide API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Pinaverium Bromide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Pinaverium Bromide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Pinaverium Bromide NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Pinaverium Bromide suppliers with NDC on PharmaCompass.

Pinaverium Bromide GMP

Pinaverium Bromide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pinaverium Bromide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pinaverium Bromide GMP manufacturer or Pinaverium Bromide GMP API supplier for your needs.

Pinaverium Bromide CoA

A Pinaverium Bromide CoA (Certificate of Analysis) is a formal document that attests to Pinaverium Bromide's compliance with Pinaverium Bromide specifications and serves as a tool for batch-level quality control.

Pinaverium Bromide CoA mostly includes findings from lab analyses of a specific batch. For each Pinaverium Bromide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pinaverium Bromide may be tested according to a variety of international standards, such as European Pharmacopoeia (Pinaverium Bromide EP), Pinaverium Bromide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pinaverium Bromide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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