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Chemistry

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Also known as: Tazocin (tn), Zosyn (tn), Piperacillin-tazobactam mixt., Piperacillin-tazobactam mixture, Niosh/xi0191450, Piperacillin sodium and tazobactam
Molecular Formula
C33H38N9NaO12S2
Molecular Weight
839.8  g/mol
InChI Key
TUPFOYXHAYOHIB-WZGOVNIISA-M

Piperacillin + Tazobactam
Piperacillin-Tazobactam is a combination formulation of the antibiotic piperacillin and the beta-lactamase inhibitor tazobactam with antibacterial activity. Piperacillin, a broad-spectrum, semisynthetic penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As a result, the cell wall is weakened and the cell lyses. Tazobactam, a penicillanic acid sulfone derivative, irreversibly binds to and inhibits bacterial beta-lactamase at or near its active site, thereby preventing the destruction of the beta-lactamase susceptible piperacillin by this bacterial enzyme.
1 2D Structure

Piperacillin + Tazobactam

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;(2S,5R,6R)-6-[[(2S)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-46-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
2.1.2 InChI
InChI=1S/C23H27N5O7S.C10H12N4O5S.Na/c1-4-26-10-11-27(19(32)18(26)31)22(35)25-13(12-8-6-5-7-9-12)16(29)24-14-17(30)28-15(21(33)34)23(2,3)36-20(14)28;1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h5-9,13-15,20H,4,10-11H2,1-3H3,(H,24,29)(H,25,35)(H,33,34);2-3,7-8H,4-5H2,1H3,(H,16,17);/q;;+1/p-1/t13-,14+,15-,20+;7-,8+,10+;/m01./s1
2.1.3 InChI Key
TUPFOYXHAYOHIB-WZGOVNIISA-M
2.1.4 Canonical SMILES
CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)O)CN3C=CN=N3.[Na+]
2.1.5 Isomeric SMILES
CCN1CCN(C(=O)C1=O)C(=O)N[C@@H](C2=CC=CC=C2)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)[O-].C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)O)CN3C=CN=N3.[Na+]
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. Tazocin (tn)

2. Zosyn (tn)

3. Piperacillin-tazobactam Mixt.

4. Piperacillin-tazobactam Mixture

5. Niosh/xi0191450

6. Piperacillin Sodium And Tazobactam

7. Dtxsid001016418

8. Tazobactam And Piperacillin (jp17)

9. Piperacillin-tazobactam Mixt. (4:1)

10. Tazobactam-piperacillin Mixt. (1:4)

11. Xi01914500

12. D02505

13. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3-methyl-7-oxo-3-(1h-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2s-(2-alpha,3-beta,5-alpha))-, Mixt. With (2s-(2-alpha,5-alpha,6-beta(s*)))-6-(((((4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid (1:4)

14. Sodium;(2s,5r,6r)-6-[[(2s)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;(2s,3s,5r)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

2.3 Create Date
2008-02-08
3 Chemical and Physical Properties
Molecular Weight 839.8 g/mol
Molecular Formula C33H38N9NaO12S2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count15
Rotatable Bond Count9
Exact Mass839.19790431 g/mol
Monoisotopic Mass839.19790431 g/mol
Topological Polar Surface Area315 Ų
Heavy Atom Count57
Formal Charge0
Complexity1560
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3

USDMF

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01

Acs Dobfar Spa

Italy

USDMF

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PharmaVenue
Not Confirmed

02

PharmaVenue
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02

PharmaVenue
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GDUFA

DMF Review : Complete

Rev. Date : 2014-01-31

Pay. Date : 2013-12-17

DMF Number : 25545

Submission : 2011-11-29

Status : Active

Type : II

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04

PharmaVenue
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04

PharmaVenue
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GDUFA

DMF Review : Complete

Rev. Date : 2015-10-07

Pay. Date : 2013-01-09

DMF Number : 26009

Submission : 2012-03-21

Status : Active

Type : II

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05

PharmaVenue
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05

PharmaVenue
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GDUFA

DMF Review : Complete

Rev. Date : 2019-05-14

Pay. Date : 2019-02-20

DMF Number : 33540

Submission : 2019-02-21

Status : Active

Type : II

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07

Sterile India Pvt Ltd

India

USDMF

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Listed Suppliers

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01

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Pharmatech Expo 2025
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Virtual BoothCentrient is a leading manufacturer of Beta-Lactam Antibiotics and a provider of next-generation Statins and Antifungals.

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Piperacillin And Tazobactam

About the Company : Established in 1869, Centrient Pharmaceuticals is a global B2B leader in sustainable, enzymatic antibiotics, next-generation statins and anti-fungals. Together with tablets, capsul...

Established in 1869, Centrient Pharmaceuticals is a global B2B leader in sustainable, enzymatic antibiotics, next-generation statins and anti-fungals. Together with tablets, capsules and finished dosage forms, it manufactures and markets intermediates and active pharmaceutical ingredients (APIs). It is a pharmaceutical company with a clear purpose — to improve lives through innovative and sustainable manufacturing of medicines. Centrient is committed to ensuring quality, reliability and sustainability for its customers, partners and patients. Its vision is to be the leading, diversified and fully integrated partner for generics marketers.
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02

Bioquim

Spain
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Virtual BoothBioquim: An European GMP-certified company manufacturing bulk APIs, specializing in sterile lyophilization and chemical synthesis.

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Piperacillin + Tazobactam

About the Company : Bioquim is a European company specializing in bulk oral & sterile APIs for the pharmaceutical industry. With over 40 years of experience, we offer high-quality corticosteroids, pep...

Bioquim is a European company specializing in bulk oral & sterile APIs for the pharmaceutical industry. With over 40 years of experience, we offer high-quality corticosteroids, peptides, amino acids, penicillin derivatives, non-penicillin antibiotics, and HPAPIs for human & veterinary markets. We adhere to stringent GMP and operate state-of-the-art facilities with advanced technology. Bioquim also provides Custom Synthesis & Contract Manufacturing services, delivering tailored solutions backed by our expertise in chemical synthesis & lyophilization of sterile APIs. Trust Bioquim for your API needs & experience our commitment to quality.
Bioquim

03

Otto Brandes

Germany
Pharmatech Expo 2025
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Otto Brandes

Germany
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Piperacillin And Tazobactam

About the Company : Otto Brandes Gmbh was founded in 1923 and is an independent distributor of high quality Pharmaceutical Active Ingredients and excipients for the pharmaceutical industry. We regard ...

Otto Brandes Gmbh was founded in 1923 and is an independent distributor of high quality Pharmaceutical Active Ingredients and excipients for the pharmaceutical industry. We regard ourselves as a service provider and focus on the customer`s interests. Our aim is to work together with you as a reliable and dependable partner, to achieve your requirements and objectives, enabling you to take a successful market position. Since 2015 we are a part of an internationally expanding group.
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Pharmatech Expo 2025
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Piperacillin + Tazobactam

About the Company : Located in Jinan, Qilu Pharmaceutical is one of the leading pharmaceutical companies in China. It focuses on developing, manufacturing and marketing of generic drugs and active pha...

Located in Jinan, Qilu Pharmaceutical is one of the leading pharmaceutical companies in China. It focuses on developing, manufacturing and marketing of generic drugs and active pharmaceutical ingredients in the therapeutic areas of Oncology, Cerebrovascular & Cardiovascular, Infections, Psychological and Neurological System, Respiratory System, Ophthalmological Diseases, etc. Always committing itself to meet the needs of the patients and the society. Qilu pharmaceutical provides high-quality products by adopting advanced technology. Qilu has 8000 employees , 5,000 of them have junior college or above educational backgrounp.
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05

Pharmatech Expo 2025
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Piperacillin & Tazobactam

About the Company : Rajasthan Antibiotics Limited (RAL-Life) is a fast track integrated pharmaceutical company which commenced its commercial production in 1991 and has grown in size and stature to b...

Rajasthan Antibiotics Limited (RAL-Life) is a fast track integrated pharmaceutical company which commenced its commercial production in 1991 and has grown in size and stature to become one of the country's largest producers of the sterile APIs (Active Pharmaceutical Ingredients). Besides being the first company in India to produce Ampicillin sodium Sterile, RAL-Life also pioneered the manufacturing of Sterile Anti Ulcer drugs namely Omeprazole sodium Sterile & Pantaprazole Sodium Sterile for which it has won worldwide acceptance. The company has two separate dedicated blocks for Lyophilisation and Crystalline facility for APIs and FDFs.
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Pharmatech Expo 2025
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Piperacillin And Tazobactam

About the Company : Established in 2002, Tecoland represents selected cGMP manufacturers with proven capabilities in organic synthesis, fermentation production as well as process and method developmen...

Established in 2002, Tecoland represents selected cGMP manufacturers with proven capabilities in organic synthesis, fermentation production as well as process and method development. Tecoland provides high quality APIs to the pharmaceutical industry, with reliable technical and regulatory support such as USDMF, CEP, EDMF that are critical to the speedy approval of our customers’ regulatory filings.
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API Reference Price

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12-Jan-2021
11-Nov-2024
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Piperacillin + Tazobactam Manufacturers

A Piperacillin + Tazobactam manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Piperacillin + Tazobactam, including repackagers and relabelers. The FDA regulates Piperacillin + Tazobactam manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Piperacillin + Tazobactam API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Piperacillin + Tazobactam manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Piperacillin + Tazobactam Suppliers

A Piperacillin + Tazobactam supplier is an individual or a company that provides Piperacillin + Tazobactam active pharmaceutical ingredient (API) or Piperacillin + Tazobactam finished formulations upon request. The Piperacillin + Tazobactam suppliers may include Piperacillin + Tazobactam API manufacturers, exporters, distributors and traders.

click here to find a list of Piperacillin + Tazobactam suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Piperacillin + Tazobactam USDMF

A Piperacillin + Tazobactam DMF (Drug Master File) is a document detailing the whole manufacturing process of Piperacillin + Tazobactam active pharmaceutical ingredient (API) in detail. Different forms of Piperacillin + Tazobactam DMFs exist exist since differing nations have different regulations, such as Piperacillin + Tazobactam USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Piperacillin + Tazobactam DMF submitted to regulatory agencies in the US is known as a USDMF. Piperacillin + Tazobactam USDMF includes data on Piperacillin + Tazobactam's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Piperacillin + Tazobactam USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Piperacillin + Tazobactam suppliers with USDMF on PharmaCompass.

Piperacillin + Tazobactam KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Piperacillin + Tazobactam Drug Master File in Korea (Piperacillin + Tazobactam KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Piperacillin + Tazobactam. The MFDS reviews the Piperacillin + Tazobactam KDMF as part of the drug registration process and uses the information provided in the Piperacillin + Tazobactam KDMF to evaluate the safety and efficacy of the drug.

After submitting a Piperacillin + Tazobactam KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Piperacillin + Tazobactam API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Piperacillin + Tazobactam suppliers with KDMF on PharmaCompass.

Piperacillin + Tazobactam WC

A Piperacillin + Tazobactam written confirmation (Piperacillin + Tazobactam WC) is an official document issued by a regulatory agency to a Piperacillin + Tazobactam manufacturer, verifying that the manufacturing facility of a Piperacillin + Tazobactam active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Piperacillin + Tazobactam APIs or Piperacillin + Tazobactam finished pharmaceutical products to another nation, regulatory agencies frequently require a Piperacillin + Tazobactam WC (written confirmation) as part of the regulatory process.

click here to find a list of Piperacillin + Tazobactam suppliers with Written Confirmation (WC) on PharmaCompass.

Piperacillin + Tazobactam NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Piperacillin + Tazobactam as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Piperacillin + Tazobactam API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Piperacillin + Tazobactam as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Piperacillin + Tazobactam and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Piperacillin + Tazobactam NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Piperacillin + Tazobactam suppliers with NDC on PharmaCompass.

Piperacillin + Tazobactam GMP

Piperacillin + Tazobactam Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Piperacillin + Tazobactam GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Piperacillin + Tazobactam GMP manufacturer or Piperacillin + Tazobactam GMP API supplier for your needs.

Piperacillin + Tazobactam CoA

A Piperacillin + Tazobactam CoA (Certificate of Analysis) is a formal document that attests to Piperacillin + Tazobactam's compliance with Piperacillin + Tazobactam specifications and serves as a tool for batch-level quality control.

Piperacillin + Tazobactam CoA mostly includes findings from lab analyses of a specific batch. For each Piperacillin + Tazobactam CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Piperacillin + Tazobactam may be tested according to a variety of international standards, such as European Pharmacopoeia (Piperacillin + Tazobactam EP), Piperacillin + Tazobactam JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Piperacillin + Tazobactam USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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