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Chemistry

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Also known as: 94-62-2, 1-piperoylpiperidine, Bioperine, Piperin, 7780-20-3, Fema no. 2909
Molecular Formula
C17H19NO3
Molecular Weight
285.34  g/mol
InChI Key
MXXWOMGUGJBKIW-YPCIICBESA-N
FDA UNII
U71XL721QK

Piperine
piperine is a natural product found in Macropiper, Piper boehmeriifolium, and other organisms with data available.
1 2D Structure

Piperine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
2.1.2 InChI
InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
2.1.3 InChI Key
MXXWOMGUGJBKIW-YPCIICBESA-N
2.1.4 Canonical SMILES
C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3
2.1.5 Isomeric SMILES
C1CCN(CC1)C(=O)/C=C/C=C/C2=CC3=C(C=C2)OCO3
2.2 Other Identifiers
2.2.1 UNII
U71XL721QK
2.3 Synonyms
2.3.1 MeSH Synonyms

1. ((1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine

2. (1-(5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine

3. 1-piperoylpiperidine

4. Piperine, (e,e)-isomer

5. Piperine, (e,z)-isomer

6. Piperine, (z,e)-isomer

7. Piperine, (z,z)-isomer

2.3.2 Depositor-Supplied Synonyms

1. 94-62-2

2. 1-piperoylpiperidine

3. Bioperine

4. Piperin

5. 7780-20-3

6. Fema No. 2909

7. (e,e)-1-piperoylpiperidine

8. N-[(e,e)-piperoyl]piperidine

9. (2e,4e)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

10. Ai 3-01439

11. Piperidine, 1-piperoyl-, (e,e)-

12. Piperidine, 1-[(2e,4e)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-

13. (2e,4e)-5-(2h-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

14. Nsc-21727

15. 1-[(2e,4e)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]piperidine

16. (2e,4e)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one

17. N-(e,e)-piperoyl-piperidine

18. Chembl43185

19. U71xl721qk

20. Chebi:28821

21. Nsc21727

22. Piperoylpiperidine

23. Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (e,e)-

24. Piperidine, 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (e,e)-

25. Dsstox_cid_1805

26. Piperidine, 1-(5-(3,4-methylenedioxyphenyl)-1-oxo-2,4-pentadienyl)-

27. 1-[(2e,4e)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine

28. Dsstox_rid_76339

29. Dsstox_gsid_21805

30. 1-[(2e,4e)-5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl]piperidine

31. 5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

32. Piperidine, 1-((2e,4e)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-

33. Piperine [usp]

34. Smr000112278

35. Ccris 5572

36. Piperine (aliphatic)

37. 1-piperoylpiperidine, (e,e)-

38. Sr-01000638580

39. Piperidine, 1-piperoyl-

40. Einecs 202-348-0

41. Nsc 21727

42. Unii-u71xl721qk

43. (2e,4e)-5-(1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

44. (2e,4e)-5-(benzo(d)(1,3)dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

45. Cas-94-62-2

46. Piperine,(s)

47. 1-piperylpiperidine

48. Prestwick_398

49. Black Pepper Extract

50. Mfcd00005839

51. 1,3-benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperine

52. 1-piperoyl-piperidine

53. Nsc 242267

54. Piperine, >=97%

55. St079380

56. Starbld0008505

57. Piperidine, (e,e)-

58. Piperine [fhfi]

59. Piperine [inci]

60. Ai3-01439

61. Piperine [mi]

62. Prestwick2_000474

63. Prestwick3_000474

64. Spectrum5_001507

65. Piperine [usp-rs]

66. Piperine [who-dd]

67. 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine, (e,e)-

68. Piperine, >=97%, Fg

69. Schembl94058

70. Schembl94059

71. Bspbio_000608

72. Bspbio_002515

73. Piperine, Analytical Standard

74. Mls002153830

75. Mls002473213

76. Bidd:er0675

77. Spectrum1500873

78. Bpbio1_000670

79. Gtpl2489

80. N-ee-piperoyl-piperidine

81. Dtxsid3021805

82. Piperine (1-piperoylpiperidine)

83. Chebi:93043

84. Fema 2909

85. Hms502p16

86. 2,4-pentadien-1-one, 5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-, (2e,4e)-

87. Hms1569o10

88. Hms1921m12

89. Hms2092m22

90. Hms2096o10

91. Hms2270m18

92. Pharmakon1600-01500873

93. 1-trans,trans-piperinoyl-piperidine

94. Amy40672

95. Bcp18901

96. Hy-n0144

97. Zinc1529772

98. Tox21_201990

99. Tox21_302746

100. 1-(5-(3,4-methylenedioxyphenyl)-1-oxo-2,4-pentadienyl)piperidine

101. 1-piperoyl-(e,e)-piperidine

102. Bbl027541

103. Bdbm50148573

104. Ccg-39991

105. Nsc757803

106. S2344

107. Stl377909

108. (2e,4e)-5-(1,3-benzodioxol-5-yl)-1-(1-piperidyl)penta-2,4-dien-1-one

109. Akos003369047

110. Cs-6155

111. Db12582

112. Nsc-757803

113. Sdccgmls-0066693.p001

114. Idi1_000954

115. (piperidin-1-yl)penta-2,4-dien-1-one

116. Ncgc00094872-01

117. Ncgc00094872-02

118. Ncgc00094872-03

119. Ncgc00094872-04

120. Ncgc00094872-05

121. Ncgc00094872-06

122. Ncgc00094872-09

123. Ncgc00256392-01

124. Ncgc00259539-01

125. Ac-11746

126. As-17442

127. Ls-14576

128. Sbi-0051621.p002

129. Cs-0368434

130. N1674

131. P0460

132. Sw196642-2

133. C03882

134. P-6920

135. Ab00052185_08

136. Ag-205/01792022

137. Q414501

138. (2e,4e)-5-(benzo[d][1,3]dioxol-5-yl)-1-

139. Sr-01000638580-1

140. Sr-01000638580-2

141. Sr-01000638580-5

142. Sr-01000638580-6

143. Brd-k59522102-001-08-8

144. Piperine (constituent Of Black Pepper) [dsc]

145. Q27164772

146. 1,3-benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperidine

147. Piperine, European Pharmacopoeia (ep) Reference Standard

148. 1-[5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl]piperidine

149. 4-(1,3-benzodioxole-5-yl)-1,3-butenylpiperidino Ketone

150. Piperine, United States Pharmacopeia (usp) Reference Standard

151. 5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-1-penta-2,4-dienone

152. Piperidine,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (e,e)-

153. (e,e) 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine

154. (e,e)-1-(5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl)piperidine

155. 1-[(2e,4e)-5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl]piperidine #

156. 147030-08-8

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 285.34 g/mol
Molecular Formula C17H19NO3
XLogP33.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass285.13649347 g/mol
Monoisotopic Mass285.13649347 g/mol
Topological Polar Surface Area38.8 Ų
Heavy Atom Count21
Formal Charge0
Complexity412
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Cytochrome P-450 Enzyme Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 ENZYMES. (See all compounds classified as Cytochrome P-450 Enzyme Inhibitors.)


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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"ISRAEL","foreign_port":"#N\/A","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00012","unit":"KGS","unitRateFc":"11050000","totalValueFC":"1361.5","currency":"USD","unitRateINR":"845182833.3","date":"29-Jan-2022","totalValueINR":"101421.94","totalValueInUsd":"1361.5","indian_port":"HYDERABAD AIR","hs_no":"29398000","bill_no":"7288724","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ISRAEL","selfForZScoreResived":"Pharma Grade","supplierPort":"#N\/A","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1652639400,"product":"PIPERINE (QTY:6X20 MG,PRICE: USD 225\/EACH)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"USP","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00012","unit":"KGS","unitRateFc":"11250000","totalValueFC":"1520.5","currency":"USD","unitRateINR":"979297500","date":"16-May-2022","totalValueINR":"117515.7","totalValueInUsd":"1520.5","indian_port":"HYDERABAD AIR","hs_no":"29397900","bill_no":"8692343","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731695400,"product":"PIPERINE (QTY: 3 X 20MG, VALUE USD: 239\/EACH) (FOC)","address":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"USP","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00006","unit":"KGS","unitRateFc":"11950000","totalValueFC":"879","currency":"USD","unitRateINR":"1236346333","date":"16-Nov-2024","totalValueINR":"74180.78","totalValueInUsd":"879","indian_port":"Hyderabad Air","hs_no":"29397900","bill_no":"6709137","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK,M D 21704 USA Frederick, , United Sta tes United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"}]
12-Apr-2021
16-Nov-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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ABOUT THIS PAGE

Piperine Manufacturers

A Piperine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Piperine, including repackagers and relabelers. The FDA regulates Piperine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Piperine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Piperine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Piperine Suppliers

A Piperine supplier is an individual or a company that provides Piperine active pharmaceutical ingredient (API) or Piperine finished formulations upon request. The Piperine suppliers may include Piperine API manufacturers, exporters, distributors and traders.

click here to find a list of Piperine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Piperine GMP

Piperine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Piperine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Piperine GMP manufacturer or Piperine GMP API supplier for your needs.

Piperine CoA

A Piperine CoA (Certificate of Analysis) is a formal document that attests to Piperine's compliance with Piperine specifications and serves as a tool for batch-level quality control.

Piperine CoA mostly includes findings from lab analyses of a specific batch. For each Piperine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Piperine may be tested according to a variety of international standards, such as European Pharmacopoeia (Piperine EP), Piperine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Piperine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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