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ACTIVE PHARMA INGREDIENTS

40 API Suppliers, 13 USDMF, 7 CEP/COS, 2 JDMF, 6 EU WC, 1 KDMF, 14 NDC API, 27 Listed Suppliers, $ API Reference Price

40 API Suppliers
13 USDMF
7 CEP/COS
2 JDMF
6 EU WC
1 KDMF
14 NDC API
27 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

4 Drugs in Development

4 Drugs in Development

INTERMEDIATES

6 Intermediates Suppliers

6 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

187 FDF Dossiers, 44 FDA Orange Book, 61 Europe, 8 Canada, 6 Australia, 16 South Africa, 52 Listed Dossiers

187 FDF Dossiers
44 FDA Orange Book
61 Europe
8 Canada
6 Australia
16 South Africa
52 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - 10MG, CAPSULE;ORAL - 20MG

drugProductComposition
CAPSULE;ORAL - 10MG
CAPSULE;ORAL - 20MG

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 8 DKSH, 5 Faran Shimi Pharmaceutical, 4 Boai NKY Pharmaceuticals Ltd, 10 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 4 ACG Worldwide, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 15 BASF, 3 DFE Pharma, 1 Finar, 3 Gangwal Chemicals, 3 Ingredion Pharma Solutions, 19 Kerry, 3 Lonza Capsugel, 8 Microlex e.U, 1 Novo Excipients, 2 Pharmatrans-Sanaq, 5 Pluviaendo, 2 Prachin Chemical, 1 Qualicaps, 10 Roquette, 2 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 4 Sigachi Industries, 1 Ulanqab Kema New Material, 1 Valens Pharmachem, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

54 Fillers, Diluents & Binders, 23 Direct Compression, 14 Granulation, 14 Lubricants & Glidants, 14 Co-Processed Excipients, 14 Disintegrants & Superdisintegrants, 12 Coating Systems & Additives, 11 Thickeners and Stabilizers, 10 Solubilizers, 8 Empty Capsules, 8 Controlled & Modified Release, 6 Taste Masking, 5 Film Formers & Plasticizers, 5 Emulsifying Agents, 5 Parenteral, 4 Topical, 3 Coloring Agents, 3 Chewable & Orodispersible Aids, 2 API Stability Enhancers, 1 Surfactant & Foaming Agents

DIGITAL CONTENT

11 NEWS #PharmaBuzz

media
11 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

3 US Medicaid Prescriptions, 63 Finished Drug Prices

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3 US Medicaid Prescriptions
63 Finished Drug Prices

MARKET PLACE

25 APIs, 1 FDF Dossiers

marketPlace
25 APIs
1 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 1 USP , 6 Others

otherSolutions
2 EDQM
1 USP
6 Others

ANALYTICAL

1 BioAnalytical Methods

otherMethods
1 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 54

MARKET PLACE

API

FDF

6INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

187

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

4DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

5,931,883

Annual Reports (USD Million)

Finished Drug Prices

132 RELATED EXCIPIENT COMPANIES

216EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 36322-90-4, Feldene, Piroxicamum, Pyroxycam, Roxicam, Piroftal

Molecular Formula

C₁₅H₁₃N₃O₄S

Molecular Weight

331.3 g/mol

InChI Key

QYSPLQLAKJAUJT-UHFFFAOYSA-N

FDA UNII

13T4O6VMAM

A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.

Piroxicam is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of piroxicam is as a Cyclooxygenase Inhibitor.

1 2D Structure

Piroxicam

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-yl-16,2-benzothiazine-3-carboxamide

2.1.2 InChI

InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)

2.1.3 InChI Key

QYSPLQLAKJAUJT-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3

2.2 Other Identifiers

2.2.1 UNII

13T4O6VMAM

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Cp 16171

2. Cp-16171

3. Cp16171

4. Feldene

2.3.2 Depositor-Supplied Synonyms

1. 36322-90-4

2. Feldene

3. Piroxicamum

4. Pyroxycam

5. Roxicam

6. Piroftal

7. Baxo

8. Cp-16171

9. 2h-1,2-benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-n-2-pyridinyl-, 1,1-dioxide

10. 4-hydroxy-2-methyl-n-(pyridin-2-yl)-2h-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide

11. Cp 16171

12. Chf 1251

13. Nsc 666076

14. Piroxicam (feldene)

15. 4-hydroxy-2-methyl-n-(2-pyridyl)-2h-1,2-benzothiazine-3-carboxamide-1,1-dioxide

16. Nsc-666076

17. 13t4o6vmam

18. 4-hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2h-1,2-benzothiazine 1,1-dioxide

19. 4-hydroxy-2-methyl-n-(2-pyridyl)-2h-1,2-benzothiazin-3-caboxyamid-1,1-dioxid

20. 4-hydroxy-2-methyl-n-2-pyridyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide

21. Cp-16,171

22. Mls000069644

23. Chebi:8249

24. Nsc666076

25. 4-hydroxy-2-methyl-n-pyridin-2-yl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide

26. Ncgc00015823-02

27. Artroxicam

28. Bruxicam

29. Caliment

30. Flogobene

31. Geldene

32. Improntal

33. Larapam

34. Piroflex

35. Reudene

36. Roxiden

37. Sasulen

38. Smr000035997

39. Solocalm

40. Erazon

41. Pirkam

42. Piroxicam Usp

43. Riacen

44. Zunden

45. Roxam

46. Cas-36322-90-4

47. Dsstox_cid_1170

48. 4-hydroxy-2-methyl-1,1-dioxo-n-pyridin-2-yl-1lambda6,2-benzothiazine-3-carboxamide

49. 4-hydroxy-2-methyl-n-2-pyridinyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide

50. Dsstox_rid_75990

51. Dsstox_gsid_21170

52. Piroxicamum [inn-latin]

53. Piroxicam D3 (n-methyl D3)

54. Rosiden

55. Felden

56. Feldene Fast

57. Feldene Gel

58. 4-hydroxy-2-methyl-n-(2-pyridyl)-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide

59. 4-hydroxy-2-methyl-n-2-pyridinyl-2h-1,2-benzothiazine-3-carboxamide-1,1-dioxide

60. (z)-3-(hydroxy(pyridin-2-ylamino)methylene)-2-methyl-2h-benzo[e][1,2]thiazin-4(3h)-one 1,1-dioxide

61. Feldene (tn)

62. Ccris 3719

63. Sr-01000000199

64. Einecs 252-974-3

65. Ak1015

66. Unii-13t4o6vmam

67. Brn 0627692

68. 4-hydroxy-2-methyl-1,1-dioxo-n-pyridin-2-yl-1?^{6},2-benzothiazine-3-carboxamide

69. Piroxicam,(s)

70. Prestwick_573

71. Mfcd00057317

72. 4-hydroxy-2-methyl-n-(2-pyridyl)-2h-1,2-benzothiazin-3-caboxyamid-1,1-dioxid [german]

73. Piroxicam [usan:usp:inn:ban:jan]

74. Piroxicam:malonic Acid

75. Spectrum_001115

76. Tocris-0960

77. Piroxicam-(methyl-d3)

78. Opera_id_442

79. Piroxicam [inn]

80. Piroxicam [jan]

81. Piroxicam: Form Alpha1

82. Piroxicam: Form Alpha2

83. Piroxicam [mi]

84. Piroxicam [usan]

85. Prestwick0_000211

86. Prestwick1_000211

87. Prestwick2_000211

88. Prestwick3_000211

89. Spectrum2_001287

90. Spectrum3_000780

91. Spectrum4_000968

92. Spectrum5_001445

93. Lopac-p-5654

94. Piroxicam [vandf]

95. Piroxicam Anhydrous

96. Chembl527

97. Piroxicam [mart.]

98. P 5654

99. Piroxicam [usp-rs]

100. Piroxicam [who-dd]

101. Bidd:pxr0154

102. Lopac0_000900

103. Oprea1_714707

104. Schembl13462

105. Schembl21350

106. Bspbio_000221

107. Bspbio_001030

108. Bspbio_002460

109. Kbiogr_000370

110. Kbiogr_001315

111. Kbioss_000370

112. Kbioss_001595

113. Mls000038002

114. Mls001148207

115. Mls001304054

116. Mls004774122

117. Divk1c_000369

118. Spectrum1500491

119. Spbio_001293

120. Spbio_002142

121. Piroxicam (jp17/usp/inn)

122. Bpbio1_000245

123. Gtpl7273

124. Piroxicam, >=98% (tlc)

125. Schembl3703617

126. Piroxicam [orange Book]

127. Piroxicam For System Suitability

128. Chembl1518938

129. Dtxsid5021170

130. Piroxicam [ep Monograph]

131. Bcbcmap01_000176

132. Bdbm85245

133. Hms501c11

134. Kbio1_000369

135. Kbio2_000370

136. Kbio2_001595

137. Kbio2_002938

138. Kbio2_004163

139. Kbio2_005506

140. Kbio2_006731

141. Kbio3_000719

142. Kbio3_000720

143. Kbio3_001680

144. Piroxicam [usp Monograph]

145. Ninds_000369

146. Piroxicam 1.0 Mg/ml In Methanol

147. Bio1_000363

148. Bio1_000852

149. Bio1_001341

150. Bio2_000355

151. Bio2_000835

152. Glxc-26155

153. Glxc-26156

154. Hms1362d11

155. Hms1568l03

156. Hms1792d11

157. Hms1920h22

158. Hms1990d11

159. Hms2089b06

160. Hms2092a05

161. Hms2095l03

162. Hms2231g03

163. Hms3262d22

164. Hms3267i03

165. Hms3369b07

166. Hms3403d11

167. Hms3414h17

168. Hms3429l03

169. Hms3655c04

170. Hms3678h15

171. Hms3712l03

172. Hms3884c08

173. Pharmakon1600-01500491

174. Bcp02919

175. Hy-b0253

176. Nsc_4856

177. Tox21_110231

178. Tox21_200151

179. Tox21_500900

180. Ccg-36403

181. Nsc757284

182. S1713

183. Stk177288

184. Zinc12466469

185. Zinc51133897

186. Zinc87724780

187. Akos000714958

188. Akos025312555

189. Akos026749939

190. Tox21_110231_1

191. Am84917

192. Db00554

193. Ks-5322

194. Lp00900

195. Nsc-757284

196. Sdccgsbi-0050875.p005

197. (4-hydroxy-2-methyl-1,1-dioxobenzo[e]1,2-thiazin-3-yl)-n-(2-pyridyl)carboxamid E

198. (4-hydroxy-2-methyl-1,1-dioxobenzo[e]1,2-thiazin-3-yl)-n-(2-pyridyl)carboxamide

199. 2h-1,2-benzothiazine-3-carboxamide,4-hydroxy-2-methyl-n-2-pyridinyl-, 1,1-dioxide

200. 3,4-dihydro-2-methyl-4-oxo-n-2-pyridyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide

201. 4-hydroxy-2-methyl-n-(pyridin-2-yl)-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide

202. Idi1_000369

203. Idi1_002110

204. Ncgc00015823-01

205. Ncgc00015823-03

206. Ncgc00015823-04

207. Ncgc00015823-05

208. Ncgc00015823-06

209. Ncgc00015823-07

210. Ncgc00015823-08

211. Ncgc00015823-09

212. Ncgc00015823-10

213. Ncgc00015823-11

214. Ncgc00015823-12

215. Ncgc00015823-13

216. Ncgc00015823-14

217. Ncgc00015823-15

218. Ncgc00015823-17

219. Ncgc00015823-18

220. Ncgc00015823-20

221. Ncgc00015823-29

222. Ncgc00021244-03

223. Ncgc00021244-05

224. Ncgc00021244-06

225. Ncgc00021244-07

226. Ncgc00021244-08

227. Ncgc00021244-09

228. Ncgc00188982-01

229. Ncgc00257705-01

230. Ncgc00261585-01

231. Piroxicam 100 Microg/ml In Acetonitrile

232. 1488516-58-0

233. Ac-24190

234. Nci60_022912

235. Bcp0726000299

236. Sbi-0050875.p004

237. Cas_36322-90-4

238. Piroxicam, Meets Usp Testing Specifications

239. Eu-0100900

240. Ft-0630590

241. Ft-0673949

242. P1905

243. Sw219862-1

244. En300-70724

245. A19556

246. C01608

247. D00127

248. D70554

249. Ab00052074-21

250. Ab00052074-22

251. Ab00052074_23

252. Ab00052074_24

253. 322p904

254. Q408676

255. Sr-01000000199-3

256. Sr-01000000199-5

257. Sr-01000000199-9

258. W-106626

259. Sr-01000000199-12

260. F0001-2399

261. Piroxicam, British Pharmacopoeia (bp) Reference Standard

262. Z1259192069

263. Piroxicam, European Pharmacopoeia (ep) Reference Standard

264. Piroxicam, United States Pharmacopeia (usp) Reference Standard

265. Piroxicam, Pharmaceutical Secondary Standard; Certified Reference Material

266. 4-hydroxy-2-methyl-1,1-dioxo-n-(2-pyridyl)-1$l^{6},2-benzothiazine-3-carboxamide

267. 4-hydroxy-2-methyl-1,1-dioxo-n-(pyridin-2-yl)-2h-1$l^{6},2-benzothiazine-3-carboxamide

268. 4-hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-2h-1,2-benzothiazine 1,1-dioxide

269. 4-hydroxy-2-methyl-n-(2-pyridyl)-2h-1,2-benzo-thiazine-3-carboxamide1,1-dioxide

270. 4-hydroxy-2-methyl-n-(pyridin-2-yl)-2h-benzo[e][1,2]thiazine-3-carboxamide1,1-dioxide

271. 4-hydroxy-2-methyl-n-2-pyridinyl-2h-1,2-benzothiazine-3-carboxamide1,1-dioxide

272. N-(2-pyridyl)-4-hydroxy-2-methyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide

273. 1044566-76-8

274. 3-{hydroxy[(pyridin-2-yl)amino]methylidene}-2-methyl-3,4-dihydro-2h-1$l^{6},2-benzothiazine-1,1,4-trione

275. 3-{hydroxy[(pyridin-2-yl)amino]methylidene}-2-methyl-3,4-dihydro-2h-1lambda6,2-benzothiazine-1,1,4-trione

276. 4-hydroxy-2-methyl-1,1-dioxo-n-(2-pyridyl)-1,2-dihydro-1lambda,2-benzothiazine-3-carboxamide

277. 4-hydroxy-2-methyl-n-(2-pyridyl)-2h-1,2-benzothiazine -3-carboxamide-1,1-dioxide Malonic Acid

2.4 Create Date

2011-12-26

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₁₃N₃O₄S
Molecular Weight	331.3 g/mol
XLogP3	3.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	331.06267708 g/mol
Monoisotopic Mass	331.06267708 g/mol
Topological Polar Surface Area	108 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	611
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Akten
PubMed Health	Lidocaine (Into the eye)
Drug Classes	Anesthetic, Local
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Gel
Route	Ophthalmic
Strength	3.5%
Market Status	Prescription
Company	Akorn

2 of 6
Drug Name	Feldene
PubMed Health	Piroxicam (By mouth)
Drug Classes	Analgesic, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent
Drug Label	FELDENEcontains piroxicam which is a member of the oxicam group of nonsteroidal anti-inflammatory drugs (NSAIDs). Each maroon and blue capsule contains 10 mg piroxicam, each maroon capsule contains 20 mg piroxicam for oral administration. The chemica...
Active Ingredient	Piroxicam
Dosage Form	Capsule
Route	Oral
Strength	10mg; 20mg
Market Status	Prescription
Company	Pfizer

3 of 6
Drug Name	Piroxicam
PubMed Health	Piroxicam (By mouth)
Drug Classes	Analgesic, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent
Drug Label	Piroxicam capsules USP contain piroxicam which is a member of the oxicam group of non-steroidal anti-inflammatory drugs (NSAIDs). Each dark green and olive capsule contains 10 mg piroxicam, each dark green capsule contains 20 mg piroxicam for oral ad...
Active Ingredient	Piroxicam
Dosage Form	Capsule
Route	Oral
Strength	10mg; 20mg
Market Status	Prescription
Company	Teva; Nostrum Labs; Mutual Pharm; Mylan

4 of 6
Drug Name	Akten
PubMed Health	Lidocaine (Into the eye)
Drug Classes	Anesthetic, Local
Active Ingredient	Lidocaine hydrochloride
Dosage Form	Gel
Route	Ophthalmic
Strength	3.5%
Market Status	Prescription
Company	Akorn

5 of 6
Drug Name	Feldene
PubMed Health	Piroxicam (By mouth)
Drug Classes	Analgesic, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent
Drug Label	FELDENEcontains piroxicam which is a member of the oxicam group of nonsteroidal anti-inflammatory drugs (NSAIDs). Each maroon and blue capsule contains 10 mg piroxicam, each maroon capsule contains 20 mg piroxicam for oral administration. The chemica...
Active Ingredient	Piroxicam
Dosage Form	Capsule
Route	Oral
Strength	10mg; 20mg
Market Status	Prescription
Company	Pfizer

6 of 6
Drug Name	Piroxicam
PubMed Health	Piroxicam (By mouth)
Drug Classes	Analgesic, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent
Drug Label	Piroxicam capsules USP contain piroxicam which is a member of the oxicam group of non-steroidal anti-inflammatory drugs (NSAIDs). Each dark green and olive capsule contains 10 mg piroxicam, each dark green capsule contains 20 mg piroxicam for oral ad...
Active Ingredient	Piroxicam
Dosage Form	Capsule
Route	Oral
Strength	10mg; 20mg
Market Status	Prescription
Company	Teva; Nostrum Labs; Mutual Pharm; Mylan

4.2 Drug Indication

For treatment of osteoarthritis and rheumatoid arthritis.

FDA Label

5 Pharmacology and Biochemistry

5.1 Pharmacology

Piroxicam is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Piroxicam works by reducing hormones that cause inflammation and pain in the body. Piroxicam is used to reduce the pain, inflammation, and stiffness caused by rheumatoid arthritis and osteoarthritis.

5.2 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

Cyclooxygenase Inhibitors

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

PIROXICAM

5.3.2 FDA UNII

13T4O6VMAM

5.3.3 Pharmacological Classes

Cyclooxygenase Inhibitors [MoA]; Nonsteroidal Anti-inflammatory Drug [EPC]; Anti-Inflammatory Agents, Non-Steroidal [CS]

5.4 ATC Code

M01AC01

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

M - Musculo-skeletal system

M01 - Antiinflammatory and antirheumatic products

M01A - Antiinflammatory and antirheumatic products, non-steroids

M01AC - Oxicams

M01AC01 - Piroxicam

M - Musculo-skeletal system

M02 - Topical products for joint and muscular pain

M02A - Topical products for joint and muscular pain

M02AA - Antiinflammatory preparations, non-steroids for topical use

M02AA07 - Piroxicam

S - Sensory organs

S01 - Ophthalmologicals

S01B - Antiinflammatory agents

S01BC - Antiinflammatory agents, non-steroids

S01BC06 - Piroxicam

5.5 Absorption, Distribution and Excretion

Absorption

Well absorbed following oral administration.

Route of Elimination

Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a piroxicam dose is excreted unchanged. However, a substantial portion of piroxicam elimination occurs by hepatic metabolism. Piroxicam is excreted into human milk.

Volume of Distribution

0.14 L/kg

5.6 Metabolism/Metabolites

Renal

Piroxicam has known human metabolites that include 5'-Hydroxypiroxicam.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

5.7 Biological Half-Life

30 to 86 hours

5.8 Mechanism of Action

The antiinflammatory effect of Piroxicam may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. The prostaglandins are produced by an enzyme called Cox-1. Piroxicam blocks the Cox-1 enzyme, resulting into the disruption of production of prostaglandins. Piroxicam also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.

API SUPPLIERS

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

USDMF

01

Dipharma Francis Srl

Italy

Medlab Asia & Asia Health

Not Confirmed

02

Esteve Quimica Sa

Spain

Medlab Asia & Asia Health

Not Confirmed

03

Fabbrica Italiana Sintetici Spa

Italy

Medlab Asia & Asia Health

Not Confirmed

04

Krka Pharmaceutical And Chemical Wor...

Slovenia

Medlab Asia & Asia Health

Not Confirmed

05

Wockhardt Ltd

India

Medlab Asia & Asia Health

Not Confirmed

06

Sibefat Spa

Country

Medlab Asia & Asia Health

Not Confirmed

07

Sumika Fine Chemicals Co Ltd

Country

Medlab Asia & Asia Health

Not Confirmed

08

Nantong Pharmaceutical Factory

Country

Medlab Asia & Asia Health

Not Confirmed

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CEP/COS

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JDMF

01

Watson Pharma Private Limited

Ireland

Medlab Asia & Asia Health

Not Confirmed

02

Arch Pharmalabs Limited

India

Medlab Asia & Asia Health

Not Confirmed

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EU WC

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIROXICAM","year":"2021","qtr":"Q1","strtotime":1611858600,"product":"PIROXICAM BP. - ( PHARMACEUTICAL INGREDI ENT OF INDIAN ORIGIN )","address":"13,VITHALDAS ROAD,BULAKHIDAS BLDG.,GROUND FLOOR,","city":"MUMBAI,MAHARASHTRA","supplier":"MEDI PHARMA DRUG ","supplierCountry":"INDIA","foreign_port":"KARACHI","customer":"J S BANK ","customerCountry":"PAKISTAN","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"47.5","totalValueFC":"1202.2","currency":"USD","unitRateINR":3517.0219999999999,"date":"29-Jan-2021","totalValueINR":"87925.55","totalValueInUsd":"1202.2","indian_port":"JNPT","hs_no":"29343000","bill_no":"8261464","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"13,VITHALDAS ROAD,BULAKHIDAS BLDG.,GROUND FLOOR,, MUMBAI,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIROXICAM","year":"2021","qtr":"Q1","strtotime":1612290600,"product":"PIROXICAM USP (MFG TAX INV NO.: 723\/20-2 1 DT.: 30.01.2021)","address":"S.S.ACCORD, 3RD FLOOR, OFFICE NO.304, 225,227, SAMUEL STREET","city":"MASJID (W), MUMBAI, M.S.","supplier":"GRADIENT EXPORTS","supplierCountry":"INDIA","foreign_port":"VIRU VIRU BOLIVIA","customer":"MERQUIMIA BOLIVIA S.R.L.","customerCountry":"BOLIVIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"67.6","totalValueFC":"6684.5","currency":"USD","unitRateINR":4866.75,"date":"03-Feb-2021","totalValueINR":"486675","totalValueInUsd":"6684.5","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"8380634","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BOLIVIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"S.S.ACCORD, 3RD FLOOR, OFFICE NO.304, 225,227, SAMUEL STREET, MASJID (W), MUMBAI, M.S.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIROXICAM","year":"2021","qtr":"Q1","strtotime":1614018600,"product":"(BULK DRUGS) PIROXICAM USP ?WE INTEND T O CLAIM BENEFIT UNDER RODTEP SCHEME? 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MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIROXICAM","year":"2021","qtr":"Q1","strtotime":1614191400,"product":"BULK DRUG : PIROXICAM USP (MICRONIZED) ( MFG TAX INV NO.: 791\/20-21 DT.: 23.02.20 21)","address":"A-201\/202, NAVBHARAT EST.,ZAKARIA BUNDER RD.,SEWRI(W),","city":"MUMBAI ,MAHARASHTRA","supplier":"GEMINI EXPORTS","supplierCountry":"INDIA","foreign_port":"GUARULHOS","customer":"UNIAO QUIMICA FARMACEUTICA NACIONAL","customerCountry":"BRAZIL","quantity":"300.00","actualQuantity":"300","unit":"KGS","unitRateFc":"82.9","totalValueFC":"24624.1","currency":"USD","unitRateINR":5976,"date":"25-Feb-2021","totalValueINR":"1792800","totalValueInUsd":"24624.1","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"8917813","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BRAZIL","selfForZScoreResived":"Micronized","supplierPort":"BOMBAY AIR","supplierAddress":"A-201\/202, NAVBHARAT EST.,ZAKARIA BUNDER RD.,SEWRI(W),, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIROXICAM","year":"2021","qtr":"Q1","strtotime":1614364200,"product":"PIROXICAM USP (DETAIL AS PER INVOICE)","address":"PLOT NO 4710 GIDC ESTATEANKLESHWAR","city":"BHARUCH","supplier":"APEX HEALTHCARE LIMITED","supplierCountry":"INDIA","foreign_port":"JAKARTA","customer":"TO THE ORDER OF,","customerCountry":"INDONESIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"46.7","totalValueFC":"92365.1","currency":"USD","unitRateINR":3362.4000000000001,"date":"27-Feb-2021","totalValueINR":"6724800","totalValueInUsd":"92365.1","indian_port":"JNPT","hs_no":"29420090","bill_no":"8970605","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"PLOT NO 4710 GIDC ESTATEANKLESHWAR, BHARUCH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIROXICAM","year":"2021","qtr":"Q1","strtotime":1614537000,"product":"OTHER ORGANIC COMPOUNDS - 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","customerCountry":"EGYPT","quantity":"7.00","actualQuantity":"7","unit":"KGS","unitRateFc":"188","totalValueFC":"1302.6","currency":"USD","unitRateINR":13547.224285714286,"date":"12-Mar-2021","totalValueINR":"94830.57","totalValueInUsd":"1302.6","indian_port":"BOMBAY AIR","hs_no":"29420090","bill_no":"9300204","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"EGYPT","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"A-201\/202, NAVBHARAT EST.,ZAKARIA BUNDER RD.,SEWRI(W),, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIROXICAM","year":"2021","qtr":"Q1","strtotime":1615487400,"product":"PHARMACEUTICAL RAW MATERIAL : PIROXICAM USP (TAX INV NO.643\/20-21 DT.29.12.2020 ) GST NO.24AAGCA2182A1ZB","address":"PLOT NO. 7314\/8, M\/S KOHINOOR METAL GIDC ESTATE","city":"ANKLESHWAR , DIST BHARUCH, GUJARAT","supplier":"SKJ PHARMACHEM","supplierCountry":"INDIA","foreign_port":"BEIRUT","customer":"TO THE ORDER OF","customerCountry":"LEBANON","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"144.8","totalValueFC":"143.3","currency":"USD","unitRateINR":10435.200000000001,"date":"12-Mar-2021","totalValueINR":"10435.2","totalValueInUsd":"143.3","indian_port":"AHMEDABAD AIR","hs_no":"29420090","bill_no":"9298601","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"LEBANON","selfForZScoreResived":"Pharma Grade","supplierPort":"AHMEDABAD AIR","supplierAddress":"PLOT NO. 7314\/8, M\/S KOHINOOR METAL GIDC ESTATE, ANKLESHWAR , DIST BHARUCH, GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIROXICAM","year":"2021","qtr":"Q1","strtotime":1616437800,"product":"PIROXICAM USP MFG INV NO 114\/20-21 DT 08 .03.2021","address":"FF\/10, NARSINGHDHAM COMPLEXSANGAM CHAR RASTA,HARNI ROAD","city":"VADODARA,GUJARAT","supplier":"SHREEJI PHARMA INTERNATIONAL","supplierCountry":"INDIA","foreign_port":"RIO HAINA","customer":"NAME OF CONSIGNEE","customerCountry":"DOMINICAN REPUBLIC","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"67.8","totalValueFC":"335.3","currency":"USD","unitRateINR":4881.8140000000003,"date":"23-Mar-2021","totalValueINR":"24409.07","totalValueInUsd":"335.3","indian_port":"JNPT","hs_no":"29343000","bill_no":"9588170","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"DOMINICAN REPULIC","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"FF\/10, NARSINGHDHAM COMPLEXSANGAM CHAR RASTA,HARNI ROAD, VADODARA,GUJARAT","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIROXICAM","year":"2021","qtr":"Q1","strtotime":1616783400,"product":"(BULK DRUGS) PIROXICAM USP ?WE INTEND TO CLAIM BENEFIT UNDER RODTEP SCHEME? 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1637692200,"product":"PIROXICAM RELATED COMPOUND A (QTY: 1 X 1 GMS ,PRICE: USD 32.91)(FOC)","address":"P.NO. 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1637692200,"product":"PIROXICAM RELATED COMPOUND A (QTY: 11 X 50 MG ,PRICE: USD 752\/EACH)(FOC)","address":"P.NO. 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1637692200,"product":"PIROXICAM RELATED COMPOUND A (QTY: 3 X 0.05 GMS ,PRICE: USD 10.25\/EACH)(FOC)","address":"P.NO. 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1637692200,"product":"PIROXICAM RELATED COMPOUND J (QTY: 2 X 50 MG ,PRICE: USD 752\/EACH)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0001","unit":"KGS","unitRateFc":"15040000","totalValueFC":"1552.2","currency":"USD","unitRateINR":"1155912800","date":"24-Nov-2021","totalValueINR":"115591.28","totalValueInUsd":"1552.2","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"6391107","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1662057000,"product":"PIROXICAM USP(REIMPORT FOR REJECTED GOODS)","address":"A-201\/202, NAVBHARAT EST.,,ZAKARIA BUNDER RD.,SEWRI WEST,","city":"MUMBAI,MAHARASHTRA","supplier":"TRUST - IMPORTACAO E EXPORTACAO EIRELI","supplierCountry":"INDIA","foreign_port":"NA","customer":"GEMINI EXPORTS","customerCountry":"INDIA","quantity":"366.42","actualQuantity":"366.416","unit":"KGS","unitRateFc":"62.9","totalValueFC":"23699.1","currency":"USD","unitRateINR":"5183.4","date":"02-Sep-2022","totalValueINR":"1899272.52","totalValueInUsd":"23699.1","indian_port":"JNPT","hs_no":"29420090","bill_no":"2274769","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"A-201\/202, NAVBHARAT EST.,,ZAKARIA BUNDER RD.,SEWRI WEST,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1666981800,"product":"PIROXICAM RELATED COMPOUND B(QTY:1 X 0.05 GMS, PRICE USD:24.94\/EACH)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00005","unit":"KGS","unitRateFc":"498800","totalValueFC":"26","currency":"USD","unitRateINR":"42823400","date":"29-Oct-2022","totalValueINR":"2141.17","totalValueInUsd":"26","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"3077939","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1666981800,"product":"PIROXICAM RELATED COMPOUND B(QTY:1 X 0.1 GMS, PRICE USD:37.18\/EACH)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0001","unit":"KGS","unitRateFc":"371800","totalValueFC":"38.8","currency":"USD","unitRateINR":"31920000","date":"29-Oct-2022","totalValueINR":"3192","totalValueInUsd":"38.8","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"3077939","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1666981800,"product":"PIROXICAM RELATED COMPOUND B(QTY:2 X 0.2 GMS, PRICE USD:61.66\/EACH)(FOC)","address":"P.NO. 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1677090600,"product":"PIROXICAM MICRONIZED 2212346 -500700","address":"201, DEVAVRATA, SECTOR 17,,VASHI, NAVI MUMBAI,","city":"NAVI MUMBAI,MAHARASHTRA","supplier":"DIPHARMA","supplierCountry":"ITALY","foreign_port":"NA","customer":"STRIDES PHARMA SCIENCE","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"450","totalValueFC":"52025.7","currency":"EUR","unitRateINR":"42968","date":"23-Feb-2023","totalValueINR":"4296802.5","totalValueInUsd":"52025.7","indian_port":"BANGALORE AIR","hs_no":"29349990","bill_no":"4773959","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"201, DEVAVRATA, SECTOR 17,,VASHI, NAVI MUMBAI,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - CAPSULE;ORAL - 10MG

USFDA APPLICATION NUMBER - 18147

DOSAGE - CAPSULE;ORAL - 20MG

USFDA APPLICATION NUMBER - 18147

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

40 API Suppliers

13 USDMF

7 CEP/COS

2 JDMF

6 EU WC

1 KDMF

14 NDC API

27 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

4 Drugs in Development

INTERMEDIATES

6 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

187 FDF Dossiers

44 FDA Orange Book

61 Europe

8 Canada

6 Australia

16 South Africa

52 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - 10MG

CAPSULE;ORAL - 20MG

RELATED EXCIPIENT COMPANIES

4 SPI Pharma

8 DKSH

5 Faran Shimi Pharmaceutical

4 Boai NKY Pharmaceuticals Ltd

10 Gangwal Healthcare

3 Nanjing Well Pharmaceutical

4 ACG Worldwide

4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

15 BASF

3 DFE Pharma

1 Finar

3 Gangwal Chemicals

3 Ingredion Pharma Solutions

19 Kerry

3 Lonza Capsugel

8 Microlex e.U

1 Novo Excipients

2 Pharmatrans-Sanaq

5 Pluviaendo

2 Prachin Chemical

1 Qualicaps

10 Roquette

2 Seppic

3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shanghai Welltone Material Technology Co., Ltd

4 Sigachi Industries

1 Ulanqab Kema New Material

1 Valens Pharmachem

2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

54 Fillers, Diluents & Binders

23 Direct Compression

14 Granulation

14 Lubricants & Glidants

14 Co-Processed Excipients

14 Disintegrants & Superdisintegrants

12 Coating Systems & Additives

11 Thickeners and Stabilizers

10 Solubilizers

8 Empty Capsules

8 Controlled & Modified Release

6 Taste Masking

5 Film Formers & Plasticizers

5 Emulsifying Agents

5 Parenteral

4 Topical

3 Coloring Agents

3 Chewable & Orodispersible Aids

2 API Stability Enhancers