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    Chemistry

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    Also known as: Pitavastatin calcium, 147526-32-7, Livalo, Nisvastatin, Nk-104, Itavastatin calcium
    Molecular Formula
    C50H46CaF2N2O8
    Molecular Weight
    881.0  g/mol
    InChI Key
    RHGYHLPFVJEAOC-FFNUKLMVSA-L
    FDA UNII
    IYD54XEG3W
    Pitavastatin
    Pitavastatin Calcium is a calcium salt formulation of pitavastatin, a novel statin that induces plaque regression and elevates HDL-cholesterol levels.
    1 2D Structure

    Pitavastatin

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    calcium;(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate
    2.1.2 InChI
    InChI=1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;/t2*18-,19-;/m11./s1
    2.1.3 InChI Key
    RHGYHLPFVJEAOC-FFNUKLMVSA-L
    2.1.4 Canonical SMILES
    C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]
    2.1.5 Isomeric SMILES
    C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.[Ca+2]
    2.2 Other Identifiers
    2.2.1 UNII
    IYD54XEG3W
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (e,3r,5s)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic Acid

    2. Itavastatin

    3. Itavastatin Calcium

    4. Nisvastatin

    5. Nk 104

    6. Nk-104

    7. P 872441

    8. P-872441

    9. Pitavastatin

    10. Pitavastatin Calcium

    11. Pitavastatin Lactone

    2.3.2 Depositor-Supplied Synonyms

    1. Pitavastatin Calcium

    2. 147526-32-7

    3. Livalo

    4. Nisvastatin

    5. Nk-104

    6. Itavastatin Calcium

    7. Pitavastatin Calcium Salt

    8. Calcium (3r,5s,e)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

    9. Nk 104

    10. Iyd54xeg3w

    11. Chebi:71258

    12. Calcium;(e,3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate

    13. P-872441

    14. Pitavastatin Calcium (jan)

    15. Pitavastatin Calcium [jan]

    16. Alipza

    17. Flovas

    18. Livazo

    19. Unii-iyd54xeg3w

    20. Nk 104 (acid)

    21. Redevant

    22. Ccris 8652

    23. Livalo (tn)

    24. Schembl22720

    25. Bis((3r,5s,6e)-7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoate), Monocalcium Salt

    26. Chembl1237061

    27. Dtxsid4046448

    28. Chebi:94569

    29. Pitavastatin Hemicalcium;nk-104

    30. Nks-104

    31. Act02718

    32. Mfcd01937979

    33. Pitavastatin Calcium [mart.]

    34. Pitavastatin Calcium [who-dd]

    35. Akos015900407

    36. Pitavastatin Calcium Salt [mi]

    37. Am84441

    38. Ks-1220

    39. (+)-monocalciumbis{(3r,5s,6e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-hepten

    40. 111ge002

    41. 6-heptenoic Acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, Calcium Salt (2:1), (s-(r*,s*-(e)))-

    42. Pitavastatin Calcium [orange Book]

    43. D01862

    44. Q-201590

    45. Q27139472

    46. (+)-monocalciumbis[(3r,5s,6e)-7-[2-cyclopropyl-4(4-fluorophenyl)-3-quinolyl]3,5-dihydroxy-6-hepteno Ate]

    47. (3r,5s,6e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid Hemicalcium Salt

    48. Bis((3r,5s,6e)-7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoate) Monocalcium Salt

    49. Calcium (3r,5s,e)-7-(2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

    50. Calcium Bis{(3r,5s,6e)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate}

    2.4 Create Date
    2005-10-11
    3 Chemical and Physical Properties
    Molecular Weight 881.0 g/mol
    Molecular Formula C50H46CaF2N2O8
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count14
    Exact Mass880.2848136 g/mol
    Monoisotopic Mass880.2848136 g/mol
    Topological Polar Surface Area187 Ų
    Heavy Atom Count63
    Formal Charge0
    Complexity626
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count2
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameLivalo
    PubMed HealthPitavastatin (By mouth)
    Drug ClassesAntihyperlipidemic
    Active IngredientPitavastatin calcium
    Dosage FormTablet
    RouteOral
    Strengtheq 4mg base; eq 2mg base; eq 1mg base
    Market StatusPrescription
    CompanyKowa

    2 of 2  
    Drug NameLivalo
    PubMed HealthPitavastatin (By mouth)
    Drug ClassesAntihyperlipidemic
    Active IngredientPitavastatin calcium
    Dosage FormTablet
    RouteOral
    Strengtheq 4mg base; eq 2mg base; eq 1mg base
    Market StatusPrescription
    CompanyKowa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Hydroxymethylglutaryl-CoA Reductase Inhibitors

    Compounds that inhibit HYDROXYMETHYLGLUTARYL COA REDUCTASES. They have been shown to directly lower CHOLESTEROL synthesis. (See all compounds classified as Hydroxymethylglutaryl-CoA Reductase Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]; HMG-CoA Reductase Inhibitor [EPC]

    API Reference Price

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    30-Jan-2021
    19-Nov-2024
    KGS
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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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