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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

43 API Suppliers, 16 USDMF, 21 JDMF, 7 EU WC, 19 KDMF, 7 NDC API, 15 Listed Suppliers, $ API Reference Price

43 API Suppliers
16 USDMF
21 JDMF
7 EU WC
19 KDMF
7 NDC API
15 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

95 FDF Dossiers, 30 FDA Orange Book, 50 Europe, 15 Listed Dossiers

95 FDF Dossiers
30 FDA Orange Book
50 Europe
15 Listed Dossiers

RELATED EXCIPIENT COMPANIES

3 DKSH, 4 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 1 Actylis, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 10 Corel Pharma Chem, 2 DFE Pharma, 5 Gangwal Chemicals, 4 Ideal Cures Pvt Ltd, 26 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 8 Microlex e.U, 1 Novo Excipients, 2 Pluviaendo, 1 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 2 Roquette, 6 Seppic, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 3 Sigachi Industries, 2 The Dow Chemical Company, 1 Vasa Pharmachem, 1 Vertellus

EXCIPIENTS BY APPLICATIONS

43 Coating Systems & Additives, 31 Fillers, Diluents & Binders, 18 Controlled & Modified Release, 10 Direct Compression, 10 Lubricants & Glidants, 9 Film Formers & Plasticizers, 6 Granulation, 5 Emulsifying Agents, 5 Co-Processed Excipients, 5 Empty Capsules, 4 Coloring Agents, 4 Vegetarian Capsules, 4 API Stability Enhancers, 3 Taste Masking, 3 Solubilizers, 3 Thickeners and Stabilizers, 2 Disintegrants & Superdisintegrants, 2 Surfactant & Foaming Agents, 1 Topical, 1 Rheology Modifiers, 1 Chewable & Orodispersible Aids, 1 Parenteral

DIGITAL CONTENT

19 NEWS #PharmaBuzz

media
19 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 47 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
47 Finished Drug Prices

MARKET PLACE

17 APIs, 1 FDF Dossiers

marketPlace
17 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

12 US Patents, 3 US Exclusivities

patents
12 US Patents
3 US Exclusivities

REF. STANDARDS & IMPURITIES

3 JP , 10 Others

otherSolutions
3 JP
10 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 10,420

MARKET PLACE

API

FDF

1INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

206,857,254

Annual Reports (USD Million)

Finished Drug Prices

102 RELATED EXCIPIENT COMPANIES

171EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Pitavastatin calcium, 147526-32-7, Livalo, Nisvastatin, Nk-104, Itavastatin calcium

Molecular Formula

C₅₀H₄₆CaF₂N₂O₈

Molecular Weight

881.0 g/mol

InChI Key

RHGYHLPFVJEAOC-FFNUKLMVSA-L

FDA UNII

IYD54XEG3W

Pitavastatin Calcium is a calcium salt formulation of pitavastatin, a novel statin that induces plaque regression and elevates HDL-cholesterol levels.

1 2D Structure

Pitavastatin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

calcium;(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate

2.1.2 InChI

InChI=1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;/t2*18-,19-;/m11./s1

2.1.3 InChI Key

RHGYHLPFVJEAOC-FFNUKLMVSA-L

2.1.4 Canonical SMILES

C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]

2.1.5 Isomeric SMILES

C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.[Ca+2]

2.2 Other Identifiers

2.2.1 UNII

IYD54XEG3W

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (e,3r,5s)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic Acid

2. Itavastatin

3. Itavastatin Calcium

4. Nisvastatin

5. Nk 104

6. Nk-104

7. P 872441

8. P-872441

9. Pitavastatin

10. Pitavastatin Calcium

11. Pitavastatin Lactone

2.3.2 Depositor-Supplied Synonyms

1. Pitavastatin Calcium

2. 147526-32-7

3. Livalo

4. Nisvastatin

5. Nk-104

6. Itavastatin Calcium

7. Pitavastatin Calcium Salt

8. Calcium (3r,5s,e)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

9. Nk 104

10. Iyd54xeg3w

11. Chebi:71258

12. Calcium;(e,3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate

13. P-872441

14. Pitavastatin Calcium (jan)

15. Pitavastatin Calcium [jan]

16. Alipza

17. Flovas

18. Livazo

19. Unii-iyd54xeg3w

20. Nk 104 (acid)

21. Redevant

22. Ccris 8652

23. Livalo (tn)

24. Schembl22720

25. Bis((3r,5s,6e)-7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoate), Monocalcium Salt

26. Chembl1237061

27. Dtxsid4046448

28. Chebi:94569

29. Pitavastatin Hemicalcium;nk-104

30. Nks-104

31. Act02718

32. Mfcd01937979

33. Pitavastatin Calcium [mart.]

34. Pitavastatin Calcium [who-dd]

35. Akos015900407

36. Pitavastatin Calcium Salt [mi]

37. Am84441

38. Ks-1220

39. (+)-monocalciumbis{(3r,5s,6e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-hepten

40. 111ge002

41. 6-heptenoic Acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, Calcium Salt (2:1), (s-(r*,s*-(e)))-

42. Pitavastatin Calcium [orange Book]

43. D01862

44. Q-201590

45. Q27139472

46. (+)-monocalciumbis[(3r,5s,6e)-7-[2-cyclopropyl-4(4-fluorophenyl)-3-quinolyl]3,5-dihydroxy-6-hepteno Ate]

47. (3r,5s,6e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid Hemicalcium Salt

48. Bis((3r,5s,6e)-7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoate) Monocalcium Salt

49. Calcium (3r,5s,e)-7-(2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

50. Calcium Bis{(3r,5s,6e)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate}

2.4 Create Date

2005-10-11

3 Chemical and Physical Properties

Molecular Formula	C₅₀H₄₆CaF₂N₂O₈
Molecular Weight	881.0 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	14
Exact Mass	880.2848136 g/mol
Monoisotopic Mass	880.2848136 g/mol
Topological Polar Surface Area	187 Å²
Heavy Atom Count	63
Formal Charge	0
Complexity	626
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Livalo
PubMed Health	Pitavastatin (By mouth)
Drug Classes	Antihyperlipidemic
Active Ingredient	Pitavastatin calcium
Dosage Form	Tablet
Route	Oral
Strength	eq 4mg base; eq 2mg base; eq 1mg base
Market Status	Prescription
Company	Kowa

2 of 2
Drug Name	Livalo
PubMed Health	Pitavastatin (By mouth)
Drug Classes	Antihyperlipidemic
Active Ingredient	Pitavastatin calcium
Dosage Form	Tablet
Route	Oral
Strength	eq 4mg base; eq 2mg base; eq 1mg base
Market Status	Prescription
Company	Kowa

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Compounds that inhibit HYDROXYMETHYLGLUTARYL COA REDUCTASES. They have been shown to directly lower CHOLESTEROL synthesis. (See all compounds classified as Hydroxymethylglutaryl-CoA Reductase Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]; HMG-CoA Reductase Inhibitor [EPC]

API SUPPLIERS

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USDMF

01

Apitoria Pharma Private Ltd

India

SupplySide West 2024

Not Confirmed

02

Hetero Drugs Ltd

India

SupplySide West 2024

Not Confirmed

03

Kowa Co Ltd

India

SupplySide West 2024

Not Confirmed

Not Confirmed

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JDMF

01

Ace Japan Co., Ltd.

Japan

India

SupplySide West 2024

Not Confirmed

Only 10 entries up to this point, click to access all

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EU WC

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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2 The Dow Chemical Company

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