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    LGM Polidocanol

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    Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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    With Fermion, start the journey of your innovative API.

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    Chemistry

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    Also known as: Dodecylheptaglycol, 3055-97-8, 3,6,9,12,15,18,21-heptaoxatritriacontan-1-ol, Laureth-7, Heptaethyleneglycolmonododecylether, 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
    Molecular Formula
    C26H54O8
    Molecular Weight
    494.7  g/mol
    InChI Key
    DWHIUNMOTRUVPG-UHFFFAOYSA-N
    Polidocanol
    An alkyl polyglycol ether of LAURYL ALCOHOL, chemically defined as an alcohol ethoxylate having an average alkyl chain of 12??14 carbon atoms, and an ethylene oxide chain of 9 ethylene oxide units. It is used as a detergent, and medically as a local anesthetic, and as a sclerosing agent for the treatment of ESOPHAGEAL AND GASTRIC VARICES and VARICOSE VEINS.
    1 2D Structure

    Polidocanol

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
    2.1.2 InChI
    InChI=1S/C26H54O8/c1-2-3-4-5-6-7-8-9-10-11-13-28-15-17-30-19-21-32-23-25-34-26-24-33-22-20-31-18-16-29-14-12-27/h27H,2-26H2,1H3
    2.1.3 InChI Key
    DWHIUNMOTRUVPG-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Aethoxysclerol

    2. Aethoxysklerol

    3. Aetoxisclerol

    4. Alpha-dodecyl-omega-hydroxypoly(oxy-1,2ethanediyl)

    5. Atossisclerol

    6. Atoxysclerol

    7. Brij 30

    8. Brij-30

    9. Brij30

    10. Dodecyl Ethyleneglycol Monoether

    11. Dodecyl Ethyleneglycol Monoethers

    12. Ether, Nonaethyleneglycol Monododecyl

    13. Ether, Polyethylene Glycol-7-lauryl

    14. Ether, Polyoxyethylene 9-lauryl

    15. Ether, Polyoxyethylene Lauryl

    16. Ether, Polyoxyethylene-4-dodecyl

    17. Ether, Tetraethyleneglycol Lauryl

    18. Ethoxysclerol

    19. Ethyleneglycol Monoether, Dodecyl

    20. Hydroxypolyethoxydodecane

    21. Laureth

    22. Laureth 1

    23. Laureth 4

    24. Laureth 7

    25. Laureth 9

    26. Laureth-1

    27. Laureth-4

    28. Laureth-7

    29. Laureth-9

    30. Laureths

    31. Lauromacrogol

    32. Lauromacrogol 400

    33. Lauromacrogols

    34. Lauryl Ether, Tetraethyleneglycol

    35. Lubrol 12a9

    36. Lubrol Px

    37. Lubrol-px

    38. Monododecyl Ether, Nonaethyleneglycol

    39. Monoether, Dodecyl Ethyleneglycol

    40. Nonaethylene Glycol Monododecyl Ether

    41. Nonaethyleneglycol Monododecyl Ether

    42. Nonaethyleneglycol Monododecyl Ethers

    43. Polidocanol

    44. Polidocanols

    45. Polyethylene Glycol 7 Lauryl Ether

    46. Polyethylene Glycol Monododecyl Ether

    47. Polyethylene Glycol-7-lauryl Ether

    48. Polyethylene Glycol-7-lauryl Ethers

    49. Polyoxyethylene 4 Dodecyl Ether

    50. Polyoxyethylene 9 Lauryl Ether

    51. Polyoxyethylene 9-lauryl Ether

    52. Polyoxyethylene 9-lauryl Ethers

    53. Polyoxyethylene Lauryl Ether

    54. Polyoxyethylene Lauryl Ethers

    55. Polyoxyethylene(4) Lauryl Ether

    56. Polyoxyethylene-4-dodecyl Ether

    57. Polyoxyethylenedodecyl Ether

    58. Polyoxyethylenedodecyl Ethers

    59. Tetraethylene Glycol Dodecyl Ether

    60. Tetraethyleneglycol Lauryl Ether

    61. Tetraethyleneglycol Lauryl Ethers

    62. Thesit

    2.2.2 Depositor-Supplied Synonyms

    1. Dodecylheptaglycol

    2. 3055-97-8

    3. 3,6,9,12,15,18,21-heptaoxatritriacontan-1-ol

    4. Laureth-7

    5. Heptaethyleneglycolmonododecylether

    6. 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

    7. Polyoxyethylene (7) Lauryl Ether

    8. C12e7

    9. Einecs 221-283-9

    10. Mfcd00043065

    11. Polyethylene Glycol (7) Lauryl Ether

    12. Peg-7 Lauryl Ether

    13. Lauryl Alcohol Hexa(oxyethylene) Ethanol

    14. Schembl60375

    15. Dtxsid8062816

    16. C12h25(oc2h4)7oh

    17. Heptaethylene Glycol Dodecyl Ether

    18. Akos025311016

    19. Zinc100014200

    20. Hy-w140896

    21. Heptaethylene Glycol Mono-n-dodecyl Ether

    22. As-78358

    23. Cs-0199396

    24. Ft-0726791

    25. H0445

    26. E78070

    27. 055h978

    28. J-018014

    29. Heptaethylene Glycol Monododecyl Ether, Bioxtra, >=98.0% (tlc)

    2.3 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 494.7 g/mol
    Molecular Formula C26H54O8
    XLogP34.2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count31
    Exact Mass494.38186868 g/mol
    Monoisotopic Mass494.38186868 g/mol
    Topological Polar Surface Area84.8 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity347
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Detergents

    Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (See all compounds classified as Detergents.)

    Sclerosing Solutions

    Chemical agents injected into blood vessels and lymphatic sinuses to shrink or cause localized THROMBOSIS; FIBROSIS, and obliteration of the vessels. This treatment is applied in a number of conditions such as VARICOSE VEINS; HEMORRHOIDS; GASTRIC VARICES; ESOPHAGEAL VARICES; PEPTIC ULCER HEMORRHAGE. (See all compounds classified as Sclerosing Solutions.)

    API SUPPLIERS

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    LGM Pharma

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    Nanjing Well Pharmaceutical

    China

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    Virtual BoothNanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.

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    Agno Pharma

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    Agno Pharma

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    GDUFA

    DMF Review : Reviewed

    Rev. Date : 2024-11-08

    Pay. Date : 2024-10-31

    DMF Number : 37637

    Submission : 2024-06-17

    Status : Active

    Type : II

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    Agno Pharma

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    Agno Pharma

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    GDUFA

    DMF Review : Complete

    Rev. Date : 2024-11-08

    Pay. Date : 2024-10-31

    DMF Number : 37637

    Submission : 2024-06-17

    Status : Active

    Type : II

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    LGM Pharma

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    Polidocanol

    About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

    LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.
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    Nanjing Well Pharmaceutical

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    Polidocanol

    About the Company : Nanjing Well Pharmaceutical Group was established in 2000 & is committed to R&D & manufacture of pharmaceutical materials, base oils of advanced synthetic lubricants, etc. The grou...

    Nanjing Well Pharmaceutical Group was established in 2000 & is committed to R&D & manufacture of pharmaceutical materials, base oils of advanced synthetic lubricants, etc. The group has 10 subsidiaries, which are distributed in Nanjing, Yangzhou, & other cities in China. Nanjing Well Pharmaceutical Technology is a wholly-owned subsidiary of the Group, & it is a new R&D & manufacturing center for pharmaceutical excipients & APIs. It is located in Nanjing Jiangbei New Material Science & Technology Park with 200+ employees & has 15 synthetic production lines which can achieve an annual output of >20,000 tons of pharmaceutical excipients & APIs.
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    API Reference Price

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    [{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711391400,"product":"POLIDOCANOL API BATCH NO: APM0011062312002, MFG DATE:12\/2023, EXP. DATE:12\/2024","address":"1\/5, SANTOSH COMPLEX, ARMUGAM","city":"BANGALORE , KARNATAKA","supplier":"MAIVA PHARMA PRIVATE ","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"SPECTRA DATA SERVICES","customerCountry":"UNITED STATES","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"0","totalValueFC":"0.1","currency":"USD","unitRateINR":1.5580000000000001,"date":"26-Mar-2024","totalValueINR":"7.79","totalValueInUsd":"0.1","indian_port":"Bangalore Air","hs_no":"29094990","bill_no":"8623698","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"1\/5, SANTOSH COMPLEX, ARMUGAM, BANGALORE , KARNATAKA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1700937000,"product":"(FOC) POLIDOCANOL API, BATCH NOS: APM001106 2310002 & APM001106 2310003","address":"1\/5, SANTOSH COMPLEX, ARMUGAM","city":"BANGALORE , KARNATAKA","supplier":"AGNO PHARMA JIANGSU","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"MAIVA PHARMA PRIVATE ","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"20","totalValueFC":"60.6","currency":"USD","unitRateINR":"1682","date":"26-Nov-2023","totalValueINR":"5046","totalValueInUsd":"60.6","indian_port":"Bangalore Air","hs_no":"29094990","bill_no":"8946639","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"68 DAPU ROAD, LIANYUNGANG ECONOMIC& TECHNOLOGY DEVELOPMENT ZONELIANYUNGANG, JIANGSU 222069 CN","customerAddress":"1\/5, SANTOSH COMPLEX, ARMUGAM"}]
    26-Nov-2023
    26-Mar-2024
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    Drugs in Development

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    10xBio Releases Interim Data from Phase 2b Showing Efficacy of Drug for Body Contouring

    Details:

    10XB101 is a novel formulation of polidocanol which is approved in the U.S. for vein sclerotherapy. It is noe being evaluated for submental body contouring.


    Lead Product(s): Polidocanol

    Therapeutic Area: Nutrition and Weight Loss Brand Name: 10XB101

    Study Phase: Phase IIProduct Type: Small molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable March 11, 2024

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    10xbio

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    Lead Product(s) : Polidocanol

    Therapeutic Area : Nutrition and Weight Loss

    Highest Development Status : Phase II

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    10xBio Releases Interim Data from Phase 2b Showing Efficacy of Drug for Body Contouring

    Details : 10XB101 is a novel formulation of polidocanol which is approved in the U.S. for vein sclerotherapy. It is noe being evaluated for submental body contouring.

    Brand Name : 10XB101

    Molecule Type : Small molecule

    Upfront Cash : Not Applicable

    March 11, 2024

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    Chemische Fabrik Berg

    Germany
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    Regulatory Info : RX

    Registration Country : USA

    POLIDOCANOL

    Brand Name : ASCLERA

    Dosage Form : SOLUTION;INTRAVENOUS

    Dosage Strength : 10MG/2ML (5MG/ML)

    Packaging :

    Approval Date : 2010-03-30

    Application Number : 21201

    Regulatory Info : RX

    Registration Country : USA

    Moehs Chemische Fabrik Berg

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    Chemische Fabrik Berg

    Germany
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    Regulatory Info : RX

    Registration Country : USA

    POLIDOCANOL

    Brand Name : ASCLERA

    Dosage Form : SOLUTION;INTRAVENOUS

    Dosage Strength : 20MG/2ML (10MG/ML)

    Packaging :

    Approval Date : 2010-03-30

    Application Number : 21201

    Regulatory Info : RX

    Registration Country : USA

    Moehs Chemische Fabrik Berg

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    PHYTOPHARM KLEKA S.A

    Poland
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    Regulatory Info :

    Registration Country : Poland

    Salvia officinalis L.; Oils, Peppermint; Riboflavin; Nicotinamide; Menthyl alcohol; eucalyptol; Xylitol; Chlorhexidine; polidocanol; Glycerol

    Brand Name :

    Dosage Form : Oral/Liquid Spray

    Dosage Strength :

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Poland

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    PHYTOPHARM KLEKA S.A

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    Regulatory Info :

    Registration Country : Poland

    Oils, Peppermint; Panthenolum; Riboflavin; Nicotinamide; Menthyl alcohol; eucalyptol; OCTENIDINE HYDROCHLORIDE; Xylitol; polidocanol; Glycerol

    Brand Name :

    Dosage Form : Oral/Liquid Spray

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    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Poland

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    PROVENSIS

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    Regulatory Info : RX

    Registration Country : USA

    POLIDOCANOL

    Brand Name : VARITHENA

    Dosage Form : SOLUTION;INTRAVENOUS

    Dosage Strength : 180MG/18ML (10MG/ML)

    Packaging :

    Approval Date : 2013-11-25

    Application Number : 205098

    Regulatory Info : RX

    Registration Country : USA

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    PROVENSIS

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    Regulatory Info : DISCN

    Registration Country : USA

    POLIDOCANOL

    Brand Name : VARITHENA

    Dosage Form : SOLUTION;INTRAVENOUS

    Dosage Strength : 77.5MG/7.75ML (10MG/ML)

    Packaging :

    Approval Date : 2017-12-21

    Application Number : 205098

    Regulatory Info : DISCN

    Registration Country : USA

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    DOSAGE - SOLUTION;INTRAVENOUS - 180MG/18ML (1...DOSAGE - SOLUTION;INTRAVENOUS - 180MG/18ML (10MG/ML)

    USFDA APPLICATION NUMBER - 205098

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    DOSAGE - SOLUTION;INTRAVENOUS - 77.5MG/7.75ML...DOSAGE - SOLUTION;INTRAVENOUS - 77.5MG/7.75ML (10MG/ML)

    USFDA APPLICATION NUMBER - 205098

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    DOSAGE - SOLUTION;INTRAVENOUS - 10MG/2ML (5MG...DOSAGE - SOLUTION;INTRAVENOUS - 10MG/2ML (5MG/ML)

    USFDA APPLICATION NUMBER - 21201

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    DOSAGE - SOLUTION;INTRAVENOUS - 20MG/2ML (10M...DOSAGE - SOLUTION;INTRAVENOUS - 20MG/2ML (10MG/ML)

    USFDA APPLICATION NUMBER - 21201

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