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LGM Polidocanol

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ACTIVE PHARMA INGREDIENTS

3 API Suppliers, 1 USDMF, 2 Listed Suppliers, $ API Reference Price

3 API Suppliers
1 USDMF
2 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

6 FDF Dossiers, 4 FDA Orange Book, 2 Listed Dossiers

6 FDF Dossiers
4 FDA Orange Book
2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION;INTRAVENOUS - 180MG/18ML (10MG/ML), SOLUTION;INTRAVENOUS - 77.5MG/7.75ML (10MG/ML), SOLUTION;INTRAVENOUS - 10MG/2ML (5MG/ML), SOLUTION;INTRAVENOUS - 20MG/2ML (10MG/ML)

drugProductComposition
SOLUTION;INTRAVENOUS - 180MG/18ML (10MG/ML)
SOLUTION;INTRAVENOUS - 77.5MG/7.75ML (10MG/ML)
SOLUTION;INTRAVENOUS - 10MG/2ML (5MG/ML)
SOLUTION;INTRAVENOUS - 20MG/2ML (10MG/ML)

RELATED EXCIPIENT COMPANIES

1 Actylis, 1 Finar

relatedExcipients
1 Actylis
1 Finar

EXCIPIENTS BY APPLICATIONS

1 Topical, 1 Parenteral

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1 Topical
1 Parenteral

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 2 NEWS #PharmaBuzz

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2 DATA COMPILATION #PharmaFlow
2 NEWS #PharmaBuzz

MARKET PLACE

3 APIs

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3 APIs

PATENTS & EXCLUSIVITIES

4 US Patents, 2 Health Canada Patents

patents
4 US Patents
2 Health Canada Patents

LGM Polidocanol

Synopsis

ACTIVE PHARMA INGREDIENTS

3

API Suppliers

1

USDMF

0

CEP/COS

CEP/COS Certifications

0

JDMF

0

EU WC

0

KDMF

0

NDC API

0

VMF

2

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 49

MARKET PLACE

3

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

6

FDF Dossiers

4

FDA Orange Book

FDA (Orange Book)

0

Europe

0

Canada

0

Australia

0

South Africa

2

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

4

US Patents

0

US Exclusivities

2

Health Canada Patents

DIGITAL CONTENT

2

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

2

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

NA

Finished Drug Prices

NA

2 RELATED EXCIPIENT COMPANIES

2EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Dodecylheptaglycol, 3055-97-8, 3,6,9,12,15,18,21-heptaoxatritriacontan-1-ol, Laureth-7, Heptaethyleneglycolmonododecylether, 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

Molecular Formula

C₂₆H₅₄O₈

Molecular Weight

494.7 g/mol

InChI Key

DWHIUNMOTRUVPG-UHFFFAOYSA-N

Polidocanol

An alkyl polyglycol ether of LAURYL ALCOHOL, chemically defined as an alcohol ethoxylate having an average alkyl chain of 12??14 carbon atoms, and an ethylene oxide chain of 9 ethylene oxide units. It is used as a detergent, and medically as a local anesthetic, and as a sclerosing agent for the treatment of ESOPHAGEAL AND GASTRIC VARICES and VARICOSE VEINS.

1 2D Structure

Polidocanol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

2.1.2 InChI

InChI=1S/C26H54O8/c1-2-3-4-5-6-7-8-9-10-11-13-28-15-17-30-19-21-32-23-25-34-26-24-33-22-20-31-18-16-29-14-12-27/h27H,2-26H2,1H3

2.1.3 InChI Key

DWHIUNMOTRUVPG-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Aethoxysclerol

2. Aethoxysklerol

3. Aetoxisclerol

4. Alpha-dodecyl-omega-hydroxypoly(oxy-1,2ethanediyl)

5. Atossisclerol

6. Atoxysclerol

7. Brij 30

8. Brij-30

9. Brij30

10. Dodecyl Ethyleneglycol Monoether

11. Dodecyl Ethyleneglycol Monoethers

12. Ether, Nonaethyleneglycol Monododecyl

13. Ether, Polyethylene Glycol-7-lauryl

14. Ether, Polyoxyethylene 9-lauryl

15. Ether, Polyoxyethylene Lauryl

16. Ether, Polyoxyethylene-4-dodecyl

17. Ether, Tetraethyleneglycol Lauryl

18. Ethoxysclerol

19. Ethyleneglycol Monoether, Dodecyl

20. Hydroxypolyethoxydodecane

21. Laureth

22. Laureth 1

23. Laureth 4

24. Laureth 7

25. Laureth 9

26. Laureth-1

27. Laureth-4

28. Laureth-7

29. Laureth-9

30. Laureths

31. Lauromacrogol

32. Lauromacrogol 400

33. Lauromacrogols

34. Lauryl Ether, Tetraethyleneglycol

35. Lubrol 12a9

36. Lubrol Px

37. Lubrol-px

38. Monododecyl Ether, Nonaethyleneglycol

39. Monoether, Dodecyl Ethyleneglycol

40. Nonaethylene Glycol Monododecyl Ether

41. Nonaethyleneglycol Monododecyl Ether

42. Nonaethyleneglycol Monododecyl Ethers

43. Polidocanol

44. Polidocanols

45. Polyethylene Glycol 7 Lauryl Ether

46. Polyethylene Glycol Monododecyl Ether

47. Polyethylene Glycol-7-lauryl Ether

48. Polyethylene Glycol-7-lauryl Ethers

49. Polyoxyethylene 4 Dodecyl Ether

50. Polyoxyethylene 9 Lauryl Ether

51. Polyoxyethylene 9-lauryl Ether

52. Polyoxyethylene 9-lauryl Ethers

53. Polyoxyethylene Lauryl Ether

54. Polyoxyethylene Lauryl Ethers

55. Polyoxyethylene(4) Lauryl Ether

56. Polyoxyethylene-4-dodecyl Ether

57. Polyoxyethylenedodecyl Ether

58. Polyoxyethylenedodecyl Ethers

59. Tetraethylene Glycol Dodecyl Ether

60. Tetraethyleneglycol Lauryl Ether

61. Tetraethyleneglycol Lauryl Ethers

62. Thesit

2.2.2 Depositor-Supplied Synonyms

1. Dodecylheptaglycol

2. 3055-97-8

3. 3,6,9,12,15,18,21-heptaoxatritriacontan-1-ol

4. Laureth-7

5. Heptaethyleneglycolmonododecylether

6. 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

7. Polyoxyethylene (7) Lauryl Ether

8. C12e7

9. Einecs 221-283-9

10. Mfcd00043065

11. Polyethylene Glycol (7) Lauryl Ether

12. Peg-7 Lauryl Ether

13. Lauryl Alcohol Hexa(oxyethylene) Ethanol

14. Schembl60375

15. Dtxsid8062816

16. C12h25(oc2h4)7oh

17. Heptaethylene Glycol Dodecyl Ether

18. Akos025311016

19. Zinc100014200

20. Hy-w140896

21. Heptaethylene Glycol Mono-n-dodecyl Ether

22. As-78358

23. Cs-0199396

24. Ft-0726791

25. H0445

26. E78070

27. 055h978

28. J-018014

29. Heptaethylene Glycol Monododecyl Ether, Bioxtra, >=98.0% (tlc)

2.3 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₅₄O₈
Molecular Weight	494.7 g/mol
XLogP3	4.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	31
Exact Mass	494.38186868 g/mol
Monoisotopic Mass	494.38186868 g/mol
Topological Polar Surface Area	84.8 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	347
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Detergents

Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (See all compounds classified as Detergents.)

Sclerosing Solutions

Chemical agents injected into blood vessels and lymphatic sinuses to shrink or cause localized THROMBOSIS; FIBROSIS, and obliteration of the vessels. This treatment is applied in a number of conditions such as VARICOSE VEINS; HEMORRHOIDS; GASTRIC VARICES; ESOPHAGEAL VARICES; PEPTIC ULCER HEMORRHAGE. (See all compounds classified as Sclerosing Solutions.)

API SUPPLIERS

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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FDF Dossiers

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FDA Orange Book

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Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - SOLUTION;INTRAVENOUS - 180MG/18ML (1...DOSAGE - SOLUTION;INTRAVENOUS - 180MG/18ML (10MG/ML)

USFDA APPLICATION NUMBER - 205098

DOSAGE - SOLUTION;INTRAVENOUS - 77.5MG/7.75ML...DOSAGE - SOLUTION;INTRAVENOUS - 77.5MG/7.75ML (10MG/ML)

USFDA APPLICATION NUMBER - 205098

DOSAGE - SOLUTION;INTRAVENOUS - 10MG/2ML (5MG...DOSAGE - SOLUTION;INTRAVENOUS - 10MG/2ML (5MG/ML)

USFDA APPLICATION NUMBER - 21201

DOSAGE - SOLUTION;INTRAVENOUS - 20MG/2ML (10M...DOSAGE - SOLUTION;INTRAVENOUS - 20MG/2ML (10MG/ML)

USFDA APPLICATION NUMBER - 21201

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