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Chemistry

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Also known as: Polymyxin b, sulfate (salt), 1405-20-5, Polymixin b sulphate, Ks-1428, Pmb, Akos025392172
Molecular Formula
C56H100N16O17S
Molecular Weight
1301.6  g/mol
InChI Key
HFMDLUQUEXNBOP-OLYKAHIFSA-N

Polymyxin B Sulfate
1 2D Structure

Polymyxin B Sulfate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
2.1.2 InChI
InChI=1S/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4)/t32?,33-,34-,36+,37+,38-,39+,40+,41+,42+,43-,45+,46+;/m1./s1
2.1.3 InChI Key
HFMDLUQUEXNBOP-OLYKAHIFSA-N
2.1.4 Canonical SMILES
CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
2.1.5 Isomeric SMILES
CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)[C@@H](C)O.OS(=O)(=O)O
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. Polymyxin B, Sulfate (salt)

2. 1405-20-5

3. Polymixin B Sulphate

4. Ks-1428

5. Pmb

6. Akos025392172

7. Polymyxin B Sulfate, Bacillus Polymyxa

8. M02428

9. Polymyxin B Sulfate (1404-26-8 Free Base)

10. 405p205

2.3 Create Date
2010-12-22
3 Chemical and Physical Properties
Molecular Weight 1301.6 g/mol
Molecular Formula C56H100N16O17S
Hydrogen Bond Donor Count20
Hydrogen Bond Acceptor Count22
Rotatable Bond Count29
Exact Mass1300.71730696 g/mol
Monoisotopic Mass1300.71730696 g/mol
Topological Polar Surface Area574 Ų
Heavy Atom Count90
Formal Charge0
Complexity2240
Isotope Atom Count0
Defined Atom Stereocenter Count12
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NamePolymyxin b sulfate
Drug LabelPolymyxin B for Injection, USP is one of a group of basic polypeptide antibiotics derived from B polymyxa (B aerosporous). Polymyxin B sulfate is the sulfate salt of Polymyxins B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmow...
Active IngredientPolymyxin b sulfate
Dosage FormInjectable
RouteInjection
Strengtheq 500,000 u base/vial
Market StatusPrescription
CompanyX Gen Pharms; Xellia Pharms Aps; Fresenius Kabi Usa; Eurohlth Intl

2 of 2  
Drug NamePolymyxin b sulfate
Drug LabelPolymyxin B for Injection, USP is one of a group of basic polypeptide antibiotics derived from B polymyxa (B aerosporous). Polymyxin B sulfate is the sulfate salt of Polymyxins B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmow...
Active IngredientPolymyxin b sulfate
Dosage FormInjectable
RouteInjection
Strengtheq 500,000 u base/vial
Market StatusPrescription
CompanyX Gen Pharms; Xellia Pharms Aps; Fresenius Kabi Usa; Eurohlth Intl

API SUPPLIERS

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01

ChemWerth Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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  • WHO-GMP

Virtual BoothChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

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02

Transo-Pharm USA LLC

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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  • fda
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Virtual BoothTransoPharm USA works in the Sourcing and Management of Active Pharmaceutical Ingredients.

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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03

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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LGM Pharma CB

04

Rochem International Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Compamed
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
Rochem

05

Pharm-RX Chemical

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
Pharm RX

06

Shanghai Minbiotech

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothShanghai Minbiotech is the leading producer of biopharmaceuticals and a variety of high-end generic & innovative drugs.

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Shanghai Minbiotech CB

07

Shandong Ruizhi Pharmaceutical Tec...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Shandong Ruizhi Pharmaceutical Tec...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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USDMF arrow-down CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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North China Pharmaceutical Huashen...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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North China Pharmaceutical Huashen...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Shandong Luxi Pharmaceutical Co.,L...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Shandong Luxi Pharmaceutical Co.,L...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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CULTOR FOOD SCIENCE INC

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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CULTOR FOOD SCIENCE INC

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USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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API Reference Price

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RENMIN ROAD(M), ZHANGJIAGANG CITY, JIANGSU ChinaSDNF China","customerAddress":"11TH FLOOR, LOTUS BUSINESS PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711132200,"product":"POLYMYXIN B SULFATE USP","address":"194 ARVIND CHAMBERS 07 SAI SERVICE","city":"MUMBAI,MAHARASHTRA","supplier":"CHEMEXCEL INTERNATIONAL ASIA ","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"RIFA PHARMA","customerCountry":"INDIA","quantity":"0.63","actualQuantity":"0.625","unit":"KGS","unitRateFc":"4950","totalValueFC":"3120.4","currency":"USD","unitRateINR":"414562.5","date":"23-Mar-2024","totalValueINR":"259101.56","totalValueInUsd":"3120.4","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"2710615","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"RM#801-2,8\/F., EASEY COMMERCIAL BUILDING , 253-261 HENNESSY ROAD, WANCHAI, HONG KONG Hong Kong","customerAddress":"194 ARVIND CHAMBERS 07 SAI SERVICE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1713119400,"product":"POLYMYXIN B SULFATE","address":"6-3-865\/1\/2, FLAT NO.201,","city":"HYDERABAD, ANDHRA PRADESH","supplier":"CHEMEXCEL INTERNATIONAL ASIA ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"GLAND PHARMA LTD","customerCountry":"INDIA","quantity":"10.25","actualQuantity":"10.25","unit":"KGS","unitRateFc":"4400","totalValueFC":"45555.1","currency":"USD","unitRateINR":"371140","date":"15-Apr-2024","totalValueINR":"3804185","totalValueInUsd":"45555.1","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"3030329","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"N\/A","customerAddress":"6-3-865\/1\/2, FLAT NO.201,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714156200,"product":"POLYMYXIN B SULFATE USP (QTY: 75BOU\/9.375KG)","address":"2NF FLOOR,BUILDING A,","city":"ANDHERI[W],MUMBAI,","supplier":"CHEMEXCEL INTERNATIONAL (ASIA) LIMI","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"GUFIC BIOSCIENCES","customerCountry":"INDIA","quantity":"9.38","actualQuantity":"9.375","unit":"KGS","unitRateFc":"3400","totalValueFC":"32215.7","currency":"USD","unitRateINR":"286960","date":"27-Apr-2024","totalValueINR":"2690250","totalValueInUsd":"32215.7","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"3232238","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"TEDRM 801-2 8\/F EASEY COMM BLDG 253-261HENNESSY RD, WANCHAI,SDNF HONG KONG","customerAddress":"2NF FLOOR,BUILDING A,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716748200,"product":"POLYMYXIN B SULFATE USP","address":"H NO.141, SILPA BRINDAVAN,","city":"KUKATPALLY, HYDERABAD, AP.","supplier":"CHEMEXCEL INTERNATIONAL ASIA ","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"ORBICULAR PHARMACEUTICAL TECHNOLOGIES ","customerCountry":"INDIA","quantity":"0.20","actualQuantity":"0.2","unit":"KGS","unitRateFc":"4400","totalValueFC":"890.5","currency":"USD","unitRateINR":"371140","date":"27-May-2024","totalValueINR":"74228","totalValueInUsd":"890.5","indian_port":"Hyderabad Air","hs_no":"29419090","bill_no":"3684016","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"801-2 EASEY COMMERCIAL BLDG. 253-261 HENNESSEY RD. 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16-Apr-2021
20-Jul-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
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(USD/KGS)
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - OINTMENT;OPHTHALMIC - 0.1%;EQ 3.5MG ...DOSAGE - OINTMENT;OPHTHALMIC - 0.1%;EQ 3.5MG BASE/GM;10,000 UNITS/GM

USFDA APPLICATION NUMBER - 50065

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DOSAGE - OINTMENT;TOPICAL - 400 UNITS/GM;1%;E...DOSAGE - OINTMENT;TOPICAL - 400 UNITS/GM;1%;EQ 3.5MG BASE/GM;5,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50168

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DOSAGE - CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/G...DOSAGE - CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/GM;10,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50218

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DOSAGE - OINTMENT;OPHTHALMIC - EQ 400 UNITS/G...DOSAGE - OINTMENT;OPHTHALMIC - EQ 400 UNITS/GM;EQ 3.5MG BASE/GM;EQ 10,000 UNITS/GM

USFDA APPLICATION NUMBER - 50417

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DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 10,000 U...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 10,000 UNITS/ML;EQ 1MG BASE/ML

USFDA APPLICATION NUMBER - 50567

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