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Chemistry

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Also known as: 2-(2-hydroxypropoxy)-1-propanol, 106-62-7, 25322-69-4, 1-propanol, 2-(2-hydroxypropoxy)-, Polyoxypropylene glycol, 2-(2-hydroxypropoxy)propanol
Molecular Formula
C6H14O3
Molecular Weight
134.17  g/mol
InChI Key
DUFKCOQISQKSAV-UHFFFAOYSA-N
FDA UNII
WNY0H4G53Q

Polypropylene Glycol
1 2D Structure

Polypropylene Glycol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(2-hydroxypropoxy)propan-1-ol
2.1.2 InChI
InChI=1S/C6H14O3/c1-5(8)4-9-6(2)3-7/h5-8H,3-4H2,1-2H3
2.1.3 InChI Key
DUFKCOQISQKSAV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(CO)OCC(C)O
2.2 Other Identifiers
2.2.1 UNII
WNY0H4G53Q
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(2-hydroxypropoxy)-1-propanol

2.3.2 Depositor-Supplied Synonyms

1. 2-(2-hydroxypropoxy)-1-propanol

2. 106-62-7

3. 25322-69-4

4. 1-propanol, 2-(2-hydroxypropoxy)-

5. Polyoxypropylene Glycol

6. 2-(2-hydroxypropoxy)propanol

7. Methyloxirane Homopolymer

8. Alpha-hydro-omega-hydroxypoly(oxypropylene)

9. Polypropylene Glycol (m W 1,200-3,000)

10. Wny0h4g53q

11. Polyoxypropylene

12. Emkapyl

13. Lineartop E

14. Niax Ppg

15. Desmophen 360c

16. Polyglycol P 400

17. Niax Ppg 425

18. Jeffox Ppg 400

19. Polyglycol P-2000

20. Polyglycol P-4000

21. Voranol P 1010

22. Laprol 2002

23. Niax Ppg 1025

24. Niax Ppg 3025

25. Polyglycol Type P250

26. Polyglycol Type P400

27. Polyglycol Type P750

28. Napter E 8075

29. Niax Polyol Ppg 4025

30. Polyglycol Type P1200

31. Polyglycol Type P2000

32. Polyglycol Type P3000

33. Propylene Oxide Homopolymer

34. Laprol 702

35. Poly(propylene Glycol)

36. Unii-wny0h4g53q

37. Propylene Oxide, Propylene Glycol Polymer

38. Polypropylene Oxide

39. Poly(propylene Glycol) Macromolecule

40. Einecs 203-416-2

41. Poly Propylene Glycol

42. Alpha-hydro-omega-hydroxypoly(oxy(methyl-1,2-ethanediyl))

43. Ppg?

44. Schembl15111

45. Chebi:53262

46. Dtxsid30861722

47. 2-methyl-3-oxahexane-1,5-diol

48. Chebi:179442

49. Akos015899603

50. Bs-23535

51. Ft-0696553

52. F71159

53. 106h627

54. Alpha-hydro-omega-hydroxypoly[oxy(1-methylethylene)]

55. Q26863457

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 134.17 g/mol
Molecular Formula C6H14O3
XLogP3-0.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass134.094294304 g/mol
Monoisotopic Mass134.094294304 g/mol
Topological Polar Surface Area49.7 Ų
Heavy Atom Count9
Formal Charge0
Complexity65.3
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Minimum/Potential Fatal Human Dose

3. 3 = moderately toxic: probable oral lethal dose (human) 0.5-5 g/kg, between 1 oz and 1 pint (or 1 lb) for 70 kg person (150 lb).

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-120


5 Pharmacology and Biochemistry
5.1 Absorption, Distribution and Excretion

Lower mol wt /PPG's (200-1200) ... are absorbed through the skin to some extent, /but/ skin penetration ... not ... serious industrial hazard ... These ... are not like low mol wt polyethylene glycols in their physiologic activity; they are rapidly absorbed from the GI tract ...

Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1523


Acute skin absorption tests ... have indicated that the materials are all poorly absorbed through the skin.

Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1525


/Male rats maintained for 100 days on diet containing 1.0% of P750/ ... postulated that material is readily metabolized or eliminated when absorbed in small doses; this probably accounts for its lack of apparent physiological effect.

Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1525


ABOUT THIS PAGE

Polypropylene Glycol Manufacturers

A Polypropylene Glycol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Polypropylene Glycol, including repackagers and relabelers. The FDA regulates Polypropylene Glycol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Polypropylene Glycol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Polypropylene Glycol Suppliers

A Polypropylene Glycol supplier is an individual or a company that provides Polypropylene Glycol active pharmaceutical ingredient (API) or Polypropylene Glycol finished formulations upon request. The Polypropylene Glycol suppliers may include Polypropylene Glycol API manufacturers, exporters, distributors and traders.

Polypropylene Glycol GMP

Polypropylene Glycol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Polypropylene Glycol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Polypropylene Glycol GMP manufacturer or Polypropylene Glycol GMP API supplier for your needs.

Polypropylene Glycol CoA

A Polypropylene Glycol CoA (Certificate of Analysis) is a formal document that attests to Polypropylene Glycol's compliance with Polypropylene Glycol specifications and serves as a tool for batch-level quality control.

Polypropylene Glycol CoA mostly includes findings from lab analyses of a specific batch. For each Polypropylene Glycol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Polypropylene Glycol may be tested according to a variety of international standards, such as European Pharmacopoeia (Polypropylene Glycol EP), Polypropylene Glycol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Polypropylene Glycol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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