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Posenacaftor

Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

Synopsis

ACTIVE PHARMA INGREDIENTS

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2DRUGS IN DEVELOPMENT

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Chemistry

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Also known as: Posenacaftor [usan], Bn5ut8i0t9, Pti-801, 2095064-05-2, Posenacaftor (usan), Posenacaftor [inn]

Molecular Formula

C₂₇H₂₇NO₅

Molecular Weight

445.5 g/mol

InChI Key

QUDOHCFOJCNKPK-QGZVFWFLSA-N

FDA UNII

BN5UT8I0T9

PTI-801 represents a new class of drugs to treat pain. PTI-801 can minimize the opioid tolerance, dependence or addiction that is often associated with repeat use of oxycodone. It is a combination of oxycodone with ultralow-dose naltrexone, an opioid antagonist.

1 2D Structure

Posenacaftor

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

8-methyl-2-(3-methyl-1-benzofuran-2-yl)-5-[(1R)-1-(oxan-4-yl)ethoxy]quinoline-4-carboxylic acid

2.1.2 InChI

InChI=1S/C27H27NO5/c1-15-8-9-23(32-17(3)18-10-12-31-13-11-18)24-20(27(29)30)14-21(28-25(15)24)26-16(2)19-6-4-5-7-22(19)33-26/h4-9,14,17-18H,10-13H2,1-3H3,(H,29,30)/t17-/m1/s1

2.1.3 InChI Key

QUDOHCFOJCNKPK-QGZVFWFLSA-N

2.1.4 Canonical SMILES

CC1=C2C(=C(C=C1)OC(C)C3CCOCC3)C(=CC(=N2)C4=C(C5=CC=CC=C5O4)C)C(=O)O

2.1.5 Isomeric SMILES

CC1=C2C(=C(C=C1)O[C@H](C)C3CCOCC3)C(=CC(=N2)C4=C(C5=CC=CC=C5O4)C)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

BN5UT8I0T9

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Posenacaftor [usan]

2. Bn5ut8i0t9

3. Pti-801

4. 2095064-05-2

5. Posenacaftor (usan)

6. Posenacaftor [inn]

7. Unii-bn5ut8i0t9

8. Posenacaftor [who-dd]

9. Chembl4594274

10. Schembl18736773

11. Glxc-25544

12. Who 11276

13. Hy-109187

14. Cs-0116460

15. D11683

16. (r)-8-methyl-2-(3-methylbenzofuran-2-yl)-5-(1-(tetrahydro-2h-pyran-4- Yl)ethoxy)quinoline-4-carboxylate

17. 4-quinolinecarboxylic Acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-((1r)-1-(tetrahydro-2h-pyran-4-yl)ethoxy)

18. 4-quinolinecarboxylic Acid, 8-methyl-2-(3-methyl-2-benzofuranyl)-5-((1r)-1-(tetrahydro-2h-pyran-4-yl)ethoxy)-

19. 8-methyl-2-(3-methyl-1-benzofuran-2-yl)-5-[(1r)-1-(oxan-4-yl)ethoxy]quinoline-4-carboxylic Acid

20. 8-methyl-2-(3-methylbenzofuran-2-yl)-5-((1r)-1-(oxan-4-yl)ethoxy)quinoline-4-carboxylic Acid

2.4 Create Date

2017-08-04

3 Chemical and Physical Properties

Molecular Formula	C₂₇H₂₇NO₅
Molecular Weight	445.5 g/mol
XLogP3	5.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	445.18892296 g/mol
Monoisotopic Mass	445.18892296 g/mol
Topological Polar Surface Area	81.8 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	681
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Investigated for use/treatment in addictions, osteoarthritis, and pain (acute or chronic).

5 Pharmacology and Biochemistry

5.1 Mechanism of Action

PTI-801 is a novel form of oxycodone that minimizes the abuse and drug dependence that is often associated with oxycodone and other narcotic painkillers. The goal of developing PTI-801 is to ensure the safety of patients who have a legitimate medical need to treat severe chronic pain with a narcotic painkiller, and to protect the public from the consequences of abuse.

Drugs in Development

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ABOUT THIS PAGE

Posenacaftor Manufacturers

A Posenacaftor manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Posenacaftor, including repackagers and relabelers. The FDA regulates Posenacaftor manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Posenacaftor API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Posenacaftor Suppliers

A Posenacaftor supplier is an individual or a company that provides Posenacaftor active pharmaceutical ingredient (API) or Posenacaftor finished formulations upon request. The Posenacaftor suppliers may include Posenacaftor API manufacturers, exporters, distributors and traders.

Posenacaftor GMP

Posenacaftor Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Posenacaftor GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Posenacaftor GMP manufacturer or Posenacaftor GMP API supplier for your needs.

Posenacaftor CoA

A Posenacaftor CoA (Certificate of Analysis) is a formal document that attests to Posenacaftor's compliance with Posenacaftor specifications and serves as a tool for batch-level quality control.

Posenacaftor CoA mostly includes findings from lab analyses of a specific batch. For each Posenacaftor CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Posenacaftor may be tested according to a variety of international standards, such as European Pharmacopoeia (Posenacaftor EP), Posenacaftor JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Posenacaftor USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.