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    Chemistry

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    Also known as: 127-08-2, Diuretic salt, Acetic acid, potassium salt, Potassium ethanoate, Potassium;acetate, Fema no. 2920
    Molecular Formula
    C2H3KO2
    Molecular Weight
    98.14  g/mol
    InChI Key
    SCVFZCLFOSHCOH-UHFFFAOYSA-M
    FDA UNII
    M911911U02
    Potassium Acetate
    A potassium salt used to replenish ELECTROLYTES, for restoration of WATER-ELECTROLYTE BALANCE, as well as a urinary and systemic alkalizer, which can be administered orally or by intravenous infusion. Formerly, it was used in DIURETICS and EXPECTORANTS.
    1 2D Structure

    Potassium Acetate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    potassium;acetate
    2.1.2 InChI
    InChI=1S/C2H4O2.K/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
    2.1.3 InChI Key
    SCVFZCLFOSHCOH-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CC(=O)[O-].[K+]
    2.2 Other Identifiers
    2.2.1 UNII
    M911911U02
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Acetate, Potassium

    2.3.2 Depositor-Supplied Synonyms

    1. 127-08-2

    2. Diuretic Salt

    3. Acetic Acid, Potassium Salt

    4. Potassium Ethanoate

    5. Potassium;acetate

    6. Fema No. 2920

    7. Koac

    8. Acetic Acid Potassium Salt

    9. Kali Aceticum

    10. Potassium Acetates

    11. Acok

    12. Mfcd00012458

    13. Acetic Acid, Potassium Salt (1:1)

    14. Ch3co2k

    15. E261

    16. Ins No.261

    17. Potassium Acetate Solution, 5m

    18. Chebi:32029

    19. Ins-261

    20. Ins-261(i)

    21. E-261

    22. M911911u02

    23. Octan Draselny [czech]

    24. Potassiumacetate

    25. Potassium Acetate [jan]

    26. Potassium Acetate (tn)

    27. Einecs 204-822-2

    28. Potassium Acetate In Plastic Container

    29. Kaliumazetat

    30. Potassium Acetate [usp:jan]

    31. Potasium Acetate

    32. Potassium Acetat

    33. Potassium-acetate

    34. Unii-m911911u02

    35. Meco2k

    36. Ch3cook

    37. Potassium Acetate Solution

    38. Dsstox_cid_7043

    39. Ec 204-822-2

    40. Dsstox_rid_78289

    41. Dsstox_gsid_27043

    42. Kali Aceticum [hpus]

    43. Potassium Acetate (jan/usp)

    44. Potassium Acetate [ii]

    45. Potassium Acetate [mi]

    46. Chembl1201058

    47. Dtxsid7027043

    48. Potassium Acetate [fhfi]

    49. Potassium Acetate [inci]

    50. Hy-y0319b

    51. Potassium Acetate [vandf]

    52. Potassium Acetate [mart.]

    53. Potassium Acetate A.c.s. Reagent

    54. Potassium Acetate [usp-rs]

    55. Potassium Acetate [who-dd]

    56. Potassium Acetate, Biochemical Grade

    57. Tox21_202740

    58. S4843

    59. Akos003052760

    60. Akos015901668

    61. Ccg-266027

    62. Cs-w020131

    63. Db14498

    64. Potassium Acetate [orange Book]

    65. Potassium Acetate Acs Grade 1kg

    66. Potassium Acetate, 8m Aqueous Solution

    67. Potassium Acetate [ep Monograph]

    68. Ncgc00260288-01

    69. Potassium Acetate [usp Monograph]

    70. Bp-21033

    71. Cas-127-08-2

    72. Ft-0645118

    73. P2786

    74. 4-chloro-n-furfuryl-5-sulfamoylanthranlic Acid

    75. D01154

    76. Potassium Acetate, Trace Metals Grade 99.98%

    77. Potassium Acetate, 1m Aqueous Solution, Ph 7.5

    78. Q409199

    79. J-005461

    80. Potassium Acetate, 8m Aqueous Solution, Rnase Free

    81. Potassium Acetate, 1m Aqueous Solution, Ph 7.5, Rnase Free

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 98.14 g/mol
    Molecular Formula C2H3KO2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count0
    Exact Mass97.97701082 g/mol
    Monoisotopic Mass97.97701082 g/mol
    Topological Polar Surface Area40.1 Ų
    Heavy Atom Count5
    Formal Charge0
    Complexity34.6
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NamePotassium acetate in plastic container
    Active IngredientPotassium acetate
    Dosage FormInjectable
    RouteInjection
    Strength2meq/ml
    Market StatusPrescription
    CompanyHospira

    2 of 2  
    Drug NamePotassium acetate in plastic container
    Active IngredientPotassium acetate
    Dosage FormInjectable
    RouteInjection
    Strength2meq/ml
    Market StatusPrescription
    CompanyHospira

    4.2 Drug Indication

    Potassium is used to regulate hypokalemia as a primary condition or secondary to other medical conditions.

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Pharmacological Classes
    Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]; Osmotic Laxative [EPC]; Potassium Compounds [CS]; Potassium Salt [EPC]; Increased Large Intestinal Motility [PE]
    5.2 ATC Code

    B - Blood and blood forming organs

    B05 - Blood substitutes and perfusion solutions

    B05X - I.v. solution additives

    B05XA - Electrolyte solutions

    B05XA17 - Potassium acetate

    5.3 Absorption, Distribution and Excretion

    Route of Elimination

    Mostly urine but also skin and feces.

    5.4 Mechanism of Action

    Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion pumps in the cell membrane. The cell membrane potential created by potassium and sodium ions allows the cell generate an action potentiala "spike" of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function. Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity.

    API Reference Price

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    20-Jan-2021
    25-Oct-2024
    KGS
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