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Also known as: 299-27-4, Potassium d-gluconate, Gluconic acid potassium salt, D-gluconic acid, monopotassium salt, Monopotassium d-gluconate, Potassium (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate
Molecular Formula
C6H11KO7
Molecular Weight
234.25  g/mol
InChI Key
HLCFGWHYROZGBI-JJKGCWMISA-M
FDA UNII
12H3K5QKN9

Potassium Gluconate API
Potassium gluconate is a salt of [DB01345] and is classified as a food additive by the FDA. It is also used as a potassium supplement. Potassium is an essential nutrient. It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function. In dietary supplements, potassium is often present as potassium chloride, but many other formsincluding potassium citrate, phosphate, aspartate, bicarbonate, and **gluconate**are also used. Potassium gluconate is believed to be more palatable and non-acidifying than potassium chloride (KCl).
1 2D Structure

Potassium Gluconate API

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
potassium;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
2.1.2 InChI
InChI=1S/C6H12O7.K/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h2-5,7-11H,1H2,(H,12,13);/q;+1/p-1/t2-,3-,4+,5-;/m1./s1
2.1.3 InChI Key
HLCFGWHYROZGBI-JJKGCWMISA-M
2.1.4 Canonical SMILES
C(C(C(C(C(C(=O)[O-])O)O)O)O)O.[K+]
2.1.5 Isomeric SMILES
C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[K+]
2.2 Other Identifiers
2.2.1 UNII
12H3K5QKN9
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Boron Gluconate

2. D-gluconate

3. D-gluconic Acid

4. Dextronic Acid

5. Gluconate

6. Gluconic Acid

7. Gluconic Acid, (113)indium-labeled

8. Gluconic Acid, (14)c-labeled

9. Gluconic Acid, (159)dysprosium-labeled Salt

10. Gluconic Acid, (99)technecium (5+) Salt

11. Gluconic Acid, 1-(14)c-labeled

12. Gluconic Acid, 6-(14)c-labeled

13. Gluconic Acid, Aluminum (3:1) Salt

14. Gluconic Acid, Ammonium Salt

15. Gluconic Acid, Calcium Salt

16. Gluconic Acid, Cesium(+3) Salt

17. Gluconic Acid, Cobalt (2:1) Salt

18. Gluconic Acid, Copper Salt

19. Gluconic Acid, Fe(+2) Salt, Dihydrate

20. Gluconic Acid, Lanthanum(+3) Salt

21. Gluconic Acid, Magnesium (2:1) Salt

22. Gluconic Acid, Manganese (2:1) Salt

23. Gluconic Acid, Monolithium Salt

24. Gluconic Acid, Monopotassium Salt

25. Gluconic Acid, Monosodium Salt

26. Gluconic Acid, Potassium Salt

27. Gluconic Acid, Sodium Salt

28. Gluconic Acid, Strontium (2:1) Salt

29. Gluconic Acid, Tin(+2) Salt

30. Gluconic Acid, Zinc Salt

31. Lithium Gluconate

32. Magnerot

33. Magnesium Gluconate

34. Maltonic Acid

35. Manganese Gluconate

36. Pentahydroxycaproic Acid

37. Sodium Gluconate

38. Zinc Gluconate

2.3.2 Depositor-Supplied Synonyms

1. 299-27-4

2. Potassium D-gluconate

3. Gluconic Acid Potassium Salt

4. D-gluconic Acid, Monopotassium Salt

5. Monopotassium D-gluconate

6. Potassium (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate

7. D-gluconic Acid Potassium Salt

8. Kali Gluconicum

9. Hsdb 3165

10. D-gluconic Acid, Potassium Salt

11. 12h3k5qkn9

12. Ins No.577

13. Potassuril

14. Ins-577

15. Kaon Elixir

16. Potassiumd-gluconate

17. Katorin

18. Potalium

19. Potasoral

20. Sirokal

21. Kalium-beta

22. E-577

23. Gluconsan K

24. Kalium Gluconate

25. Potassiumgluconate

26. K-iao

27. Gluconic Acid, Monopotassium Salt

28. Einecs 206-074-2

29. Unii-12h3k5qkn9

30. Potassium Gluconate [usp:jan]

31. D-gluconic Acid, Potassium Salt (1:1)

32. Einecs 252-355-8

33. Gluconsan-k (tn)

34. Mfcd00064211

35. Gluconic Acid, Monopotassium Salt, D-

36. D-gluconic Acid, Potassium Salt (1:?)

37. Dsstox_cid_9617

38. Ec 206-074-2

39. Dsstox_rid_78789

40. Gluconic Acid (food Grade)

41. Dsstox_gsid_29617

42. Schembl40567

43. 2,3,4,5,6-pentahydroxycaproic Acid Potassium Salt

44. Potassium Gluconate (jan/usp)

45. Chembl2106978

46. Dtxsid7029617

47. Potassium D-gluconate, >=99%

48. Chebi:32032

49. Gluconic Acid (technical Grade)

50. Hy-y0569c

51. Potassium Gluconate [fcc]

52. Potassium Gluconate [jan]

53. Potassium Gluconate [hsdb]

54. Potassium Gluconate [inci]

55. Potassium Gluconate [vandf]

56. Potassium Gluconate [mart.]

57. Tox21_202774

58. Potassium Gluconate [usp-rs]

59. Potassium Gluconate [who-dd]

60. Akos000277995

61. Db13620

62. Ncgc00260321-01

63. Ac-15968

64. As-83530

65. Cas-299-27-4

66. Gluconic Acid Potassium Salt [mi]

67. Potassium Gluconate [usp Monograph]

68. Cs-0108842

69. G0040

70. D01298

71. A876352

72. Q1122870

73. W-202242

74. Potassium Gluconate, Meets Usp Testing Specifications, Anhydrous

75. Potassium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate

76. D-gluconic Acid Monopotassium Salt; Gluconic Acid Potassium Salt;

77. Potassium Gluconate, United States Pharmacopeia (usp) Reference Standard

78. Potassium Gluconate, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date
2007-11-13
3 Chemical and Physical Properties
Molecular Weight 234.25 g/mol
Molecular Formula C6H11KO7
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass234.01418417 g/mol
Monoisotopic Mass234.01418417 g/mol
Topological Polar Surface Area141 Ų
Heavy Atom Count14
Formal Charge0
Complexity176
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Therapeutic Uses

IRRESPECTIVE OF THE SALT USED, POTASSIUM IS COMPLETELY DISSOCIABLE & HENCE IS UNAFFECTED IN ITS IRRITANT ACTIONS & ABSORPTION BY THE ANION IN THE COMPD. /POTASSIUM SALTS/

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 771


A SOURCE OF POTASSIUM FOR MGMNT OF HYPOKALEMIC STATES, SUCH AS OCCUR CONSEQUENT TO ADRENOCORTICOID THERAPY OR USE OF THIAZIDE DIURETICS, OR FOR DELIBERATE PRODN OF HYPERKALEMIA, AS FOR TREATMENT OF DIGITALIS INTOXICATION.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 771


...USED TO TREAT HYPOKALEMIA ASSOC WITH HYPERCHLOREMIA (EG RENAL TUBULAR ACIDOSIS, HYPOKALEMIA ASSOC WITH ACIDOSIS). IF...USED IN PT WITH HYPOKALEMIC HYPOCHLOREMIC ALKALOSIS, A SOURCE OF CHLORIDE ION (EG, AMMONIUM CHLORIDE, LYSINE MONOHYDROCHLORIDE) SHOULD BE PROVIDED. /POTASSIUM PREPN/

American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 238


4.2 Drug Warning

SUGAR-COATED POTASSIUM GLUCONATE TABLETS DISSOLVE @ HIGHER LEVEL /IN GI TRACT/ THAN DO ENTERIC-COATED TABLETS OF POTASSIUM CHLORIDE BUT, BY THIS VERY FACT, ARE FREE TO CAUSE THE IRRITATION FOR WHICH CHLORIDE TABLET WAS COATED. /THUS/...GLUCONATE HAS NO ADVANTAGE OVER NONENTERIC-COATED POTASSIUM CHLORIDE TABLETS.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 771


A FULL GLASS OF WATER TAKEN WITH /POTASSIUM GLUCONATE/...GREATLY REDUCES THE IRRITANT EFFECTS... HYPOCHLOREMIA IS FREQUENT ACCOMPANIMENT OF HYPOKALEMIA; IN SUCH INSTANCES /POTASSIUM/ CHLORIDE IS DEFINITELY PREFERRED /OVER POTASSIUM GLUCONATE/.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 771


...SINCE GLUCONATE METABOLIZES TO BICARBONATE, IT CONTRIBUTES TO ALKALOSIS, WHICH MAY BE...PRESENT IN HYPOKALEMIA. THUS IT WOULD BE DIFFICULT TO FIND SITUATIONS IN WHICH GLUCONATE WOULD BE SUPERIOR /TO POTASSIUM CHLORIDE/.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 771


4.3 Drug Indication

Because of potassiums wide-ranging roles in the body, low intakes can increase the risk of illness. Potassium supplements are indicated to prevent hypokalemia in patients who would be at particular risk if hypokalemia were to develop (e.g., digitalis treated patients with significant cardiac arrhythmias). Potassium deficiency occurs when the rate of loss through renal excretion and/or loss from the gastrointestinal tract is higher than the rate of potassium intake. In addition to serving as a preventative supplement, potassium gluconate also serves as a treatment for decreased potassium levels,,.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Potassium is an essential nutrient. It is the most abundant cation in intracellular fluid, where it plays a key role in maintaining cell function, especially in excitable cells such as skeletal muscles, the heart, and nerves. Increases in interstitial potassium play an important role in eliciting rapid vasodilation, allowing for blood flow to increase in exercising muscle.


5.2 ATC Code

A - Alimentary tract and metabolism

A12 - Mineral supplements

A12B - Potassium

A12BA - Potassium

A12BA05 - Potassium gluconate


5.3 Absorption, Distribution and Excretion

Absorption

Potassium is rapidly and well absorbed. A 2016 dose-response trial found that humans absorb about 94% of potassium gluconate in supplements, and this absorption rate is similar to that of potassium from potatoes.


Route of Elimination

90% of potassium is eliminated via the kidneys. A small amount is eliminated in feces and sweat.


Volume of Distribution

Distribution is largely intracellular, but it is the intravascular concentration that is primarily responsible for toxicity.


Clearance

Potassium is freely filtered by the glomerulus in the kidney. The majority of filtered potassium is reabsorbed in the proximal tubule and loop of Henle. Less than 10% of the filtered load reaches the distal nephron. In the proximal tubule of the nephron, potassium absorption is mainly passive and proportional to Na+ and water. K+ reabsorption in the thick ascending limb of Henle occurs through both transcellular and paracellular pathways. The transcellular component is regulated by potassium transport on the apical membrane Na+-K+-2Cl cotransporter. The secretion of potassium begins in the early distal convoluted tubule of the nephron and progressively increases along the distal nephron into the cortical collecting duct. Most urinary K+ can be accounted for by electrogenic K+ secretion mediated by principal cells in the initial collecting duct and the cortical collecting duct. An electroneutral K+ and Cl cotransport mechanism is also present on the apical surface of the distal nephron. Under conditions of potassium deficiency, reabsorption of the cation occurs in the collecting duct. This process is regulated by the upregulation in the apically located H+-K+-ATPase on -intercalated cells.


5.4 Mechanism of Action

Potassium is the most abundant cation (approximately 150 to 160 mEq per liter) within human cells. Intracellular sodium content is relatively low. In the extracellular fluid, sodium predominates and the potassium content is low (3.5 to 5 mEq per liter). A membrane-bound enzyme, sodium-potassiumactivated adenosinetriphosphatase (Na +K +ATPase), actively transports or pumps sodium out and potassium into cells to maintain the concentration gradients. The intracellular to extracellular potassium gradients are necessary for nerve impulse signaling in such specialized tissues as the heart, brain, and skeletal muscle, and for the maintenance of physiologic renal function and maintenance of acid-base balance. High intracellular potassium concentrations are necessary for numerous cellular metabolic processes. Intracellular K+ serves as a reservoir to limit the fall in extracellular potassium concentrations occurring under pathologic conditions with loss of potassium from the body.


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