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Chemistry

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Also known as: 298-14-6, Potassium hydrogen carbonate, Potassium hydrogencarbonate, Potassium acid carbonate, Monopotassium carbonate, Carbonic acid, monopotassium salt
Molecular Formula
CHKO3
Molecular Weight
100.115  g/mol
InChI Key
TYJJADVDDVDEDZ-UHFFFAOYSA-M
FDA UNII
HM5Z15LEBN

Potassium hydrogen carbonate
Potassium bicarbonate is a white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide through an aqueous potassium carbonate solution. It is used in medicine as an antacid. It is registered in the FDA under the section of suitable, safe and effective ingredients for OTC antacids. This FDA denomination classifies potassium bicarbonate as a GRAS ingredient.
1 2D Structure

Potassium hydrogen carbonate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
potassium;hydrogen carbonate
2.1.2 InChI
InChI=1S/CH2O3.K/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
2.1.3 InChI Key
TYJJADVDDVDEDZ-UHFFFAOYSA-M
2.1.4 Canonical SMILES
C(=O)(O)[O-].[K+]
2.2 Other Identifiers
2.2.1 UNII
HM5Z15LEBN
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Khco3

2. Potassium Hydrocarbonate

2.3.2 Depositor-Supplied Synonyms

1. 298-14-6

2. Potassium Hydrogen Carbonate

3. Potassium Hydrogencarbonate

4. Potassium Acid Carbonate

5. Monopotassium Carbonate

6. Carbonic Acid, Monopotassium Salt

7. Potassiumbicarbonate

8. Khco3

9. Potassium;hydrogen Carbonate

10. Armicarb

11. Kafylox

12. Kaligreen

13. Milstop

14. Purple K

15. Hm5z15lebn

16. Potassium Carbonate Solution

17. Potassium Bicarbonate [usp]

18. Chebi:81862

19. Ins-501(ii)

20. E-501(ii)

21. Mfcd00011402

22. Potassium Bicarbonate (usp)

23. Ccris 3510

24. Einecs 206-059-0

25. Unii-hm5z15lebn

26. Epa Pesticide Chemical Code 073508

27. Potasium Bicarbonate

28. Potassium Bicabonate

29. Potassium Bicarbonat

30. Pbc

31. Einecs 241-378-9

32. K-vescent (tn)

33. Potassiumhydrogencarbonate

34. Potassium Hydogencarbonate

35. Potassium;hydron;carbonate

36. Ec 206-059-0

37. Potassium Hydrogen-carbonate

38. Schembl2420

39. Ins No.501(ii)

40. Chembl2106975

41. Dtxsid0021177

42. Potassium Bicarbonate, Acs Grade

43. Potassium Bicarbonate [ii]

44. Potassium Bicarbonate [mi]

45. Potassium Bicarbonate [fcc]

46. Potassium Bicarbonate [inci]

47. Potassium Bicarbonate [vandf]

48. Potassium Bicarbonate [mart.]

49. Akos009159056

50. Carbonic Acid, Potassium Salt (1:1)

51. Potassium Bicarbonate [usp-rs]

52. Potassium Bicarbonate [who-dd]

53. Db11098

54. E501

55. Potassium Carbonate Solution [fcc]

56. Ft-0645098

57. Potassium Bicarbonate [usp Monograph]

58. C18606

59. D02077

60. Potassium Bicarbonate, Trace Metals Grade 99.98%

61. Potassium Hydrogen Carbonate [ep Monograph]

62. Q410529

63. J-017655

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 100.115 g/mol
Molecular Formula CHKO3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass99.95627537 g/mol
Monoisotopic Mass99.95627537 g/mol
Topological Polar Surface Area60.4 Ų
Heavy Atom Count5
Formal Charge0
Complexity33.9
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Potassium bicarbonate is used as an antacid, electrolyte replenisher and potassium supplement. It can also be used as an excipient in drug formulations. An antacid is a medication used to neutralize gastric acid in a short timeframe after ingestion and the effect is soon overcome by meal-stimulated acid secretion.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Potassium is the principal intracellular cation in most body tissues. The concentration of potassium ions is essential to conduct nerve impulses in specialized tissues like brain, heart and skeletal muscle, as well as to maintain normal renal function, acid-base balance, and cellular metabolic functions. The use of compounds containing bicarbonate is showed to produce the release of CO2. This effect has been one of the problems of the use of potassium bicarbonate as it can cause eructation.


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]; Osmotic Laxative [EPC]; Potassium Compounds [CS]; Potassium Salt [EPC]; Increased Large Intestinal Motility [PE]
5.3 ATC Code

A - Alimentary tract and metabolism

A12 - Mineral supplements

A12B - Potassium

A12BA - Potassium

A12BA04 - Potassium hydrogencarbonate


5.4 Absorption, Distribution and Excretion

Absorption

Potassium bicarbonate intake is done mainly in the small intestine in which approximately 90% of the potassium will be absorbed by passive diffusion.


Route of Elimination

Approximately 90% of the exogenous potassium consumed is lost in the urine while the other 10% is excreted in feces and a very small amount can be found in the sweat. The excreted potassium is freely filtered by the glomerulus of the kidney.


5.5 Biological Half-Life

Some reports have shown that after absorption, most body potassium exchanges rapidly with a half-life of less than 7 hours.


5.6 Mechanism of Action

The antacid potential of potassium bicarbonate is attained by increasing the gastrointestinal pH by neutralizing hydrochloric acid. The increase in pH results in suppression of the action of pepsin which is the enzyme that exacerbates ulceration due to the presence of acid.


API SUPPLIERS

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Rochem International Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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Rochem

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USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Fi Europe 2024
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USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Fi Europe 2024
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Sudeep Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Fi Europe 2024
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Vinati Organics

India

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Fi Europe 2024
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Vinati Organics

India

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Macco Organiques, Spol. s.r o

Czech Republic

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FDF Dossiers

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BMWS24
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Succinic Acid; Potassium Citrate; L-Tartaric Acid; Potassium hydrogen carbonate

Brand Name : Potassion

Dosage Form : Granules

Dosage Strength : 100MG; 250MG; 50MG; 500MG

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Registration Country : Italy

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BMWS24
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POTASSIUM BICARBONATE

Brand Name : ZEV

Dosage Form : LIQUID

Dosage Strength : 52.7MG/ML

Packaging : 250ML/2/4L

Approval Date :

Application Number : 549312

Regulatory Info : OTC

Registration Country : Canada

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BMWS24
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sodium alginate; Potassium Bicarbonate; Calcium Carbonate

Brand Name : Refubel Advance

Dosage Form : Oral Suspension

Dosage Strength : 1G/10ML; 0.2G/10ML; 0.2G/10ML

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Regulatory Info :

Registration Country : Turkey

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04

Reckitt Benckiser

United Kingdom
BMWS24
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Reckitt Benckiser

United Kingdom
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sodium alginate; Potassium Bicarbonate

Brand Name : Gavion Advance

Dosage Form : Sodium Alginate+Potassium Bicarbonate 200Ml Oral Use

Dosage Strength : os suspe 200 ml

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Regulatory Info :

Registration Country : Italy

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Reckitt Benckiser

United Kingdom
BMWS24
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Reckitt Benckiser

United Kingdom
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sodium alginate; Potassium Bicarbonate

Brand Name : Gavion Advance

Dosage Form : Sodium Alginate+Potassium Bicarbonate 200Ml Oral Use

Dosage Strength : os suspe 200 ml mint 1,000 mg/10 ml + 200 mg/10 ml

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Registration Country : Italy

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06

Reckitt Benckiser

United Kingdom
BMWS24
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Reckitt Benckiser

United Kingdom
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sodium alginate; Potassium Bicarbonate

Brand Name : Gavion Advance

Dosage Form : Sodium Alginate+Potassium Bicarbonate 500Ml Oral Use

Dosage Strength : os suspe 500 ml

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Registration Country : Italy

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07

Reckitt Benckiser

United Kingdom
BMWS24
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Reckitt Benckiser

United Kingdom
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sodium alginate; Potassium Bicarbonate

Brand Name : Gavion Advance

Dosage Form : Sodium Alginate+Potassium Bicarbonate 500Ml Oral Use

Dosage Strength : os suspe 500 ml mint 1,000 mg/10 ml + 200 mg/10 ml

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Registration Country : Italy

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Vefa Ilac

Turkey
BMWS24
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Vefa Ilac

Turkey
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Kaltostat; Potassium Bicarbonate

Brand Name : Refcon Advance

Dosage Form : ORAL SUSPENSION

Dosage Strength : 1000MG/10ML; 200MG/10ML

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Regulatory Info : Generic CTD

Registration Country : Turkey

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09

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BMWS24
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Sodium Bicarbonate; Potassium Bicarbonate

Brand Name : Eurocollins Solution

Dosage Form :

Dosage Strength : To Soluz 400 Ml/500 Ml  

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Registration Country : Italy

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BMWS24
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Sodium Bicarbonate; Potassium Bicarbonate

Brand Name : Eurocollins Solution

Dosage Form :

Dosage Strength : B Soluz 100 Ml  

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Regulatory Info :

Registration Country : Italy

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Europe

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Fi Europe 2024
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sodium alginate; Potassium Bicarbonate; Calcium Carbonate

Brand Name : Refubel Advance

Dosage Form : Oral Suspension

Dosage Strength : 1G/10ML; 0.2G/10ML; 0.2G/10ML

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Approval Date :

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Registration Country : Turkey

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Fi Europe 2024
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sodium alginate; Potassium Bicarbonate

Brand Name : Gavion Advance

Dosage Form : Sodium Alginate+Potassium Bicarbonate 10Ml 20 Joined' Oral Use

Dosage Strength : 20 bust os suspe 10 ml mint

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Registration Country : Italy

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Fi Europe 2024
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sodium alginate; Potassium Bicarbonate

Brand Name : Gavion Advance

Dosage Form : Sodium Alginate+Potassium Bicarbonate 200Ml Oral Use

Dosage Strength : os suspe 200 ml

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Registration Country : Italy

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Fi Europe 2024
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sodium alginate; Potassium Bicarbonate

Brand Name : Gavion Advance

Dosage Form : Sodium Alginate+Potassium Bicarbonate 200Ml Oral Use

Dosage Strength : os suspe 200 ml mint 1,000 mg/10 ml + 200 mg/10 ml

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Registration Country : Italy

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Fi Europe 2024
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Fi Europe 2024
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sodium alginate; Potassium Bicarbonate

Brand Name : Gavion Advance

Dosage Form : Sodium Alginate+Potassium Bicarbonate 500Ml Oral Use

Dosage Strength : os suspe 500 ml

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Regulatory Info :

Registration Country : Italy

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Fi Europe 2024
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Fi Europe 2024
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sodium alginate; Potassium Bicarbonate

Brand Name : Gavion Advance

Dosage Form : Sodium Alginate+Potassium Bicarbonate 500Ml Oral Use

Dosage Strength : os suspe 500 ml mint 1,000 mg/10 ml + 200 mg/10 ml

Packaging :

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Application Number :

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Registration Country : Italy

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Vefa Ilac

Turkey
Fi Europe 2024
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Vefa Ilac

Turkey
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Kaltostat; Potassium Bicarbonate

Brand Name : Refcon Advance

Dosage Form : ORAL SUSPENSION

Dosage Strength : 1000MG/10ML; 200MG/10ML

Packaging :

Approval Date :

Application Number :

Regulatory Info : Generic CTD

Registration Country : Turkey

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SALF SpA

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Fi Europe 2024
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SALF SpA

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Sodium Bicarbonate; Potassium Bicarbonate

Brand Name : Sodium Bicarbonate, Potassium Bicarbonate

Dosage Form :

Dosage Strength : 5 Vials 20 Meq 20 Ml

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Application Number :

Regulatory Info :

Registration Country : Italy

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MONICO SpA

Country
Fi Europe 2024
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MONICO SpA

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Sodium Bicarbonate; Potassium Bicarbonate

Brand Name : Eurocollins Solution

Dosage Form :

Dosage Strength : To Soluz 400 Ml/500 Ml  

Packaging :

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Application Number :

Regulatory Info :

Registration Country : Italy

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SALF SpA

Country
Fi Europe 2024
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SALF SpA

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Sodium Bicarbonate; Potassium Bicarbonate

Brand Name : Eurocollins Solution

Dosage Form :

Dosage Strength : 1 Bottle 400 Ml  

Packaging :

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Regulatory Info :

Registration Country : Italy

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