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    Chemistry

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    Also known as: 298-14-6, Potassium hydrogen carbonate, Potassium hydrogencarbonate, Potassium acid carbonate, Monopotassium carbonate, Carbonic acid, monopotassium salt
    Molecular Formula
    CHKO3
    Molecular Weight
    100.115  g/mol
    InChI Key
    TYJJADVDDVDEDZ-UHFFFAOYSA-M
    FDA UNII
    HM5Z15LEBN
    Potassium hydrogen carbonate
    Potassium bicarbonate is a white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide through an aqueous potassium carbonate solution. It is used in medicine as an antacid. It is registered in the FDA under the section of suitable, safe and effective ingredients for OTC antacids. This FDA denomination classifies potassium bicarbonate as a GRAS ingredient.
    1 2D Structure

    Potassium hydrogen carbonate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    potassium;hydrogen carbonate
    2.1.2 InChI
    InChI=1S/CH2O3.K/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
    2.1.3 InChI Key
    TYJJADVDDVDEDZ-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    C(=O)(O)[O-].[K+]
    2.2 Other Identifiers
    2.2.1 UNII
    HM5Z15LEBN
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Khco3

    2. Potassium Hydrocarbonate

    2.3.2 Depositor-Supplied Synonyms

    1. 298-14-6

    2. Potassium Hydrogen Carbonate

    3. Potassium Hydrogencarbonate

    4. Potassium Acid Carbonate

    5. Monopotassium Carbonate

    6. Carbonic Acid, Monopotassium Salt

    7. Potassiumbicarbonate

    8. Khco3

    9. Potassium;hydrogen Carbonate

    10. Armicarb

    11. Kafylox

    12. Kaligreen

    13. Milstop

    14. Purple K

    15. Hm5z15lebn

    16. Potassium Carbonate Solution

    17. Potassium Bicarbonate [usp]

    18. Chebi:81862

    19. Ins-501(ii)

    20. E-501(ii)

    21. Mfcd00011402

    22. Potassium Bicarbonate (usp)

    23. Ccris 3510

    24. Einecs 206-059-0

    25. Unii-hm5z15lebn

    26. Epa Pesticide Chemical Code 073508

    27. Potasium Bicarbonate

    28. Potassium Bicabonate

    29. Potassium Bicarbonat

    30. Pbc

    31. Einecs 241-378-9

    32. K-vescent (tn)

    33. Potassiumhydrogencarbonate

    34. Potassium Hydogencarbonate

    35. Potassium;hydron;carbonate

    36. Ec 206-059-0

    37. Potassium Hydrogen-carbonate

    38. Schembl2420

    39. Ins No.501(ii)

    40. Chembl2106975

    41. Dtxsid0021177

    42. Potassium Bicarbonate, Acs Grade

    43. Potassium Bicarbonate [ii]

    44. Potassium Bicarbonate [mi]

    45. Potassium Bicarbonate [fcc]

    46. Potassium Bicarbonate [inci]

    47. Potassium Bicarbonate [vandf]

    48. Potassium Bicarbonate [mart.]

    49. Akos009159056

    50. Carbonic Acid, Potassium Salt (1:1)

    51. Potassium Bicarbonate [usp-rs]

    52. Potassium Bicarbonate [who-dd]

    53. Db11098

    54. E501

    55. Potassium Carbonate Solution [fcc]

    56. Ft-0645098

    57. Potassium Bicarbonate [usp Monograph]

    58. C18606

    59. D02077

    60. Potassium Bicarbonate, Trace Metals Grade 99.98%

    61. Potassium Hydrogen Carbonate [ep Monograph]

    62. Q410529

    63. J-017655

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 100.115 g/mol
    Molecular Formula CHKO3
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count0
    Exact Mass99.95627537 g/mol
    Monoisotopic Mass99.95627537 g/mol
    Topological Polar Surface Area60.4 Ų
    Heavy Atom Count5
    Formal Charge0
    Complexity33.9
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Potassium bicarbonate is used as an antacid, electrolyte replenisher and potassium supplement. It can also be used as an excipient in drug formulations. An antacid is a medication used to neutralize gastric acid in a short timeframe after ingestion and the effect is soon overcome by meal-stimulated acid secretion.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Potassium is the principal intracellular cation in most body tissues. The concentration of potassium ions is essential to conduct nerve impulses in specialized tissues like brain, heart and skeletal muscle, as well as to maintain normal renal function, acid-base balance, and cellular metabolic functions. The use of compounds containing bicarbonate is showed to produce the release of CO2. This effect has been one of the problems of the use of potassium bicarbonate as it can cause eructation.

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]; Osmotic Laxative [EPC]; Potassium Compounds [CS]; Potassium Salt [EPC]; Increased Large Intestinal Motility [PE]
    5.3 ATC Code

    A - Alimentary tract and metabolism

    A12 - Mineral supplements

    A12B - Potassium

    A12BA - Potassium

    A12BA04 - Potassium hydrogencarbonate

    5.4 Absorption, Distribution and Excretion

    Absorption

    Potassium bicarbonate intake is done mainly in the small intestine in which approximately 90% of the potassium will be absorbed by passive diffusion.

    Route of Elimination

    Approximately 90% of the exogenous potassium consumed is lost in the urine while the other 10% is excreted in feces and a very small amount can be found in the sweat. The excreted potassium is freely filtered by the glomerulus of the kidney.

    5.5 Biological Half-Life

    Some reports have shown that after absorption, most body potassium exchanges rapidly with a half-life of less than 7 hours.

    5.6 Mechanism of Action

    The antacid potential of potassium bicarbonate is attained by increasing the gastrointestinal pH by neutralizing hydrochloric acid. The increase in pH results in suppression of the action of pepsin which is the enzyme that exacerbates ulceration due to the presence of acid.

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