In hyperthyroid patients, potassium iodide produces rapid remission of symptoms by inhibiting the release of thyroid hormone into the circulation. The effects of potassium iodide on the thyroid gland include reduction of vascularity, a firming of the glandular tissue, shrinkage of the size of individual cells, reaccumulation of colloid in the follicles, and increases in bound iodine. These actions may facilitate thyroidectomy when the medication is given prior to surgery.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.

When administered prior to and following administration of radioactive isotopes and in radiation emergencies involving the release of radioactive iodine, potassium iodide protects the thyroid gland by blocking the thyroidal uptake of radioactive isotopes of iodine.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.

The mechanism of action of potassium iodide's antifungal activity against Sporothix schenckii has not been determined. Potassium iodide does not appear to increase monocyte or neutrophil killing of S. schenckii in in vitro studies. However, exposure of the yeast form of S. schenckii to various concentrations of iodine (iodine and potassium iodide solution) has resulted in rapid cell destruction.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2005. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2005 (Plus Supplements)., p. 3126

Potassium iodide is thought to act as an expectorant by increasing respiratory tract secretions and thereby decreasing the viscosity of mucous ...

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2005. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2005 (Plus Supplements)., p. 3126

When potassium iodide is administered simultaneously with radiation exposure, the protectant effect is approximately 97%. Potassium iodide given 12 and 24 hours before exposure yields a 90% and 70% protectant effect, respectively. However, potassium iodide administered 1 and 3 hours after exposure results in an 85% and 50% protectant effect, respectively. Potassium iodide administered more than 6 hours after exposure is thought to have a negligible protectant effect.

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2006.

Molecular Formula	IK
Molecular Weight	166.0028 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	165.86818 g/mol
Monoisotopic Mass	165.86818 g/mol
Topological Polar Surface Area	0 Å²
Heavy Atom Count	2
Formal Charge	0
Complexity	2
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

1 of 6
Drug Name	Iosat
PubMed Health	Potassium Iodide (By mouth)
Drug Classes	Antithyroid Agent, Expectorant, Iodide Supplement, Radiation Emergency, Thyroid Blocking Agent
Drug Label	Each white, round, cross-scoredthe name IOSAT stamped on one sidetablet contains 130 mg of potassium iodide....
Active Ingredient	Potassium iodide
Dosage Form	Tablet
Route	Oral
Strength	65mg; 130mg
Market Status	Over the Counter
Company	Anbex

2 of 6
Drug Name	Thyrosafe
Drug Label	Each milliliter (1 mL) of ThyroShield contains 65 mg of potassium iodide (USP) in a black raspberry-flavored solution. Inactive ingredients are: FD&C Red #40 and Blue #1, methylparaben, natural and artificial black raspberry flavor, propylene glyco...
Active Ingredient	Potassium iodide
Dosage Form	Tablet
Route	Oral
Strength	65mg
Market Status	Over the Counter
Company	Recip

3 of 6
Drug Name	Thyroshield
Active Ingredient	Potassium iodide
Dosage Form	Solution
Route	Oral
Strength	65mg/ml
Market Status	Over the Counter
Company	Arco Pharms

4 of 6
Drug Name	Iosat
PubMed Health	Potassium Iodide (By mouth)
Drug Classes	Antithyroid Agent, Expectorant, Iodide Supplement, Radiation Emergency, Thyroid Blocking Agent
Drug Label	Each white, round, cross-scoredthe name IOSAT stamped on one sidetablet contains 130 mg of potassium iodide....
Active Ingredient	Potassium iodide
Dosage Form	Tablet
Route	Oral
Strength	65mg; 130mg
Market Status	Over the Counter
Company	Anbex

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