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    Chemistry

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    Also known as: 7758-11-4, Dipotassium phosphate, Potassium phosphate dibasic, Dipotassium hydrogenphosphate, Dibasic potassium phosphate, Potassium hydrogen phosphate
    Molecular Formula
    HK2O4P
    Molecular Weight
    174.176  g/mol
    InChI Key
    ZPWVASYFFYYZEW-UHFFFAOYSA-L
    FDA UNII
    CI71S98N1Z
    Potassium Phosphate
    Potassium Phosphate, Dibasic is the dipotassium form of phosphoric acid, that can be used as an electrolyte replenisher and with radio-protective activity. Upon oral administration, potassium phosphate is able to block the uptake of the radioactive isotope phosphorus P 32 (P-32).
    1 2D Structure

    Potassium Phosphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    dipotassium;hydrogen phosphate
    2.1.2 InChI
    InChI=1S/2K.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2
    2.1.3 InChI Key
    ZPWVASYFFYYZEW-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    OP(=O)([O-])[O-].[K+].[K+]
    2.2 Other Identifiers
    2.2.1 UNII
    CI71S98N1Z
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. K2hpo4

    2. Kd2po4

    3. Potassium Acid Phosphate

    4. Potassium Dideuterium Phosphate

    5. Potassium Dihydrogen Phosphate

    6. Potassium Monohydrogen Phosphate

    7. Potassium Phosphate

    8. Potassium Phosphate (k-h2po4)

    9. Potassium Phosphate (k-h3po4(1:2))

    10. Potassium Phosphate (k2-hpo4)

    11. Potassium Phosphate (k3-po4)

    12. Potassium Phosphate, Dibasic

    13. Potassium Phosphate, Monobasic

    14. Potassium Phosphate, Unspecified Form

    2.3.2 Depositor-Supplied Synonyms

    1. 7758-11-4

    2. Dipotassium Phosphate

    3. Potassium Phosphate Dibasic

    4. Dipotassium Hydrogenphosphate

    5. Dibasic Potassium Phosphate

    6. Potassium Hydrogen Phosphate

    7. Potassium Phosphate, Dibasic

    8. Phosphoric Acid, Dipotassium Salt

    9. Potassium Dibasic Phosphate

    10. Dipotassium Monophosphate

    11. Potassium Monohydrogen Phosphate

    12. K2hpo4

    13. Potassium Monophosphate

    14. Dipotassium Hydrogenorthophosphate

    15. Dipotassium Monohydrogen Phosphate

    16. Dipotassium Orthophosphate

    17. Mfcd00011383

    18. Hydrogen Dipotassium Phosphate

    19. Potassium Phosphate (dibasic)

    20. Di-potassium Hydrogen Phosphate

    21. Dipotassium Hydrogen Orthophosphate

    22. Sec.-potassium Phosphate

    23. Dipotassium Acid Phosphate

    24. Potassium Hydrogenphosphate

    25. Phosphoric Acid, Potassium Salt (1:2)

    26. Secondary Potassium Phosphate

    27. Ci71s98n1z

    28. Ins No.340(ii)

    29. Ins-340(ii)

    30. Dipotassium Hydrogen Monophosphate

    31. E-340(ii)

    32. Potassium Phosphate Dibasic, Acs Reagent

    33. Isolyte

    34. Dipotassium-o-phosphate

    35. Dipotassium;hydrogen Phosphate

    36. Ccris 6544

    37. Hsdb 935

    38. Kali Phosphoricum

    39. Leex-a-phos

    40. Einecs 231-834-5

    41. Mediject P (tn)

    42. Di Potassium Phosphate

    43. Potassiumhydrogenphosphate

    44. Potassium Phosphate,dibasic

    45. Dipotasium Hydrogen Phosphate

    46. Unii-ci71s98n1z

    47. Potassium Monohydrogenphosphate

    48. Potassium Hydrogen Monophosphate

    49. Chembl1200459

    50. Dtxsid8035506

    51. Kali Phosphoricum [hpus]

    52. Chebi:32031

    53. Chebi:131527

    54. Dipotassium Phosphate [inci]

    55. Dipotassium Monohydrogen Orthophosphate

    56. Potassium Dibasic Phosphate Trihydrate

    57. Potassium Phosphate (k2hpo4)

    58. Akos015915872

    59. Akos016371887

    60. Db09414

    61. Potassium Hydrogen Phosphate, Anhydrous

    62. Potassium Phosphate [green Book]

    63. Potassium Phosphate, Dibasic, Anhydrous

    64. Potassium Phosphate, Dibasic (jan/usp)

    65. Potassium Phosphate, Dibasic [usp:jan]

    66. Potassium Phosphate Dibasic, Lr, >=98%

    67. Potassium Phosphate, Dibasic [ii]

    68. Potassium Phosphate, Dibasic [mi]

    69. Sy010082

    70. Di-potassium Hydrogen Orthophosphate

    71. Dipotassium Phosphate [ep Impurity]

    72. Potassium Phosphate, Dibasic [fcc]

    73. Potassium Phosphate, Dibasic [jan]

    74. Potassium Phosphate,dibasic [vandf]

    75. Dipotassium Phosphate [ep Monograph]

    76. Potassium Phosphate Dibasic Anhydrate

    77. Potassium Phosphate, Dibasic [hsdb]

    78. Dibasic Potassium Phosphate [usp-rs]

    79. Potassium Phosphate Dibasic [who-dd]

    80. Potassium Phosphate Dibasic Solution, 1.0 M

    81. Potassium Phosphate Dibasic, Biochemical Grade

    82. Potassium Phosphate Dibasic, Puriss., >=99%

    83. D02403

    84. Dipotassium Hydrogen Phosphate (k2hpo4)

    85. Ec 231-834-5

    86. Dibasic Potassium Phosphate [usp Impurity]

    87. Dibasic Potassium Phosphate [usp Monograph]

    88. Potassium Phosphate Dibasic, Acs Reagent, >=98%

    89. Potassium Phosphate Dibasic, Usp, 98.0-100.5%

    90. Potassium Phosphate, Dibasic [orange Book]

    91. Q403721

    92. Potassium Phosphate Dibasic, Ar, Anhydrous, >=99%

    93. Potassium Phosphate, Dibasic [usp Impurity]

    94. Potassium Phosphate Dibasic, Reagent Grade, >=98.0%

    95. Potassium Phosphate Dibasic, 99.95% Trace Metals Basis

    96. Potassium Phosphate Dibasic, Saj First Grade, >=98.0%

    97. Potassium Phosphate Dibasic, Trace Metals Grade 99.95%

    98. Potassium Phosphate Dibasic, Jis Special Grade, >=99.0%

    99. Potassium Phosphate Dibasic, Vetec(tm) Reagent Grade, 98%

    100. Potassium Phosphate Dibasic, Meets Usp Testing Specifications

    101. Dibasic Potassium Phosphate Component Of Potassium Phosphates

    102. Potassium Phosphates Component Dibasic Potassium Phosphate

    103. Dibasic Potassium Phosphate, United States Pharmacopeia (usp) Reference Standard

    104. Potassium Phosphate Dibasic, Anhydrous, Free-flowing, Redi-dri(tm), Acs Reagent, >=98%

    105. Potassium Phosphate Dibasic, Puriss. P.a., Acs Reagent, Anhydrous, >=99.0% (t)

    106. Potassium Phosphate Dibasic Anhydrous, Pharmagrade, Usp, Manufactured Under Appropriate Gmp Controls For Pharma Or Biopharmaceutical Production.

    107. Potassium Phosphate Dibasic, Anhydrous, For Luminescence, For Molecular Biology, Bioultra, >=99.0% (t)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 174.176 g/mol
    Molecular Formula HK2O4P
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count0
    Exact Mass173.88865848 g/mol
    Monoisotopic Mass173.88865848 g/mol
    Topological Polar Surface Area83.4 Ų
    Heavy Atom Count7
    Formal Charge0
    Complexity46.5
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    CATHARTIC

    Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 1216

    Factors affecting calcium-phosphate solubility in parenteral nutrition solutions used in neonates were studied. Six neonatal parenteral nutrition solutions were prepared using either Aminosyn or FreAmine II and various amino acid and dextrose concentrations. Phosphorus (as mono- and dibasic potassium phosphate) and calcium (as 10% calcium gluconate) were added in concentrations of calcium 2.5-100 meq/l and phosphorus 2.5-100 mmol/l. Duplicate samples were prepared and analyzed either after they were heated in a water bath (37 C) for 20 min or after 18 hr at 25 C followed by 30 min in a water bath (37 C). Precipitation was detected visually and spectrophotometrically, and pH was measured. Lipid emulsion was added to 2 FreAmine II solutions in a ratio of 7.5:1 (parenteral nutrition solution:lipid) and the resulting pH was measured. Time and temperature affected calcium-phosphate solubility in all solutions tested. Precipitation curves of amount of calcium versus amount of phosphate added were prepared for each solution. Amino acid and dextrose concentrations affected the pH of the solutions, and when a lipid emulsion was added, the pH rose more in the 1% than in the 2% FreAmine II solution. In selected solutions, as much as 120 mg/kg/day calcium and 55 mg/kg/day phosphate can be administered, approximating daily third trimester accumulation of these minerals. Use of the precipitation curves in this paper, with attention to their limitations, should aid in the safe delivery of calcium and phosphorus IV to neonates.

    PMID:6798868 Eggert LD et al; Am J Hosp Pharm 39 (Jan): 49-53 (1982)

    SALINE BULK CATHARTIC

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 744

    4.2 Drug Warning

    Oral administration is safer, but careful monitoring of serum electrolyte levels and renal function is necessary. Nausea, vomiting, and diarrhea may occur and may be dose dependent. Concomitant use of antacids containing aluminum and/or magnesium should be avoided, because they may bind phosphate and prevent it absorption (calcium antacids also may bind phosphate, and it is assumed that these agents are not given to hypercalcemic patients).

    American Medical Association, Department of Drugs. Drug Evaluations. 6th ed. Chicago, Ill: American Medical Association, 1986., p. 897

    Phosphate should not be given to patients with impaired renal function or hyperphosphatemia. They should not be given to patients with alkaline urine due to urinary tract infections because increased calcium and phosphate concentrations in the alkaline urine increase the risk of calcium phosphate stones.

    American Medical Association, Department of Drugs. Drug Evaluations. 6th ed. Chicago, Ill: American Medical Association, 1986., p. 897

    Intravenous administration of phosphates is dangerous. Hypocalcemia, hypotension and shock, myocardial infarction, tetany, and acute renal failure have occurred, and deaths have been reported. Deposition of calcium phosphate in the kidney, heart, lung, and blood vessels also may be fatal. For these reasons, intravenous therapy is not justified in the treatment of hypercalcemia. Phosphates should not be administered to patients with impaired renal function or hyperphosphatemia. They also should not be given to patients with alkaline urine due to urinary tract infections because increased calcium and phosphate concentrations in the alkaline urine increase the risk of calcium phosphate stones. Phosphate should be given as the potassium rather than the sodium salt because the latter causes volume expansion and inhibits phosphate reabsorption, thus negating the therapeutic effect. /Phosphate salt/

    American Medical Association. AMA Drug Evaluations Annual 1991. Chicago, IL: American Medical Association, 1991., p. 1951

    The most common adverse effect of phosphate salts is diarrhea. Patients with kidney stones may pass old stones when phosphate therapy is started and should be warned of this possibility. Phosphates are contraindicated in patients with infected stones and in those with renal function less than 30% of normal. /Orthophosphates/

    American Medical Association, Department of Drugs. Drug Evaluations. 6th ed. Chicago, Ill: American Medical Association, 1986., p. 584

    4.3 Drug Indication

    Dipotassium phosphate is used in imitation dairy creamers, dry powder beverages, mineral supplements, and starter cultures as an additive. It is used in non-dairy creamers to prevent coagulation. Dipotassium phosphate is also used to make buffer solutions and it is used in the production of trypticase soy agar which is used to make agar plates for culturing bacteria.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions.

    5.2 MeSH Pharmacological Classification

    Cariostatic Agents

    Substances that inhibit or arrest DENTAL CARIES formation. (Boucher's Clinical Dental Terminology, 4th ed) (See all compounds classified as Cariostatic Agents.)

    Buffers

    A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer. (See all compounds classified as Buffers.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]; Osmotic Laxative [EPC]; Potassium Compounds [CS]; Potassium Salt [EPC]; Increased Large Intestinal Motility [PE]
    5.4 Absorption, Distribution and Excretion

    Absorption

    Potassium salts are well absorbed from gastro intestinal tract. Net phosphorus absorption may occur in the small intestine in some species but is primarily a function of the colon in horses.

    Route of Elimination

    Potassium is excreted primarily by kidney.

    Volume of Distribution

    Distribution is largely intracellular, but it is the intravascular concentration that is primarily responsible for toxicity.

    Clearance

    Phosphates are rapidly cleared by dialysis.

    POTASSIUM SALTS ARE WELL ABSORBED FROM THE GASTROINTESTINAL TRACT. ... POTASSIUM IS EXCRETED PRIMARILY BY THE KIDNEY. /POTASSIUM SALTS/

    McEvoy, G.K. (ed.). AHFS Drug Information 90. Bethesda, MD: American Society of Hospital Pharmacists, Inc., 1990 (Plus Supplements 1990)., p. 1425

    Net phosphorus absorption may occur in the small intestine in some species but is primarily a function of the colon in horses. /SRP: Phosphates/

    Booth, N.H., L.E. McDonald (eds.). Veterinary Pharmacology and Therapeutics. 5th ed. Ames, Iowa: Iowa State University Press, 1982., p. 640

    /Ortho/ phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine. In growing children, phosphate balance is positive. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/

    Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1524

    5.5 Metabolism/Metabolites

    Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues.

    5.6 Biological Half-Life

    In healthy children with phosphate overdose, half-life was 4.8 to 10.6 hours, and was prolonged to 17 hours in a child with renal insufficiency.

    5.7 Mechanism of Action

    Once phosphate gains access to the body fluids and tissues, it exerts little pharmacological effect. If the ion is introduced into the intestine, the absorbed phosphate is rapidly excreted. If large amounts are given by this route, much of it may escape absorption. Because this property leads to a cathartic action, phosphate salts are employed as mild laxatives.

    Once phosphate gains access to the body fluids and tissues, it exerts little pharmacological effect. If the ion is introduced into the intestine, the absorbed phosphate is rapidly excreted. If large amounts are given by this route, much of it may escape absorption. Because this property leads to a cathartic action, phosphate salts are employed as mild laxatives. Inorganic phosphate poisoning following ingestion of laxatives that contain phosphate salts has been reported in adults and children. Ingestion of large amounts of sodium dihydrogen phosphate lowers urinary pH. If excessive phosphate salts are introduced intravenously or orally, they may prove toxic by reducing the concentration of Ca 2+ in the circulation and from the precipitation of calcium phosphate in soft tissues. /Phosphates/

    Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1525

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ESTILL, S.C. 29918SDNF UNITED STATES","customerAddress":"28\/A, IDA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727807400,"product":"POTASSIUM PHOSPHATE TRIBASIC ANHYDROUS","address":"28\/A, IDA,","city":"HYDERABAD, AP","supplier":"OAKWOOD PRODUCTS INC","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK","customer":"ARAGEN LIFE SCIENCES LIMITED","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"45.6","totalValueFC":"274","currency":"USD","unitRateINR":"4605","date":"02-Oct-2024","totalValueINR":"23025.16","totalValueInUsd":"274","indian_port":"Bangalore Air","hs_no":"29339990","bill_no":"5911743","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"730 COLUMBIA HWY, N. ESTILL, S,C 29 918 USA SDNF UNITED STATES","customerAddress":"28\/A, IDA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728585000,"product":"DIPOTASSIUM HYDROGEN PHOSPHATE, USED IN MOLECULAR BIOLOGY, = 99.0% - CS-0160157 - 7758-11-4","address":"102\/12 KRISHNA GREENLAND PARK,KASA","city":"THANE,MAHARASHTRA","supplier":"SHANGHAI KAIXIN PHARMACEUTICALS CO.","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"JINAY PHARMACEUTICALS PRIVATE ","customerCountry":"INDIA","quantity":"0.55","actualQuantity":"550","unit":"GMS","unitRateFc":"0","totalValueFC":"20.9","currency":"USD","unitRateINR":"3.2","date":"11-Oct-2024","totalValueINR":"1756.38","totalValueInUsd":"20.9","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"6076934","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":",LTD ROOM 502,5\/F NO.2 BUILDING 720 CAIL ZHANGJIANG HIGH-TECH PARK SHANGHAI CHINA","customerAddress":"102\/12 KRISHNA GREENLAND PARK,KASA"}]
    19-Mar-2021
    11-Oct-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - SOLUTION;INTRAVENOUS - 1.18GM/5ML (2...DOSAGE - SOLUTION;INTRAVENOUS - 1.18GM/5ML (236MG/ML);1.12GM/5ML (224MG/ML)

    USFDA APPLICATION NUMBER - 212832

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    DOSAGE - SOLUTION;INTRAVENOUS - 11.8GM/50ML (...DOSAGE - SOLUTION;INTRAVENOUS - 11.8GM/50ML (236MG/ML);11.2GM/50ML (224MG/ML)

    USFDA APPLICATION NUMBER - 212832

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    DOSAGE - SOLUTION;INTRAVENOUS - 3.54GM/15ML (...DOSAGE - SOLUTION;INTRAVENOUS - 3.54GM/15ML (236MG/ML);3.36GM/15ML (224MG/ML)

    USFDA APPLICATION NUMBER - 212832

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