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Chemistry

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Also known as: 88-12-0, 1-vinylpyrrolidin-2-one, N-vinylpyrrolidone, 1-vinyl-2-pyrrolidone, N-vinyl-2-pyrrolidinone, Polyvinylpyrrolidone
Molecular Formula
C6H9NO
Molecular Weight
111.14  g/mol
InChI Key
WHNWPMSKXPGLAX-UHFFFAOYSA-N
FDA UNII
76H9G81541

Povidone API
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. See [povidone] for full details.
1 2D Structure

Povidone API

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-ethenylpyrrolidin-2-one
2.1.2 InChI
InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
2.1.3 InChI Key
WHNWPMSKXPGLAX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C=CN1CCCC1=O
2.2 Other Identifiers
2.2.1 UNII
76H9G81541
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-vinyl-2-pyrrolidone

2. N- Vinyl Pyrrolidone

3. N-vinyl-2-pyrrolidinone

4. N-vinylpyrrolidone

2.3.2 Depositor-Supplied Synonyms

1. 88-12-0

2. 1-vinylpyrrolidin-2-one

3. N-vinylpyrrolidone

4. 1-vinyl-2-pyrrolidone

5. N-vinyl-2-pyrrolidinone

6. Polyvinylpyrrolidone

7. Vinylpyrrolidone

8. 9003-39-8

9. 1-vinyl-2-pyrrolidinone

10. Povidone

11. 2-pyrrolidinone, 1-ethenyl-

12. 1-ethenylpyrrolidin-2-one

13. N-vinylpyrrolidinone

14. Polyvidone

15. 1-vinylpyrrolidone

16. Vinylbutyrolactam

17. Plasdone

18. Vinylpyrrolidinone

19. V-pyrol

20. Luviskol

21. 1-vinylpyrrolidinone

22. Vinyl-2-pyrrolidone

23. 25249-54-1

24. Polyclar At

25. N-vinyl Pyrrolidone

26. 1-ethenyl-2-pyrrolidinone

27. N-vinylpyrrolidone-2

28. 2-pyrrolidinone, 1-vinyl-

29. Poly(n-vinylpyrrolidone)

30. 1-vinyl-2-pyrrolidinone, Monomer

31. Poly(1-vinyl-2-pyrrolidone)

32. Pvp 40

33. Pvp

34. Nsc 10222

35. Mpk 90

36. 143 Rp

37. At 717

38. 1-vinyl-pyrrolidin-2-one

39. K 15

40. K 90

41. Pvp-40

42. Dtxsid2021440

43. Chebi:82551

44. Poly[1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl]

45. Mfcd00003197

46. Nsc-10222

47. 2-pyrrolidinone, 1-ethenyl-, Trimer

48. 2-pyrrolidinone, Polymers

49. 76h9g81541

50. Dsstox_cid_1440

51. Dsstox_rid_76160

52. Dsstox_gsid_21440

53. Wln: /t5nvtj Ay*1*/

54. Mfcd01076626

55. Cas-88-12-0

56. Polyvinylpyrrolidine

57. 109412-11-5

58. K 25

59. K 115

60. Hsdb 7231

61. Einecs 201-800-4

62. Polyvinylpyrrolidone K 90

63. Polyvinylpyrrolidone K-30

64. 2-pyrrolidinone, Polymers, Compd. With Aluminum Acetate

65. Brn 0110513

66. Ccris 8581

67. Povidonepvp

68. Vinyl Pyrrolidone

69. Polyvinylpyrrolidon

70. Poly[1-(2-oxo-1-pyrrolidinyl)-1, .alpha.-hydro-.omega.-[[4-(iodo-131i)phenyl]methyl]-

71. Unii-76h9g81541

72. N-vinyl-pyrrolidone

73. N -vinylpyrrolidinone

74. 1-vinyl-2-pyrrolidon

75. Povidone Monomer

76. Vinylbutylolactam

77. N-vinylpyrrolidin-2-one

78. N-vinyl Pyrrolidin-2-one

79. N-vinyl-pyrrolidin-2-one

80. Pvp K3o

81. Crospovidone ~40,000

82. Ec 201-800-4

83. Poly (n-vinyl Pyrrolidone)

84. Schembl10869

85. Wln: T5nvtj A1u1

86. Pvp K15

87. Pvp K30

88. Pvp-k30

89. Polyvinylpyrrolidone Pvp K30

90. Povidone Monomer [mi]

91. Vinyl Pyrrolidone (vp)

92. Poly(1-vinylpyrrolidin-2-one)

93. Chembl1878943

94. Pvp - K-30 (pharm Grade)

95. Polyvinylpyrrolidone, Cross Linked

96. N-vinyl Pyrrolidone [inci]

97. 1-vinyl-2-pyrrolidone(stabilized With 200ppm Ammonium Hydroxide)

98. Nsc10222

99. Zinc3590964

100. Polyvinylpyrrolidone, M.w. 8,000

101. Tox21_202462

102. Tox21_300073

103. Nsc114022

104. Nsc142693

105. Nsc683040

106. N-vinyl-2-pyrrolidone, Optical Grade

107. Polyvinylpyrrolidone (mw ~40,000)

108. Polyvinylpyrrolidone, M.w. 10.000

109. Polyvinylpyrrolidone, M.w. 40.000

110. Polyvinylpyrrolidone, M.w. 58,000

111. Akos000119985

112. N-vinyl-2-pyrrolidone [iarc]

113. At18510

114. Cs-w020981

115. Fg-0420

116. Nsc-114022

117. Nsc-142693

118. Nsc-683040

119. Polyvinylpyrrolidone, M.w. 360.000

120. Ncgc00166252-01

121. Ncgc00166252-02

122. Ncgc00166252-03

123. Ncgc00254200-01

124. Ncgc00260011-01

125. Polyvinylpyrrolidone, M.w. 1,300,000

126. 2-pyrrolidinone, 1-ethenyl-[hsdb]

127. Ft-0608329

128. Ft-0645144

129. Ft-0655284

130. V0026

131. C19548

132. A817742

133. A843417

134. Poly(n-vinyl-2-pyrrolidone) (low M.wt.)

135. Q420628

136. Sr-01000944531

137. J-015891

138. Sr-01000944531-1

139. W-100417

140. 1-vinyl-2-pyrrolidinone, Saj First Grade, >=99.0%

141. F8881-5579

142. 3-chloro-5,6-difluoro-1-benzothiophene-2-carbonylchloride

143. 1-vinyl-2-pyrrolidinone, Contains Sodium Hydroxide As Inhibitor, >=99%

144. 1-vinyl-2-pyrrolidinone, Pharmaceutical Secondary Standard; Certified Reference Material

145. 1-vinyl-2-pyrrolidone (stabilized With N,n'-di-sec-butyl-p-phenylenediamine)

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 111.14 g/mol
Molecular Formula C6H9NO
XLogP30.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Exact Mass111.068413911 g/mol
Monoisotopic Mass111.068413911 g/mol
Topological Polar Surface Area20.3 Ų
Heavy Atom Count8
Formal Charge0
Complexity120
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Pharmaceutic Aids; Plasma Substitutes

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


CLINICAL INDICATIONS: ...FOR ALL PATHOLOGICAL CONDITIONS WHERE THERE IS DECR IN MASS OF LIQ BLOOD: SHOCK STATE... HEMORRHAGE...SERIOUS BURNS. ANTHREPSIA & NEURO-TOXICOSES OF INFANTS.

Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968., p. 292


...HAS BEEN USED IN A...SERIES OF PATIENTS TO REPLACE THE AQ HUMOR AFTER EXTRACTION OF CATARACTS, CORNEAL TRANSPLANTS, & ANTIGLAUCOMA OPERATIONS.

Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 758


4.2 Minimum/Potential Fatal Human Dose

1. 1= PRACTICALLY NONTOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) ABOVE 15 G/KG, MORE THAN 1 QUART (2.2 LB) FOR 70 KG PERSON (150 LB).

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-245


4.3 Drug Indication

When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.


When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Povidone itself has no microbicidal activity. [DB06812] exhibits rapid, potent, broad-spectrum antimicrobial properties. The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application.


Povidone itself has no microbicidal activity. [Povidone-iodine] exhibits rapid, potent, broad-spectrum antimicrobial properties. The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application.


5.2 MeSH Pharmacological Classification

Biocompatible Materials

Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function. (See all compounds classified as Biocompatible Materials.)


5.3 Absorption, Distribution and Excretion

Absorption

This pharmacokinetic data does not apply to povidone.


Route of Elimination

This pharmacokinetic data does not apply to povidone.


Volume of Distribution

This pharmacokinetic data does not apply to povidone.


Clearance

This pharmacokinetic data does not apply to povidone.


Absorption

This pharmacokinetic data does not apply to povidone.


Route of Elimination

This pharmacokinetic data does not apply to povidone.


Volume of Distribution

This pharmacokinetic data does not apply to povidone.


Clearance

This pharmacokinetic data does not apply to povidone.


WHEN GIVEN PARENTERALLY, UNEXCRETED PARTICLES ARE PHAGOCYTIZED BY CELLS OF RETICULOENDOTHELIAL SYSTEM & DEPOSITED IN STORAGE SITES IN LIVER, SPLEEN, LUNG, BONE MARROW...

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-245


...30-40% OF SUBTOSAN PASSES INTO THE URINE IN THE FIRST 24 HR & ABOUT 50% IN THE FIRST 2 DAYS. ...SMALLEST MOLECULES ARE...FIRST & MOST RAPIDLY EXCRETED. IT TAKES 10 DAYS AFTER PERFUSION FOR 80% OF AMT INJECTED TO BE ELIMINATED.

Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968., p. 292


INTERMEDIATE MOLECULR WT PARTICLES MAY BE SLOWLY EXCRETED OVER SEVERAL MONTHS TO A YR.

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-245


IN GROUPS OF RATS FED DIETS CONTAINING 1 & 10% PVP (MOLECULAR WEIGHT 38,000) FOR 2 YEARS...THERE WAS NO EVIDENCE THAT PVP WAS ABSORBED FROM THE INTESTINAL TRACT.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V19 471


For more Absorption, Distribution and Excretion (Complete) data for POLYVINYLPYRROLIDONE (6 total), please visit the HSDB record page.


5.4 Metabolism/Metabolites

This pharmacokinetic data does not apply to povidone.


This pharmacokinetic data does not apply to povidone.


PVP LABELLED WITH (14)C OR (131)I WAS NOT METABOLIZED TO ANY SIGNIFICANT DEGREE BY RATS, RABBITS OR DOGS FOLLOWING ITS IV INJECTION.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V19 472


5.5 Biological Half-Life

This pharmacokinetic data does not apply to povidone.


This pharmacokinetic data does not apply to povidone.


5.6 Mechanism of Action

Povidone-iodine is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen. Please refer to the drug entry for [DB06812] for the full mechanism of action of the complex.


Povidone-iodine is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen. Please refer to the drug entry for [Povidone-iodine] for the full mechanism of action of the complex.


ONE OF MAJOR PROPERTIES OF PVP IS ITS PHYSIO-CHEMICAL BEHAVIOR, WHICH IS... COMPARABLE TO THAT OF SERUM ALBUMEN... THUS IT FIXES & TRANSPORTS WATER AS WELL AS THE PRODUCTS FIXED BY SERUM ALBUMEN... IT CAN ALSO CARRY SUCH SUBSTANCES AS UREA, CREATININE, LACTOFLAVIN, COLORING MATTERS, HORMONES, & GLUCOSE.

Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968., p. 290


API Reference Price

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WING, DELPHI,,HIRANANDA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727721000,"product":"140925000 N-VINYL-2-PYRROLIDONE, STABILIZED WITH NAOH, 99%","address":"403-404, B WING, DELPHI,,HIRANANDA","city":"MUMBAI,MAHARASHTRA","supplier":"ACROS OITOANLCS BVBA","supplierCountry":"BELGIUM","foreign_port":"BRUSSELS","customer":"THERMO FISHER SCIENTIFIC","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"LTR","unitRateFc":"98","totalValueFC":"125.8","currency":"USD","unitRateINR":"10570.1","date":"01-Oct-2024","totalValueINR":"10570.09","totalValueInUsd":"125.8","indian_port":"Hyderabad Air","hs_no":"29337990","bill_no":"5900198","productDescription":"API","marketType":"REGULATED MARKET","country":"BELGIUM","selfForZScoreResived":"Pharma Grade","supplierPort":"BRUSSELS","supplierAddress":"ENA23, ZONE 1, NR 1350 JANSSEN PHAR MACEUTICALAAN 3A B-2440 GEEL BTW-BE -0451.781.854 RPR TURNHOUT Brussel Belgium","customerAddress":"403-404, B WING, DELPHI,,HIRANANDA"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731868200,"product":"140925000 N-VINYL-2-PYRROLIDONE, STABILIZED WITH NAOH, 99%","address":"403-404, B WING, DELPHI,,HIRANANDA","city":"MUMBAI,MAHARASHTRA","supplier":"ACROS OITOANLCS BVBA","supplierCountry":"BELGIUM","foreign_port":"BRUSSELS","customer":"THERMO FISHER SCIENTIFIC","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"LTR","unitRateFc":"98","totalValueFC":"124.8","currency":"USD","unitRateINR":"10533.7","date":"18-Nov-2024","totalValueINR":"10533.74","totalValueInUsd":"124.8","indian_port":"Hyderabad Air","hs_no":"29337990","bill_no":"6741574","productDescription":"API","marketType":"REGULATED MARKET","country":"BELGIUM","selfForZScoreResived":"Pharma Grade","supplierPort":"BRUSSELS","supplierAddress":"ENA23, ZONE 1, NR 1350 JANSSEN PHAR MACEUTICALAAN 3A B-2440 GEEL BTW-BE -0451.781.854 RPR TURNHOUT Brussel Belgium","customerAddress":"403-404, B WING, DELPHI,,HIRANANDA"}]
09-Feb-2021
18-Nov-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

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Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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(USD/KGS)
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ABOUT THIS PAGE

Povidone API Manufacturers

A Povidone API manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Povidone API, including repackagers and relabelers. The FDA regulates Povidone API manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Povidone API API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Povidone API manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Povidone API Suppliers

A Povidone API supplier is an individual or a company that provides Povidone API active pharmaceutical ingredient (API) or Povidone API finished formulations upon request. The Povidone API suppliers may include Povidone API API manufacturers, exporters, distributors and traders.

click here to find a list of Povidone API suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Povidone API USDMF

A Povidone API DMF (Drug Master File) is a document detailing the whole manufacturing process of Povidone API active pharmaceutical ingredient (API) in detail. Different forms of Povidone API DMFs exist exist since differing nations have different regulations, such as Povidone API USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Povidone API DMF submitted to regulatory agencies in the US is known as a USDMF. Povidone API USDMF includes data on Povidone API's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Povidone API USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Povidone API suppliers with USDMF on PharmaCompass.

Povidone API CEP

A Povidone API CEP of the European Pharmacopoeia monograph is often referred to as a Povidone API Certificate of Suitability (COS). The purpose of a Povidone API CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Povidone API EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Povidone API to their clients by showing that a Povidone API CEP has been issued for it. The manufacturer submits a Povidone API CEP (COS) as part of the market authorization procedure, and it takes on the role of a Povidone API CEP holder for the record. Additionally, the data presented in the Povidone API CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Povidone API DMF.

A Povidone API CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Povidone API CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Povidone API suppliers with CEP (COS) on PharmaCompass.

Povidone API GMP

Povidone API Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Povidone API GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Povidone API GMP manufacturer or Povidone API GMP API supplier for your needs.

Povidone API CoA

A Povidone API CoA (Certificate of Analysis) is a formal document that attests to Povidone API's compliance with Povidone API specifications and serves as a tool for batch-level quality control.

Povidone API CoA mostly includes findings from lab analyses of a specific batch. For each Povidone API CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Povidone API may be tested according to a variety of international standards, such as European Pharmacopoeia (Povidone API EP), Povidone API JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Povidone API USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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