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Chemistry

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Also known as: Povorcitinib [inn], N0jwc7ro00, (s)-4-(3-(cyanomethyl)-3-(3',5'-dimethyl-1h,1'h-(4,4'-bipyrazol)-1-yl)azetidin-1-yl)-2,5-difluoro-n-(1,1,1-trifluoropropan-2-yl)benzamide, 1637677-22-5, 4-(3-(cyanomethyl)-3-(3',5'-dimethyl-1h,1'h-4,4'-bipyrazol-1-yl)azetidin-1-yl)-2,5-difluoro-n-((1s)-2,2,2-trifluoro-1-methylethyl)benzamide, 4-[3-(cyanomethyl)-3-(3',5'-dimethyl-1h,1'h-4,4'-bipyrazol-1-yl) azetidin-1-yl]-2,5-difluoro-n-[(1s)-2,2,2-trifluoro-1-methylethyl]benzamide
Molecular Formula
C23H22F5N7O
Molecular Weight
507.5  g/mol
InChI Key
MSGYSFWCPOBHEV-AWEZNQCLSA-N
FDA UNII
N0JWC7RO00

Povorcitinib
1 2D Structure

Povorcitinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[3-(cyanomethyl)-3-[4-(3,5-dimethyl-1H-pyrazol-4-yl)pyrazol-1-yl]azetidin-1-yl]-2,5-difluoro-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzamide
2.1.2 InChI
InChI=1S/C23H22F5N7O/c1-12-20(13(2)33-32-12)15-8-30-35(9-15)22(4-5-29)10-34(11-22)19-7-17(24)16(6-18(19)25)21(36)31-14(3)23(26,27)28/h6-9,14H,4,10-11H2,1-3H3,(H,31,36)(H,32,33)/t14-/m0/s1
2.1.3 InChI Key
MSGYSFWCPOBHEV-AWEZNQCLSA-N
2.1.4 Canonical SMILES
CC1=C(C(=NN1)C)C2=CN(N=C2)C3(CN(C3)C4=C(C=C(C(=C4)F)C(=O)NC(C)C(F)(F)F)F)CC#N
2.1.5 Isomeric SMILES
CC1=C(C(=NN1)C)C2=CN(N=C2)C3(CN(C3)C4=C(C=C(C(=C4)F)C(=O)N[C@@H](C)C(F)(F)F)F)CC#N
2.2 Other Identifiers
2.2.1 UNII
N0JWC7RO00
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Povorcitinib [inn]

2. N0jwc7ro00

3. (s)-4-(3-(cyanomethyl)-3-(3',5'-dimethyl-1h,1'h-(4,4'-bipyrazol)-1-yl)azetidin-1-yl)-2,5-difluoro-n-(1,1,1-trifluoropropan-2-yl)benzamide

4. 1637677-22-5

5. 4-(3-(cyanomethyl)-3-(3',5'-dimethyl-1h,1'h-4,4'-bipyrazol-1-yl)azetidin-1-yl)-2,5-difluoro-n-((1s)-2,2,2-trifluoro-1-methylethyl)benzamide

6. 4-[3-(cyanomethyl)-3-(3',5'-dimethyl-1h,1'h-4,4'-bipyrazol-1-yl) Azetidin-1-yl]-2,5-difluoro-n-[(1s)-2,2,2-trifluoro-1-methylethyl]benzamide

7. Benzamide, 4-(3-(cyanomethyl)-3-(3',5'-dimethyl(4,4'-bi-1h-pyrazol)-1-yl)-1-azetidinyl)-2,5-difluoro-n-((1s)-2,2,2-trifluoro-1-methylethyl)-

8. 4-[3-(cyanomethyl)-3-(3',5'-dimethyl-1h,1'h-4,4'-bipyrazol-1-yl)azetidin-1-yl]-2,5-difluoro-n-[(1s)-2,2,2-trifluoro-1-methylethyl]benzamide

9. Unii-n0jwc7ro00

10. Schembl16240136

11. Gtpl11881

12. Compound 7 [us20210238168a1]

13. Hy-145588

14. Cs-0376529

15. 4-[3-(cyanomethyl)-3-[4-(3,5-dimethyl-1h-pyrazol-4-yl)pyrazol-1-yl]azetidin-1-yl]-2,5-difluoro-n-[(2s)-1,1,1-trifluoropropan-2-yl]benzamide

2.4 Create Date
2014-12-08
3 Chemical and Physical Properties
Molecular Weight 507.5 g/mol
Molecular Formula C23H22F5N7O
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Exact Mass507.18059916 g/mol
Monoisotopic Mass507.18059916 g/mol
Topological Polar Surface Area103 Ų
Heavy Atom Count36
Formal Charge0
Complexity860
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Povorcitinib Manufacturers

A Povorcitinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Povorcitinib, including repackagers and relabelers. The FDA regulates Povorcitinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Povorcitinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Povorcitinib Suppliers

A Povorcitinib supplier is an individual or a company that provides Povorcitinib active pharmaceutical ingredient (API) or Povorcitinib finished formulations upon request. The Povorcitinib suppliers may include Povorcitinib API manufacturers, exporters, distributors and traders.

Povorcitinib GMP

Povorcitinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Povorcitinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Povorcitinib GMP manufacturer or Povorcitinib GMP API supplier for your needs.

Povorcitinib CoA

A Povorcitinib CoA (Certificate of Analysis) is a formal document that attests to Povorcitinib's compliance with Povorcitinib specifications and serves as a tool for batch-level quality control.

Povorcitinib CoA mostly includes findings from lab analyses of a specific batch. For each Povorcitinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Povorcitinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Povorcitinib EP), Povorcitinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Povorcitinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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