Find Poziotinib manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

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API

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FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

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FDF Dossiers

FDF Dossiers

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

DIGITAL CONTENT

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Stock Recap #PipelineProspector

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Weekly News Recap #Phispers

GLOBAL SALES INFORMATION

US Medicaid

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Finished Drug Prices

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0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 1092364-38-9, Hm781-36b, Nov120101, Unii-oei6oou6ik, Poziotinib [inn], Nov-120101
Molecular Formula
C23H21Cl2FN4O3
Molecular Weight
491.3  g/mol
InChI Key
LPFWVDIFUFFKJU-UHFFFAOYSA-N
FDA UNII
OEI6OOU6IK

Poziotinib
Poziotinib is an orally bioavailable, quinazoline-based, irreversible pan-epidermal growth factor receptor (EGFR or HER) inhibitor, with potential antineoplastic activity. Upon oral administration, poziotinib inhibits EGFR (HER1 or ErbB1), HER2 and HER4, thereby inhibiting proliferation of tumor cells in which these receptors are overexpressed and/or mutated. EGFRs, cell surface receptor tyrosine kinases upregulated or mutated in a variety of cancer cell types, play key roles in cellular proliferation and survival.
1 2D Structure

Poziotinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one
2.1.2 InChI
InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)
2.1.3 InChI Key
LPFWVDIFUFFKJU-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C
2.2 Other Identifiers
2.2.1 UNII
OEI6OOU6IK
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Hm781-36

2. Hm781-36b

2.3.2 Depositor-Supplied Synonyms

1. 1092364-38-9

2. Hm781-36b

3. Nov120101

4. Unii-oei6oou6ik

5. Poziotinib [inn]

6. Nov-120101

7. Hm-781-36b

8. Poziotinib [usan]

9. 1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one

10. 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one

11. Oei6oou6ik

12. Hm-781-36

13. Nov-1201

14. Mfcd28044290

15. Hm 781-36b

16. 1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one

17. 2-propen-1-one, 1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-

18. 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one

19. 1-[4-({4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]prop-2-en-1-one

20. 2-propen-1-one, 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxy-6-quinazolinyl)oxy)-1-piperidinyl)-

21. Hm-78136b

22. Poziotinib [who-dd]

23. C23h21cl2fn4o3

24. Poziotinib (hm781-36b)

25. Gtpl7903

26. Schembl3391764

27. Chembl3545154

28. Dtxsid80148853

29. Ex-a528

30. Hms3673k03

31. Amy24248

32. Bcp08270

33. Who 9736

34. Bdbm50468247

35. Nsc783296

36. Nsc800856

37. S7358

38. Zinc95930125

39. Akos026674078

40. Ccg-264748

41. Cs-3942

42. Db12114

43. Nov 120101

44. Nsc-783296

45. Nsc-800856

46. Sb16882

47. Ncgc00386427-01

48. Ncgc00386427-02

49. Ac-29021

50. As-74851

51. Bp161454

52. Da-47945

53. Hy-15730

54. Sy235762

55. Hm 781-36

56. Ft-0752903

57. A13044

58. J-690026

59. Q27088426

60. 1-(4-((4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl)oxy(piperidin-1-yl)prop-2-en-1-one

61. 1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazoline-6-yloxy]-1-piperidinyl]-2-propene-1-one

2.4 Create Date
2009-01-19
3 Chemical and Physical Properties
Molecular Weight 491.3 g/mol
Molecular Formula C23H21Cl2FN4O3
XLogP35.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass490.0974741 g/mol
Monoisotopic Mass490.0974741 g/mol
Topological Polar Surface Area76.6 Ų
Heavy Atom Count33
Formal Charge0
Complexity684
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1092364-38-9 / Poziotinib API manufacturers, exporters & distributors?

Poziotinib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Poziotinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Poziotinib manufacturer or Poziotinib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Poziotinib manufacturer or Poziotinib supplier.

PharmaCompass also assists you with knowing the Poziotinib API Price utilized in the formulation of products. Poziotinib API Price is not always fixed or binding as the Poziotinib Price is obtained through a variety of data sources. The Poziotinib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Poziotinib

Synonyms

1092364-38-9, Hm781-36b, Nov120101, Unii-oei6oou6ik, Poziotinib [inn], Nov-120101

Cas Number

1092364-38-9

Unique Ingredient Identifier (UNII)

OEI6OOU6IK

About Poziotinib

Poziotinib is an orally bioavailable, quinazoline-based, irreversible pan-epidermal growth factor receptor (EGFR or HER) inhibitor, with potential antineoplastic activity. Upon oral administration, poziotinib inhibits EGFR (HER1 or ErbB1), HER2 and HER4, thereby inhibiting proliferation of tumor cells in which these receptors are overexpressed and/or mutated. EGFRs, cell surface receptor tyrosine kinases upregulated or mutated in a variety of cancer cell types, play key roles in cellular proliferation and survival.

Poziotinib Manufacturers

A Poziotinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Poziotinib, including repackagers and relabelers. The FDA regulates Poziotinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Poziotinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Poziotinib manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Poziotinib Suppliers

A Poziotinib supplier is an individual or a company that provides Poziotinib active pharmaceutical ingredient (API) or Poziotinib finished formulations upon request. The Poziotinib suppliers may include Poziotinib API manufacturers, exporters, distributors and traders.

click here to find a list of Poziotinib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Poziotinib GMP

Poziotinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Poziotinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Poziotinib GMP manufacturer or Poziotinib GMP API supplier for your needs.

Poziotinib CoA

A Poziotinib CoA (Certificate of Analysis) is a formal document that attests to Poziotinib's compliance with Poziotinib specifications and serves as a tool for batch-level quality control.

Poziotinib CoA mostly includes findings from lab analyses of a specific batch. For each Poziotinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Poziotinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Poziotinib EP), Poziotinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Poziotinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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