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Chemistry

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Also known as: Lcq-908, 956136-95-1, Lcq908, Pradigastat free acid, Lcq-908nxa, Lcq908-nxa
Molecular Formula
C25H24F3N3O2
Molecular Weight
455.5  g/mol
InChI Key
GXALXAKNHIROPE-UHFFFAOYSA-N
FDA UNII
2U23G6VNUZ

Pradigastat
Pradigastat has been used in trials studying the treatment of Non-alcoholic Fatty Liver Disease (NAFLD).
1 2D Structure

Pradigastat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-[4-[5-[[6-(trifluoromethyl)pyridin-3-yl]amino]pyridin-2-yl]phenyl]cyclohexyl]acetic acid
2.1.2 InChI
InChI=1S/C25H24F3N3O2/c26-25(27,28)23-12-10-21(15-30-23)31-20-9-11-22(29-14-20)19-7-5-18(6-8-19)17-3-1-16(2-4-17)13-24(32)33/h5-12,14-17,31H,1-4,13H2,(H,32,33)
2.1.3 InChI Key
GXALXAKNHIROPE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)C3=NC=C(C=C3)NC4=CN=C(C=C4)C(F)(F)F
2.2 Other Identifiers
2.2.1 UNII
2U23G6VNUZ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Lcq908

2.3.2 Depositor-Supplied Synonyms

1. Lcq-908

2. 956136-95-1

3. Lcq908

4. Pradigastat Free Acid

5. Lcq-908nxa

6. Lcq908-nxa

7. Lcq-908-nxa

8. 2u23g6vnuz

9. Lcq908 - Dgat-1-inhibitor

10. 956136-95-1 (free Acid)

11. Pradigastat (usan)

12. Lcq 908

13. Pradigastat [usan]

14. 2-((1s,4s)-4-(4-(5-((6-(trifluoromethyl)pyridin-3-yl)amino)pyridin-2-yl)phenyl)cyclohexyl)acetic Acid

15. 2-[4-[4-[5-[[6-(trifluoromethyl)pyridin-3-yl]amino]pyridin-2-yl]phenyl]cyclohexyl]acetic Acid

16. 2-{4-[4-(5-{[6-(trifluoromethyl)pyridin-3-yl]amino}pyridin-2-yl)phenyl]cyclohexyl}acetic Acid

17. Pradigastat [inn]

18. Pradigastat [usan:inn]

19. Unii-2u23g6vnuz

20. Lcq 908nxa

21. Schembl180536

22. Gtpl7830

23. Schembl1289309

24. Chembl2364624

25. Schembl16104874

26. Schembl18286769

27. Dtxsid401026085

28. Bcp21089

29. Lcq908; Lcq 908; Pradigastat

30. Bdbm50502586

31. Zinc253387875

32. Cs-1222

33. Db12866

34. Sb16971

35. Ncgc00378933-01

36. Ncgc00378933-02

37. Hy-16278

38. Db-125833

39. D10664

40. A900338

41. Q27088438

42. (4-{4-[5-(6-trifluoromethyl-pyridin-3-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic Acid

43. Cyclohexaneacetic Acid, 4-(4-(5-((6-(trifluoromethyl)-3-pyridinyl)amino)-2-pyridinyl)phenyl)-, Trans-

44. Lcq-908; Trans-4-[4-[5-[[6-(trifluoromethyl)-3-pyridinyl]amino]-2-pyridinyl]phenyl]cyclohexaneacetic Acid;lcq-908

45. Trans-4-[4-[5-[[6-(trifluoromethyl)-3-pyridinyl]amino]-2-pyridinyl]phenyl]cyclohexaneacetic Acid

2.4 Create Date
2011-10-17
3 Chemical and Physical Properties
Molecular Weight 455.5 g/mol
Molecular Formula C25H24F3N3O2
XLogP35.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass455.18206150 g/mol
Monoisotopic Mass455.18206150 g/mol
Topological Polar Surface Area75.1 Ų
Heavy Atom Count33
Formal Charge0
Complexity631
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of familial chylomicronaemia syndrome (type I hyperlipoproteinaemia


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Looking for 956136-95-1 / Pradigastat API manufacturers, exporters & distributors?

Pradigastat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Pradigastat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pradigastat manufacturer or Pradigastat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Pradigastat manufacturer or Pradigastat supplier.

PharmaCompass also assists you with knowing the Pradigastat API Price utilized in the formulation of products. Pradigastat API Price is not always fixed or binding as the Pradigastat Price is obtained through a variety of data sources. The Pradigastat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Pradigastat

Synonyms

Lcq-908, 956136-95-1, Lcq908, Pradigastat free acid, Lcq-908nxa, Lcq908-nxa

Cas Number

956136-95-1

Unique Ingredient Identifier (UNII)

2U23G6VNUZ

About Pradigastat

Pradigastat has been used in trials studying the treatment of Non-alcoholic Fatty Liver Disease (NAFLD).

Pradigastat Manufacturers

A Pradigastat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pradigastat, including repackagers and relabelers. The FDA regulates Pradigastat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pradigastat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Pradigastat Suppliers

A Pradigastat supplier is an individual or a company that provides Pradigastat active pharmaceutical ingredient (API) or Pradigastat finished formulations upon request. The Pradigastat suppliers may include Pradigastat API manufacturers, exporters, distributors and traders.

Pradigastat GMP

Pradigastat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pradigastat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pradigastat GMP manufacturer or Pradigastat GMP API supplier for your needs.

Pradigastat CoA

A Pradigastat CoA (Certificate of Analysis) is a formal document that attests to Pradigastat's compliance with Pradigastat specifications and serves as a tool for batch-level quality control.

Pradigastat CoA mostly includes findings from lab analyses of a specific batch. For each Pradigastat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pradigastat may be tested according to a variety of international standards, such as European Pharmacopoeia (Pradigastat EP), Pradigastat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pradigastat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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