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Prajmaline

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Prajmalium, N-propylajmaline, 35080-11-6, 75934ud4gj, Ajmalanium, 17,21-dihydroxy-4-propyl-, (17r,21-alpha)-, N-propylajmalinium

Molecular Formula

C₂₃H₃₃N₂O₂+

Molecular Weight

369.5 g/mol

InChI Key

UAUHEPXILIZYCU-ALHOSYKFSA-N

FDA UNII

75934UD4GJ

A derivative of the rauwolfia alkaloid AJMALINE. It is an anti-arrhythmia agent but may cause liver damage.

1 2D Structure

Prajmaline

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,9R,10S,12R,13S,14R,15R,16S,17S,18R)-13-ethyl-8-methyl-15-propyl-8-aza-15-azoniahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-14,18-diol

2.1.2 InChI

InChI=1S/C23H33N2O2/c1-4-10-25-17-11-14(13(5-2)22(25)27)19-18(25)12-23(21(19)26)15-8-6-7-9-16(15)24(3)20(17)23/h6-9,13-14,17-22,26-27H,4-5,10-12H2,1-3H3/q+1/t13-,14-,17-,18-,19-,20-,21+,22+,23+,25-/m0/s1

2.1.3 InChI Key

UAUHEPXILIZYCU-ALHOSYKFSA-N

2.1.4 Canonical SMILES

CCC[N+]12C3CC(C(C1O)CC)C4C2CC5(C3N(C6=CC=CC=C65)C)C4O

2.1.5 Isomeric SMILES

CCC[N@@+]12[C@H]3C[C@@H]([C@@H]([C@H]1O)CC)[C@H]4[C@@H]2C[C@@]5([C@H]3N(C6=CC=CC=C65)C)[C@@H]4O

2.2 Other Identifiers

2.2.1 UNII

75934UD4GJ

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bitartrate, Prajmaline

2. Bitartrate, Prajmalium

3. N-propylajmaline

4. Neo Gilurytmal

5. Neo-gilurytmal

6. Neogilurytmal

7. Prajmaline Bitartrate

8. Prajmalium

9. Prajmalium Bitartrate

2.3.2 Depositor-Supplied Synonyms

1. Prajmalium

2. N-propylajmaline

3. 35080-11-6

4. 75934ud4gj

5. Ajmalanium, 17,21-dihydroxy-4-propyl-, (17r,21-alpha)-

6. N-propylajmalinium

7. Prajmalium Ion

8. Prajmalium Cation

9. Prajmalum

10. N(sup 4)-propylajmalinium

11. Unii-75934ud4gj

12. Prajmaline [mi]

13. Prajmalium [who-dd]

14. (17r,21-alpha)-17,21-dihydroxy-4-propylajmalanium

15. Chebi:135560

16. Zinc252462538

17. Db13555

18. Q7238143

19. Ajmalanine, 17,21-dihydroxy-4-propyl-, (17r,21.alpha.)-

20. (1r,9r,10s,12r,13s,14r,15r,16s,17s,18r)-13-ethyl-8-methyl-15-propyl-8-aza-15-azoniahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-14,18-diol

2.4 Create Date

2014-08-25

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₃₃N₂O₂+
Molecular Weight	369.5 g/mol
XLogP3	2.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	369.254203300 g/mol
Monoisotopic Mass	369.254203300 g/mol
Topological Polar Surface Area	43.7 Å²
Heavy Atom Count	27
Formal Charge	1
Complexity	642
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

4.2 ATC Code

C - Cardiovascular system

C01 - Cardiac therapy

C01B - Antiarrhythmics, class i and iii

C01BA - Antiarrhythmics, class ia

C01BA08 - Prajmaline

ABOUT THIS PAGE

Prajmaline Manufacturers

A Prajmaline manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Prajmaline, including repackagers and relabelers. The FDA regulates Prajmaline manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Prajmaline API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Prajmaline Suppliers

A Prajmaline supplier is an individual or a company that provides Prajmaline active pharmaceutical ingredient (API) or Prajmaline finished formulations upon request. The Prajmaline suppliers may include Prajmaline API manufacturers, exporters, distributors and traders.

Prajmaline GMP

Prajmaline Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Prajmaline GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Prajmaline GMP manufacturer or Prajmaline GMP API supplier for your needs.

Prajmaline CoA

A Prajmaline CoA (Certificate of Analysis) is a formal document that attests to Prajmaline's compliance with Prajmaline specifications and serves as a tool for batch-level quality control.

Prajmaline CoA mostly includes findings from lab analyses of a specific batch. For each Prajmaline CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Prajmaline may be tested according to a variety of international standards, such as European Pharmacopoeia (Prajmaline EP), Prajmaline JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Prajmaline USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.