1. Centrax
2. Demetrin
3. Lysanxia
4. Mono Demetrin
5. Reapam
1. Demetrin
2. Lysanxia
3. Centrax
4. Trepidan
5. Verstran
6. 2955-38-6
7. Prazepamum [inn-latin]
8. W 4020
9. K-373
10. Prazepam Civ
11. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-
12. Nsc 277179
13. 7-chloro-1-(cyclopropylmethyl)-5-phenyl-3h-1,4-benzodiazepin-2-one
14. 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-2h-1,4-benzodiazepin-2-one
15. W-4020
16. Nsc-277179
17. 7-chloro-1-cyclopropylmethyl-5-phenyl-1h-1,4-benzodiazepin-2(3h)-one
18. Chebi:8362
19. Q30vcc064m
20. Prazene
21. Sedapran
22. 7-chloro-1-(cyclopropylmethyl)-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one
23. Ncgc00168256-01
24. Prazeene
25. Prazepamum
26. Settima
27. Dsstox_cid_1181
28. 2h-1,4-benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(cyclopropylmethyl)-5-phenyl-
29. Dsstox_rid_75994
30. Dsstox_gsid_21181
31. 7-chloro-1-(cyclopropylmethyl)-5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-2-one
32. Centrax (tn)
33. Cas-2955-38-6
34. Einecs 220-975-8
35. Brn 0895797
36. Unii-q30vcc064m
37. Dea No. 2764
38. Prazepam [usan:usp:inn:ban:jan]
39. Prazepam [iarc]
40. Prazepam [usan]
41. Prazepam [inn]
42. Prazepam [jan]
43. Prazepam [mi]
44. Prazepam [vandf]
45. Prazepam [mart.]
46. Chembl969
47. Prazepam [who-dd]
48. Schembl78272
49. Mls003899231
50. Prazepam [orange Book]
51. Prazepam Civ [usp-rs]
52. Gtpl7275
53. Prazepam (jp17/usan/inn)
54. Zinc1971
55. Prazepam [ep Monograph]
56. Dtxsid4021181
57. Prazepam 0.1 Mg/ml In Methanol
58. Prazepam 1.0 Mg/ml In Methanol
59. Tox21_112615
60. Tox21_200076
61. Nsc277179
62. Prazepam 1000 Microg/ml In Methanol
63. Db01588
64. Ncgc00168256-02
65. Ncgc00257630-01
66. Smr000058725
67. Db-047601
68. C07366
69. D00470
70. Wln: T67 Gnv Jn Ihj Cg Kr& G1- Al3tj
71. Q2149443
72. 7-chloro-1-(cyclopropylmethyl)-1,4-benzodiazepin-2-one
73. Prazepam, European Pharmacopoeia (ep) Reference Standard
74. 2h-1, 1,3-dihydro-7-chloro-1-(cyclopropylmethyl)-5-phenyl-
75. 2h-1, 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-
76. Prazepam, United States Pharmacopeia (usp) Reference Standard
77. 7-chloro-1-(cyclopropylmethyl)-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one #
78. Prazepam Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material
| Molecular Weight | 324.8 g/mol |
|---|---|
| Molecular Formula | C19H17ClN2O |
| XLogP3 | 3.6 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 3 |
| Exact Mass | 324.1029409 g/mol |
| Monoisotopic Mass | 324.1029409 g/mol |
| Topological Polar Surface Area | 32.7 Ų |
| Heavy Atom Count | 23 |
| Formal Charge | 0 |
| Complexity | 482 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the treatment of anxiety disorders.
Prazepam is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant activity. Benzodiazepines may be habit-forming (causing mental or physical dependence), especially when taken for a long time or in high doses.
Anti-Anxiety Agents
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)
GABA Modulators
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)
N05BA11
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
N - Nervous system
N05 - Psycholeptics
N05B - Anxiolytics
N05BA - Benzodiazepine derivatives
N05BA11 - Prazepam
Hepatic.
36-200 hours
Prazepam is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation.
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